bilirubin (BioDeep_00000229611)
Main id: BioDeep_00000407567
human metabolite
代谢物信息卡片
bilirubin
化学式: C33H36N4O6 (584.2634716)
中文名称: 胆红素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=CC1=C(C)C(=O)N/C/1=C\c1c(C)c(CCC(=O)O)c(Cc2c(CCC(=O)O)c(C)c(/C=C\3/C(=C(C=C)C(=O)N3)C)[nH]2)[nH]1
InChI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
描述信息
D020011 - Protective Agents > D000975 - Antioxidants
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:16990
- KEGG: C00486
- PubChem: 5280352
- HMDB: HMDB00054
- ChEMBL: CHEMBL501680
- MeSH: Bilirubin
- CAS: 93891-87-3
- CAS: 18422-02-1
- CAS: 635-65-4
- MoNA: MT000136
- PubChem: 3769
- KNApSAcK: C00029828
- PDB-CCD: BLR
- 3DMET: B01261
- NIKKAJI: J674.476A
- RefMet: Bilirubin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 4111 - Solanum melongena: 10.3358/SHOKUEISHI.37.5_295
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yusheng Zhao, Hui Kong, Yuru Li, Yafang Zhao, Yue Zhang, Yan Zhao, Huihua Qu. Inhibitory effects of Curcumae Radix carbonisata-based carbon dots against liver fibrosis induced by carbon tetrachloride in mice.
Artificial cells, nanomedicine, and biotechnology.
2024 Dec; 52(1):23-34. doi:
10.1080/21691401.2023.2239522. [PMID: 38035609] - Kazuya Ishikawa, Yutaka Kodama. Bilirubin Distribution in Plants at the Subcellular and Tissue Levels.
Plant & cell physiology.
2024 May; 65(5):762-769. doi:
10.1093/pcp/pcae017. [PMID: 38466577] - Yueying Zhao, Cheng Xi, Donghan Liu, Xiaoqiao Ren, Jiayi Fan, Jakkree Tangthianchaichana, Yang Lu, Huichao Wu. Chemical components with antibacterial properties found in sanchen powder from traditional Tibetan medicine.
Journal of ethnopharmacology.
2024 May; 326(?):117981. doi:
10.1016/j.jep.2024.117981. [PMID: 38417599] - Guillaume Feugray, Maximilien Grall, Cécile Dumesnil, Valéry Brunel, Ygal Benhamou, Muriel Quillard Muraine, Paul Billoir. Lipid and hemolysis parameters predicting acute chest syndrome in adulthood with sickle cell disease.
Lipids in health and disease.
2024 May; 23(1):140. doi:
10.1186/s12944-024-02135-8. [PMID: 38755670] - Shiming Song, Yanxia Gao, Shuai Feng, Zhipeng Cheng, Haibao Huang, Jingchuan Xue, Tao Zhang, Hongwen Sun. Widespread occurrence of two typical N, N'-substituted p-phenylenediamines and their quinones in humans: Association with oxidative stress and liver damage.
Journal of hazardous materials.
2024 Apr; 468(?):133835. doi:
10.1016/j.jhazmat.2024.133835. [PMID: 38394895] - Zhan Feng, Lan Chen, Qing Wu, Fan Xu, Qian Tong, Guofu Wang. Acute Helicobacter pylori infection prevalence and association with metabolic abnormality in general Chinese population: A retrospective study.
Medicine.
2024 Mar; 103(12):e37117. doi:
10.1097/md.0000000000037117. [PMID: 38518022] - Mingsu Zhu, Huan He, Dongdong Yu, Fengjing Geng, Mingwei Qu, Chaoping Yang. Prediction of prognosis in patients with ischemic stroke combined with type 2 diabetes mellitus based on serum total bilirubin levels.
Medicine.
2024 Mar; 103(12):e37468. doi:
10.1097/md.0000000000037468. [PMID: 38518031] - Q Wei, L Li, X Q Zeng, Bai He Ti Ya Er Abidan, J Yin, H Gao, J S Guo. [An analysis on clinical characteristics and prognosis-related risk factors in patients with drug-induced liver injury].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2024 Mar; 32(3):214-221. doi:
10.3760/cma.j.cn501113-20240201-00072. [PMID: 38584102] - Hui Han, Qingtao Yu, Nina Qin, Bin Song, Yan Meng, Zuojing Feng, Zhaoping Li, Liyong Chen. Non-linear associations of circulating total bilirubin concentration with the risk of nonalcoholic fatty liver disease and all-cause mortality.
Annals of hepatology.
2024 Mar; 29(2):101177. doi:
10.1016/j.aohep.2023.101177. [PMID: 37924867] - Junting Cao, Zhiguo Wen, Yunsheng Zhang, Bo Zhang, Ying Chen, Guangnan Xing, Yongbao Wu, Zhengkui Zhou, Xiaolin Liu, Shuisheng Hou. Effects of DHAV-3 infection on innate immunity, antioxidant capacity, and lipid metabolism in ducks with different DHAV-3 susceptibilities.
Poultry science.
2024 Mar; 103(3):103374. doi:
10.1016/j.psj.2023.103374. [PMID: 38295495] - Fanyuan Ma, Qian Zhang, Jinke Li, Liping Wu, Hua Zhang. Risk factors for post-cerebral infarction cognitive dysfunction in older adults: a retrospective study.
BMC neurology.
