2-Chloro-5-nitro-N-phenylbenzamide (BioDeep_00000010797)
Secondary id: BioDeep_00001871442
human metabolite blood metabolite
代谢物信息卡片
2-Chloro-5-nitro-N-phenylbenzene-1-carboximidate
化学式: C13H9ClN2O3 (276.0302)
中文名称: 2-氯-5-硝基-N-苯基苯酰胺
谱图信息:
最多检出来源 Homo sapiens(blood) 43.33%
分子结构信息
SMILES: C1=CC=C(C=C1)NC(=O)C2=C(C=CC(=C2)[N+](=O)[O-])Cl
InChI: InChI=1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17)
描述信息
CONFIDENCE standard compound; INTERNAL_ID 929; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4257; ORIGINAL_PRECURSOR_SCAN_NO 4255
CONFIDENCE standard compound; INTERNAL_ID 929; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3923; ORIGINAL_PRECURSOR_SCAN_NO 3921
CONFIDENCE standard compound; INTERNAL_ID 929; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4307; ORIGINAL_PRECURSOR_SCAN_NO 4305
CONFIDENCE standard compound; INTERNAL_ID 929; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3920; ORIGINAL_PRECURSOR_SCAN_NO 3918
GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively.
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:79993
- KEGG: C15627
- PubChem: 644213
- HMDB: HMDB0252995
- Metlin: METLIN63072
- DrugBank: DB07863
- ChEMBL: CHEMBL375270
- CAS: 22978-25-2
- MoNA: LU092954
- MoNA: LU092952
- MoNA: LU092953
- MoNA: LU092951
- PMhub: MS000024693
- PubChem: 17396617
- PDB-CCD: GW9
- NIKKAJI: J1.074.057F
- medchemexpress: HY-16578
- KNApSAcK: 79993
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiajia Liao, Lingyun Fu, Shidie Tai, Yini Xu, Shengquan Wang, Linlin Guo, Die Guo, Youqi Du, Jinggang He, Hong Yang, Xiaoxia Hu, Ling Tao, Xiangchun Shen. Essential oil from Fructus Alpiniae zerumbet ameliorates vascular endothelial cell senescence in diabetes by regulating PPAR-γ signalling: A 4D label-free quantitative proteomics and network pharmacology study.
Journal of ethnopharmacology.
2024 Mar; 321(?):117550. doi:
10.1016/j.jep.2023.117550. [PMID: 38065350] - Yang Yang, Yue Tao, Rongyi Yang, Xiaodong Yi, Guanyu Zhong, Yanyan Gu, Ying Zhang. Ca2+ homeostasis imbalance induced by Pparg: A key factor in di (2-ethylhexyl) phthalate (DEHP)-induced cardiac dysfunction in zebrafish larvae.
The Science of the total environment.
2024 Jan; ?(?):170436. doi:
10.1016/j.scitotenv.2024.170436. [PMID: 38281650] - Fernanda Frederico Gava, Raquel Jaconi De Carli, Solange Stork, Lucineia Gainski Danielski, Sandra Bonfante, Larissa Joaquim, Kiuanne Lino Lobo Metzker, Khiany Mathias, David Santos, Guilherme Darós, Marina Goulart, Rafael Mariano de Bitencourt, Josiane Somariva Prophiro, Cinara Ludvig Gonçalves, Jaqueline Generoso, Tatiana Barichello, Fabricia Petronilho. Cannabidiol effect on long-term brain alterations in septic rats: Involvement of PPARγ activation.
Brain research.
2024 Jan; 1828(?):148771. doi:
10.1016/j.brainres.2024.148771. [PMID: 38242525] - Jing Xiao, Huanyu Xiang, Hongyan Xiang, Zilin Sun, Jing Xu, Hong Ren, Peng Hu, Mingli Peng. GW9662 ameliorates nonalcoholic steatohepatitis by inhibiting the PPARγ/CD36 pathway and altering the gut microbiota.
European journal of pharmacology.
2023 Oct; ?(?):176113. doi:
10.1016/j.ejphar.2023.176113. [PMID: 37838102] - Qian Zeng, Ting-Ting Zhou, Wen-Jie Huang, Xiao-Ting Huang, Lei Huang, Xiao-Hua Zhang, Xiao-Xue Sang, Yu-Yang Luo, Yu-Mei Tian, Bin Wu, Lin Liu, Zi-Qiang Luo, Bin He, Wei Liu, Si-Yuan Tang. Asarinin attenuates bleomycin-induced pulmonary fibrosis by activating PPARγ.
Scientific reports.
2023 09; 13(1):14706. doi:
10.1038/s41598-023-41933-5. [PMID: 37679587] - Xiangbao Meng, Yuan Zhang, Zongyang Li, Guoxu Ma, Xiejun Zhang, Di Zhang, Weiwei Cao, Sicen Wang, Qian Cai, Ping Cui, Guodong Huang. Increasing brain glucose uptake by Gypenoside LXXV ameliorates cognitive deficits in a mouse model of diabetic Alzheimer's disease.
Phytotherapy research : PTR.
