Cefepime (BioDeep_00000006663)

 

Secondary id: BioDeep_00001868076

human metabolite blood metabolite


代谢物信息卡片


(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

化学式: C19H24N6O5S2 (480.125)
中文名称: 头孢吡肟
谱图信息: 最多检出来源 Mentha canadensis(plant) 6.76%

分子结构信息

SMILES: CON=C(C(=O)NC1C(=O)N2C(C(=O)[O-])=C(C[N+]3(C)CCCC3)CSC12)c1csc(=N)[nH]1
InChI: InChI=1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1

描述信息

Cefepime is a fourth-generation cephalosporin antibiotic developed in 1994. Cefepime has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents. Cefepime is usually reserved to treat severe nosocomial pneumonia, infections caused by multi-resistant microorganisms (e.g. Pseudomonas aeruginosa) and empirical treatment of febrile neutropenia.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DE - Fourth-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

16 个代谢物同义名

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 1-{[(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-methylpyrrolidin-1-ium; Bristol-myers squibb brand OF cefepime dihydrochloride; Bristol-myers brand OF cefepime dihydrochloride; Elan brand OF cefepime dihydrochloride; Cefepime hydrochloride; Quadrocef; Cefepimum; Cefepima; cefepime; Maxipime; Cefepim; Axépim; CFPM; Cefepime



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, CAT, CST3, ELANE, SLC22A5
Peripheral membrane protein 1 CYP27A1
Mitochondrion membrane 1 CYP27A1
Nucleus 3 ALB, IKZF2, OMP
cytosol 8 ALB, CAT, ELANE, GPT, LIPE, OMP, SLC22A5, STX1A
phagocytic vesicle 1 ELANE
centrosome 1 ALB
Cell membrane 3 LIPE, SLC22A5, STX1A
lamellipodium 1 STX2
Multi-pass membrane protein 1 SLC22A5
Synapse 1 OMP
cell surface 2 ELANE, TNR
glutamatergic synapse 1 TNR
Golgi apparatus 2 ALB, CST3
mitochondrial inner membrane 1 CYP27A1
neuronal cell body 1 OMP
synaptic vesicle 2 STX1A, STX2
Cytoplasm, cytosol 1 LIPE
plasma membrane 6 CST3, IGHE, SLC22A5, ST14, STX1A, STX2
synaptic vesicle membrane 1 STX1A
Membrane 5 CAT, LIPE, SLC22A5, ST14, STX2
apical plasma membrane 1 SLC22A5
axon 2 OMP, STX1A
basolateral plasma membrane 2 ST14, STX2
caveola 1 LIPE
extracellular exosome 6 ALB, CAT, CST3, ELANE, GPT, SLC22A5
endoplasmic reticulum 3 ALB, CST3, SLC22A5
extracellular space 10 ALB, CPZ, CRP, CSF3, CST3, ELANE, IGHE, ST14, STX2, TNR
lysosomal lumen 1 CSF3
Schaffer collateral - CA1 synapse 1 TNR
mitochondrion 2 CAT, CYP27A1
protein-containing complex 3 ALB, CAT, STX2
intracellular membrane-bounded organelle 2 CAT, STX2
Single-pass type I membrane protein 1 IGHE
Secreted 5 ALB, CRP, CSF3, CST3, HTRA3
extracellular region 10 ALB, CAT, CRP, CSF3, CST3, ELANE, HTRA3, IGHE, STX1A, TNR
[Isoform 2]: Secreted 1 STX1A
mitochondrial matrix 2 CAT, CYP27A1
anchoring junction 1 ALB
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 STX1A
nuclear membrane 1 STX1A
external side of plasma membrane 1 ST14
Secreted, extracellular space, extracellular matrix 2 CPZ, TNR
Single-pass type II membrane protein 1 ST14
vesicle 1 CST3
presynaptic active zone membrane 2 STX1A, STX2
Apical cell membrane 1 SLC22A5
Mitochondrion inner membrane 1 CYP27A1
Membrane raft 1 TNR
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 2 ELANE, TNR
secretory granule 1 ELANE
neuron projection 1 STX1A
ciliary basal body 1 ALB
IgE immunoglobulin complex 1 IGHE
centriole 1 ALB
brush border membrane 1 SLC22A5
spindle pole 1 ALB
blood microparticle 1 ALB
[Isoform 2]: Cell membrane 1 IGHE
Endomembrane system 2 STX1A, STX2
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
basal plasma membrane 1 SLC22A5
SNARE complex 2 STX1A, STX2
ficolin-1-rich granule lumen 2 CAT, CST3
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 2 ALB, CST3
transcription repressor complex 1 ELANE
platelet alpha granule lumen 1 ALB
specific granule lumen 1 ELANE
tertiary granule lumen 1 CST3
azurophil granule lumen 1 ELANE
perineuronal net 1 TNR
Single-pass type IV membrane protein 1 STX1A
Synapse, synaptosome 1 STX1A
Basal cell membrane 1 SLC22A5
Cytoplasmic vesicle, phagosome 1 ELANE
[Isoform 3]: Endoplasmic reticulum 1 SLC22A5
[Isoform 3]: Cell membrane 1 IGHE
endocytic vesicle lumen 1 CSF3
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
catalase complex 1 CAT
tenascin complex 1 TNR
ciliary transition fiber 1 ALB
synaptobrevin 2-SNAP-25-syntaxin-1a complex 1 STX1A


