Butyryl-CoA (BioDeep_00000017804)

Main id: BioDeep_00000001326

 

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


{[5-(6-amino-9H-purin-9-yl)-2-[({[({3-[(2-{[2-(butanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid

化学式: C25H42N7O17P3S (837.1571)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O
InChI: InChI=1S/C25H42N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h12-14,18-20,24,35-36H,4-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)

描述信息

Butyryl-CoA is an intermediate in the metabolism of Butanoate. It is a substrate for Acyl-coenzyme A oxidase 3 (peroxisomal), 3-ketoacyl-CoA thiolase (mitochondrial), 3-ketoacyl-CoA thiolase (peroxisomal), Acyl-coenzyme A oxidase 1 (peroxisomal), Acyl-CoA dehydrogenase (medium-chain specific, mitochondrial), Acyl-CoA dehydrogenase (long-chain specific, mitochondrial), Acyl-coenzyme A oxidase 2 (peroxisomal), Acetyl-CoA acetyltransferase (mitochondrial), Acetyl-CoA acetyltransferase (cytosolic), Acyl-CoA dehydrogenase (short-chain specific, mitochondrial) and Trifunctional enzyme beta subunit (mitochondrial).

同义名列表

6 个代谢物同义名

{[5-(6-amino-9H-purin-9-yl)-2-[({[({3-[(2-{[2-(butanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid; Butanoyl-coenzyme A; Butyryl-coenzyme A; Butanoyl-CoA; Butyryl-CoA; Q42412398



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

58 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(57)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 COASY, CYP2B6, EMD, FASN, KAT2A, MMUT
Peripheral membrane protein 2 CYP2B6, HSD17B6
Endoplasmic reticulum membrane 2 ACAT1, CYP2B6
Nucleus 3 ACADS, CS, KAT2A
cytosol 5 EMD, FASN, HBD, LIPE, PCCB
mitochondrial membrane 1 IVD
centrosome 2 ACADS, KAT2A
nucleoplasm 5 ACADS, ATP2B1, EMD, IVD, KAT2A
Cell membrane 2 ATP2B1, LIPE
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 2 ACAT1, ATP2B1
Synapse 1 ATP2B1
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 FASN
mitochondrial inner membrane 1 ATP5ME
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 LIPE
plasma membrane 2 ATP2B1, FASN
synaptic vesicle membrane 1 ATP2B1
Membrane 7 ACAT1, ATP2B1, CS, EMD, FASN, HBD, LIPE
basolateral plasma membrane 1 ATP2B1
caveola 1 LIPE
extracellular exosome 5 ACAT1, ATP2B1, COASY, CS, FASN
Lumenal side 1 HSD17B6
endoplasmic reticulum 3 ACAT1, EMD, HSD17B6
extracellular space 1 KAT2A
mitochondrion 12 ACAD8, ACADS, ACAT1, ATP5ME, COASY, CS, ETFA, ETFB, GCDH, IVD, MMUT, PCCB
intracellular membrane-bounded organelle 3 ATP2B1, CYP2B6, HSD17B6
Microsome membrane 2 CYP2B6, HSD17B6
mitochondrial outer membrane 1 COASY
Mitochondrion matrix 9 ACADS, COASY, CS, ETFA, ETFB, GCDH, IVD, MMUT, PCCB
mitochondrial matrix 11 ACAD8, ACADS, ACAT1, COASY, CS, ETFA, ETFB, GCDH, IVD, MMUT, PCCB
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 KAT2A
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 1 EMD
microtubule 1 EMD
spindle 1 EMD
lateral plasma membrane 1 ATP2B1
Nucleus inner membrane 1 EMD
nuclear inner membrane 1 EMD
nuclear outer membrane 1 EMD
cell projection 1 ATP2B1
mitotic spindle 1 KAT2A
Chromosome 1 KAT2A
blood microparticle 1 HBD
Basolateral cell membrane 1 ATP2B1
nuclear envelope 1 EMD
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Melanosome 1 FASN
Presynaptic cell membrane 1 ATP2B1
transcription factor TFTC complex 1 KAT2A
Nucleoplasmic side 1 EMD
immunological synapse 1 ATP2B1
SAGA complex 1 KAT2A
histone acetyltransferase complex 1 KAT2A
ATAC complex 1 KAT2A
proton-transporting ATP synthase complex 1 ATP5ME
hemoglobin complex 1 HBD
haptoglobin-hemoglobin complex 1 HBD
proton-transporting ATP synthase complex, coupling factor F(o) 1 ATP5ME
catalytic complex 1 PCCB
photoreceptor ribbon synapse 1 ATP2B1
electron transfer flavoprotein complex 2 ETFA, ETFB
glycogen granule 1 FASN
TMEM240-body 1 EMD
acetyl-CoA carboxylase complex 1 PCCB


文献列表

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  • Thi Thuy Tien Nguyen, Yuta Fujimura, Iyo Mimura, Yusuke Fujii, Ngoc Luong Nguyen, Kensuke Arakawa, Hidetoshi Morita. Cultivable butyrate-producing bacteria of elderly Japanese diagnosed with Alzheimer's disease. Journal of microbiology (Seoul, Korea). 2018 Oct; 56(10):760-771. doi: 10.1007/s12275-018-8297-7. [PMID: 30136260]
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  • Malene Hornbak, Karina Banasik, Johanne M Justesen, Nikolaj T Krarup, Camilla H Sandholt, Åsa Andersson, Annelli Sandbæk, Torsten Lauritzen, Charlotta Pisinger, Daniel R Witte, Thorkild A A Sørensen, Oluf Pedersen, Torben Hansen. The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load. BMC medical genetics. 2011 Jan; 12(?):4. doi: 10.1186/1471-2350-12-4. [PMID: 21211036]
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