2024 Feb; 24(1):72. doi:
10.1186/s12883-024-03574-7. [PMID: 38378548] - Brian D Piccolo, Athena Chen, Samantha Louey, Kent L R Thornburg, Sonnet S Jonker. Physiological response to fetal intravenous lipid emulsion.
Clinical science (London, England : 1979).
2024 02; 138(3):117-134. doi:
10.1042/cs20231419. [PMID: 38261523] - Can Cao, Shuwu Wei, Leijuan He, Chunyao Li, Yizhen Lu, Weiwei Sun, Yaoxian Wang. Temporal alteration of serum bilirubin levels and its renoprotective effects in diabetic kidney disease: exploring the hormonal mechanisms.
Frontiers in endocrinology.
2024; 15(?):1361840. doi:
10.3389/fendo.2024.1361840. [PMID: 38756998] - Daniel B Rosoff, Andrew S Bell, Josephin Wagner, Lucas A Mavromatis, Ali Hamandi, Lauren Park, Jeesun Jung, Falk W Lohoff. Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries.
Cellular and molecular gastroenterology and hepatology.
2024; 17(1):29-40. doi:
10.1016/j.jcmgh.2023.09.001. [PMID: 37703945] - Alex Boye, Ernest Amponsah Asiamah, Orleans Martey, Frederick Ayertey. Citrus limon (L.) Osbeck Fruit Peel Extract Attenuates Carbon Tetrachloride-Induced Hepatocarcinogenesis in Sprague-Dawley Rats.
BioMed research international.
2024; 2024(?):6673550. doi:
10.1155/2024/6673550. [PMID: 38204757] - Xin Bai, Jing Qiao, Hong Zhang. Mildly elevated serum bilirubin and its correlations with lipid levels among male patients undergoing health checkups.
Lipids in health and disease.
2023 Dec; 22(1):213. doi:
10.1186/s12944-023-01979-w. [PMID: 38049818] - H Feng, Q S Yu, J X Wang, Y Y Yuan, W L Rao, X Liang, S S Yu, F S Wei. [Establishment and validation of nomogram prediction model for complicated acute appendicitis].
Zhonghua wai ke za zhi [Chinese journal of surgery].
2023 Dec; 61(12):1074-1079. doi:
10.3760/cma.j.cn112139-20230104-00005. [PMID: 37932143] - Bimei Hu, Linjie Xu, Xu Yang, Shiwen Qu, Lan Wu, Yumei Sun, Jun Yan, Yexiao Zhang, Zhaoer Yu, Yixiao Wang, Ruizhe Jia. Association between ambient air pollution exposure in pregnant women with antiphospholipid syndrome in Nanjing, China.
Environmental science and pollution research international.
2023 Nov; ?(?):. doi:
10.1007/s11356-023-29937-0. [PMID: 37910359] - Fangye Zhou, Min Huang, Guangjie Zhang. Coagulation profile of neonates with hyperbilirubinaemia in full-term newborns.
The Journal of international medical research.
2023 Nov; 51(11):3000605231207531. doi:
10.1177/03000605231207531. [PMID: 37917827] - Jialin Ren, Min Wu. Causal effects of genetically determined blood metabolites on multiple myeloma: a Mendelian randomization study.
Scientific reports.
2023 11; 13(1):18818. doi:
10.1038/s41598-023-45801-0. [PMID: 37914749] - Muhammad Sajid, Syed Atif Hasan Naqvi, Muhammad Riaz, Ummad Ud Din Umar, Nasreen Nasreen, Adil Khan, Mourad Ben Said. Molecular detection of Babesia ovis and blood parameters' investigation reveal hematological and biochemical alterations in babesiosis-infected Lohi sheep in Multan, Pakistan.
Open veterinary journal.
2023 Nov; 13(11):1400-1408. doi:
10.5455/ovj.2023.v13.i11.2. [PMID: 38107231] - Hang Zhao, Hongyang Tian. Icariin alleviates high-fat diet-induced nonalcoholic fatty liver disease via up-regulating miR-206 to mediate NF-κB and MAPK pathways.
Journal of biochemical and molecular toxicology.
2023 Oct; ?(?):e23566. doi:
10.1002/jbt.23566. [PMID: 37888945] - Hao Gao, Qian Zhao, Jian-Gang Song, Guo-Xia Hu, Wei-Feng Yu, Ying-Fu Jiao, Jin-Chao Song. Bilirubin potentiates etomidate-induced sedation by enhancing GABA-induced currents after bile duct ligation.
BMC pharmacology & toxicology.
2023 09; 24(1):46. doi:
10.1186/s40360-023-00675-w. [PMID: 37740245] - Swati Sharma, Vishal Sharma, Sunil Taneja, Alka Bhatia, Aishwarya Anand, Amol N Patil, Dibyajyoti Banerjee. Scopoletin a potential phytochemical therapy for antitubercular treatment drug induced liver injury (ATT-DILI) model in Wistar rats.
Journal of complementary & integrative medicine.
2023 Sep; ?(?):. doi:
10.1515/jcim-2023-0168. [PMID: 37732506] - Firoozeh Niazvand, Atefeh Ashtari, Narges Chamkouri, Mahdi Azari. Hepatoprotective effects of Alpinia officinarum rhizome extract on cisplatin-induced hepatotoxicity in rats: A biochemical, histopathological and immunohistochemical study.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2023 Sep; 80(?):127306. doi:
10.1016/j.jtemb.2023.127306. [PMID: 37757646] - Sajida Sumaiya, Aisha Siddiqui, Shahid Shah Chaudhary, Mohd Aslam, Sayeed Ahmad, Mairaj Ahmed Ansari. Isolation and characterization of bioactive components from hydroalcoholic extract of Cymbopogon jwarancusa (Jones) Schult. To evaluate its hepatoprotective activity.