文献列表

  • Gisele Canan-Rochenbach, Marco A B Barreiros, André O S Lima, Pascale Bauda, Eric Sanches-Simões, Wendell Pimentel-Almeida, Rafael Ariente-Neto, Cleder A Somensi, Tito C M Almeida, Rogério Corrêa, Claudemir M Radetski. Characterization of bacterial resistance in treated hospital wastewater. Environmental technology. 2024 Jan; 45(1):120-128. doi: 10.1080/09593330.2022.2100282. [PMID: 35802062]
  • Jiaojiao Fu, Fangting He, Jinming Xiao, Zhengyue Liao, Liying He, Jing He, Jinlin Guo, Sijing Liu. Rapid AMR prediction in Pseudomonas aeruginosa combining MALDI-TOF MS with DNN model. Journal of applied microbiology. 2023 Nov; 134(11):. doi: 10.1093/jambio/lxad248. [PMID: 37930836]
  • Muriel Masi, Julia Vergalli, Ishan Ghai, Andrea Barba-Bon, Thérèse Schembri, Werner M Nau, Daniel Lafitte, Mathias Winterhalter, Jean-Marie Pagès. Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane. Communications biology. 2022 10; 5(1):1059. doi: 10.1038/s42003-022-04035-y. [PMID: 36198902]
  • Gwendolyn M Pais, Jack Chang, Erin F Barreto, Gideon Stitt, Kevin J Downes, Mohammad H Alshaer, Emily Lesnicki, Vaidehi Panchal, Maria Bruzzone, Argyle V Bumanglag, Sara N Burke, Marc H Scheetz. Clinical Pharmacokinetics and Pharmacodynamics of Cefepime. Clinical pharmacokinetics. 2022 07; 61(7):929-953. doi: 10.1007/s40262-022-01137-y. [PMID: 35764774]
  • Khalil S Husari, Eva K Ritzl, Peter W Kaplan. Acute Toxicity and Triphasic Waves-The Example of Cefepime. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 2022 Jul; 39(5):419-426. doi: 10.1097/wnp.0000000000000791. [PMID: 33086250]
  • Hiie Soeorg, Aveli Noortoots, Maarja Karu, Kadri Saks, Jana Lass, Irja Lutsar, Lenne-Triin Kõrgvee. Estimation of cefepime, piperacillin, and tazobactam clearance with iohexol-based glomerular filtration rate in paediatric patients. European journal of clinical pharmacology. 2022 Jun; 78(6):989-1001. doi: 10.1007/s00228-022-03307-0. [PMID: 35275224]
  • Tomoyuki Nakamura, Tomoaki Yatabe, Naohide Kuriyama, Toshihisa Hiraiwa, Kana Matsumoto, Osamu Nishida. Cefepime-induced encephalopathy in a COVID-19 patient: a case report. Journal of anesthesia. 2022 Jun; 36(3):432-435. doi: 10.1007/s00540-022-03068-1. [PMID: 35487992]
  • Dhakrit Rungkitwattanakul, Amy L Ives, Nicole G Harriott, Sarah Pan-Chen, Lan Duong. Comparative incidence of acute kidney injury in patients on vancomycin therapy in combination with cefepime, piperacillin-tazobactam or meropenem. Journal of chemotherapy (Florence, Italy). 2022 Apr; 34(2):103-109. doi: 10.1080/1120009x.2021.1965334. [PMID: 34424136]
  • Taylor A Imburgia, Samantha R Engdahl, Rebecca S Pettit. Evaluation of the safety of cefepime prolonged infusions in pediatric patients with cystic fibrosis. Pediatric pulmonology. 2022 04; 57(4):919-925. doi: 10.1002/ppul.25817. [PMID: 34989183]
