3-methyl-2-oxovalerate (BioDeep_00000229621)

Main id: BioDeep_00000265241

 

human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019 natural product


代谢物信息卡片


(3S)-3-Methyl-2-oxopentanoic acid

化学式: C6H10O3 (130.063)
中文名称: 3-甲基-2-氧代戊酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C(=O)C(=O)O
InChI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)

描述信息

3-Methyl-2-oxovaleric acid is a neurotoxin, an acidogen, and a metabotoxin, and also an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids.

同义名列表

4 个代谢物同义名

(3S)-3-Methyl-2-oxopentanoic acid; 3-methyl-2-oxovalerate; 3-Methyl-2-oxovaleric acid; 3-Methyl-2-oxopentanoate



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 BCAT1, CASP3, CAT, CIT, CRYZ, GCK
Peripheral membrane protein 2 ACHE, GCK
Endoplasmic reticulum membrane 2 PGAP2, PSEN1
Nucleus 5 ACHE, CASP3, CS, GCK, PSEN1
cytosol 8 BCAT1, CASP3, CAT, CIT, CRYZ, GCK, GHR, GPT
dendrite 1 PSEN1
centrosome 2 PSEN1, SLC16A1
nucleoplasm 4 BCAT2, CASP3, GCK, PSEN1
Cell membrane 4 ACHE, GHR, PSEN1, SLC16A1
Cell projection, axon 1 PSEN1
Cell projection, growth cone 1 PSEN1
Cytoplasmic granule 1 PSEN1
Early endosome membrane 1 PSEN1
Multi-pass membrane protein 3 PGAP2, PSEN1, SLC16A1
Golgi apparatus membrane 3 GCK, PGAP2, PSEN1
Synapse 3 ACHE, PSEN1, SLC16A1
cell cortex 1 PSEN1
cell junction 2 PSEN1, SLC16A1
cell surface 4 ACHE, ADIPOQ, GHR, PSEN1
ciliary rootlet 1 PSEN1
dendritic shaft 1 PSEN1
gamma-secretase complex 1 PSEN1
glutamatergic synapse 2 CASP3, PSEN1
Golgi apparatus 2 ACHE, PSEN1
Golgi membrane 4 GCK, INS, PGAP2, PSEN1
growth cone 1 PSEN1
lysosomal membrane 1 PSEN1
mitochondrial inner membrane 1 PSEN1
neuromuscular junction 2 ACHE, PSEN1
neuronal cell body 3 CASP3, GHR, PSEN1
postsynapse 1 PSEN1
presynaptic membrane 1 PSEN1
sarcolemma 1 PSEN1
smooth endoplasmic reticulum 1 PSEN1
synaptic vesicle 1 PSEN1
plasma membrane 6 ACHE, GCG, GHR, KNG1, PSEN1, SLC16A1
Membrane 8 ACHE, CAT, CIT, CS, GHR, PGAP2, PSEN1, SLC16A1
apical plasma membrane 1 SLC16A1
axon 1 PSEN1
basolateral plasma membrane 2 GCK, SLC16A1
extracellular exosome 6 CAT, CRYZ, CS, GPT, KNG1, SLC16A1
endoplasmic reticulum 2 ADIPOQ, PSEN1
extracellular space 7 ACHE, ADIPOQ, GCG, GHR, IGF1, INS, KNG1
perinuclear region of cytoplasm 1 ACHE
mitochondrion 7 BCAT1, BCAT2, CAT, CRYZ, CS, GCK, PSEN1
protein-containing complex 2 CAT, PSEN1
intracellular membrane-bounded organelle 2 CAT, SLC16A1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 GHR
Secreted 6 ACHE, ADIPOQ, GCG, GHR, IGF1, INS
extracellular region 8 ACHE, ADIPOQ, CAT, GCG, GHR, IGF1, INS, KNG1
Mitochondrion matrix 1 CS
mitochondrial matrix 3 BCAT2, CAT, CS
Extracellular side 1 ACHE
nuclear membrane 1 PSEN1
external side of plasma membrane 1 GHR
Early endosome 1 PSEN1
Apical cell membrane 1 SLC16A1
Membrane raft 1 PSEN1
focal adhesion 1 CAT
Peroxisome 1 CAT
basement membrane 1 ACHE
collagen trimer 1 ADIPOQ
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 2 ADIPOQ, KNG1
lateral plasma membrane 1 SLC16A1
nuclear outer membrane 1 PSEN1
receptor complex 1 GHR
Cell projection, neuron projection 1 PSEN1
neuron projection 1 PSEN1
cytoplasmic ribonucleoprotein granule 1 GHR
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
Basolateral cell membrane 2 GCK, SLC16A1
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 2]: Cell membrane 1 GHR
endosome lumen 1 INS
side of membrane 1 ACHE
basal plasma membrane 1 SLC16A1
exocytic vesicle 1 IGF1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 GCG, INS, KNG1
platelet alpha granule lumen 2 IGF1, KNG1
kinetochore 1 PSEN1
transport vesicle 1 INS
azurophil granule membrane 1 PSEN1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
aggresome 1 PSEN1
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
Rough endoplasmic reticulum 1 PSEN1
growth hormone receptor complex 1 GHR
[Glucagon-like peptide 1]: Secreted 1 GCG
catalase complex 1 CAT
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
[Growth hormone-binding protein]: Secreted 1 GHR
[Isoform H]: Cell membrane 1 ACHE