Journal of ethnopharmacology.
2023 Sep; ?(?):117185. doi:
10.1016/j.jep.2023.117185. [PMID: 37714225] - Siyu Zhu, Tehasi Wang, Qingyi Wang, Mengyu Du. Application of Atorvastatin Combined with Ezetimibe in Elderly Patients with Hypertension Combined with T2DM and Analysis of Significance of Changes in Serum Bilirubin Levels During Treatment.
Alternative therapies in health and medicine.
2023 Aug; ?(?):. doi:
. [PMID: 37632947] - Melva Silitonga, Erlintan Sinaga, Meida Nugrahalia, Pasar M Silitonga. Hepatoprotective activity of ethanolic extract of Plectranthus amboinicus (lour.) spreng leaf in DMBA induced rats.
Toxicon : official journal of the International Society on Toxinology.
2023 Aug; 232(?):107212. doi:
10.1016/j.toxicon.2023.107212. [PMID: 37419284] - Xiaoqing Jia, Rong Li, Xiaoting Zhang, Tao Zhou, Dalong Sun, Na Yang, Zheng Luo. Increased age, bilirubin, international normalized ratio, and creatinine score to triglyceride ratio are associated with alcohol-associated primary liver carcinoma: a single-centered retrospective study.
Lipids in health and disease.
2023 Aug; 22(1):117. doi:
10.1186/s12944-023-01888-y. [PMID: 37537579] - Nima Aramipour, Maryam Gholami, Mohammad Saber, Soroor Jafar Gandomi, Naser-Aldin Lashgari, Arash Sadri, Omid Sabzevari. Evaluation of acute and sub-chronic oral toxicities of Neoneaster in rats.
Journal of ethnopharmacology.
2023 Jul; 311(?):116388. doi:
10.1016/j.jep.2023.116388. [PMID: 37001767] - Lindsay F Holzapfel, Cody Arnold, Jon E Tyson, Steven M Shapiro, Eric W Reynolds, Claudia Pedroza, Emily K Stephens, Alan Kleinfeld, Andrew H Huber, Matthew A Rysavy, Maria Del Mar Romero Lopez, Amir M Khan. Effect of reduced versus usual lipid emulsion dosing on bilirubin neurotoxicity and neurodevelopmental impairment in extremely preterm infants: study protocol for a randomized controlled trial.
BMC pediatrics.
2023 07; 23(1):347. doi:
10.1186/s12887-023-04149-0. [PMID: 37430233] - Yunna Zhang, Linxia Wang, Xue Zheng, Hailun Wang, Guijiang Wang. Risk factors for macro vascular disease in type 2 diabetes mellitus patients with non-alcoholic fatty liver disease.
Pakistan journal of pharmaceutical sciences.
2023 Jul; 36(4(Special)):1297-1303. doi:
". [PMID: 37606019] - Wei Yi, Suqi Yan, Jianqiao Tang, Xiang Ma, Mengjie Su, Hong Li. [Effects of Li-Dan-He-Ji on regulating oxidative stress and antagonising infantile cholestatic hepatic fibrosis].
Zhonghua wei zhong bing ji jiu yi xue.
2023 Jul; 35(7):741-745. doi:
10.3760/cma.j.cn121430-20230316-00186. [PMID: 37545453] - Jie Wu, Ma-Yi-Jie Cao, Ying Peng, Bao-Hua Dong, Yun-Xiu Jiang, Peng-Jin Zhu, Chang-Jiang Hu, Run-Chun Xu, Zhi-Min Chen. [Effect of processing with vinegar on efficacy of Curcuma longa in treatment of dysmenorrhea in rats with syndrome of liver depression and Qi stagnation].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jul; 48(13):3498-3507. doi:
10.19540/j.cnki.cjcmm.20230403.302. [PMID: 37475002] - Wenxia Chen, Sihong Huang, Yue Huang, Bo Duan, Zhengmin Xu, Yi Wang. Short-term outcomes of infants with hyperbilirubinemia-associated auditory neuropathy spectrum disorder in neonatal intensive care unit.
International journal of pediatric otorhinolaryngology.
2023 Jul; 170(?):111562. doi:
10.1016/j.ijporl.2023.111562. [PMID: 37172369] - Linzhang Zhang, Jiewen Shi, Qin Shen, Yadong Fu, Shenglan Qi, Jianjun Wu, Jiamei Chen, Hua Zhang, Yongping Mu, Gaofeng Chen, Ping Liu, Wei Liu. Astragalus saponins protect against extrahepatic and intrahepatic cholestatic liver fibrosis models by activation of farnesoid X receptor.
Journal of ethnopharmacology.
2023 Jul; 318(Pt A):116833. doi:
10.1016/j.jep.2023.116833. [PMID: 37400008] - Zhejie Chen, Yi Chen, Wei Hao, Mingju Shui, Jinming Zhang, Hefeng Zhou, Chen Zhang, Yitao Wang, Shengpeng Wang. Oral Delivery of Transformable Bilirubin Self-assembled System for Targeted Therapy of Colitis.
Advanced healthcare materials.