  • Céline Thibault, Ganesh S Moorthy, Christina Vedar, Maryam Y Naim, Mary Ann DiLiberto, Athena F Zuppa. Pharmacokinetics of Cefepime in Children on Extracorporeal Membrane Oxygenation: External Model Validation, Model Improvement and Dose Optimization. The Pediatric infectious disease journal. 2022 03; 41(3):217-223. doi: 10.1097/inf.0000000000003371. [PMID: 34817416]
  • Maxwell J Lasko, David P Nicolau, Tomefa E Asempa. Clinical exposure-response relationship of cefepime/taniborbactam against Gram-negative organisms in the murine complicated urinary tract infection model. The Journal of antimicrobial chemotherapy. 2022 02; 77(2):443-447. doi: 10.1093/jac/dkab405. [PMID: 34747449]
  • Mitchell S Buckley, Ivan A Komerdelj, Paul A D'Alessio, Pooja Rangan, Sumit K Agarwal, Nicole C Tinta, Brandon K Martinez, Delia S Ziadat, Melanie J Yerondopoulos, Emir Kobic, Sandra L Kane-Gill. Vancomycin with concomitant piperacillin/tazobactam vs. cefepime or meropenem associated acute kidney injury in the critically ill: A multicenter propensity score-matched study. Journal of critical care. 2022 02; 67(?):134-140. doi: 10.1016/j.jcrc.2021.10.018. [PMID: 34768175]
  • Dorothy Dao Nguyen, Samuel Lai. Prolonged Cefepime-Induced Neurotoxicity in a Patient with End-Stage Renal Disease. The American journal of case reports. 2022 Jan; 23(?):e934083. doi: 10.12659/ajcr.934083. [PMID: 35067669]
  • Mohammad H Al-Shaer, Kelly Maguigan, Jennifer Ashton, Veena Venugopalan, Molly E Droege, Carolyn D Philpott, Christopher A Droege, Daniel P Healy, Eric W Mueller, Charles A Peloquin. Applying Cefepime Population Pharmacokinetics to Critically Ill Patients Receiving Continuous Renal Replacement Therapy. Antimicrobial agents and chemotherapy. 2022 01; 66(1):e0161121. doi: 10.1128/aac.01611-21. [PMID: 34662194]
  • Brian Pacca Elliott, Michael M Tang, Joshua Alexander Madden, Ronald James Markert, Steven Dale Burdette, Craig Matthew Pleiman, Emily Claire Speelmon. A retrospective cohort study assessing acute kidney injury and renal recovery among septic patients empirically treated with vancomycin piperacillin-tazobactam versus vancomycin cefepime. Internal and emergency medicine. 2022 Jan; 17(1):91-99. doi: 10.1007/s11739-021-02772-2. [PMID: 34089468]
  • Ibtisam H Al-Azawi, Mahasin S Al-Bidiri. DISTRIBUTION OF INTEGRON III AND PHYLOGENIC CLADE AMONG MDR UROPATHOGENIC E. COLI FROM PATIENT IN AL-DIWANIYAH CITY, IRAQ. Wiadomosci lekarskie (Warsaw, Poland : 1960). 2022; 75(5 pt 2):1254-1260. doi: 10.36740/wlek202205205. [PMID: 35758440]
  • Yi-Fan Lo, Chien-Wen Chien, Yueh-Ming Tai, Shin-Chang Kuo, Shih-Hua Lin, Nian-Sheng Tzeng. Cefepime-Induced Depressive Disorder in a Patient With End-Stage Renal Disease. American journal of therapeutics. 2022 Jan; 29(1):e111-e113. doi: 10.1097/mjt.0000000000001229. [PMID: 34994352]
  • Matthias Gijsen, Britt Bekkers, Johan Maertens, Katrien Lagrou, Stefanie Desmet, Erwin Dreesen, Willy E Peetermans, Yves Debaveye, Isabel Spriet. Prospective assessment of breakthrough infections and neurotoxicity and their association with cefepime trough concentrations in patients with febrile neutropenia. International journal of antimicrobial agents. 2022 Jan; 59(1):106472. doi: 10.1016/j.ijantimicag.2021.106472. [PMID: 34757136]