2023 Feb; 37(2):611-626. doi:
10.1002/ptr.7639. [PMID: 36325883] - Faisal K Alkholifi, Sushma Devi, Hasan S Yusufoglu, Aftab Alam. The Cardioprotective Effect of Corosolic Acid in the Diabetic Rats: A Possible Mechanism of the PPAR-γ Pathway.
Molecules (Basel, Switzerland).
2023 Jan; 28(3):. doi:
10.3390/molecules28030929. [PMID: 36770602] - Douglas L Orsi, Steven J Ferrara, Stephan Siegel, Anders Friberg, Léa Bouché, Elisabeth Pook, Philip Lienau, Joseph P Bluck, Christopher T Lemke, Gizem Akcay, Timo Stellfeld, Hanna Meyer, Vera Pütter, Simon J Holton, Daniel Korr, Isabel Jerchel-Furau, Constantia Pantelidou, Craig A Strathdee, Matthew Meyerson, Knut Eis, Jonathan T Goldstein. Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.
Bioorganic & medicinal chemistry.
2023 01; 78(?):117130. doi:
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Metabolism: clinical and experimental.
2022 08; 133(?):155233. doi:
10.1016/j.metabol.2022.155233. [PMID: 35654114] - Muneera Waheed Alfarhan, Heba Al-Hussaini, Narayana Kilarkaje. Role of PPAR-γ in diabetes-induced testicular dysfunction, oxidative DNA damage and repair in leptin receptor-deficient obese type 2 diabetic mice.
Chemico-biological interactions.
2022 Jul; 361(?):109958. doi:
10.1016/j.cbi.2022.109958. [PMID: 35472412] - Xiangbao Meng, Yuan Zhang, Zongyang Li, Jinxian Hu, Di Zhang, Weiwei Cao, Min Li, Guoxu Ma, Sicen Wang, Ping Cui, Qian Cai, Guodong Huang. A novel natural PPARγ agonist, Gypenoside LXXV, ameliorates cognitive deficits by enhancing brain glucose uptake via the activation of Akt/GLUT4 signaling in db/db mice.
Phytotherapy research : PTR.
2022 Apr; 36(4):1770-1784. doi:
10.1002/ptr.7413. [PMID: 35192202] - Stacey Herriage, Guangping Chen, Carey Pope. Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2022 Feb; 78(?):105268. doi:
10.1016/j.tiv.2021.105268. [PMID: 34756920] - X Qi, W Lin, Y Wu, Q Li, X Zhou, H Li, Q Xiao, Y Wang, B Shao, Q Yuan. CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome.
Journal of dental research.
2022 02; 101(2):206-215. doi:
10.1177/00220345211024528. [PMID: 34269108] - Zeyu Li, Tong Liu, Yang Feng, Yingmu Tong, Yifan Jia, Cong Wang, Ruixia Cui, Kai Qu, Chang Liu, Jingyao Zhang. PPARγ Alleviates Sepsis-Induced Liver Injury by Inhibiting Hepatocyte Pyroptosis via Inhibition of the ROS/TXNIP/NLRP3 Signaling Pathway.
Oxidative medicine and cellular longevity.
2022; 2022(?):1269747. doi:
10.1155/2022/1269747. [PMID: 35136484] - Yuvaraj Sivamani, Dhivya Shanmugarajan, T Durai Ananda Kumar, Syed Faizan, Bhavya Channappa, Namburu Lalitha Naishima, B R Prashantha Kumar. A promising in silico protocol to develop novel PPARγ antagonists as potential anticancer agents: Design, synthesis and experimental validation via PPARγ protein activity and competitive binding assay.
Computational biology and chemistry.
2021 Dec; 95(?):107600. doi:
10.1016/j.compbiolchem.2021.107600. [PMID: 34794076] - Qingzhong Hua, Xiaoting Huang, Weixi Xie, Feiyan Zhao, Haipeng Cheng, Ziqiang Luo, Jianzhong Han, Zun Wang, Qian Zeng, Miao Lin, Tingting Zhou, Jialu Zhang, Can Gu, Wei Liu, Siyuan Tang. PPARγ mediates the anti-pulmonary fibrosis effect of icaritin.
Toxicology letters.
2021 Oct; 350(?):81-90. doi:
10.1016/j.toxlet.2021.06.014. [PMID: 34153405] - May A Abd El Fattah, Yasmine A Abdelhamid, Mohammed F Elyamany, Osama A Badary, Ola A Heikal. Rice Bran Extract Protected against LPS-Induced Neuroinflammation in Mice through Targeting PPAR-γ Nuclear Receptor.
Molecular neurobiology.
2021 Apr; 58(4):1504-1516. doi:
10.1007/s12035-020-02196-7. [PMID: 33205365] - Serena Stopponi, Yannick Fotio, Carlo Cifani, Hongwu Li, Carolina L Haass-Koffler, Nazzareno Cannella, Gregory Demopulos, George Gaitanaris, Roberto Ciccocioppo. Andrographis paniculata and Its Main Bioactive Ingredient Andrographolide Decrease Alcohol Drinking and Seeking in Rats Through Activation of Nuclear PPARγ Pathway.
Alcohol and alcoholism (Oxford, Oxfordshire).
