Mesna (BioDeep_00000003574)
Secondary id: BioDeep_00000400443
natural product human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
2-Mercaptoethanesulfonic acid solution
化学式: C2H6O3S2 (141.9758)
中文名称: 2-巯基乙磺酸
谱图信息:
最多检出来源 Homo sapiens(blood) 31.98%
分子结构信息
SMILES: C(CS(=O)(=O)O)S
InChI: InChI=1S/C2H6O3S2/c3-7(4,5)2-1-6/h6H,1-2H2,(H,3,4,5)
描述信息
Mesna is a chemoprotectant. Chemoprotectants have been developed as a means of ameliorating the toxicity associated with cytotoxic agents by providing site-specific protection for normal tissues, without compromising antitumour efficacy. Mesna eliminates the risk of therapy-limiting urotoxic side effects of oxazaphosphorines. Mesna is widely used for the prevention of cyclophosphamide-related hemorrhagic cystitis. It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients. Mesna offers significant uroprotection in patients receiving high dose cyclophosphamide, and is widely used in paediatric oncology practice It is, therefore, important to recognize that it may be associated with a rare but significant systemic adverse reaction. A hypersensitivity-like reaction to mesna was first reported in a young adult receiving treatment for Hodgkin disease over 20 years ago. Oral administration of mesna can facilitate outpatient ifosfamide therapy. Blood and urinary mesna concentrations are more steady and prolonged after oral delivery compared with after intravenous delivery. (PMID: 16333822, 10193684, 1485175) [HMDB]
Mesna is a chemoprotectant. Chemoprotectants have been developed as a means of ameliorating the toxicity associated with cytotoxic agents by providing site-specific protection for normal tissues, without compromising antitumour efficacy. Mesna eliminates the risk of therapy-limiting urotoxic side effects of oxazaphosphorines. Mesna is widely used for the prevention of cyclophosphamide-related hemorrhagic cystitis. It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients. Mesna offers significant uroprotection in patients receiving high dose cyclophosphamide, and is widely used in paediatric oncology practice It is, therefore, important to recognize that it may be associated with a rare but significant systemic adverse reaction. A hypersensitivity-like reaction to mesna was first reported in a young adult receiving treatment for Hodgkin disease over 20 years ago. Oral administration of mesna can facilitate outpatient ifosfamide therapy. Blood and urinary mesna concentrations are more steady and prolonged after oral delivery compared with after intravenous delivery. (PMID: 16333822, 10193684, 1485175).
Acquisition and generation of the data is financially supported in part by CREST/JST.
D020011 - Protective Agents
同义名列表
65 个代谢物同义名
2-Mercaptoethanesulfonic acid solution; Bristol myers squibb brand OF mesna; Bristol-myers squibb brand OF mesna; 2-Mercaptoethanesulphonate, sodium; beta-Mercaptoethanesulphonic acid; Sodium 2-mercaptoethanesulphonate; beta-Mercaptoethanesulfonic acid; Sodium 2-mercaptoethanesulfonate; 2-sulfanylethane-1-sulfonic acid; b-Mercaptoethanesulphonic acid; Β-mercaptoethanesulphonic acid; 2-Mercaptoethanesulphonic acid; 2-Sulphanylethylsulphonic acid; 2-Mercaptoethylsulphonic acid; Β-mercaptoethanesulfonic acid; 2-Mercaptoethanesulfonic acid; b-Mercaptoethanesulfonic acid; beta-Mercaptoethanesulphonate; beta-Mercaptoethanesulfonate; 2-Mercaptoethylsulfonic acid; 2-Sulfanylethylsulfonic acid; ASTA medica brand OF mesna; 2-Sulphanylethylsulphonate; Β-mercaptoethanesulphonate; b-Mercaptoethanesulphonate; 2-Mercaptoethanesulphonate; 1-THIOETHANEsulphonic acid; Cell pharm brand OF mesna; 2-Mercaptoethylsulphonate; 2 Mercaptoethanesulfonate; b-Mercaptoethanesulfonate; 2-Mercaptoethanesulfonate; Β-mercaptoethanesulfonate; 1-THIOETHANEsulfonIC ACID; 2-Mercaptoethylsulfonate; 2-Sulfanylethylsulfonate; Kendrick brand OF mesna; 1-THIOETHANEsulphonate; 1-THIOETHANEsulfonate; Sanfer brand OF mesna; Mesna kendrick brand; UCB brand OF mesna; Reduced coenzyme m; Mesna sanfer brand; Mistabronco; ASTA-D 7093; ASTA D 7093; Reduced com; Coenzyme M; Coenzima m; Uromitexan; ASTAD 7093; MESNA cell; MESNA-cell; Mistabron; Coenzym m; Mucofluid; Mitexan; Mesnex; HS-CoM; Mesnum; Ziken; MESNA; CoM; Coenzyme M
数据库引用编号
32 个数据库交叉引用编号
- ChEBI: CHEBI:17905
- KEGG: C03576
- PubChem: 598
- HMDB: HMDB0003745
- Metlin: METLIN598
- DrugBank: DB09110
- ChEMBL: CHEMBL1098319
- Wikipedia: Coenzyme M
- MeSH: Mesna
- MetaCyc: CoM
- KNApSAcK: C00000761
- foodb: FDB023220
- chemspider: 578
- CAS: 3375-50-6
- CAS: 9005-46-3
- MoNA: PS071209
- MoNA: PS015405
- MoNA: PS071207
- MoNA: PS015401
- MoNA: PS015402
- MoNA: PS015407
- MoNA: PS071201
- MoNA: PS071203
- MoNA: PR100753
- MoNA: PS071208
- MoNA: PS071202
- PMhub: MS000010050
- PubChem: 6368
- PDB-CCD: COM
- 3DMET: B00605
- NIKKAJI: J135.783B
- KNApSAcK: 17905
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kathrine J Vinknes, Thomas Olsen, Hasse Khiabani Zaré, Nasser E Bastani, Emma Stolt, Anja F Dahl, Roger D Cox, Helga Refsum, Kjetil Retterstøl, Anders Åsberg, Amany Elshorbagy. Cysteine-lowering treatment with mesna against obesity: Proof of concept and results from a human phase I, dose-finding study.
Diabetes, obesity & metabolism.
2023 Jul; ?(?):. doi:
10.1111/dom.15210. [PMID: 37435697] - Abigail B Donkor, Carl W White, Heidi J Nick, Brian A Logue. Analysis of sodium 2-mercaptoethane sulfonate in rat plasma using high performance liquid chromatography tandem-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Jan; 1189(?):123088. doi:
10.1016/j.jchromb.2021.123088. [PMID: 34974317] - Jonathan Fishman, Edward W Fisher. 'Chemically assisted dissection' in cholesteatoma surgery, Eustachian tube balloon dilatation post-irradiation, and coronavirus disease 2019 and the undergraduate curriculum.
The Journal of laryngology and otology.
2021 08; 135(8):659. doi:
10.1017/s0022215121001870. [PMID: 34342557] - Hanan H Hagar, Sarah A Almubrik, Nada M Attia, Sarah N Aljasser. Mesna Alleviates Cerulein-Induced Acute Pancreatitis by Inhibiting the Inflammatory Response and Oxidative Stress in Experimental Rats.
Digestive diseases and sciences.
2020 12; 65(12):3583-3591. doi:
10.1007/s10620-020-06072-1. [PMID: 32088797] - Sarita Rani Jaiswal, Paras Singhal, Atul Thatai, Gitali Bhagwati, Hema Malini Aiyer, Aditi Chakrabarti, Suparno Chakrabarti. Impact of extended infusional mesna prophylaxis on the incidence of BK viruria and hemorrhagic cystitis following post-transplantation cyclophosphamide and CTLA4Ig-based haploidentical transplantation.
Annals of hematology.
2020 Apr; 99(4):839-845. doi:
10.1007/s00277-020-03930-w. [PMID: 32025839] - Nathan A Hirshman, Francis M Hughes, