Rotundifolone (BioDeep_00000019569)

 

Secondary id: BioDeep_00000007667, BioDeep_00001869000

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


6-Methyl-3-(1-methylethylidene)-7-oxabicyclo[4.1.0]heptan-2-one, 9ci

化学式: C10H14O2 (166.0994)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 7.83%

分子结构信息

SMILES: CC(=C1CCC2(C(C1=O)O2)C)C
InChI: InChI=1S/C10H14O2/c1-6(2)7-4-5-10(3)9(12-10)8(7)11/h9H,4-5H2,1-3H3

描述信息

Rotundifolone is found in cornmint. Rotundifolone is a constituent of Mentha rotundifolia and other Mentha species Rotundifolone is a flavouring ingredient.
Constituent of Mentha rotundifolia and other Mentha subspecies Flavouring ingredient. Rotundifolone is found in cornmint, spearmint, and herbs and spices.

同义名列表

7 个代谢物同义名

6-Methyl-3-(1-methylethylidene)-7-oxabicyclo[4.1.0]heptan-2-one, 9ci; 6-methyl-3-(propan-2-ylidene)-7-oxabicyclo[4.1.0]heptan-2-one; 2,3-Epoxy-6-isopropylidene-3-methylcyclohexanone; 1,2-Epoxy-P-menth-4(8)-en-3-one; Piperitenone oxide; Rotundifolone; Rotundifolone



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ACTB, AKT1, AKT2, ANXA5, BRAF, CASP3, CASP8, CASP9, EGFR, ITPR3, MSMP, PIK3CA, PTEN, RAF1, TP53
Peripheral membrane protein 1 ANXA5
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 EGFR, ITPR3, TRPM8
Nucleus 12 ACTB, AKT1, AKT2, BRAF, CASP3, CASP8, CASP9, EGFR, MMP2, PTEN, RAF1, TP53
cytosol 12 ACTB, AKT1, AKT2, ANXA5, BRAF, CASP3, CASP8, CASP9, PIK3CA, PTEN, RAF1, TP53
centrosome 1 TP53
nucleoplasm 8 ACTB, AKT1, AKT2, CASP3, CASP8, ITPR3, PTEN, TP53
Cell membrane 6 AKT1, BRAF, EGFR, RAF1, TRPM8, TRPV1
lamellipodium 4 ACTB, AKT1, CASP8, PIK3CA
ruffle membrane 2 AKT2, EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 3 ITPR3, TRPM8, TRPV1
Synapse 1 ACTB
cell cortex 2 AKT1, AKT2
cell junction 1 EGFR
cell surface 1 EGFR
glutamatergic synapse 5 ACTB, AKT1, BRAF, CASP3, EGFR
Golgi apparatus 1 RAF1
Golgi membrane 1 EGFR
lysosomal membrane 1 GAA
neuronal cell body 3 CASP3, ITPR3, TRPV1
postsynapse 2 AKT1, BRAF
sarcolemma 1 ANXA5
Lysosome 1 GAA
Presynapse 2 ACTB, BRAF
endosome 1 EGFR
plasma membrane 13 ACTB, AKT1, AKT2, BRAF, EGFR, GAA, ITPR3, MMP2, PIK3CA, PTEN, RAF1, TRPM8, TRPV1
Membrane 9 ACTB, AKT1, ANXA5, EGFR, GAA, ITPR3, TP53, TRPM8, TRPV1
apical plasma membrane 2 EGFR, PTEN
axon 1 ACTB
basolateral plasma membrane 1 EGFR
brush border 2 ACTB, ITPR3
extracellular exosome 4 ACTB, ANXA5, GAA, MMP9
Lysosome membrane 1 GAA
endoplasmic reticulum 2 ITPR3, TP53
extracellular space 5 ACTB, EGFR, MMP2, MMP9, MSMP
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 EGFR, PIK3CA
Schaffer collateral - CA1 synapse 1 ACTB
adherens junction 1 ACTB
intercalated disc 1 PIK3CA
mitochondrion 6 BRAF, CASP8, CASP9, MMP2, RAF1, TP53
protein-containing complex 6 ACTB, AKT1, CASP8, CASP9, EGFR, TP53
intracellular membrane-bounded organelle 3 AKT2, BRAF, GAA
postsynaptic density 2 CASP3, PTEN
Single-pass type I membrane protein 1 EGFR
Secreted 2 GAA, MSMP
extracellular region 5 ANXA5, GAA, MMP2, MMP9, PTEN
cytoplasmic side of plasma membrane 1 PTEN
mitochondrial outer membrane 2 CASP8, RAF1
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
nuclear membrane 1 EGFR
external side of plasma membrane 3 ANXA5, TRPM8, TRPV1
Secreted, extracellular space, extracellular matrix 1 MMP9
actin cytoskeleton 1 ACTB
dendritic spine 1 PTEN
microtubule cytoskeleton 1 AKT1
nucleolus 2 ITPR3, TP53
Early endosome 1 AKT2
apical part of cell 1 ITPR3
cell-cell junction 2 ACTB, AKT1
vesicle 2 ACTB, AKT1
postsynaptic membrane 1 TRPV1
Cell projection, lamellipodium 1 CASP8
Membrane raft 2 EGFR, TRPM8
Cytoplasm, cytoskeleton 2 ACTB, TP53
focal adhesion 3 ACTB, ANXA5, EGFR
spindle 1 AKT1
GABA-ergic synapse 1 TRPV1
extracellular matrix 1 MMP2
intracellular vesicle 1 EGFR
sarcoplasmic reticulum 1 ITPR3
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 2 PTEN, TP53
PML body 2 PTEN, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 3 ANXA5, MMP2, MMP9
nuclear outer membrane 1 ITPR3
Postsynaptic cell membrane 1 TRPV1
sarcomere 1 MMP2
receptor complex 2 EGFR, ITPR3
Cell projection, neuron projection 2 PTEN, TRPV1
Zymogen granule membrane 1 ANXA5
neuron projection 2 BRAF, PTEN
ciliary basal body 1 AKT1
chromatin 2 ACTB, TP53
cell projection 1 PTEN
cytoskeleton 2 ACTB, CASP8
cytoplasmic ribonucleoprotein granule 1 ACTB
actin filament 1 ACTB
blood microparticle 1 ACTB
NuA4 histone acetyltransferase complex 1 ACTB
site of double-strand break 1 TP53
tertiary granule membrane 1 GAA
cell body 2 BRAF, CASP8
germ cell nucleus 1 TP53
replication fork 1 TP53
pseudopodium 1 RAF1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
plasma membrane raft 1 TRPM8
ficolin-1-rich granule lumen 1 MMP9
secretory granule membrane 1 ITPR3
nuclear matrix 2 ACTB, TP53
transcription repressor complex 1 TP53
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
tertiary granule lumen 1 MMP9
kinetochore 1 ACTB
azurophil granule membrane 1 GAA
[Isoform 1]: Secreted, extracellular space, extracellular matrix 1 MMP2
Schmidt-Lanterman incisure 1 PTEN
tight junction 1 ACTB
bBAF complex 1 ACTB
brahma complex 1 ACTB
nBAF complex 1 ACTB
npBAF complex 1 ACTB
SWI/SNF complex 1 ACTB
apoptosome 1 CASP9
calyx of Held 1 ACTB
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 EGFR
ribonucleoprotein complex 1 ACTB
platelet dense tubular network membrane 1 ITPR3
[Isoform 1]: Nucleus 1 TP53
ficolin-1-rich granule membrane 1 GAA
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
apical junction complex 1 ACTB
nucleosome 1 ACTB
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
postsynaptic actin cytoskeleton 1 ACTB
Cell projection, dendritic spine membrane 1 TRPV1
dendritic spine membrane 1 TRPV1
GBAF complex 1 ACTB
RSC-type complex 1 ACTB
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
transport vesicle membrane 1 ITPR3
cortical cytoskeleton 1 ACTB
myelin sheath adaxonal region 1 PTEN
endothelial microparticle 1 ANXA5
autolysosome lumen 1 GAA
[Isoform alpha]: Secreted 1 PTEN
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
dense body 1 ACTB


文献列表

  • Israel Gomes de Amorim Santos, Ricardo Scher, Marilise Brittes Rott, Leociley Rocha Menezes, Emmanoel Vilaça Costa, Sócrates Cabral de Holanda Cavalcanti, Arie Fitzgerald Blank, Jaciana dos Santos Aguiar, Teresinha Gonçalves da Silva, Silvio Santana Dolabella. Amebicidal activity of the essential oils of Lippia spp. (Verbenaceae) against Acanthamoeba polyphaga trophozoites. Parasitology research. 2016 Feb; 115(2):535-40. doi: 10.1007/s00436-015-4769-4. [PMID: 26446087]
  • Ricardo G Amaral, Cecília S Fonseca, Tayane Kayne M Silva, Luciana N Andrade, Maria E França, José M Barbosa-Filho, Damião P de Sousa, Manoel O Moraes, Cláudia Ó Pessoa, Adriana A Carvalho, Sara Maria Thomazzi. Evaluation of the cytotoxic and antitumour effects of the essential oil from Mentha x villosa and its main compound, rotundifolone. The Journal of pharmacy and pharmacology. 2015 Aug; 67(8):1100-6. doi: 10.1111/jphp.12409. [PMID: 25787872]
  • Nilmara Nunes Santos, Leociley Rocha Alencar Menezes, Jamyle Andrade Ferreira dos Santos, Cássio Santana Meira, Elisalva Teixeira Guimarhes, Milena Botelho Pereira Soares, Angelita Nepel, Andersson Barisone, Emmanoel Vilaça Costa. A new source of (R)-limonene and rotundifolone from leaves of Lippia pedunculosa (verbenaceae) and their trypanocidal properties. Natural product communications. 2014 Jun; 9(6):737-9. doi: . [PMID: 25115066]
  • Thiago José Matos-Rocha, Marília Gabriela dos Santos Cavalcanti, José Maria Barbosa-Filho, Ana Silvia Suassuna Carneiro Lúcio, Dyana Leal Veras, Ana Paula Sampaio Feitosa, José Pinto de Siqueira Júnior, Reinaldo Nóbrega de Almeida, Márcia Ortiz Mayo Marques, Luiz Carlos Alves, Fábio André Brayner. In vitro evaluation of schistosomicidal activity of essential oil of Mentha x villosa and some of its chemical constituents in adult worms of Schistosoma mansoni. Planta medica. 2013 Sep; 79(14):1307-12. doi: 10.1055/s-0033-1350732. [PMID: 23945759]
  • D N Guedes, D F Silva, J M Barbosa-Filho, I A Medeiros. Calcium antagonism and the vasorelaxation of the rat aorta induced by rotundifolone. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2004 Dec; 37(12):1881-7. doi: 10.1590/s0100-879x2004001200014. [PMID: 15558195]