2021 Feb; 56(2):240-249. doi:
10.1093/alcalc/agaa136. [PMID: 33401299] - Jinlei Liu, Yao Sun, Hongwei Zheng, Jing Wang, Lili Liu, Bing Song, Haoqiang Zhang. Emodin Attenuated the Kidney Damage of High-Fat-Diet Mice via the Upregulation of Glucagon-Like Peptide-1 Receptor.
BioMed research international.
2021; 2021(?):6662704. doi:
10.1155/2021/6662704. [PMID: 34159197] - Corena V Grant, Shengxin Cai, April L Risinger, Huiyun Liang, Barry R O'Keefe, John G Doench, Robert H Cichewicz, Susan L Mooberry. CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells.
Journal of natural products.
2020 10; 83(10):3080-3092. doi:
10.1021/acs.jnatprod.0c00642. [PMID: 33021790] - Haifa Xia, Yangyang Ge, Fuquan Wang, Yu Ming, Zhouyang Wu, Jingxu Wang, Shujun Sun, Shiqian Huang, Ming Chen, Weimin Xiao, Shanglong Yao. Protectin DX ameliorates inflammation in sepsis-induced acute lung injury through mediating PPARγ/NF-κB pathway.
Immunologic research.
2020 10; 68(5):280-288. doi:
10.1007/s12026-020-09151-7. [PMID: 32845434] - Hao Fan, Jing-Wen Yang, Jin Huang, Lu Wang, Na-Na Yang, Jian-Feng Tu, Cun-Zhi Liu. Peroxisome proliferator-activated receptor-γ mediates the antihypertensive effects of acupuncture in spontaneously hypertensive rats.
Neuroreport.
2020 09; 31(13):952-958. doi:
10.1097/wnr.0000000000001496. [PMID: 32568773] - Side Gao, Bing Hua, Qingbo Liu, Huirong Liu, Weiping Li, Hongwei Li. Role of peroxisome proliferators-activated receptor-gamma in advanced glycation end product-mediated functional loss of voltage-gated potassium channel in rat coronary arteries.
BMC cardiovascular disorders.
2020 07; 20(1):337. doi:
10.1186/s12872-020-01613-y. [PMID: 32664860] - Martin Schubert, Stefanie Becher, Maria Wallert, Marten B Maeß, Masoumeh Abhari, Knut Rennert, Alexander S Mosig, Silke Große, Regine Heller, Michael Grün, Stefan Lorkowski. The Peroxisome Proliferator-Activated Receptor (PPAR)-γ Antagonist 2-Chloro-5-Nitro-N-Phenylbenzamide (GW9662) Triggers Perilipin 2 Expression via PPARδ and Induces Lipogenesis and Triglyceride Accumulation in Human THP-1 Macrophages.
Molecular pharmacology.
2020 03; 97(3):212-225. doi:
10.1124/mol.119.117887. [PMID: 31871304] - Zhi-Hao Zhang, Jun-Qiu He, Ying-Yong Zhao, Hua-Chao Chen, Ning-Hua Tan. Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
Acta pharmacologica Sinica.
2020 Mar; 41(3):373-382. doi:
10.1038/s41401-019-0319-4. [PMID: 31705123] - Ze-Fen Wang, Jie Li, Chao Ma, Chong Huang, Zhi-Qiang Li. Telmisartan ameliorates Aβ oligomer-induced inflammation via PPARγ/PTEN pathway in BV2 microglial cells.
Biochemical pharmacology.
2020 01; 171(?):113674. doi:
10.1016/j.bcp.2019.113674. [PMID: 31634455] - Lianying Zhang, Weijie Sun, Xiaoyu Duan, Yishuang Duan, Hongwen Sun. Promoting differentiation and lipid metabolism are the primary effects for DINP exposure on 3T3-L1 preadipocytes.
Environmental pollution (Barking, Essex : 1987).
2019 Dec; 255(Pt 1):113154. doi:
10.1016/j.envpol.2019.113154. [PMID: 31546122] - Lamei Yu, Weijian Li, Byung Mun Park, Gi-Ja Lee, Suhn Hee Kim. Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1α and PPAR-γ pathway.
Peptides.
2019 11; 121(?):170123. doi:
10.1016/j.peptides.2019.170123. [PMID: 31386893] - Shumei Ding, Jiajun Huang, Hongmei Qiu, Rongchun Chen, Jie Zhang, Bo Huang, Oumei Cheng, Qingsong Jiang. Effects of PPARs/20-HETE on the renal impairment under diabetic conditions.
Experimental cell research.
2019 09; 382(1):111455. doi:
10.1016/j.yexcr.2019.05.036. [PMID: 31163124] - Vafa Baradaran Rahimi, Vahid Reza Askari, Seyed Hadi Mousavi. Ellagic acid dose and time-dependently abrogates d-galactose-induced animal model of aging: Investigating the role of PPAR-γ.
Life sciences.
2019 Sep; 232(?):116595. doi:
10.1016/j.lfs.2019.116595. [PMID: 31238053] - Haiqin Fang, Weiting Fang, Hanwen Cao, Sha Luo, Jingdong Cong, Sana Liu, Feng Pan, Xudong Jia. Di-(2-ethylhexyl)-phthalate induces apoptosis via the PPARγ/PTEN/AKT pathway in differentiated human embryonic stem cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Sep; 131(?):110552. doi:
10.1016/j.fct.2019.05.060. [PMID: 31163220] - Jun Liu, Tao Tang, Guo-Dong Wang, Bo Liu. LncRNA-H19 promotes hepatic lipogenesis by directly regulating miR-130a/PPARγ axis in non-alcoholic fatty liver disease.
