butanoyl-CoA (BioDeep_00000001326)

Main id: BioDeep_00000630354

Secondary id: BioDeep_00000017804, BioDeep_00001868839

natural product human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


(2R)-4-({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-N-(2-{[2-(butanoylsulfanyl)ethyl]-C-hydroxycarbonimidoyl}ethyl)-2-hydroxy-3,3-dimethylbutanimidic acid

化学式: C25H42N7O17P3S (837.1570672000001)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 2.94%

分子结构信息

SMILES: CCCC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O
InChI: InChI=1S/C25H42N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h12-14,18-20,24,35-36H,4-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,18-,19-,20+,24-/m1/s1

描述信息

Butyryl-coa, also known as 4:0-coa or butanoyl-coa, is a member of the class of compounds known as acyl coas. Acyl coas are organic compounds containing a coenzyme A substructure linked to an acyl chain. Thus, butyryl-coa is considered to be a fatty ester lipid molecule. Butyryl-coa is slightly soluble (in water) and an extremely strong acidic compound (based on its pKa). Butyryl-coa can be synthesized from coenzyme A and butyric acid. Butyryl-coa is also a parent compound for other transformation products, including but not limited to, (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA, acetoacetyl-CoA, and 2-methylacetoacetyl-CoA. Butyryl-coa can be found in a number of food items such as wild carrot, persian lime, redcurrant, and arrowroot, which makes butyryl-coa a potential biomarker for the consumption of these food products. Butyryl-coa may be a unique E.coli metabolite.

同义名列表

17 个代谢物同义名

(2R)-4-({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-N-(2-{[2-(butanoylsulfanyl)ethyl]-C-hydroxycarbonimidoyl}ethyl)-2-hydroxy-3,3-dimethylbutanimidic acid; (2R)-4-[({[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxy]-N-(2-{[2-(butanoylsulfanyl)ethyl]-C-hydroxycarbonimidoyl}ethyl)-2-hydroxy-3,3-dimethylbutanimidic acid; S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] butanethioate; n-Butyryl coenzyme A lithium salt hydrate; coenzyme A, S-Butanoic acid; coenzyme A, S-Butanoate; S-Butanoyl-coenzyme A; S-Butyryl-coenzyme A; Butanoyl-coenzyme A; S-Butyryl-coenzym-a; Butyryl-coenzyme A; S-Butanoyl-CoA; S-Butyryl-CoA; Butanoyl-CoA; Butyryl-CoA; C4:0-CoA; 4:0-CoA



