2-trans,6-trans-Farnesal (BioDeep_00000005215)

 

Secondary id: BioDeep_00000638406, BioDeep_00001868125

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(2-trans,6-trans)-3,7,11-Trimethyldodeca-2,6,10-trienal

化学式: C15H24O (220.1827)
中文名称: 法尼醛, 法尼萨尔
谱图信息: 最多检出来源 Homo sapiens(plant) 13.19%

分子结构信息

SMILES: CC(=CCCC(=CCCC(=CC=O)C)C)C
InChI: InChI=1S/C15H24O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11-12H,5-6,8,10H2,1-4H3/b14-9+,15-11+

描述信息

Farnesal, also known as (2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrienal or 2-trans,6-trans-farnesal, is a member of the class of compounds known as sesquiterpenoids. Sesquiterpenoids are terpenes with three consecutive isoprene units. Thus, farnesal is considered to be an isoprenoid lipid molecule. Farnesal is practically insoluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Farnesal is a floral and minty tasting compound and can be found in a number of food items such as bamboo shoots, dandelion, italian sweet red pepper, and chicory roots, which makes farnesal a potential biomarker for the consumption of these food products.
This compound belongs to the family of Sesquiterpenes. These are terpenes with three consecutive isoprene units.

同义名列表

16 个代谢物同义名

(2-trans,6-trans)-3,7,11-Trimethyldodeca-2,6,10-trienal; (2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienal; (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienal; (e,e)-3,7,11-Trimethyl-2,6,10-dodecatrienal; 3,7,11-trimethyl-2,6,10-dodecatrienal; trans,trans-2,6-farnesal; 2-trans,6-trans-Farnesal; trans,trans-Farnesal; (2E,6E)-Farnesal; trans-farnesal; E,E-farnesal; FARNESAL; 2-trans,6-trans-Farnesal; Farnesal; Farnesal; Farnesal



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(1)

