Acetylhydrazine (BioDeep_00000006497)
Secondary id: BioDeep_00001868005
human metabolite Endogenous blood metabolite
代谢物信息卡片
Acetylhydrazine, (e)-2-fumarate (1:1)
化学式: C2H6N2O (74.048)
中文名称: 乙酰肼
谱图信息:
最多检出来源 Viridiplantae(lipidsearch) 10.41%
分子结构信息
SMILES: CC(=O)NN
InChI: InChI=1S/C2H6N2O/c1-2(5)4-3/h3H2,1H3,(H,4,5)
描述信息
The acetylhydrazine metabolite was found to be much less cytotoxic than hydrazine in this hepatocyte inflammation model. (PMID: 18295292) In the pathogenesis of isoniazid-induced hepatic injury, cytochrome P450-dependent metabolic activation of the metabolite, acetylhydrazine (AcHz), is the crucial step. (PMID: 8852701) The mechanism of action of acetylphosphabenzide is likely to involve the formation of acetylhydrazine, capable of producing active electrophiles attacking DNA. (PMID: 9589859)
D009676 - Noxae > D002273 - Carcinogens
同义名列表
18 个代谢物同义名
Acetylhydrazine, (e)-2-fumarate (1:1); Acetylhydrazine monohydrochloride; Ethanehydrazonic acid; Acetic acid hydrazide; Monoacetyl hydrazine; Monoacetylhydrazine; Ethanehydrazonate; N-Acetylhydrazine; Acetate hydrazide; Acetyl hydrazide; Acetic hydrazide; Acetylhydrazine; Acetylhydrazide; acetohydrazide; Acethydrazide; Acethydrazine; Acetylhydrazine; Acethydrazide
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:48978
- ChEBI: CHEBI:2422
- KEGG: C07447
- PubChem: 14039
- HMDB: HMDB0060428
- Metlin: METLIN66644
- ChEMBL: CHEMBL3091859
- CAS: 1068-57-1
- PMhub: MS000019546
- PubChem: 9650
- NIKKAJI: J7.446B
- KNApSAcK: 2422
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mahmoud F Ismail, Amira A El-Sayed, Eslam M Hosni, Aya I Hassaballah. Synthesis and evaluation of larvicidal efficacy against C. pipiens of some new heterocyclic compounds emanated from 2-cyano-N'-(2-(2,4-dichlorophenoxy)acetyl)acetohydrazide.
Chemistry & biodiversity.
2024 Feb; 21(2):e202301560. doi:
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Scientific reports.
2022 07; 12(1):11749. doi:
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Bioorganic chemistry.
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10.1093/toxsci/kfh232. [PMID: 15282401] - Abbas Afkhami, Ali Reza Zarei. Simultaneous kinetic-spectrophotometric determination of hydrazine and acetylhydrazine in micellar media using the H-point standard addition method.
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1991 May; 41(9):1319-24. doi:
10.1016/0006-2952(91)90103-c. [PMID: 2018564] - E Peretti, G Karlaganis, B H Lauterburg. Acetylation of acetylhydrazine, the toxic metabolite of isoniazid, in humans. Inhibition by concomitant administration of isoniazid.
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1987 Sep; 420(1):171-7. doi:
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