  • Cindy Lau, Deborah Marriott, Hayley B Schultz, Michael Gould, David Andresen, Sebastian G Wicha, Jan-Willem Alffenaar, Jonathan Penm, Stephanie E Reuter. Assessment of cefepime toxicodynamics: comprehensive examination of pharmacokinetic/pharmacodynamic targets for cefepime-induced neurotoxicity and evaluation of current dosing guidelines. International journal of antimicrobial agents. 2021 Dec; 58(6):106443. doi: 10.1016/j.ijantimicag.2021.106443. [PMID: 34551358]
  • Vesa Cheng, Mohd H Abdul-Aziz, Fay Burrows, Hergen Buscher, Amanda Corley, Arne Diehl, Stephan M Jakob, Bianca J Levkovich, Vincent Pellegrino, Yok-Ai Que, Claire Reynolds, Sam Rudham, Steven C Wallis, Susan A Welch, David Zacharias, Jason A Roberts, Kiran Shekar, John F Fraser. Population pharmacokinetics of cefepime in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study). International journal of antimicrobial agents. 2021 Dec; 58(6):106466. doi: 10.1016/j.ijantimicag.2021.106466. [PMID: 34688834]
  • Mohamed Aboubakr, Afaf Abdelkader, Ola A Habotta, Nisreen Adel, Mahmoud A Emam, Ehab Y Abdelhiee, Obeid Shanab, Khaled Shoghy, Heba Elnoury, Mohamed M Soliman, Samah F Ibrahim, Ahmed Abdeen. Cefepime and diclofenac sodium combined treatment-potentiated multiple organ injury: Role of oxidative damage and disrupted lipid metabolism. Journal of biochemical and molecular toxicology. 2021 Dec; 35(12):e22929. doi: 10.1002/jbt.22929. [PMID: 34676623]
  • Xiaocong Liu, Qingfan Wei, Xiaowei Yang, Xiaojie Wang, Jiamei Zhang, Rui Xu, Haoluo Zhang, Shaomin Wang, Xuemei Wan, Linhong Jiang, Yuman He, Shu Li, Rong Chen, Yonghai Wang, Yaxing Chen, Feng Qin, Yuanyuan Chen, Yanping Dai, Hongchun Li, Ying Zhao, Huaqin Zhang, Qian Bu, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Cen. Lipidomics Reveals Dysregulated Glycerophospholipid Metabolism in the Corpus Striatum of Mice Treated with Cefepime. ACS chemical neuroscience. 2021 12; 12(23):4449-4464. doi: 10.1021/acschemneuro.1c00608. [PMID: 34762393]
  • Naoto Okada, Yuki Izumi, Aki Nakamoto, Masayuki Chuma, Mitsuhiro Goda, Kenta Yagi, Fuka Aizawa, Hirofumi Hamano, Yoshito Zamami, Momoyo Azuma, Keisuke Ishizawa. Impact of Area Under the Concentration-Time Curve on the Prevalence of Vancomycin-Induced Nephrotoxicity in Combination With Tazobactam/Piperacillin or Cefepime: A Single-Institution Retrospective Study. Clinical therapeutics. 2021 11; 43(11):1910-1920.e3. doi: 10.1016/j.clinthera.2021.09.007. [PMID: 34642081]
  • Jazmin D Lee, Brett H Heintz, Hilary J Mosher, Daniel J Livorsi, Jason A Egge, Brian C Lund. Risk of Acute Kidney Injury and Clostridioides difficile Infection With Piperacillin/Tazobactam, Cefepime, and Meropenem With or Without Vancomycin. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 10; 73(7):e1579-e1586. doi: 10.1093/cid/ciaa1902. [PMID: 33382398]