2023 Jun; ?(?):e2300946. doi:
10.1002/adhm.202300946. [PMID: 37317667] - Kazuya Ishikawa, Xiaonan Xie, Yasuhide Osaki, Atsushi Miyawaki, Keiji Numata, Yutaka Kodama. Bilirubin is produced nonenzymatically in plants to maintain chloroplast redox status.
Science advances.
2023 06; 9(23):eadh4787. doi:
10.1126/sciadv.adh4787. [PMID: 37285441] - Zenzi Rosseel, Pieter-Jan Cortoos, Joop Jonckheer, Wilfried Cools, Mathieu Vinken, Hendrik Reynaert, Elisabeth De Waele. Parenteral Nutrition, Sepsis, Acute Heart Failure and Hepatotoxic Drugs Are Related to Liver Test Disturbances in Critically Ill Patients.
Nutrients.
2023 Jun; 15(11):. doi:
10.3390/nu15112612. [PMID: 37299575] - Fang Xiong, Chao Yu, Ling-Juan Zhu, Tao Wang, Wei Zhou, Hui-Hui Bao, Xiao-Shu Cheng. [Associations Between Insulin Resistance Indexes and Hyperuricemia in Hypertensive Population].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
2023 Jun; 45(3):390-398. doi:
10.3881/j.issn.1000-503x.15414. [PMID: 37407524] - Alexandra S Hudson, Nicole Tyminski, Justine M Turner, Jason A Silverman. Intestinal Failure-Associated Liver Disease and Growth Pre- and Post-Transition to a Composite Lipid Emulsion.
Journal of pediatric gastroenterology and nutrition.
2023 06; 76(6):830-836. doi:
10.1097/mpg.0000000000003763. [PMID: 36930972] - Mao Ning, Yihan Zhao, Dongmei Dai, Chang Yao, Huatao Liu, Lingzhao Fang, Bo Wang, Yi Zhang, Jie Cao. Gene co-expression network and differential expression analyses of subcutaneous white adipose tissue reveal novel insights into the pathological mechanisms underlying ketosis in dairy cows.
Journal of dairy science.
2023 May; ?(?):. doi:
10.3168/jds.2022-22941. [PMID: 37268588] - B F Zhang, J Fang, Z Q Zhang, X L Ao, L Xia, H C Wu, S A Zhang, Z X Wu, D L Li. [Factors influencing bilirubin elevation and its correlation with UGT1A1 gene polymorphism in the early postoperative period of transjugular intrahepatic portosystemic shunt].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2023 May; 31(5):524-531. doi:
10.3760/cma.j.cn501113-20220527-00285. [PMID: 37365030] - Min Su, Zhimin Li, Siyu Zhou, Hong Zhang, Ying Xiao, Wei Li, Hongli Shang, Jiao Li. Kaempferitrin, a major compound from ethanol extract of Chenopodium ambrosioides, exerts antitumour and hepatoprotective effects in the mice model of human liver cancer xenografts.
The Journal of pharmacy and pharmacology.
2023 May; ?(?):. doi:
10.1093/jpp/rgad046. [PMID: 37203217] - Qing Yang, Juan Kong, Rui-Miao Bai, Wen-Ting Yu, Juan Zhang, Wei Shen, Li-Xia Tang, Yao Zhu, Ya-Sen Wang, Si-Yu Song, Dong Yang, Shi-Rong Song, Yi-Jia Zhang, Xin-Zhu Lin, Fan Wu, Zhan-Kui Li, Jian Mao, Xiao-Mei Tong. Effects of mixed oil emulsion on short-term clinical outcomes in premature infants: A prospective, multicenter, randomized controlled trial.
European journal of clinical nutrition.
2023 May; ?(?):. doi:
10.1038/s41430-023-01288-6. [PMID: 37138099] - Katie A Huff, Wendy Cruse, Charles Vanderpool. Lipid strategies to prevent intestinal failure-associated liver disease in neonates: A pilot trial.
JPEN. Journal of parenteral and enteral nutrition.
2023 05; 47(4):482-493. doi:
10.1002/jpen.2483. [PMID: 36772964] - Shu Teng, Nan Zheng, Arwa A Al-Huqail, Yanjie Lu, Elimam Ali, H Elhosiny Ali, Huajun Zhao. Effect of nanoparticle macroalgae in the treatment of fatty liver disease using logistic regression, and support vector machine.
Environmental research.
2023 05; 224(?):115426. doi:
10.1016/j.envres.2023.115426. [PMID: 36781010] - Yasasvhinie Santharam, Christopher R Nitkin, Ayan Rajgarhia, Alexandra Oschman, Brian Lee, Ryan Fischer, Keith Feldman. Association between congenital heart disease and parenteral nutrition-associated liver disease in neonates: A retrospective cohort study.
JPEN. Journal of parenteral and enteral nutrition.
2023 05; 47(4):501-510. doi:
10.1002/jpen.2484. [PMID: 36772965] - Yufei Zhao, Weiguo Fu, Lixin Wang. Letter by Zhao et al Regarding Article, 'Association Between Serum Bilirubin, Lipid Levels, and Prevalence of Femoral and Carotid Atherosclerosis: A Population-Based Cross-Sectional Study'.
Arteriosclerosis, thrombosis, and vascular biology.
2023 04; 43(4):e121-e122. doi:
10.1161/atvbaha.122.318939. [PMID: 36947605] - Qingling Su, Weimin Ye. Response by Su and Ye to Letter Regarding Article, 'Association Between Serum Bilirubin, Lipid Levels, and Prevalence of Femoral and Carotid Atherosclerosis: A Population-Based Cross-Sectional Study'.