Bioscience reports.
2019 07; 39(7):. doi:
10.1042/bsr20181722. [PMID: 31064820] - Chi-Hsin Lin, Li-Ya Liao, Tsung-Ying Yang, Yi-Jyun Chang, Chia-Wen Tung, Shih-Lan Hsu, Chi-Mei Hsueh. Microglia-Derived Adiposomes are Potential Targets for the Treatment of Ischemic Stroke.
Cellular and molecular neurobiology.
2019 Jul; 39(5):591-604. doi:
10.1007/s10571-019-00665-9. [PMID: 30852719] - Sungjin Ahn, Seungchan An, Moonyoung Lee, Eunyoung Lee, Jeong Joo Pyo, Jeong Hyeon Kim, Min Won Ki, Sun Hee Jin, Jaehyoun Ha, Minsoo Noh. A long-wave UVA filter avobenzone induces obesogenic phenotypes in normal human epidermal keratinocytes and mesenchymal stem cells.
Archives of toxicology.
2019 07; 93(7):1903-1915. doi:
10.1007/s00204-019-02462-1. [PMID: 31016361] - Yuki Utsugi, Hirona Kobuchi, Yukio Kawamura, Ahmed Salahelden Aboelhamd Atito, Masaya Nagao, Hiroko Isoda, Yusaku Miyamae. Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists.
Molecules (Basel, Switzerland).
2019 May; 24(10):. doi:
10.3390/molecules24102019. [PMID: 31137814] - Songtao Cheng, Kaiyu Qian, Yejinpeng Wang, Gang Wang, Xuefeng Liu, Yu Xiao, Xinghuan Wang. PPARγ inhibition regulates the cell cycle, proliferation and motility of bladder cancer cells.
Journal of cellular and molecular medicine.
2019 05; 23(5):3724-3736. doi:
10.1111/jcmm.14280. [PMID: 30912275] - Yan Wang, Jingjing Xue, Yan Li, Xin Zhou, Shun Qiao, Dewu Han. Telmisartan protects against high glucose/high lipid-induced apoptosis and insulin secretion by reducing the oxidative and ER stress.
Cell biochemistry and function.
2019 Apr; 37(3):161-168. doi:
10.1002/cbf.3383. [PMID: 30907023] - Kiana Rafiepour, Saeed Esmaeili-Mahani, Ali Salehzadeh, Vahid Sheibani. Phytohormone Abscisic Acid Protects Human Neuroblastoma SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Neurotoxicity Through Its Antioxidant and Antiapoptotic Properties.
Rejuvenation research.
2019 Apr; 22(2):99-108. doi:
10.1089/rej.2018.2062. [PMID: 30091676] - Yi Li, Nian Wang, Yongfang Jiang. Geraniol protects against lipopolysaccharide and D-galactosamine-induced fulminant hepatic failure by activating PPARγ.
Microbial pathogenesis.
2019 Mar; 128(?):7-12. doi:
10.1016/j.micpath.2018.11.054. [PMID: 30550845] - Julie M Hall, Heather A Powell, Lara Rajic, Kenneth S Korach. The Role of Dietary Phytoestrogens and the Nuclear Receptor PPARγ in Adipogenesis: An in Vitro Study.
Environmental health perspectives.
2019 03; 127(3):37007. doi:
10.1289/ehp3444. [PMID: 30920877] - Shujue Li, Yu Lan, Wenzheng Wu, Xiaolu Duan, Zhenzhen Kong, Wenqi Wu, Guohua Zeng. Peroxisome proliferator-activated receptor γ modulates renal crystal retention associated with high oxalate concentration by regulating tubular epithelial cellular transdifferentiation.
Journal of cellular physiology.
2019 03; 234(3):2837-2850. doi:
10.1002/jcp.27102. [PMID: 30317563] - Yuanyou Li, Ziyan Yin, Yewei Dong, Shuqi Wang, Óscar Monroig, Douglas R Tocher, Cuihong You. Pparγ Is Involved in the Transcriptional Regulation of Liver LC-PUFA Biosynthesis by Targeting the Δ6Δ5 Fatty Acyl Desaturase Gene in the Marine Teleost Siganus canaliculatus.
Marine biotechnology (New York, N.Y.).
2019 Feb; 21(1):19-29. doi:
10.1007/s10126-018-9854-0. [PMID: 30206714] - Francesca Felicia Caputi, Laura Rullo, Elio Acquas, Roberto Ciccocioppo, Sanzio Candeletti, Patrizia Romualdi. Evidence of a PPARγ-mediated mechanism in the ability of Withania somnifera to attenuate tolerance to the antinociceptive effects of morphine.
Pharmacological research.
