ARGININOSUCCINATE (BioDeep_00000176200)

Main id: BioDeep_00000001299

 

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


2-[N-(4-amino-4-carboxybutyl)carbamimidamido]butanedioic acid

化学式: C10H18N4O6 (290.1226)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC(C(=O)O)N)CN=C(N)NC(CC(=O)O)C(=O)O
InChI: InChI=1S/C10H18N4O6/c11-5(8(17)18)2-1-3-13-10(12)14-6(9(19)20)4-7(15)16/h5-6H,1-4,11H2,(H,15,16)(H,17,18)(H,19,20)(H3,12,13,14)



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ARG1, ARG2, ASL, ASS1, ATF4, CTNNB1, DDIT3, DLK1, FH, HIF1A, MTOR, MYC, NOS3, STAT3, TP53
Peripheral membrane protein 1 MTOR
Endoplasmic reticulum membrane 2 MTOR, PTGDS
Nucleus 12 ARG1, ATF4, CTNNB1, DDIT3, FH, HIF1A, MKI67, MTOR, MYC, NOS3, STAT3, TP53
cytosol 12 ARG1, ASL, ASS1, ATF4, CTNNB1, DDIT3, FH, HIF1A, MTOR, NOS3, STAT3, TP53
dendrite 1 MTOR
nuclear body 2 HIF1A, MKI67
phagocytic vesicle 1 MTOR
centrosome 3 ATF4, CTNNB1, TP53
nucleoplasm 10 ASS1, ATF4, CTNNB1, HIF1A, MKI67, MTOR, MYC, NOS3, STAT3, TP53
RNA polymerase II transcription regulator complex 4 ATF4, DDIT3, HIF1A, STAT3
Cell membrane 3 ATF4, CD8A, CTNNB1
Cytoplasmic side 1 MTOR
lamellipodium 1 CTNNB1
Cytoplasmic granule 1 ARG1
Golgi apparatus membrane 1 MTOR
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
glutamatergic synapse 1 CTNNB1
Golgi apparatus 2 NOS3, PTGDS
Golgi membrane 3 INS, MTOR, NOS3
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 OTC
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 1 ASS1
Lysosome 1 MTOR
plasma membrane 4 CD8A, CTNNB1, NOS3, STAT3
Membrane 6 CTNNB1, DLK1, MKI67, MTOR, MYC, TP53
basolateral plasma membrane 1 CTNNB1
caveola 1 NOS3
extracellular exosome 5 ASL, ASS1, CTNNB1, FH, PTGDS
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 TP53
extracellular space 4 ARG1, DLK1, INS, PTGDS
perinuclear region of cytoplasm 3 CTNNB1, NOS3, PTGDS
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 4 ARG2, FH, OTC, TP53
protein-containing complex 5 ATF4, CTNNB1, HIF1A, MYC, TP53
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 CD8A
Secreted 2 INS, PTGDS
extracellular region 4 ARG1, CD8A, INS, PTGDS
Mitochondrion outer membrane 1 MTOR
Single-pass membrane protein 1 DLK1
mitochondrial outer membrane 2 ASS1, MTOR
[Isoform 2]: Secreted 1 CD8A
Mitochondrion matrix 2 OTC, TP53
mitochondrial matrix 4 ARG2, FH, OTC, TP53
transcription regulator complex 4 CTNNB1, DDIT3, STAT3, TP53
motile cilium 1 HIF1A
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 ATF4, TP53
Nucleus membrane 1 PTGDS
nuclear membrane 1 PTGDS
external side of plasma membrane 1 CD8A
perikaryon 1 ASS1
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 3 MKI67, MYC, TP53
Wnt signalosome 1 CTNNB1
axon cytoplasm 1 HIF1A
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
Cytoplasm, perinuclear region 1 PTGDS
Cytoplasm, cytoskeleton 2 CTNNB1, TP53
focal adhesion 1 CTNNB1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
nuclear speck 2 ATF4, HIF1A
Late endosome 1 DDIT3
receptor complex 1 CD8A
neuron projection 1 ATF4
chromatin 6 ATF4, DDIT3, HIF1A, MYC, STAT3, TP53
cell periphery 1 CTNNB1
Chromosome 2 FH, MKI67
cytoskeleton 1 NOS3
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Nucleus, nucleolus 2 MKI67, MYC
spindle pole 1 CTNNB1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
site of double-strand break 2 FH, TP53
nuclear envelope 2 MTOR, MYC
Endomembrane system 2 CTNNB1, MTOR
endosome lumen 1 INS
cell body fiber 1 ASS1
Nucleus, nucleoplasm 1 MYC
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
Nucleus speckle 2 ATF4, HIF1A
euchromatin 2 CTNNB1, HIF1A
germ cell nucleus 1 TP53
replication fork 1 TP53
plasma membrane raft 1 CD8A
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
specific granule lumen 1 ARG1
endocytic vesicle membrane 1 NOS3
transport vesicle 1 INS
RNA polymerase II transcription repressor complex 1 MYC
beta-catenin-TCF complex 1 CTNNB1
azurophil granule lumen 1 ARG1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
presynaptic active zone cytoplasmic component 1 CTNNB1
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 2 CTNNB1, DDIT3
[Isoform 1]: Cell membrane 1 CD8A
dendrite membrane 1 ATF4
Rough endoplasmic reticulum 2 MYC, PTGDS
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
nuclear periphery 1 ATF4
Myc-Max complex 1 MYC
T cell receptor complex 1 CD8A
[Isoform Mitochondrial]: Mitochondrion 1 FH
[Isoform Cytoplasmic]: Cytoplasm, cytosol 1 FH
beta-catenin-TCF7L2 complex 1 CTNNB1
ATF4-CREB1 transcription factor complex 1 ATF4
CHOP-C/EBP complex 1 DDIT3
ATF1-ATF4 transcription factor complex 1 ATF4
CHOP-ATF3 complex 1 DDIT3
CHOP-ATF4 complex 2 ATF4, DDIT3
Lewy body core 1 ATF4
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
nucleoplasmic reticulum 1 MYC


文献列表

  • Bianca Seminotti, Janaína Camacho da Silva, Rafael Teixeira Ribeiro, Guilhian Leipnitz, Moacir Wajner. Free Radical Scavengers Prevent Argininosuccinic Acid-Induced Oxidative Stress in the Brain of Developing Rats: a New Adjuvant Therapy for Argininosuccinate Lyase Deficiency?. Molecular neurobiology. 2020 Feb; 57(2):1233-1244. doi: 10.1007/s12035-019-01825-0. [PMID: 31707633]
  • Hanna-Riikka Heinonen, Miika Mehine, Netta Mäkinen, Annukka Pasanen, Esa Pitkänen, Auli Karhu, Nanna S Sarvilinna, Jari Sjöberg, Oskari Heikinheimo, Ralf Bützow, Lauri A Aaltonen, Eevi Kaasinen. Global metabolomic profiling of uterine leiomyomas. British journal of cancer. 2017 Dec; 117(12):1855-1864. doi: 10.1038/bjc.2017.361. [PMID: 29073636]
  • . . . . doi: . [PMID: 17651442]