Biotin amide (BioDeep_00000004788)

 

Secondary id: BioDeep_00001869578

human metabolite Endogenous


代谢物信息卡片


5-[(3AS,6R,6ar)-2-hydroxy-1H,3ah,4H,6H,6ah-thieno[3,4-D]imidazol-6-yl]pentanimidate

化学式: C10H17N3O2S (243.1041)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(viridiplantae) 12.76%

分子结构信息

SMILES: C(CCC(=O)N)C[C@H]1[C@@H]2[C@H](CS1)NC(=O)N2
InChI: InChI=1S/C10H17N3O2S/c11-8(14)4-2-1-3-7-9-6(5-16-7)12-10(15)13-9/h6-7,9H,1-5H2,(H2,11,14)(H2,12,13,15)/t6-,7-,9-/m0/s1

描述信息

The enzyme biotinidase (EC-Number 3.5.1.12 ) is involved in the recycling of the vitamin biotin, cleaving D-biotinylamides and esters, in a reaction including biotin amide and water. (PMID 1719240, 171927). Late-onset multiple carboxylase deficiency (MCD) with biotinidase deficiency is caused by mutation in the biotinidase gene. MCD is an autosomal recessive metabolic disorder characterized primarily by cutaneous and neurologic abnormalities. Symptoms result from the patients inability to reutilize biotin, a necessary nutrient. (OMIM 253260).
The enzyme biotinidase (EC-Number 3.5.1.12 ) is involved in the recycling of the vitamin biotin, cleaving D-biotinylamides and esters, in a reaction including biotin amide and water. (PMID 1719240, 171927)

同义名列表

7 个代谢物同义名

5-[(3AS,6R,6ar)-2-hydroxy-1H,3ah,4H,6H,6ah-thieno[3,4-D]imidazol-6-yl]pentanimidate; 5-[(3aR,4R,6aS)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamide; 5-[(3aR,4R,6aS)-2-oxo-hexahydrothieno[3,4-d]imidazolidin-4-yl]pentanamide; SCHEMBL8932330; Biotin amide; Biotinamide; Biotin amide