2019 01; 139(?):422-430. doi:
10.1016/j.phrs.2018.11.033. [PMID: 30503841] - Vafa Baradaran Rahimi, Vahid Reza Askari, Seyed Hadi Mousavi. Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Dec; 108(?):1712-1724. doi:
10.1016/j.biopha.2018.10.024. [PMID: 30372874] - Mohammad Shahidur Rahman, Pinky Karim Syeda, Michael N N Nartey, Md Mazharul Islam Chowdhury, Hidehisa Shimizu, Kohji Nishimura, Mitsuo Jisaka, Fumiaki Shono, Kazushige Yokota. Comparison of pro-adipogenic effects between prostaglandin (PG) D2 and its stable, isosteric analogue, 11-deoxy-11-methylene-PGD2, during the maturation phase of cultured adipocytes.
Prostaglandins & other lipid mediators.
2018 11; 139(?):71-79. doi:
10.1016/j.prostaglandins.2018.10.006. [PMID: 30393164] - Lijiao Geng, Tao Zhang, Wei Liu, Yong Chen. Inhibition of miR-128 Abates Aβ-Mediated Cytotoxicity by Targeting PPAR-γ via NF-κB Inactivation in Primary Mouse Cortical Neurons and Neuro2a Cells.
Yonsei medical journal.
2018 Nov; 59(9):1096-1106. doi:
10.3349/ymj.2018.59.9.1096. [PMID: 30328325] - Jessica K Hartman, Tyler Beames, Bethany Parks, Daniel Doheny, Gina Song, Alina Efremenko, Miyoung Yoon, Briana Foley, Chad Deisenroth, Patrick D McMullen, Rebecca A Clewell. An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis.
Toxicology and applied pharmacology.
2018 09; 355(?):112-126. doi:
10.1016/j.taap.2018.05.016. [PMID: 29782964] - Makoto Kurano, Hitoshi Ikeda, Naoyuki Iso-O, Masumi Hara, Kazuhisa Tsukamoto, Yutaka Yatomi. Regulation of the metabolism of apolipoprotein M and sphingosine 1-phosphate by hepatic PPARγ activity.
The Biochemical journal.
2018 06; 475(12):2009-2024. doi:
10.1042/bcj20180052. [PMID: 29712716] - Xi Zhao, Feng Wang, Ruijun Zhou, Zengyan Zhu, Meilin Xie. PPARα/γ antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats.
Inflammopharmacology.
2018 Apr; 26(2):425-433. doi:
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Journal of applied toxicology : JAT.
2018 03; 38(3):398-407. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 50(2):585-596. doi:
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PloS one.
2018; 13(9):e0203466. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2017 Dec; 160(2):217-229. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Nov; 95(?):129-136. doi:
10.1016/j.biopha.2017.08.041. [PMID: 28837879] - Myeongjin Yi, Jae-Gook Shin, Su-Jun Lee. Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma.
Toxicology and applied pharmacology.
2017 09; 330(?):100-106. doi:
10.1016/j.taap.2017.07.009. [PMID: 28729181] - A Mastrofrancesco, M Ottaviani, G Cardinali, E Flori, S Briganti, M Ludovici, C C Zouboulis, V Lora, E Camera, M Picardo. Pharmacological PPARγ modulation regulates sebogenesis and inflammation in SZ95 human sebocytes.
Biochemical pharmacology.
2017 08; 138(?):96-106. doi:
10.1016/j.bcp.2017.04.030. [PMID: 28461124] - Yousuf M Al Suleimani, Ahmed S Al Mahruqi. The endogenous lipid N-arachidonoyl glycine is hypotensive and nitric oxide-cGMP-dependent vasorelaxant.
European journal of pharmacology.
2017 Jan; 794(?):209-215. doi:
10.1016/j.ejphar.2016.11.040. [PMID: 27890711] - Jichun Han, Dong Wang, Lei Ye, Peng Li, Wenjin Hao, Xiaoyu Chen, Jun Ma, Bo Wang, Jing Shang, Defang Li, Qiusheng Zheng. Rosmarinic Acid Protects against Inflammation and Cardiomyocyte Apoptosis during Myocardial Ischemia/Reperfusion Injury by Activating Peroxisome Proliferator-Activated Receptor Gamma.
Frontiers in pharmacology.
2017; 8(?):456. doi:
10.3389/fphar.2017.00456. [PMID: 28744220] - Emily W Y Tung, Shaimaa Ahmed, Vian Peshdary, Ella Atlas. Firemaster® 550 and its components isopropylated triphenyl phosphate and triphenyl phosphate enhance adipogenesis and transcriptional activity of peroxisome proliferator activated receptor (Pparγ) on the adipocyte protein 2 (aP2) promoter.
PloS one.
2017; 12(4):e0175855. doi:
10.1371/journal.pone.0175855. [PMID: 28437481] - Yuncheng Bei, Jiajia Chen, Feifei Zhou, Yahong Huang, Nan Jiang, Renxiang Tan, Pingping Shen. BZ-26, a novel GW9662 derivate, attenuated inflammation by inhibiting the differentiation and activation of inflammatory macrophages.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Dec; 84(?):730-739. doi:
10.1016/j.biopha.2016.08.069. [PMID: 27710897] - Marika Cordaro, Daniela Impellizzeri, Enrico Gugliandolo, Rosalba Siracusa, Rosalia Crupi, Emanuela Esposito, Salvatore Cuzzocrea. Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease.
Molecular pharmacology.
