Biotin amide (BioDeep_00000004788)
Secondary id: BioDeep_00001869578
human metabolite Endogenous
代谢物信息卡片
化学式: C10H17N3O2S (243.1041)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(viridiplantae) 12.76%
分子结构信息
SMILES: C(CCC(=O)N)C[C@H]1[C@@H]2[C@H](CS1)NC(=O)N2
InChI: InChI=1S/C10H17N3O2S/c11-8(14)4-2-1-3-7-9-6(5-16-7)12-10(15)13-9/h6-7,9H,1-5H2,(H2,11,14)(H2,12,13,15)/t6-,7-,9-/m0/s1
描述信息
The enzyme biotinidase (EC-Number 3.5.1.12 ) is involved in the recycling of the vitamin biotin, cleaving D-biotinylamides and esters, in a reaction including biotin amide and water. (PMID 1719240, 171927). Late-onset multiple carboxylase deficiency (MCD) with biotinidase deficiency is caused by mutation in the biotinidase gene. MCD is an autosomal recessive metabolic disorder characterized primarily by cutaneous and neurologic abnormalities. Symptoms result from the patients inability to reutilize biotin, a necessary nutrient. (OMIM 253260).
The enzyme biotinidase (EC-Number 3.5.1.12 ) is involved in the recycling of the vitamin biotin, cleaving D-biotinylamides and esters, in a reaction including biotin amide and water. (PMID 1719240, 171927)
同义名列表
7 个代谢物同义名
5-[(3AS,6R,6ar)-2-hydroxy-1H,3ah,4H,6H,6ah-thieno[3,4-D]imidazol-6-yl]pentanimidate; 5-[(3aR,4R,6aS)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamide; 5-[(3aR,4R,6aS)-2-oxo-hexahydrothieno[3,4-d]imidazolidin-4-yl]pentanamide; SCHEMBL8932330; Biotin amide; Biotinamide; Biotin amide
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:16615
- KEGG: C01893
- PubChem: 439597
- PubChem: 83831
- PubChem: 497
- HMDB: HMDB0001458
- Metlin: METLIN6255
- foodb: FDB022636
- chemspider: 388677
- CAS: 6929-42-6
- PMhub: MS000017387
- PubChem: 5006
- NIKKAJI: J2.734.777K
- RefMet: Biotin amide
- KNApSAcK: 16615
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- D Scott Wilbur, Donald K Hamlin, Ming-Kuan Chyan. Biotin reagents for antibody pretargeting. 7. Investigation of chemically inert biotinidase blocking functionalities for synthetic utility.
Bioconjugate chemistry.
2006 Nov; 17(6):1514-22. doi:
10.1021/bc060084m
. [PMID: 17105231] - Anna Bogusiewicz, Nell I Mock, Donald M Mock. A biotin-protein bond with stability in plasma.
Analytical biochemistry.
2005 Feb; 337(1):98-102. doi:
10.1016/j.ab.2004.10.023
. [PMID: 15649381] - Shiro Okumura, Tetsuyuki Akao, Satoko Yamashita, Tokio Ichimatsu, Kuniyo Inouye. Determination of Biotinylated Proteins as an Index for Purification of Plasma Membrane using Surface Plasmon Resonance-based Optical Biosensor.
Cytotechnology.
2005 Jan; 47(1-3):59-67. doi:
10.1007/s10616-005-3757-4
. [PMID: 19003045] - D S Wilbur, D K Hamlin, M K Chyan, B B Kegley, P M Pathare. Biotin reagents for antibody pretargeting. 5. Additional studies of biotin conjugate design to provide biotinidase stability.
Bioconjugate chemistry.
2001 Jul; 12(4):616-23. doi:
10.1021/bc0100096
. [PMID: 11459467] - A C Buck. Disorders of micturition in bacterial prostatitis.
Proceedings of the Royal Society of Medicine.
1975 Aug; 68(8):508-11. doi:
NULL
. [PMID: 681]