文献列表

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  • Cláudia Funchal, Patrícia Fernanda Schuck, André Quincozes Dos Santos, Maria Caroline Jacques-Silva, Carmem Gottfried, Regina Pessoa-Pureur, Moacir Wajner. Creatine and antioxidant treatment prevent the inhibition of creatine kinase activity and the morphological alterations of C6 glioma cells induced by the branched-chain alpha-keto acids accumulating in maple syrup urine disease. Cellular and molecular neurobiology. 2006 Feb; 26(1):67-79. doi: 10.1007/s10571-006-9098-9. [PMID: 16633902]
  • Cláudia Funchal, André Quincozes Dos Santos, Maria Caroline Jacques-Silva, Ariane Zamoner, Carmem Gottfried, Moacir Wajner, Regina Pessoa-Pureur. Branched-chain alpha-keto acids accumulating in maple syrup urine disease induce reorganization of phosphorylated GFAP in C6-glioma cells. Metabolic brain disease. 2005 Sep; 20(3):205-17. doi: 10.1007/s11011-005-7208-x. [PMID: 16167198]
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  • Cláudia Funchal, Carmem Gottfried, Lúcia Maria Vieira De Almeida, Moacir Wajner, Regina Pessoa-Pureur. Evidence that the branched-chain alpha-keto acids accumulating in maple syrup urine disease induce morphological alterations and death in cultured astrocytes from rat cerebral cortex. Glia. 2004 Nov; 48(3):230-40. doi: 10.1002/glia.20072. [PMID: 15390119]
  • Cláudia Funchal, Franciele Dall Bello Pessutto, Lúcia Maria Vieira de Almeida, Priscila de Lima Pelaez, Samanta Oliveira Loureiro, Lilian Vivian, Moacir Wajner, Regina Pessoa-Pureur. Alpha-keto-beta-methylvaleric acid increases the in vitro phosphorylation of intermediate filaments in cerebral cortex of young rats through the gabaergic system. Journal of the neurological sciences. 2004 Jan; 217(1):17-24. doi: 10.1016/j.jns.2003.08.003. [PMID: 14675604]
  • Vilson de Castro Vasques, Melissa Avila de Boer, Felipe Diligenti, Fabrício Brinco, Fabrício Mallmann, Carlos Fernando Mello, Moacir Wajner. Intrahippocampal administration of the alpha-keto acids accumulating in maple syrup urine disease provokes learning deficits in rats. Pharmacology, biochemistry, and behavior. 2004 Jan; 77(1):183-90. doi: 10.1016/j.pbb.2003.10.013. [PMID: 14724056]
  • Angela M Sgaravatti, Rafael B Rosa, Patrícia F Schuck, César A J Ribeiro, Clóvis M D Wannmacher, Angela T S Wyse, Carlos S Dutra-Filho, Moacir Wajner. Inhibition of brain energy metabolism by the alpha-keto acids accumulating in maple syrup urine disease. Biochimica et biophysica acta. 2003 Nov; 1639(3):232-8. doi: 10.1016/j.bbadis.2003.09.010. [PMID: 14636955]
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