2016 Nov; 90(5):549-561. doi:
10.1124/mol.116.105668. [PMID: 27625036] - Gang Wang, Rui Cao, Yongzhi Wang, Guofeng Qian, Han C Dan, Wei Jiang, Lingao Ju, Min Wu, Yu Xiao, Xinghuan Wang. Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway.
Scientific reports.
2016 10; 6(?):35783. doi:
10.1038/srep35783. [PMID: 27779188] - S Ahmed, E Atlas. Bisphenol S- and bisphenol A-induced adipogenesis of murine preadipocytes occurs through direct peroxisome proliferator-activated receptor gamma activation.
International journal of obesity (2005).
2016 10; 40(10):1566-1573. doi:
10.1038/ijo.2016.95. [PMID: 27273607] - Cheng-Hung Chuang, Chiao-Lin Yeh, Shu-Lan Yeh, En-Shyh Lin, Li-Yu Wang, Ying-Hsuna Wang. Quercetin metabolites inhibit MMP-2 expression in A549 lung cancer cells by PPAR-γ associated mechanisms.
The Journal of nutritional biochemistry.
2016 07; 33(?):45-53. doi:
10.1016/j.jnutbio.2016.03.011. [PMID: 27260467] - Yan Song, Hongfeng Zhao, Jinyang Liu, Chao Fang, Renying Miao. Effects of Citral on Lipopolysaccharide-Induced Inflammation in Human Umbilical Vein Endothelial Cells.
Inflammation.
2016 Apr; 39(2):663-71. doi:
10.1007/s10753-015-0292-0. [PMID: 26658749] - Shireesha Sankella, Abhimanyu Garg, Anil K Agarwal. Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells.
PloS one.
2016; 11(9):e0162504. doi:
10.1371/journal.pone.0162504. [PMID: 27611931] - Anna Ohtera, Yusaku Miyamae, Kotaro Yoshida, Kazuhiro Maejima, Toru Akita, Akira Kakizuka, Kazuhiro Irie, Seiji Masuda, Taiho Kambe, Masaya Nagao. Identification of a New Type of Covalent PPARγ Agonist using a Ligand-Linking Strategy.
ACS chemical biology.
2015 Dec; 10(12):2794-804. doi:
10.1021/acschembio.5b00628. [PMID: 26414848] - Yan Zhang, Yan Cui, Xiao-Li Wang, Xiang Shang, Zhi-Gang Qi, Jie Xue, Xi Zhao, Min Deng, Mei-Lin Xie. PPARα/γ agonists and antagonists differently affect hepatic lipid metabolism, oxidative stress and inflammatory cytokine production in steatohepatitic rats.
Cytokine.
2015 Sep; 75(1):127-35. doi:
10.1016/j.cyto.2015.05.031. [PMID: 26194065] - David Contador, Fernando Ezquer, Maximiliano Espinosa, Martha Arango-Rodriguez, Carlos Puebla, Luis Sobrevia, Paulette Conget. Dexamethasone and rosiglitazone are sufficient and necessary for producing functional adipocytes from mesenchymal stem cells.
Experimental biology and medicine (Maywood, N.J.).
2015 Sep; 240(9):1235-46. doi:
10.1177/1535370214566565. [PMID: 25595190] - Jared Ching, Stephanie Amiridis, Stanley S Stylli, Andrew R Bjorksten, Nicole Kountouri, Thomas Zheng, Lucy Paradiso, Rodney B Luwor, Andrew P Morokoff, Terence J O'Brien, Andrew H Kaye. The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells.
Oncotarget.
2015 Aug; 6(25):21301-14. doi:
10.18632/oncotarget.4019. [PMID: 26046374] - Yang Yu, Bao-Jian Xue, Shun-Guang Wei, Zhi-Hua Zhang, Terry G Beltz, Fang Guo, Alan Kim Johnson, Robert B Felder. Activation of central PPAR-γ attenuates angiotensin II-induced hypertension.
Hypertension (Dallas, Tex. : 1979).
2015 Aug; 66(2):403-11. doi:
10.1161/hypertensionaha.115.05726. [PMID: 26101342] - Jing Xiao, Weijun Chen, Yijun Lu, Xiaoli Zhang, Chensheng Fu, Zhenwen Yan, Zhenxing Zhang, Zhibin Ye. Crosstalk between peroxisome proliferator-activated receptor-γ and mineralcorticoid receptor in TNF-α activated renal tubular cell.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2015 Aug; 64(8):603-14. doi:
10.1007/s00011-015-0838-5. [PMID: 26072064] - Yizhu Sun, Jing Wang, Luxin Yu, Lin Dai. [The role of peroxisome proliferator-activated receptor-γ/nuclear factor-ΚB transduction pathway on coagulation disorders induced by sepsis].
Zhonghua wei zhong bing ji jiu yi xue.
2015 Jun; 27(6):520-4. doi:
10.3760/cma. j. issn.2095-4352.2015.06.020. [PMID: 26049195] - Tilo Knape, Daniel Flesch, Laura Kuchler, Lisa K Sha, Annika K Giegerich, Sandra Labocha, Nerea Ferreirós, Tobias Schmid, Mario Wurglics, Manfred Schubert-Zsilavecz, Eugen Proschak, Bernhard Brüne, Michael J Parnham, Andreas von Knethen. Identification and characterisation of a prototype for a new class of competitive PPARγ antagonists.