Arteriosclerosis, thrombosis, and vascular biology.
2023 04; 43(4):e123. doi:
10.1161/atvbaha.123.319052. [PMID: 36947607] - Kassahun Dires Ayenew, Yared Wasihun. Hepatoprotective effect of methanol extract of Agave americana leaves on paracetamol induced hepatotoxicity in Wistar albino rats.
BMC complementary medicine and therapies.
2023 Apr; 23(1):99. doi:
10.1186/s12906-023-03931-y. [PMID: 37005601] - Rui Chen, Huagen Ma, Xiaopeng Li, Meijun Wang, Yunbo Yang, Tong Wu, Yue Zhang, Hui Kong, Huihua Qu, Yan Zhao. A Novel Drug with Potential to Treat Hyperbilirubinemia and Prevent Liver Damage Induced by Hyperbilirubinemia: Carbon Dots Derived from Platycodon grandiflorum.
Molecules (Basel, Switzerland).
2023 Mar; 28(6):. doi:
10.3390/molecules28062720. [PMID: 36985691] - Weiyu Chen, Sergey Tumanov, Christopher P Stanley, Stephanie M Y Kong, James Nadel, Niv Vigder, Darren Newington, Xiaosuo Wang, Louise L Dunn, Roland Stocker. Destabilization of Atherosclerotic Plaque by Bilirubin Deficiency.
Circulation research.
2023 Mar; ?(?):. doi:
10.1161/circresaha.122.322418. [PMID: 36876485] - Xiaofei Niu, Lu Liu, Hong Li, Jing Wang, Jiwei Zhao, Jinlin Liu. Bilirubin crystals in neutrophils of a newborn with Rh incompatibility.
Pediatric blood & cancer.
2023 03; 70(3):e30040. doi:
10.1002/pbc.30040. [PMID: 36317559] - Jinjin Luo, Xi Liang, Jiaojiao Xin, Jiaqi Li, Peng Li, Qian Zhou, Shaorui Hao, Huafen Zhang, Yingyan Lu, Tianzhou Wu, Lingling Yang, Jiang Li, Tan Li, Keke Ren, Beibei Guo, Xingping Zhou, Jiaxian Chen, Lulu He, Hui Yang, Wen Hu, Shaoli You, Shaojie Xin, Jing Jiang, Dongyan Shi, Xin Chen, Jun Li. Predicting the Onset of Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2023 03; 21(3):681-693. doi:
10.1016/j.cgh.2022.03.016. [PMID: 35337983] - Evelyn A Bates, Zachary A Kipp, Genesee J Martinez, Olufunto O Badmus, Mangala M Soundarapandian, Donald Foster, Mei Xu, Justin F Creeden, Jennifer R Greer, Andrew J Morris, David E Stec, Terry D Hinds. Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease.
Biomolecules.
2023 Jan; 13(2):. doi:
10.3390/biom13020252. [PMID: 36830621] - Yuanyuan Shi, Yifeng Wang, Yue Shen, Qiuyu Zhu, Feng Ding. Superior Dialytic Removal of Bilirubin and Bile Acids by Free Fatty Acid Displacement and Its Synergy With Albumin-Based Dialysis.
ASAIO journal (American Society for Artificial Internal Organs : 1992).
2023 01; 69(1):127-135. doi:
10.1097/mat.0000000000001720. [PMID: 35412475] - Zhishen Ruan, Dan Li, Xianhai Chen, Zhanjun Qiu. Association of serum total bilirubin and potential predictors with mortality in acute respiratory failure: A retrospective cohort study.
Heart & lung : the journal of critical care.
2023 Jan; 57(?):12-18. doi:
10.1016/j.hrtlng.2022.08.006. [PMID: 35987112] - Yanjie Qin, Jingxuan Tan, Xuemei Han, Nanxi Wang, Xuejia Zhai, Yongning Lu. Effects of Yinzhihuang on Alleviating Cyclosporine A-Induced Cholestatic Liver Injury via Farnesoid X Receptor-Mediated Regulation of Transporters and Enzymes in Vitro and in Vivo.
Biological & pharmaceutical bulletin.
2023; 46(12):1810-1819. doi:
10.1248/bpb.b23-00580. [PMID: 38044100] - Katie A Huff, Sujir Pritha Nayak, Irfan Ahmad, Robert DiGeronimo, Amy Hair, Jae H Kim, Troy Markel, Anthony Piazza, Kristina Reber, Jessica Roberts, Jotishna Sharma, Kevin Sullivan, Kaashif A Ahmad, Toby Yanowitz, Muralidhar H Premkumar. Patterns of lipid-injectable emulsion use in neonatal intensive care units across the United States: A multi-institution survey.
JPEN. Journal of parenteral and enteral nutrition.
2023 01; 47(1):51-58. doi:
10.1002/jpen.2422. [PMID: 35689505] - Qingling Su, Hongyu Chen, Shanshan Du, Yiquan Dai, Cheng Chen, Tianmin He 何天敏, Ruimei Feng, Tao Tao, Zhijian Hu, Hongwei Zhao, Pingfan Guo, Weimin Ye. Association Between Serum Bilirubin, Lipid Levels, and Prevalence of Femoral and Carotid Atherosclerosis: A Population-Based Cross-Sectional Study.
Arteriosclerosis, thrombosis, and vascular biology.