代谢反应

126 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(6)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(120)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKR1B1, AKR1C4, ALDH3A1, ALDH3A2, CDH1, FDPS, FNTA, MVD, MVK, RAF1, RER
Endoplasmic reticulum membrane 3 ACAT1, ALDH3A2, HMGCR
Nucleus 3 CDH1, RAF1, RER
cytosol 13 AKR1B1, AKR1B10, AKR1C1, AKR1C4, ALDH3A1, ALDH3A2, CDH1, FDPS, FNTA, MVD, MVK, PMVK, RAF1
trans-Golgi network 1 CDH1
nucleoplasm 4 AKR1B1, CDH1, FDPS, RER
Cell membrane 3 CDH1, ITGB2, RAF1
Cytoplasmic side 1 ALDH3A2
lamellipodium 1 CDH1
Multi-pass membrane protein 3 ACAT1, HMGCR, SLC5A1
cell junction 1 CDH1
cell surface 1 ITGB2
glutamatergic synapse 1 CDH1
Golgi apparatus 2 CDH1, RAF1
lysosomal membrane 1 GAA
postsynapse 1 CDH1
Cytoplasm, cytosol 3 AKR1C1, AKR1C4, PMVK
Lysosome 2 AKR1B10, GAA
endosome 1 CDH1
plasma membrane 7 ALDH3A1, CDH1, FNTA, GAA, ITGB2, RAF1, SLC5A1
Membrane 8 ACAT1, ALDH3A2, CDH1, FDPS, GAA, HMGCR, ITGB2, PMVK
apical plasma membrane 1 SLC5A1
extracellular exosome 9 ACAT1, AKR1B1, AKR1C1, AKR1C4, CDH1, GAA, ITGB2, PMVK, SLC5A1
Lysosome membrane 1 GAA
endoplasmic reticulum 3 ACAT1, ALDH3A1, HMGCR
extracellular space 2 AKR1B1, ALDH3A1
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 CDH1, SLC5A1
adherens junction 1 CDH1
mitochondrion 4 ACAT1, AKR1B1, AKR1B10, RAF1
intracellular membrane-bounded organelle 3 ALDH3A2, GAA, MVK
Microsome membrane 1 ALDH3A2
Single-pass type I membrane protein 2 CDH1, ITGB2
Secreted 2 AKR1B10, GAA
extracellular region 3 AKR1B10, CDH1, GAA
cytoplasmic side of plasma membrane 1 CDH1
Single-pass membrane protein 1 ALDH3A2
mitochondrial outer membrane 1 RAF1
mitochondrial matrix 2 ACAT1, FDPS
nuclear membrane 1 CDH1
external side of plasma membrane 1 ITGB2
Extracellular vesicle 1 ITGB2
actin cytoskeleton 1 CDH1
Early endosome 1 SLC5A1
Apical cell membrane 1 SLC5A1
Membrane raft 1 ITGB2
focal adhesion 1 ITGB2
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
Peroxisome 4 ALDH3A2, FDPS, MVK, PMVK
intracellular vesicle 1 SLC5A1
peroxisomal membrane 2 ALDH3A2, HMGCR
lateral plasma membrane 1 CDH1
nuclear speck 1 RER
receptor complex 1 ITGB2
microtubule associated complex 1 FNTA
Chromosome 1 RER
brush border membrane 1 SLC5A1
Golgi apparatus, trans-Golgi network 1 CDH1
spindle pole 1 RER
Cytoplasm, cytoskeleton, spindle pole 1 RER
Nucleus, nucleoplasm 1 RER
specific granule membrane 1 ITGB2
tertiary granule membrane 2 GAA, ITGB2
pseudopodium 1 RAF1
Peroxisome membrane 1 HMGCR
plasma membrane raft 1 ITGB2
azurophil granule membrane 1 GAA
anaphase-promoting complex 1 CDH1
[Isoform 2]: Nucleus 1 CDH1
ficolin-1-rich granule membrane 2 GAA, ITGB2
U2-type precatalytic spliceosome 1 RER
apical junction complex 1 CDH1
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 1 CDH1
integrin complex 1 ITGB2
integrin alphaL-beta2 complex 1 ITGB2
integrin alphaM-beta2 complex 1 ITGB2
integrin alphaX-beta2 complex 1 ITGB2
autolysosome lumen 1 GAA
intracellular organelle 1 SLC5A1
CAAX-protein geranylgeranyltransferase complex 1 FNTA
protein farnesyltransferase complex 1 FNTA


文献列表

  • Marta Balsells-Llauradó, Núria Vall-Llaura, Josep Usall, Christian J Silva, Barbara Blanco-Ulate, Neus Teixidó, Maria Caballol, Rosario Torres. Transcriptional profiling of the terpenoid biosynthesis pathway and in vitro tests reveal putative roles of linalool and farnesal in nectarine resistance against brown rot. Plant science : an international journal of experimental plant biology. 2023 Feb; 327(?):111558. doi: 10.1016/j.plantsci.2022.111558. [PMID: 36493930]
  • Ahmad-Faris Seman-Kamarulzaman, Zeti-Azura Mohamed-Hussein, Chyan Leong Ng, Maizom Hassan. Novel NAD+-Farnesal Dehydrogenase from Polygonum minus Leaves. Purification and Characterization of Enzyme in Juvenile Hormone III Biosynthetic Pathway in Plant. PloS one. 2016; 11(8):e0161707. doi: 10.1371/journal.pone.0161707. [PMID: 27560927]
  • René F Ramos Alvarenga, Baojie Wan, Taichi Inui, Scott G Franzblau, Guido F Pauli, Birgit U Jaki. Airborne antituberculosis activity of Eucalyptus citriodora essential oil. Journal of natural products. 2014 Mar; 77(3):603-10. doi: 10.1021/np400872m. [PMID: 24641242]
  • . . . . doi: . [PMID: 11598232]