  • Kevin Doello, Víctor Amezcua. Effect of adding bemiparin and cefepime to routine treatment in cancer patients with SARS-CoV-2 infection. Medicina clinica. 2021 09; 157(6):299-300. doi: 10.1016/j.medcli.2021.03.010. [PMID: 34083071]
  • Matthew W Bjergum, Erin F Barreto, Marc H Scheetz, Andrew D Rule, Paul J Jannetto. Stability and Validation of a High-Throughput LC-MS/MS Method for the Quantification of Cefepime, Meropenem, and Piperacillin and Tazobactam in Serum. The journal of applied laboratory medicine. 2021 09; 6(5):1202-1212. doi: 10.1093/jalm/jfab036. [PMID: 34086904]
  • Maxwell J Lasko, Kamilia Abdelraouf, David P Nicolau. Comparative in vivo activity of human-simulated plasma and epithelial lining fluid exposures of WCK 5222 (cefepime/zidebactam) against KPC- and OXA-48-like-producing Klebsiella pneumoniae in the neutropenic murine pneumonia model. The Journal of antimicrobial chemotherapy. 2021 08; 76(9):2310-2316. doi: 10.1093/jac/dkab183. [PMID: 34096601]
  • Sylvain Goutelle, Lucille Jay, Clément Boidin, Sabine Cohen, Laurent Bourguignon, Nathalie Bleyzac, Florent Wallet, Olivia Vassal, Arnaud Friggeri. Pharmacokinetic/Pharmacodynamic Dosage Individualization of Cefepime in Critically Ill Patients: A Case Study. Therapeutic drug monitoring. 2021 08; 43(4):451-454. doi: 10.1097/ftd.0000000000000896. [PMID: 33883521]
  • Alexandre Meurant, François Guérin, Simon Le Hello, Guillaume Saint-Lorant, Arnaud de La Blanchardière. Cefepime use: A need for antimicrobial stewardship. Infectious diseases now. 2021 Aug; 51(5):445-450. doi: 10.1016/j.idnow.2020.10.001. [PMID: 33960301]
  • Adrien Contejean, Caroline Charlier, Jean-Marc Treluyer, Solen Kernéis, Laurent Chouchana. A worldwide pharmacovigilance database analysis to assess the risk of acute kidney injury in patients receiving teicoplanin in association with piperacillin, cefepime or meropenem. The Journal of antimicrobial chemotherapy. 2021 07; 76(8):2221-2223. doi: 10.1093/jac/dkab144. [PMID: 34008026]
  • Mohammad H Al-Shaer, Carolyn D Philpott, Christopher A Droege, Joshua D Courter, Daniel P Healy, Molly E Droege, Neil E Ernst, Eric W Mueller, Charles A Peloquin. Cefepime Population Pharmacokinetics and Target Attainment in Critically Ill Patients on Continuous Renal Replacement Therapy. Antimicrobial agents and chemotherapy. 2021 05; 65(6):. doi: 10.1128/aac.00144-21. [PMID: 33722885]
  • Michael Saad-Naguib, Deborah Barbouth, Willa Thorson, Stephanie Hacker, Mustafa Tekin. COVID-19 in a child with severe propionic acidemia. Pediatrics international : official journal of the Japan Pediatric Society. 2021 05; 63(5):606-607. doi: 10.1111/ped.14633. [PMID: 34002470]
  • Matthew S Sussman, Michelle B Mulder, Emily L Ryon, Eva M Urrechaga, Gabriel A Lama, Amritpal Bahga, Sarah A Eidelson, Howard M Lieberman, Carl I Schulman, Nicholas Namias, Kenneth G Proctor. Acute Kidney Injury Risk in Patients Treated with Vancomycin Combined with Meropenem or Cefepime. Surgical infections. 2021 May; 22(4):415-420. doi: 10.1089/sur.2020.105. [PMID: 32783764]