European journal of pharmacology.
2015 May; 755(?):16-26. doi:
10.1016/j.ejphar.2015.02.034. [PMID: 25746464] - Jing Wang, Lin Dai, Luxin Yu, Yizhu Sun. [Effects of proliferator-activated receptor-γ agonist on vascular endothelial injuries in septic rats].
Zhonghua yi xue za zhi.
2015 Apr; 95(15):1179-83. doi:
. [PMID: 26081365] - Liu-bin Liu, Chang-nong Duan, Zeng-yi Ma, Gang Xu. [Curcumin inhibited rat colorectal carcinogenesis by activating PPAR-γ: an experimental study].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2015 Apr; 35(4):471-5. doi:
. [PMID: 26043573] - Hua-Yu Zhu, Chao Li, Zhao Zheng, Qin Zhou, Hao Guan, Lin-Lin Su, Jun-Tao Han, Xiong-Xiang Zhu, Shu-yue Wang, Jun Li, Da-Hai Hu. Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist inhibits collagen synthesis in human hypertrophic scar fibroblasts by targeting Smad3 via miR-145.
Biochemical and biophysical research communications.
2015 Mar; 459(1):49-53. doi:
10.1016/j.bbrc.2015.02.061. [PMID: 25704091] - John T Garretson, Brett J W Teubner, Kevin L Grove, Almira Vazdarjanova, Vitaly Ryu, Timothy J Bartness. Peroxisome proliferator-activated receptor γ controls ingestive behavior, agouti-related protein, and neuropeptide Y mRNA in the arcuate hypothalamus.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015 Mar; 35(11):4571-81. doi:
10.1523/jneurosci.2129-14.2015. [PMID: 25788674] - Li Sun, Yan-Wei Xu, Jing Han, Hao Liang, Ning Wang, Yan Cheng. 12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain.
Journal of lipid research.
2015 Mar; 56(3):502-514. doi:
10.1194/jlr.m053058. [PMID: 25605873] - Rui Li, Xizhen Xu, Chen Chen, Yan Wang, Artiom Gruzdev, Darryl C Zeldin, Dao Wen Wang. CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPARγ.
American journal of physiology. Endocrinology and metabolism.
2015 Feb; 308(4):E270-82. doi:
10.1152/ajpendo.00118.2014. [PMID: 25389363] - Cuifen Wang, Xiaoniu Dai, Hua Liu, Hongwei Yi, Dongrui Zhou, Chunhui Liu, Min Ma, Zhenzhou Jiang, Luyong Zhang. Involvement of PPARγ in emodin-induced HK-2 cell apoptosis.
Toxicology in vitro : an international journal published in association with BIBRA.
2015 Feb; 29(1):228-33. doi:
10.1016/j.tiv.2014.10.021. [PMID: 25448808] - Shizhan Ma, Fei Jing, Chao Xu, Lingyan Zhou, Yongfeng Song, Chunxiao Yu, Dongqing Jiang, Ling Gao, Yujie Li, Qingbo Guan, Jiajun Zhao. Thyrotropin and obesity: increased adipose triglyceride content through glycerol-3-phosphate acyltransferase 3.
Scientific reports.
2015 Jan; 5(?):7633. doi:
10.1038/srep07633. [PMID: 25559747] - Ellen L Berg, Mark A Polokoff, Alison O'Mahony, Dat Nguyen, Xitong Li. Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.
International journal of molecular sciences.
2015 Jan; 16(1):1008-29. doi:
10.3390/ijms16011008. [PMID: 25569083] - Graziela Rosa Ravacci, Maria Mitzi Brentani, Tharcisio Citrângulo Tortelli, Raquel Suzana M M Torrinhas, Jéssica Reis Santos, Angela Flávia Logullo, Dan Linetzky Waitzberg. Docosahexaenoic Acid Modulates a HER2-Associated Lipogenic Phenotype, Induces Apoptosis, and Increases Trastuzumab Action in HER2-Overexpressing Breast Carcinoma Cells.
BioMed research international.
2015; 2015(?):838652. doi:
10.1155/2015/838652. [PMID: 26640797] - Jocelijn Meijerink, Mieke Poland, Michiel G J Balvers, Pierluigi Plastina, Carolien Lute, Jvalini Dwarkasing, Klaske van Norren, Renger F Witkamp. Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages.
British journal of pharmacology.
2015 Jan; 172(1):24-37. doi:
10.1111/bph.12747. [PMID: 24780080] - Wenshu Chen, Shijiang Yang, Wei Ping, Xiangning Fu, Qinzi Xu, Jianing Wang. CYP2J2 and EETs protect against lung ischemia/reperfusion injury via anti-inflammatory effects in vivo and in vitro.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2015; 35(5):2043-54. doi:
10.1159/000374011. [PMID: 25870948] - Huibin Nie, Xia Xue, Jie Li, Xiangchun Liu, Shasha Lv, Guangju Guan, Haiying Liu, Gang Liu, Shanshan Liu, Zhixin Chen. Nitro-oleic acid attenuates OGD/R-triggered apoptosis in renal tubular cells via inhibition of Bax mitochondrial translocation in a PPAR-γ-dependent manner.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2015; 35(3):1201-18. doi:
10.1159/000373944. [PMID: 25766531] - Ki Rim Kim, Hyun Jeong Kim, Sun Kyoung Lee, Gwang Taek Ma, Kwang Kyun Park, Won Yoon Chung. 15-deoxy-δ12,14-prostaglandin j2 inhibits osteolytic breast cancer bone metastasis and estrogen deficiency-induced bone loss.