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 AXIN2, CHAT, GAD1, PVALB, S100A12, TH
Peripheral membrane protein 1 S100A12
Endoplasmic reticulum membrane 2 PNMT, SLC18A1
Mitochondrion membrane 1 PNMT
Nucleus 7 AXIN2, CALB2, CHAT, FOS, NANOG, S100A12, TH
cytosol 8 AXIN2, CALB2, CHAT, FOS, PNMT, S100A12, SST, TH
dendrite 3 CALB2, PENK, TH
mitochondrial membrane 1 PNMT
centrosome 1 AXIN2
nucleoplasm 2 FOS, NANOG
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 4 S100A12, SLC17A6, SLC17A7, SLC6A5
Cell projection, axon 1 TH
Multi-pass membrane protein 6 PNMT, SLC17A6, SLC17A7, SLC18A1, SLC18A3, SLC6A5
Synapse 4 CALB2, CHAT, PVALB, TAC1
cell cortex 1 GAD1
cell surface 1 SLC6A5
Golgi apparatus 1 NPY
neuronal cell body 3 PENK, SST, TAC1
presynaptic membrane 1 SLC6A5
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
Presynapse 1 SLC18A1
endosome 1 SLC6A5
plasma membrane 8 AXIN2, GAD1, PENK, S100A12, SLC17A6, SLC17A7, SLC18A3, SLC6A5
presynaptic active zone 2 GAD1, SLC17A7
synaptic vesicle membrane 5 SLC17A6, SLC17A7, SLC18A1, SLC18A3, SLC6A5
terminal bouton 4 CALB2, SLC18A1, SLC18A3, TH
Membrane 3 SLC17A7, SLC18A1, SLC6A5
axon 4 PVALB, SLC6A5, TAC1, TH
extracellular exosome 1 BTD
endoplasmic reticulum 2 FOS, PNMT
extracellular space 4 BTD, NPY, SST, TAC1
perinuclear region of cytoplasm 2 GAD1, TH
gap junction 1 CALB2
mitochondrion 2 PNMT, TH
intracellular membrane-bounded organelle 2 NANOG, PNMT
Secreted 4 NPY, PENK, S100A12, SST
extracellular region 6 BTD, NPY, PENK, S100A12, SST, TAC1
cytoplasmic side of plasma membrane 1 TH
excitatory synapse 2 SLC17A6, SLC17A7
neuronal cell body membrane 1 SLC6A5
mitochondrial matrix 1 BTD
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 4 SLC17A6, SLC17A7, SLC18A1, SLC18A3
neuronal dense core vesicle lumen 1 PENK
perikaryon 2 PENK, TH
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 TH
nucleolus 1 NANOG
Melanosome membrane 1 TH
Cytoplasm, perinuclear region 1 TH
Cytoplasm, cytoskeleton 1 S100A12
GABA-ergic synapse 3 GAD1, NPY, SST
neuron projection 4 CHAT, SLC17A6, SLC17A7, TH
chromatin 2 FOS, NANOG
cytoskeleton 1 S100A12
Secreted, extracellular space 1 BTD
chloride channel complex 2 SLC17A6, SLC17A7
[Isoform 1]: Endoplasmic reticulum membrane 1 PNMT
cell body fiber 1 PENK
secretory granule lumen 1 S100A12
secretory granule membrane 1 SLC18A1
endoplasmic reticulum lumen 1 PENK
nuclear matrix 1 FOS
axon terminus 2 GAD1, PENK
dense core granule 1 SLC6A5
neuronal dense core vesicle 2 NPY, SST
parallel fiber to Purkinje cell synapse 1 CALB2
vesicle membrane 1 GAD1
clathrin-coated endocytic vesicle membrane 1 SLC18A3
Synapse, synaptosome 2 SLC17A6, SLC17A7
protein-DNA complex 1 FOS
Cytoplasmic vesicle, secretory vesicle membrane 1 SLC18A1
AP-1 adaptor complex 1 SLC18A3
[Isoform 2]: Endoplasmic reticulum membrane 2 PNMT, SLC18A1
inhibitory synapse 1 GAD1
AP-2 adaptor complex 1 SLC18A3
transcription factor AP-1 complex 1 FOS
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 PENK
chromaffin granule lumen 1 PENK
symmetric synapse 1 PENK
synaptic vesicle lumen 1 PENK
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
glycinergic synapse 1 SLC6A5
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane 1 GAD1
clathrin-sculpted acetylcholine transport vesicle membrane 1 SLC18A3
clathrin-sculpted glutamate transport vesicle membrane 1 SLC17A7
clathrin-sculpted monoamine transport vesicle membrane 1 SLC18A1
[Isoform 1]: Cytoplasmic vesicle, secretory vesicle membrane 1 SLC18A1


文献列表

  • D Scott Wilbur, Donald K Hamlin, Ming-Kuan Chyan. Biotin reagents for antibody pretargeting. 7. Investigation of chemically inert biotinidase blocking functionalities for synthetic utility. Bioconjugate chemistry. 2006 Nov; 17(6):1514-22. doi: 10.1021/bc060084m. [PMID: 17105231]
  • Anna Bogusiewicz, Nell I Mock, Donald M Mock. A biotin-protein bond with stability in plasma. Analytical biochemistry. 2005 Feb; 337(1):98-102. doi: 10.1016/j.ab.2004.10.023. [PMID: 15649381]
  • Shiro Okumura, Tetsuyuki Akao, Satoko Yamashita, Tokio Ichimatsu, Kuniyo Inouye. Determination of Biotinylated Proteins as an Index for Purification of Plasma Membrane using Surface Plasmon Resonance-based Optical Biosensor. Cytotechnology. 2005 Jan; 47(1-3):59-67. doi: 10.1007/s10616-005-3757-4. [PMID: 19003045]
  • D S Wilbur, D K Hamlin, M K Chyan, B B Kegley, P M Pathare. Biotin reagents for antibody pretargeting. 5. Additional studies of biotin conjugate design to provide biotinidase stability. Bioconjugate chemistry. 2001 Jul; 12(4):616-23. doi: 10.1021/bc0100096. [PMID: 11459467]
  • A C Buck. Disorders of micturition in bacterial prostatitis. Proceedings of the Royal Society of Medicine. 1975 Aug; 68(8):508-11. doi: NULL. [PMID: 681]