2023 01; 43(1):136-145. doi:
10.1161/atvbaha.122.318086. [PMID: 36453272] - N A Janovick, E Trevisi, G Bertoni, H M Dann, J K Drackley. Prepartum plane of energy intake affects serum biomarkers for inflammation and liver function during the periparturient period.
Journal of dairy science.
2023 Jan; 106(1):168-186. doi:
10.3168/jds.2022-22286. [PMID: 36400615] - Alessio Nocentini, Alessandro Bonardi, Simone Pratesi, Paola Gratteri, Carlo Dani, Claudiu T Supuran. Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin.
Journal of enzyme inhibition and medicinal chemistry.
2022 Dec; 37(1):487-501. doi:
10.1080/14756366.2021.2020773. [PMID: 34986721] - L I Xiaoling, Sun Fengxia, Shang Zimeng, Zhang Yingxue, L I Jie, Zhang Qiuxiang. Effect of Dangfei Liganning capsule on liver X receptor α/steroid regulatory element binding protein-1/fatty acid synthase signal pathway in rats with metabolic- associated fatty liver disease.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2022 12; 42(6):940-947. doi:
10.19852/j.cnki.jtcm.2022.06.007. [PMID: 36378052] - Jonathan Sasenick, Alan Kleinfeld, Andrew Huber, William Oh, Thomas Hegyi, Barry Weinberger. Effects of lipid emulsions on unbound bilirubin and response to phototherapy in preterm infants.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2022 Dec; 35(26):10395-10400. doi:
10.1080/14767058.2022.2128656. [PMID: 36176060] - Qian Ma, Feng-Bo Zhang, En-Sheng Yao, Shuo Pan. Neutrophilic granulocyte percentage is associated with anxiety in Chinese hospitalized heart failure patients.
BMC cardiovascular disorders.
2022 11; 22(1):494. doi:
10.1186/s12872-022-02940-y. [PMID: 36404328] - Chandan Sarkar, Milon Mondal, Khattab Al-Khafaji, Dina M El-Kersh, Sarmin Jamaddar, Pranta Ray, Uttam Kumar Roy, Mirola Afroze, Md Moniruzzaman, Mala Khan, Umma Hafsa Asha, Abul Bashar Ripon Khalipha, Edna Mori, Bruna Caroline Gonçalves Vasconcelos de Lacerda, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Manik Chandra Shill, Muhammad Torequl Islam. GC-MS analysis, and evaluation of protective effect of Piper chaba stem bark against paracetamol-induced liver damage in Sprague-Dawley rats: Possible defensive mechanism by targeting CYP2E1 enzyme through in silico study.
Life sciences.
2022 Nov; 309(?):121044. doi:
10.1016/j.lfs.2022.121044. [PMID: 36208657] - Samuel Oladeji Oguntuase, Olamide Wilson Fasakin, Sunday Idowu Oyeleye, Ganiyu Oboh. Effects of dietary inclusion of Bambara groundnut and sweet orange peels on streptozotocin/HFD type-2 induced diabetes mellitus complications and related biochemical parameters.
Journal of food biochemistry.
2022 11; 46(11):e14373. doi:
10.1111/jfbc.14373. [PMID: 35933697] - Muhammad Tahir Akhtar, Hafiz Faisal Ilyas, Usman Ali Shaukat, Rahman Qadir, Sahrish Masood, Sajida Batool, Sadaf Zahoor, Mubshara Saadia. Comparative study of hypoglycaemic and antioxidant potential of methanolic seed extract and oil of Nigella sativa on alloxanized diabetic rabbits.
Pakistan journal of pharmaceutical sciences.
2022 Nov; 35(6(Special)):1755-1760. doi:
". [PMID: 36861239] - Marcelo Gustavo Paulino, Priscila Adriana Rossi, Francine Perri Venturini, Driele Tavares, Marise Margareth Sakuragui, Gilberto Moraes, Ana Paula Terezan, João Batista Fernandes, Alessandra Giani, Marisa Narciso Fernandes. Liver dysfunction and energy storage mobilization in traíra, Hoplias malabaricus (Teleostei, Erythrinidae) induced by subchronic exposure to toxic cyanobacterial crude extract.
Environmental toxicology.
2022 Nov; 37(11):2683-2691. doi:
10.1002/tox.23628. [PMID: 35920046] - Samuel K Handelman, Yindra M Puentes, Annapurna Kuppa, Yanhua Chen, Xiaomeng Du, Mary F Feitosa, Nicholette D Palmer, Elizabeth K Speliotes. Population-based meta-analysis and gene-set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids.
Hepatology communications.
2022 11; 6(11):3120-3131. doi:
10.1002/hep4.2066. [PMID: 36098472] - Chang Chen, Jiahui Qian, Xinyu Zhao, Xuyang Han, Xu Tang, Junfeng Gao, Yan Liu, Jinzhu Jiang, Binyu Wen. Metabolic profiling of emodin drug-induced liver injury and silybin treatment in rats using ultra-performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry: A metabolomic and mechanistic approach.
Biomedical chromatography : BMC.
2022 Nov; 36(11):e5469. doi:
10.1002/bmc.5469. [PMID: 35904380] - Krista L Haines, Tetsu Ohnuma, Charles Trujillo, Obanor Osamudiamen, Vijay Krishnamoorthy, Karthik Raghunathan, Paul E Wischmeyer. Hospital change to mixed lipid emulsion from soybean oil-based lipid emulsion for parenteral nutrition in hospitalized and critically ill adults improves outcomes: a pre-post-comparative study.
Critical care (London, England).
