Ellipticine (BioDeep_00000017215)

 

Secondary id: BioDeep_00000867284

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


5,11-dimethyl-6H-pyrido[4,3-b]carbazole

化学式: C17H14N2 (246.1157)
中文名称: 椭圆玫瑰树碱, 玫瑰树碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 79.12%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Ellipticine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/ellipticine (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000017215). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC1=C(C=NC=C2)C2=C(C)C(N3)=C1C4=C3C=CC=C4
InChI: InChI=1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3

描述信息

Ellipticine is a organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11. It has a role as an antineoplastic agent and a plant metabolite. It is an organic heterotetracyclic compound, an organonitrogen heterocyclic compound, a polycyclic heteroarene and an indole alkaloid.
Ellipticine is a potent antineoplastic agent.
Ellipticine is a natural product found in Asparagus cochinchinensis, Aspergillus sclerotiorum, and other organisms with data available.
A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.

Ellipticine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=519-23-3 (retrieved 2024-06-29) (CAS RN: 519-23-3). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

同义名列表

33 个代谢物同义名

5-23-09-00417 (Beilstein Handbook Reference); 6H-Pyrido[4,3-b]carbazole, 5,11-dimethyl-; 6H-Pyrido(4,3-b)carbazole, 5,11-dimethyl-; 5,11-dimethyl-2H-pyrido[4,3-b]carbazole; 5,11-dimethyl-6H-pyrido(4,3-b)carbazole; 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole; 5,11-Dimethylpyrido[4,3-b]carbazole; WLN: T D6 B656 FN LMJ C1 J1; CTSPAMFJBXKSOY-UHFFFAOYSA-N; ellipticine hydrochloride; Ellipticine, synthetic; ellipticine tartrate; Prestwick3_000614; Prestwick1_000614; Prestwick0_000614; Prestwick2_000614; ELLIPTICINE [MI]; ellipticine, HCl; 5,3-b]carbazole; Probes2_000130; Probes1_000152; BPBio1_000604; Lopac0_000531; NCI60_040685; Tox21_500531; Elliptisine; Ellipticine; elliptecine; Ellipticin; CP 5; NSC 71795; Ellipticine; Ellipticine



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

31 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ABCB1, AKT1, ANXA5, BCL2, CASP3, CASP9, CDKN1A, CYP1A1, CYP3A4, LPO, MYC, PIK3CA
Peripheral membrane protein 3 ANXA5, CYP1A1, CYP1B1
Endoplasmic reticulum membrane 5 BCL2, CYP1A1, CYP1A2, CYP1B1, CYP3A4
Nucleus 7 AKT1, BCL2, CASP3, CASP9, CDKN1A, MPO, MYC
cytosol 7 AKT1, ANXA5, BCL2, CASP3, CASP9, CDKN1A, PIK3CA
nuclear body 1 CDKN1A
nucleoplasm 5 AKT1, CASP3, CDKN1A, MPO, MYC
Cell membrane 5 ABCB1, AKT1, CNTN6, KIT, TNF
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 3 ABCB1, MT-CYB, SLC45A2
Synapse 1 CNTN6
cell cortex 1 AKT1
cell surface 2 ABCB1, TNF
glutamatergic synapse 2 AKT1, CASP3
mitochondrial inner membrane 2 CYP1A1, MT-CYB
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
presynaptic membrane 1 CNTN6
sarcolemma 1 ANXA5
Lysosome 1 MPO
acrosomal vesicle 1 KIT
plasma membrane 6 ABCB1, AKT1, CNTN6, KIT, PIK3CA, TNF
Membrane 11 ABCB1, AKT1, ANXA5, BCL2, CNTN6, CYP1B1, CYP3A4, KIT, MT-CYB, MYC, SLC45A2
apical plasma membrane 1 ABCB1
axon 1 CNTN6
basolateral plasma membrane 1 LPO
extracellular exosome 4 ABCB1, ANXA5, LPO, MPO
endoplasmic reticulum 1 BCL2
extracellular space 4 KIT, LPO, MPO, TNF
perinuclear region of cytoplasm 2 CDKN1A, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CASP9, CYP1A1, CYP1B1, MT-CYB
protein-containing complex 5 AKT1, BCL2, CASP9, CDKN1A, MYC
intracellular membrane-bounded organelle 5 CYP1A1, CYP1A2, CYP1B1, CYP3A4, MPO
Microsome membrane 4 CYP1A1, CYP1A2, CYP1B1, CYP3A4
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 KIT
Secreted 1 LPO
extracellular region 4 ANXA5, LPO, MPO, TNF
cytoplasmic side of plasma membrane 1 KIT
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 ANXA5, KIT, TNF
microtubule cytoskeleton 1 AKT1
nucleolus 2 CDKN1A, MYC
Melanosome membrane 1 SLC45A2
cell-cell junction 2 AKT1, KIT
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 1 ABCB1
Mitochondrion inner membrane 2 CYP1A1, MT-CYB
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 ANXA5
spindle 1 AKT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 MPO
receptor complex 1 KIT
Zymogen granule membrane 1 ANXA5
ciliary basal body 1 AKT1
chromatin 1 MYC
phagocytic cup 1 TNF
Nucleus, nucleolus 1 MYC
Lipid-anchor, GPI-anchor 1 CNTN6
fibrillar center 1 KIT
nuclear envelope 1 MYC
Nucleus, nucleoplasm 1 MYC
side of membrane 1 CNTN6
myelin sheath 1 BCL2
azurophil granule 1 MPO
[Isoform 3]: Cytoplasm 1 KIT
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
RNA polymerase II transcription repressor complex 1 MYC
azurophil granule lumen 1 MPO
apoptosome 1 CASP9
parallel fiber to Purkinje cell synapse 1 CNTN6
vesicle membrane 1 ANXA5
respiratory chain complex III 1 MT-CYB
phagocytic vesicle lumen 1 MPO
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
Rough endoplasmic reticulum 1 MYC
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
Myc-Max complex 1 MYC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
PCNA-p21 complex 1 CDKN1A
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
nucleoplasmic reticulum 1 MYC


文献列表

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