PloS one.
2015; 10(4):e0122764. doi:
10.1371/journal.pone.0122764. [PMID: 25859665] - Zhi Li, Hang Li, Chunhui Zhao, Cui Lv, Changjia Zhong, Wenfeng Xin, Wensheng Zhang. Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer's Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting Aβ Accumulation.
CNS & neurological disorders drug targets.
2015; 14(3):360-9. doi:
10.2174/1871527314666150225141521. [PMID: 25714973] - Xiaolei Zhou, Shengyi You. Rosiglitazone inhibits hepatic insulin resistance induced by chronic pancreatitis and IKK-β/NF-κB expression in liver.
Pancreas.
2014 Nov; 43(8):1291-8. doi:
10.1097/mpa.0000000000000173. [PMID: 25036911] - Ze-Ping Hu, Xiao-Ling Fang, Hai-Yan Qian, Nan Fang, Bang-Ning Wang, Yuan Wang. Telmisartan prevents angiotensin II-induced endothelial dysfunction in rabbit aorta via activating HGF/Met system and PPARγ pathway.
Fundamental & clinical pharmacology.
2014 Oct; 28(5):501-11. doi:
10.1111/fcp.12057. [PMID: 24188213] - Norihiro Yoshizaki, Takahiro Fujii, Hitoshi Masaki, Takeshi Okubo, Kunio Shimada, Ron Hashizume. Orange peel extract, containing high levels of polymethoxyflavonoid, suppressed UVB-induced COX-2 expression and PGE2 production in HaCaT cells through PPAR-γ activation.
Experimental dermatology.
2014 Oct; 23 Suppl 1(?):18-22. doi:
10.1111/exd.12394. [PMID: 25234831] - Xin Fu, Ai-Guo Xu, Meng-Ying Yao, Li Guo, Luo-Sha Zhao. Emodin enhances cholesterol efflux by activating peroxisome proliferator-activated receptor-γ in oxidized low density lipoprotein-loaded THP1 macrophages.
Clinical and experimental pharmacology & physiology.
2014 Sep; 41(9):679-84. doi:
10.1111/1440-1681.12262. [PMID: 24837536] - Zhi-qiang Pan, Ding Xie, Vivek Choudhary, Mutsa Seremwe, Ying-Ying Tsai, Lawrence Olala, Xunsheng Chen, Wendy B Bollag. The effect of pioglitazone on aldosterone and cortisol production in HAC15 human adrenocortical carcinoma cells.
Molecular and cellular endocrinology.
2014 Aug; 394(1-2):119-28. doi:
10.1016/j.mce.2014.07.007. [PMID: 25038520] - Cecilia I Casali, Karen Weber, Daniela Faggionato, Emanuel Morel Gómez, María C Fernández Tome. Coordinate regulation between the nuclear receptor peroxisome proliferator-activated receptor-γ and cyclooxygenase-2 in renal epithelial cells.
Biochemical pharmacology.
2014 Aug; 90(4):432-9. doi:
10.1016/j.bcp.2014.06.002. [PMID: 24915420] - Yogeeta O Agrawal, Pankaj Kumar Sharma, Birendra Shrivastava, Dharamvir Singh Arya, Sameer N Goyal. Hesperidin blunts streptozotocin-isoproternol induced myocardial toxicity in rats by altering of PPAR-γ receptor.
Chemico-biological interactions.
2014 Aug; 219(?):211-20. doi:
10.1016/j.cbi.2014.06.010. [PMID: 24954035] - Eileen Frenzel, Sabine Wrenger, Stephan Immenschuh, Rembert Koczulla, Ravi Mahadeva, H Joachim Deeg, Charles A Dinarello, Tobias Welte, A Mario Q Marcondes, Sabina Janciauskiene. Acute-phase protein α1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion.
Journal of immunology (Baltimore, Md. : 1950).
2014 Jun; 192(11):5354-62. doi:
10.4049/jimmunol.1400378. [PMID: 24760148] - Yan Chi, Le Wang, Yuanyuan Liu, Yanhua Ma, Renjun Wang, Xiaofei Han, Hui Qiao, Jiabin Lin, Eiji Matsuura, Shuqian Liu, Qingping Liu. 7-ketocholesteryl-9-carboxynonanoate enhances ATP binding cassette transporter A1 expression mediated by PPARγ in THP-1 macrophages.
Atherosclerosis.
2014 Jun; 234(2):461-8. doi:
10.1016/j.atherosclerosis.2014.01.052. [PMID: 24814410] - Swei Sunny Hahn, Qing Tang, Fang Zheng, Shunyu Zhao, Jingjing Wu. GW1929 inhibits α7 nAChR expression through PPARγ-independent activation of p38 MAPK and inactivation of PI3-K/mTOR: The role of Egr-1.
Cellular signalling.
2014 Apr; 26(4):730-9. doi:
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