  • Sonya C Tang Girdwood, Peter H Tang, Mark E Murphy, Andrea R Chamberlain, Laura A Benken, Rhonda L Jones, Erin M Stoneman, Jennifer M Kaplan, Alexander A Vinks. Demonstrating Feasibility of an Opportunistic Sampling Approach for Pharmacokinetic Studies of β-Lactam Antibiotics in Critically Ill Children. Journal of clinical pharmacology. 2021 04; 61(4):565-573. doi: 10.1002/jcph.1773. [PMID: 33111331]
  • Walaa Mohammed Noor Obeid, Iman Hassan Abdoon, Bashier Osman, Wadah J A Osman, Hayat Mohamed Suliman, Elwasila M Mohamed, Ramzi A A Mothana. Drug use evaluation of cefepime at Khartoum North Teaching Hospital in Sudan. International journal of clinical practice. 2021 Apr; 75(4):e13882. doi: 10.1111/ijcp.13882. [PMID: 33277753]
  • Christian M Gill, Kamilia Abdelraouf, David P Nicolau. In vivo activity of WCK 4282 (high-dose cefepime/tazobactam) against serine β-lactamase-producing Enterobacterales and Pseudomonas aeruginosa in the neutropenic murine thigh infection model. The Journal of antimicrobial chemotherapy. 2021 03; 76(4):993-1000. doi: 10.1093/jac/dkaa551. [PMID: 33438033]
  • Akram Al-Makki, Tim Taber. Neutropenic fever in COVID-19 in kidney transplant patient. Reviews in medical virology. 2021 01; 31(1):1-2. doi: 10.1002/rmv.2156. [PMID: 32856324]
  • Shampa Das, Richard Fitzgerald, Asad Ullah, Marcin Bula, Andrea M Collins, Elena Mitsi, Jesus Reine, Helen Hill, Jamie Rylance, Daniela M Ferreira, Karen Tripp, Andrea Bertasini, Samantha Franzoni, Mameli Massimiliano, Omar Lahlou, Paola Motta, Philip Barth, Patrick Velicitat, Philipp Knechtle, William Hope. Intrapulmonary Pharmacokinetics of Cefepime and Enmetazobactam in Healthy Volunteers: Towards New Treatments for Nosocomial Pneumonia. Antimicrobial agents and chemotherapy. 2020 12; 65(1):. doi: 10.1128/aac.01468-20. [PMID: 33077666]
  • Kyle C Molina, Jeffrey F Barletta, Scott T Hall, Cyrus Yazdani, Vanthida Huang. The Risk of Acute Kidney Injury in Critically Ill Patients Receiving Concomitant Vancomycin With Piperacillin-Tazobactam or Cefepime. Journal of intensive care medicine. 2020 Dec; 35(12):1434-1438. doi: 10.1177/0885066619828290. [PMID: 30741072]
  • Tarun D Singh, John C O'Horo, Courtney N Day, Jay Mandrekar, Alejandro A Rabinstein. Cefepime is Associated with Acute Encephalopathy in Critically Ill Patients: A Retrospective Case-Control Study. Neurocritical care. 2020 12; 33(3):695-700. doi: 10.1007/s12028-020-01035-w. [PMID: 32613426]
  • Xavier Engalenc, Caroline Monchaud, Naïma Tafzi, Jean-Baptiste Woillard. Neurotoxicity Despite a Renal Function-Adjusted Cefepime Regimen: A Case Study. Therapeutic drug monitoring. 2020 10; 42(5):655-657. doi: 10.1097/ftd.0000000000000786. [PMID: 32618881]
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