benzenecarbothioamide (BioDeep_00000011094)
Secondary id: BioDeep_00001871966
human metabolite blood metabolite
代谢物信息卡片
化学式: C7H7NS (137.0299)
中文名称: 硫代苯甲酰胺
谱图信息:
最多检出来源 Homo sapiens(blood) 49.66%
分子结构信息
SMILES: C1=CC=C(C=C1)C(=S)N
InChI: InChI=1S/C7H7NS/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:80418
- KEGG: C16281
- PubChem: 683563
- HMDB: HMDB0259002
- Metlin: METLIN71171
- ChEMBL: CHEMBL3739883
- chemspider: 595481
- CAS: 2227-79-4
- PMhub: MS000025034
- PubChem: 47205589
- NIKKAJI: J29.488H
- KNApSAcK: 80418
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Diganta Sarma, Heather Hajovsky, Yakov M Koen, Nadezhda A Galeva, Todd D Williams, Jeffrey L Staudinger, Robert P Hanzlik. Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites.
Chemical research in toxicology.
2012 Sep; 25(9):1868-77. doi:
10.1021/tx3001658. [PMID: 22667464] - Fantao Meng, Belur N Manjula, Amy G Tsai, Pedro Cabrales, Marcos Intaglietta, Paul K Smith, Muthuchidambaram Prabhakaran, Seetharama A Acharya. Hexa-thiocarbamoyl phenyl PEG5K Hb: vasoactivity and structure: influence of rigidity of the conjugation linkage on the PEGylation induced plasma expander-like solution properties of PEG-Hb adducts.
The protein journal.
2009 Jun; 28(5):199-212. doi:
10.1007/s10930-009-9185-0. [PMID: 19653083] - Tao Ji, Keisuke Ikehata, Yakov M Koen, Steven W Esch, Todd D Williams, Robert P Hanzlik. Covalent modification of microsomal lipids by thiobenzamide metabolites in vivo.
Chemical research in toxicology.
2007 Apr; 20(4):701-8. doi:
10.1021/tx600362h. [PMID: 17381136] - T Mizutani, K Suzuki. Relative hepatotoxicity of 2-(substituted phenyl)thiazoles and substituted thiobenzamides in mice: evidence for the involvement of thiobenzamides as ring cleavage metabolites in the hepatotoxicity of 2-phenylthiazoles.
Toxicology letters.
1996 May; 85(2):101-5. doi:
10.1016/0378-4274(96)03646-6. [PMID: 8650692] - S J Grossman, D H Patrick, D Kornbrust, P F Smith, E G Herold, J G DeLuca, A G Zacchei. Thiobenzamide-induced hepatotoxicity: effects of substituents and route of administration on the nature and extent of liver injury.
Toxicology and applied pharmacology.
1991 Dec; 111(3):388-408. doi:
10.1016/0041-008x(91)90245-a. [PMID: 1746022] - V P Davidson, G J Traiger. Determination of p-methylthiobenzamide and p-methylthiobenzamide-S-oxide from rat plasma using solid-phase extraction and high-performance liquid chromatography.
Journal of chromatography.
1991 Jun; 567(1):213-20. doi:
10.1016/0378-4347(91)80324-6. [PMID: 1918248] - E Chieli, M Saviozzi, P Puccini, V Longo, P G Gervasi. Possible role of the acetone-inducible cytochrome P-450IIE1 in the metabolism and hepatotoxicity of thiobenzamide.
Archives of toxicology.
1990; 64(2):122-7. doi:
10.1007/bf01974397. [PMID: 2350230] - L S Gibbs, G J Traiger. Determination of N-methylthiobenzamide in rat plasma by high-performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis.
1990; 8(5):463-6. doi:
10.1016/0731-7085(90)80077-3. [PMID: 2081210] - G J Traiger, L M Gammal, D N Cox, W M Haschek. Nephrotoxicity of para-substituted thiobenzamide derivatives in the rat.
Toxicology.
1989 Sep; 58(1):43-56. doi:
10.1016/0300-483x(89)90103-0. [PMID: 2510368] - J Drsata, J Chloupek, K Waisser. [Adverse biological effects of potential antitubercular agents. XIII. Use of serum aspartate aminotransferase in the study of organ toxicity of thiobenzamide].
Ceskoslovenska farmacie.
1988 Jul; 37(6):243-5. doi:
. [PMID: 3180265] - R P Hanzlik. Chemistry of covalent binding: studies with bromobenzene and thiobenzamide.
Advances in experimental medicine and biology.
1986; 197(?):31-40. doi:
10.1007/978-1-4684-5134-4_3. [PMID: 3766265] - E Chieli, G Malvaldi. Methimazole-induced modulation of thiobenzamide bioactivation and toxicity.
Toxicology letters.
1983 Aug; 18(1-2):147-52. doi:
10.1016/0378-4274(83)90085-1. [PMID: 6623539] - G Malvaldi, E Chieli, M Pollera. Liver cell proliferation induced by single administration of thiobenzamide.
Toxicology letters.
1982 Feb; 10(2-3):259-63. doi:
10.1016/0378-4274(82)90085-6. [PMID: 7080095] - J R Cashman, R P Hanzlik. Microsomal oxidation of thiobenzamide. A photometric assay for the flavin-containing monooxygenase.
Biochemical and biophysical research communications.
1981 Jan; 98(1):147-53. doi:
10.1016/0006-291x(81)91881-7. [PMID: 7213381] - E Chieli, G Malvaldi, D Segnini. The hepatotoxicity of thiobenzamide-S-oxide.
Toxicology letters.
1980 Dec; 7(2):175-80. doi:
10.1016/0378-4274(80)90053-3. [PMID: 7292528] - E Chieli, G Malvaldi, R Tongiani. Early biochemical liver changes following thiobenzamide poisoning.
Toxicology.
1979 Jun; 13(2):101-14. doi:
. [PMID: 516072] - E Chieli, A Paolicchi, P F Parra, G Malvaldi. [Early changes of liver microsomal lipids in acute thiobenzamide poisoning].
Bollettino della Societa italiana di biologia sperimentale.
1979 May; 55(10):981-5. doi:
. [PMID: 508414]
