8,9-DiHETrE (BioDeep_00000004030)

 

Secondary id: BioDeep_00000629609

human metabolite Endogenous blood metabolite


代谢物信息卡片


(±)8,9-dihydroxy-5Z,11Z,14Z-eicosatrienoic acid

化学式: C20H34O4 (338.2457)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 19.81%

分子结构信息

SMILES: CCCCC/C=C\C/C=C\CC(C(C/C=C\CCCC(=O)O)O)O
InChI: InChI=1S/C20H34O4/c1-2-3-4-5-6-7-8-9-12-15-18(21)19(22)16-13-10-11-14-17-20(23)24/h6-7,9-10,12-13,18-19,21-22H,2-5,8,11,14-17H2,1H3,(H,23,24)

描述信息

8,9-DiHETrE is a Cytochrome P450 (P450) eicosanoid. Eicosanoids generated from arachidonic acid (AA) metabolism by cytochrome P450 (P450) enzymes are important autocrine and paracrine factors that have diverse biological functions. P450 eicosanoids are involved in the regulation of vascular tone, renal tubular transport, cardiac contractility, cellular proliferation, and inflammation. P450converts AA to 8,9- dihydroxyeicosatrienoic acid. This enzymatic pathway was first described in liver; however, it is now clear that AA can be metabolized by P450 in many tissues including the pituitary gland, eye, kidney, adrenal gland, and blood vessels. (PMID: 17431031, 11700990) [HMDB]
8,9-DiHETrE is a Cytochrome P450 (P450) eicosanoid. Eicosanoids generated from arachidonic acid (AA) metabolism by cytochrome P450 (P450) enzymes are important autocrine and paracrine factors that have diverse biological functions. P450 eicosanoids are involved in the regulation of vascular tone, renal tubular transport, cardiac contractility, cellular proliferation, and inflammation. P450converts AA to 8,9- dihydroxyeicosatrienoic acid. This enzymatic pathway was first described in liver; however, it is now clear that AA can be metabolized by P450 in many tissues including the pituitary gland, eye, kidney, adrenal gland, and blood vessels. (PMID: 17431031, 11700990).

同义名列表

16 个代谢物同义名

(±)8,9-dihydroxy-5Z,11Z,14Z-eicosatrienoic acid; (5Z,11Z,14Z)-8,9-Dihydroxyeicosa-5,11,14-trienoic acid; (5Z,11Z,14Z)-8,9-Dihydroxyicosa-5,11,14-trienoic acid; (5Z,11Z,14Z)-8,9-Dihydroxyeicosa-5,11,14-trienoate; (5Z,11Z,14Z)-8,9-Dihydroxyicosa-5,11,14-trienoate; 8,9-dihydroxy-5Z,11Z,14Z-eicosatrienoic acid; 8,9-Dihydroxy-5Z,11Z,14Z-icosatrienoic acid; 8,9-Dihydroxy-5Z,11Z,14Z-eicosatrienoate; 8,9-Dihydroxyicosa-5,11,14-trienoic acid; 8,9-Dihydroxy-5Z,11Z,14Z-icosatrienoate; 8,9-Dihydroxyeicosatrienoic acid; 8,9-Dihydroxyeicosatrienoate; (±)8,9-DHET; (+/-)8,9-DiHETrE; 8,9-DiHETrE; 8,9-DHET