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

11 个相关的代谢反应过程信息。

Reactome(7)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Aasia Khaliq, Resmi Ravindran, Samia Afzal, Prasant Kumar Jena, Muhammad Waheed Akhtar, Atiqa Ambreen, Yu-Jui Yvonne Wan, Kauser Abdulla Malik, Muhammad Irfan, Imran H Khan. Gut microbiome dysbiosis and correlation with blood biomarkers in active-tuberculosis in endemic setting. PloS one. 2021; 16(1):e0245534. doi: 10.1371/journal.pone.0245534. [PMID: 33481833]
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  • Thi Thuy Tien Nguyen, Yuta Fujimura, Iyo Mimura, Yusuke Fujii, Ngoc Luong Nguyen, Kensuke Arakawa, Hidetoshi Morita. Cultivable butyrate-producing bacteria of elderly Japanese diagnosed with Alzheimer's disease. Journal of microbiology (Seoul, Korea). 2018 Oct; 56(10):760-771. doi: 10.1007/s12275-018-8297-7. [PMID: 30136260]
  • Julian Trachsel, Darrell O Bayles, Torey Looft, Uri Y Levine, Heather K Allen. Function and Phylogeny of Bacterial Butyryl Coenzyme A:Acetate Transferases and Their Diversity in the Proximal Colon of Swine. Applied and environmental microbiology. 2016 11; 82(22):6788-6798. doi: 10.1128/aem.02307-16. [PMID: 27613689]
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  • Natalie M Gallant, Karen Leydiker, Hao Tang, Lisa Feuchtbaum, Fred Lorey, Rebecca Puckett, Joshua L Deignan, Julie Neidich, Naghmeh Dorrani, Erica Chang, Bruce A Barshop, Stephen D Cederbaum, Jose E Abdenur, Raymond Y Wang. Biochemical, molecular, and clinical characteristics of children with short chain acyl-CoA dehydrogenase deficiency detected by newborn screening in California. Molecular genetics and metabolism. 2012 May; 106(1):55-61. doi: 10.1016/j.ymgme.2012.02.007. [PMID: 22424739]
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  • Malene Hornbak, Karina Banasik, Johanne M Justesen, Nikolaj T Krarup, Camilla H Sandholt, Åsa Andersson, Annelli Sandbæk, Torsten Lauritzen, Charlotta Pisinger, Daniel R Witte, Thorkild A A Sørensen, Oluf Pedersen, Torben Hansen. The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load. BMC medical genetics. 2011 Jan; 12(?):4. doi: 10.1186/1471-2350-12-4. [PMID: 21211036]
  • Alain Perret, Christophe Lechaplais, Sabine Tricot, Nadia Perchat, Carine Vergne, Christine Pellé, Karine Bastard, Annett Kreimeyer, David Vallenet, Anne Zaparucha, Jean Weissenbach, Marcel Salanoubat. A novel acyl-CoA beta-transaminase characterized from a metagenome. PloS one. 2011; 6(8):e22918. doi: 10.1371/journal.pone.0022918. [PMID: 21826218]
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  • Ronald J A Wanders, Jos P N Ruiter, Lodewijk IJLst, Hans R Waterham, Sander M Houten. The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results. Journal of inherited metabolic disease. 2010 Oct; 33(5):479-94. doi: 10.1007/s10545-010-9104-8. [PMID: 20490924]
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  • Wenjing Jia, Rebekah N Whitehead, Lesley Griffiths, Claire Dawson, Rosemary H Waring, David B Ramsden, John O Hunter, Jeffrey A Cole. Is the abundance of Faecalibacterium prausnitzii relevant to Crohn's disease?. FEMS microbiology letters. 2010 Sep; 310(2):138-44. doi: 10.1111/j.1574-6968.2010.02057.x. [PMID: 20695899]
  • Alexis Samba Mialoundama, Dimitri Heintz, Nurul Jadid, Paul Nkeng, Alain Rahier, Jozsef Deli, Bilal Camara, Florence Bouvier. Characterization of plant carotenoid cyclases as members of the flavoprotein family functioning with no net redox change. Plant physiology. 2010 Jul; 153(3):970-9. doi: 10.1104/pp.110.155440. [PMID: 20460582]
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  • Christina B Pedersen, Zarazuela Zolkipli, Søren Vang, Johan Palmfeldt, Margrethe Kjeldsen, Vibeke Stenbroen, Stinne P Schmidt, Ronald J A Wanders, Jos P N Ruiter, Flemming Wibrand, Ingrid Tein, Niels Gregersen. Antioxidant dysfunction: potential risk for neurotoxicity in ethylmalonic aciduria. Journal of inherited metabolic disease. 2010 Jun; 33(3):211-22. doi: 10.1007/s10545-010-9086-6. [PMID: 20443061]
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  • Bianca T van Maldegem, Marinus Duran, Ronald J A Wanders, Hans R Waterham, Frits A Wijburg. Flavin adenine dinucleotide status and the effects of high-dose riboflavin treatment in short-chain acyl-CoA dehydrogenase deficiency. Pediatric research. 2010 Mar; 67(3):304-8. doi: 10.1203/pdr.0b013e3181cbd57b. [PMID: 19952864]
  • Patrícia Fernanda Schuck, Estela Natacha Brandt Busanello, Alana Pimentel Moura, Anelise Miotti Tonin, Mateus Grings, Luciana Ritter, Carmen Regla Vargas, Gustavo da Costa Ferreira, Moacir Wajner. Promotion of lipid and protein oxidative damage in rat brain by ethylmalonic acid. Neurochemical research. 2010 Feb; 35(2):298-305. doi: 10.1007/s11064-009-0055-0. [PMID: 19757035]
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