Uridine diphosphate-N-acetylgalactosamine (BioDeep_00000027529)
Main id: BioDeep_00000014571
human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019
代谢物信息卡片
化学式: C17H27N3O17P2 (607.0816)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC1C(C(C(OC1OP(=O)(O)OP(=O)(O)OCC2C(C(C(O2)N3C=CC(=O)NC3=O)O)O)CO)O)O
InChI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)
描述信息
Uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) is a sugar donor metabolite, transferring N-acetylgalactosamine (GalNAc, an O-glycan) from UDP-GalNAc to serine and threonine residues, forming an alpha-anomeric linkage in a reaction catalyzed by enzymes known as UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferases. The addition of GalNAc to serine or threonine represents the first committed step in mucin biosynthesis. O-Glycans impart unique structural features to mucin glycoproteins and numerous membrane receptors, and resistance to thermal change and proteolytic attack in a number of diverse proteins. O-Linked carbohydrate side chains function as ligands for receptors, lymphocyte and leukocyte homing, and as signals for protein sorting (PMID: 12634319). Animal studies suggest that overactivity of the hexosamine pathway, resulting in increased UDP-hexosamines (i.e. UDP-GalNAc) is an important mechanism by which hyperglycemia causes insulin resistance. However, to date, human studies concerning the role of the hexosamine pathway in hyperglycemia-induced insulin resistance are scarce and restricted to measurements of glutamine fructose-6-phosphate amidotransferase (GFAT) enzyme activity. Both positive and negative correlations between GFAT activity in human muscle tissue from patients with type 2 DM and glucose disposal rate have been reported (PMID: 12414889).
Uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) is a sugar donor metabolite, transferring N-acetylgalactosamine (GalNAc, an O-glycan) from UDP-GalNAc to serine and threonine residues, forming an alpha anomeric linkage in a reaction catalyzed by enzymes known as UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferases; addition of GalNAc to serine or threonine represents the first committed step in mucin biosynthesis. O-glycans impart unique structural features to mucin glycoproteins and numerous membrane receptors, and resistance to thermal change and proteolytic attack in a number of diverse proteins. O-linked carbohydrate side chains function as ligands for receptors; lymphocyte and leukocyte homing and as signals for protein sorting. (PMID: 12634319)
同义名列表
41 个代谢物同义名
N-[2-({[({[3,4-dihydroxy-5-(4-hydroxy-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]ethanimidate; [({[5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphinic acid; {[5-(2,4-dioxo-3H-pyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy([3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy)phosphinic acid; Uridine pyrophosphate 2-acetamido-2-deoxy-alpha-delta-galactopyranosyl ester; Uridine pyrophosphate 2-acetamido-2-deoxy-alpha-D-galactopyranosyl ester; Uridine pyrophosphate 2-acetamido-2-deoxy-a-D-galactopyranosyl ester; Uridine pyrophosphate N-acetyl-alpha-delta-chondrosamine ester; Uridine pyrophosphate N-acetyl-alpha-D-chondrosamine ester; Uridine pyrophosphate N-acetyl-a-D-chondrosamine ester; Uridine diphospho-2-acetamido-2-deoxy-delta-galactose; Uridine diphospho-2-acetamido-2-deoxy-D-galactose; Uridine diphosphate-N-acetyl-delta-galactosamine; Uridine diphosphoric acid-N-acetylgalactosamine; Uridine diphosphate-N-acetyl-D-galactosamine; N-Acetylgalactosamine, uridine diphosphate; Diphosphate N-acetylgalactosamine, uridine; Uridine diphosphate-N-acetylgalactosamine; Uridine diphosphate N-acetylgalactosamine; Uridine diphosphate N acetylgalactosamine; Uridine 5-diphospho-N-acetylgalactosamine; Diphosphate N-acetylglucosamine, uridine; N-Acetylglucosamine, uridine diphosphate; Uridine diphosphate N acetylglucosamine; Uridine diphospho-N-acetylgalactosamine; Uridine diphosphate N-acetylglucosamine; Uridine pyrophosphoacetylgalactosamine; Diphospho-N-acetylglucosamine, uridine; Pyrophosphoacetylglucosamine, uridine; Uridine diphospho N acetylglucosamine; Uridine diphospho-N-acetylglucosamine; Uridine diphosphoacetylgalactosamine; Uridine pyrophosphoacetylglucosamine; UDP-N-Acetyl-delta-galactosamine; UDP-N-Acetyl-D-galactosamine; UDP-N-Acetylgalactosamine; Acetylgalactosamine, UDP; UDP Acetylgalactosamine; Acetylglucosamine, UDP; UDP Acetylglucosamine; UDPGNAc; UDP-N-acetyl-alpha-D-glucosamine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
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