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

47 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ACSL4, AIFM2, APOB, CYP2B6, NOS3, PPARG, SLC40A1, TXNRD2
Peripheral membrane protein 2 AOC1, CYP2B6
Endosome membrane 1 APOB
Endoplasmic reticulum membrane 3 ACSL4, APOB, CYP2B6
Mitochondrion membrane 1 AIFM2
Nucleus 6 AIFM2, GPX4, KLF9, NOS3, PPARG, THRB
cytosol 9 AIFM2, APOB, EPHX2, GPX4, KLF9, NOS3, PPARG, SLC40A1, TXNRD2
dendrite 1 TXNRD2
nuclear body 1 THRB
nucleoplasm 5 KLF9, NOS3, PPARG, SLC40A1, THRB
RNA polymerase II transcription regulator complex 2 PPARG, THRB
Cell membrane 5 ACSL4, AIFM2, AOC1, SLC40A1, TNF
Lipid-anchor 1 AIFM2
Multi-pass membrane protein 1 SLC40A1
cell surface 3 CD40, TNF, TPO
Golgi apparatus 1 NOS3
Golgi membrane 1 NOS3
neuronal cell body 4 APOB, CD40, TNF, TXNRD2
smooth endoplasmic reticulum 1 APOB
synaptic vesicle 1 SLC40A1
plasma membrane 11 ACSL4, AIFM2, AOC1, APOB, CD40, CSF2, KLF9, NOS3, SLC40A1, TNF, TPO
Membrane 4 ACSL4, CD40, SLC40A1, TPO
axon 1 TXNRD2
basolateral plasma membrane 1 SLC40A1
caveola 1 NOS3
extracellular exosome 6 ACSL4, AOC1, APOB, CD40, EPHX2, GPX4
endoplasmic reticulum 1 ACSL4
extracellular space 10 AIFM2, AOC1, APOB, CD40, CRP, CSF2, IL6, TG, TNF, TPO
lysosomal lumen 1 APOB
perinuclear region of cytoplasm 2 NOS3, PPARG
bicellular tight junction 1 AOC1
mitochondrion 4 ACSL4, AIFM2, GPX4, TXNRD2
protein-containing complex 1 GPX4
intracellular membrane-bounded organelle 5 APOB, CD40, CSF2, CYP2B6, PPARG
Microsome membrane 2 ACSL4, CYP2B6
Single-pass type I membrane protein 2 CD40, TPO
Secreted 5 APOB, CRP, CSF2, IL6, TG
extracellular region 7 AOC1, APOB, CRP, CSF2, IL6, TG, TNF
Mitochondrion outer membrane 1 ACSL4
mitochondrial outer membrane 2 ACSL4, AIFM2
mitochondrial matrix 1 TXNRD2
Extracellular side 1 AOC1
CD40 receptor complex 1 CD40
external side of plasma membrane 2 CD40, TNF
varicosity 1 CD40
chylomicron 1 APOB
low-density lipoprotein particle 1 APOB
very-low-density lipoprotein particle 1 APOB
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Early endosome 1 APOB
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
Peroxisome 2 AOC1, EPHX2
peroxisomal matrix 1 EPHX2
peroxisomal membrane 1 ACSL4
lateral plasma membrane 1 SLC40A1
receptor complex 1 PPARG
chromatin 3 KLF9, PPARG, THRB
phagocytic cup 1 TNF
cytoskeleton 1 NOS3
Secreted, extracellular space 1 AOC1
Basolateral cell membrane 1 SLC40A1
nuclear envelope 1 GPX4
endosome lumen 1 APOB
Lipid droplet 3 ACSL4, AIFM2, APOB
mitochondria-associated endoplasmic reticulum membrane contact site 1 ACSL4
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
Peroxisome membrane 1 ACSL4
endoplasmic reticulum lumen 2 APOB, IL6
specific granule lumen 1 AOC1
endocytic vesicle membrane 1 NOS3
Single-pass type III membrane protein 1 ACSL4
endoplasmic reticulum exit site 1 APOB
clathrin-coated endocytic vesicle membrane 1 APOB
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
endocytic vesicle lumen 1 APOB
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chylomicron remnant 1 APOB
intermediate-density lipoprotein particle 1 APOB
mature chylomicron 1 APOB
interleukin-6 receptor complex 1 IL6
[Isoform Mitochondrial]: Mitochondrion 1 GPX4
[Isoform Cytoplasmic]: Cytoplasm 1 GPX4
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]