2022 10; 26(1):317. doi:
10.1186/s13054-022-04194-8. [PMID: 36258222] - Shahid Jamil, Ghulam Dastagir, Ahmed Ibrahim Foudah, Mohammed Hamed Alqarni, Hasan Soliman Yusufoglu, Huda Mohammed Alkreathy, Ömer Ertürk, Muhammad Abdur Rehman Shah, Rahmat Ali Khan. Carduus edelbergii Rech. f. Mediated Fabrication of Gold Nanoparticles; Characterization and Evaluation of Antimicrobial, Antioxidant and Antidiabetic Potency of the Synthesized AuNPs.
Molecules (Basel, Switzerland).
2022 Oct; 27(19):. doi:
10.3390/molecules27196669. [PMID: 36235206] - Jessica Wassef, Elizabeth Lipkin, Patrick Hardigan, Debora Duro. Trends in liver profile and nutrition outcomes in children undergoing intestinal rehabilitation using a mixed lipid injectable emulsion.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.
2022 Oct; 37(5):1180-1189. doi:
10.1002/ncp.10782. [PMID: 34618376] - Wen-Zhang Dai, Zhao-Fang Bai, Ting-Ting He, Xiao-Yan Zhan, Qiang Li, Jing Zhao, Xiao-He Xiao. [Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Oct; 47(19):5299-5305. doi:
10.19540/j.cnki.cjcmm.20220421.704. [PMID: 36472037] - Smruti R Sahoo, Sandy Huey-Jen Hsu, Dev-Aur Chou, Gou-Jen Wang, Cheng-Chung Chang. Surface plasmon-enhanced fluorescence and surface-enhanced Raman scattering dual-readout chip constructed with silver nanowires: Label-free clinical detection of direct-bilirubin.
Biosensors & bioelectronics.
2022 Oct; 213(?):114440. doi:
10.1016/j.bios.2022.114440. [PMID: 35667289] - Bilal Sahin, Sebahattin Karabulut, Ahmet Kemal Filiz, Mustafa Özkaraca, Arzu Gezer, Hüseyin Aşkın Akpulat, Hilmi Ataseven. Galium aparine L. protects against acetaminophen-induced hepatotoxicity in rats.
Chemico-biological interactions.
2022 Oct; 366(?):110119. doi:
10.1016/j.cbi.2022.110119. [PMID: 36029804] - Muhammad Imran Qayyum, Sami Ullah, Umer Rashid, Abdul Sadiq, Obaidullah, Mater H Mahnashi, Osama M Alshehri, Mohammed M Jalal, Khalid J Alzahrani, Ibrahim F Halawani. Synthesis, Molecular Docking, and Preclinical Evaluation of a New Succinimide Derivative for Cardioprotective, Hepatoprotective and Lipid-Lowering Effects.
Molecules (Basel, Switzerland).
2022 Sep; 27(19):. doi:
10.3390/molecules27196199. [PMID: 36234730] - Fei Teng, Xiang-Wei Li, Min Li, Dong-Dong Fan, Jing-Jing Zhu, Hui-Min Gao, Zhi-Min Wang. [Components and lipid-lowering effect of total saponins from underground part of Gynostemma pentaphyllum].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Sep; 47(18):5022-5031. doi:
10.19540/j.cnki.cjcmm.20220613.701. [PMID: 36164912] - Khaled Mohamed Mohamed Koriem, Marwa A El-Attar. Almond oil restores blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism.
Journal of complementary & integrative medicine.
2022 Sep; 19(3):599-606. doi:
10.1515/jcim-2022-0086. [PMID: 35751565] - Haiyang Shen, Qian Li, Youtao Yu. Chemoprotective Effect of Decalactone on Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress.
Journal of oleo science.
2022 Sep; 71(9):1327-1335. doi:
10.5650/jos.ess22033. [PMID: 35965085] - Yufei Li, Hongda Sheng, Ziwei Yan, Bin Guan, Shifa Qiang, Jing Qian, Yi Wang. Bilirubin stabilizes the mitochondrial membranes during NLRP3 inflammasome activation.
Biochemical pharmacology.
2022 09; 203(?):115204. doi:
10.1016/j.bcp.2022.115204. [PMID: 35944727] - Jun-Jian Liu, Yan Xu, Shuai Chen, Cheng-Fei Hao, Jing Liang, Zhong-Lian Li. The mechanism of Yinchenhao decoction in treating obstructive-jaundice-induced liver injury based on Nrf2 signaling pathway.
World journal of gastroenterology.
2022 Aug; 28(32):4635-4648. doi:
10.3748/wjg.v28.i32.4635. [PMID: 36157920] - Takahiro Shinozuka, Mitsuro Kanda, Dai Shimizu, Chie Tanaka, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Masahiko Koike, Yasuhiro Kodera. Prognostic Value of a Modified Albumin-Bilirubin Score Designed for Patients with Esophageal Squamous Cell Carcinoma After Radical Resection.
Annals of surgical oncology.
2022 Aug; 29(8):4889-4896. doi:
10.1245/s10434-022-11654-6. [PMID: 35381933] - Shaoming Song, Haojie Jin, Qinghao Cheng, Shiyi Gong, Kun Lv, Ting Lei, Hongwei Tian, Xiaofei Li, Caining Lei, Wenwen Yang, Kehu Yang, Tiankang Guo. Local palliative therapies for unresectable malignant biliary obstruction: radiofrequency ablation combined with stent or biliary stent alone? An updated meta-analysis of nineteen trials.
Surgical endoscopy.
2022 Aug; 36(8):5559-5570. doi:
10.1007/s00464-022-09181-2. [PMID: 35296949] - V A Aneesha, Asif Qayoom, S Anagha, Shah Ayub Almas, V K Naresh, Sanjay Kumawat, W Ramdas Singh, Abdul Sadam, M Dinesh, T S Shyamkumar, Monalisa Sahoo, Madhu C Lingaraju, Thakur Uttam Singh, Dinesh Kumar. Topical bilirubin-deferoxamine hastens excisional wound healing by modulating inflammation, oxidative stress, angiogenesis, and collagen deposition in diabetic rats.
Journal of tissue viability.
2022 Aug; 31(3):474-484. doi:
10.1016/j.jtv.2022.04.009. [PMID: 35595596] - Katiuska Satué, Esterina Fazio, Ana Muñoz, Pietro Medica. Successful Pregnancy Outcome in Mares: The Potential Role of Body Conditional Score, Age and Biochemical Parameter's Adjustments.
Journal of equine veterinary science.
2022 Aug; 115(?):104023. doi:
10.1016/j.jevs.2022.104023. [PMID: 35643379] - Jill M Larson-Peine, Meera C Heller, Abigail R Rathert-Williams, Kimberly A Pearl, Natalie B Duncan, Brian L Vander Ley, Allison M Meyer. Blood chemistry and rectal temperature changes in a population of healthy, fall-born, suckling beef calves from birth to 72 h of age.
Theriogenology.
2022 Aug; 188(?):145-155. doi:
10.1016/j.theriogenology.2022.05.024. [PMID: 35689944] - Qian Zhang, Baoxian Shi, Liang Wu. Characteristics and risk factors of urinary tract infection in patients with HBV-related acute-on-chronic liver failure: A retrospective study.
Medicine.
2022 Jul; 101(28):e29913. doi:
10.1097/md.0000000000029913. [PMID: 35839063] - Prateek Pathak, Vikas Kumar, Habibullah Khalilullah, Maria Grishina, HariOm Singh, Amita Verma. Debelalactone Prevents Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress on Male Wistar Rats.
Molecules (Basel, Switzerland).
2022 Jul; 27(14):. doi:
10.3390/molecules27144499. [PMID: 35889371] - Yumiko Uchida, Yukihiro Takahashi, Yukihiro Morimoto, Peter Greimel, Asako Tosaki, Akiko Kumagai, Toshiya Nishikubo, Atsushi Miyawaki. Noninvasive monitoring of bilirubin photoisomer excretion during phototherapy.
Scientific reports.
2022 Jul; 12(1):11798. doi:
10.1038/s41598-022-16180-9. [PMID: 35821401] - Fei Qiao, Qinlei Chen, Weiting Lu, Nanyuan Fang. Plasma exchange treats severe intrahepatic cholestasis caused by dacomitinib: A case report.
Medicine.
2022 Jul; 101(27):e29629. doi:
10.1097/md.0000000000029629. [PMID: 35801736] - Fangda Peng, Jing Dai, Qingjun Qian, Xiangfu Cao, Lifang Wang, Min Zhu, Shujin Han, Wubin Liu, Yan Li, Teng Xue, Xianyang Chen, Xiaoli Yang, Jiaolei Wang, Huanqiang Wang, Tao Li, Chunguang Ding. Serum metabolic profiling of coal worker's pneumoconiosis using untargeted lipidomics.
Environmental science and pollution research international.
2022 Jul; ?(?):. doi:
10.1007/s11356-022-21905-4. [PMID: 35796929] - Jing Wu, Jiali Su, Yangyang Wang, Jianfeng Chen, Yuanyuan Shang, Jing Li. Association between total bilirubin and bone mineral density level in adolescents.
BMC musculoskeletal disorders.
2022 Jul; 23(1):639. doi:
10.1186/s12891-022-05592-3. [PMID: 35788217] - Sania Ishtiaq, Shamim Akhtar Qureshi, Syed Abdul Aziz. Protective role of Avena fatua against drug-induced liver toxicity.
Pakistan journal of pharmaceutical sciences.
2022 Jul; 35(4):1023-1030. doi:
. [PMID: 36008898] - J J Lei, J Zhang, C Chen, Q Li, J B Su, D Zhang, R Zhang, Z C Jin, Z M Geng. [Analysis of perineural invasion with clinicopathological factors and prognosis for curatively resected gallbladder carcinoma].
Zhonghua wai ke za zhi [Chinese journal of surgery].
2022 Jul; 60(7):695-702. doi:
10.3760/cma.j.cn112139-20220108-00016. [PMID: 35775263] - Shweta Urva, Tonya Quinlan, John Landry, Xiaosu Ma, Jennifer A Martin, Charles T Benson. Effects of Hepatic Impairment on the Pharmacokinetics of the Dual GIP and GLP-1 Receptor Agonist Tirzepatide.
Clinical pharmacokinetics.
2022 07; 61(7):1057-1067. doi:
10.1007/s40262-022-01140-3. [PMID: 35674880] - Karim C El Kasmi, Aimee L Anderson, Michael W Devereaux, Natarajan Balasubramaniyan, Frederick J Suchy, David J Orlicky, Colin T Shearn, Ronald J Sokol. Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition-associated cholestasis in mice.
JPEN. Journal of parenteral and enteral nutrition.
2022 07; 46(5):1096-1106. doi:
10.1002/jpen.2279. [PMID: 34664730]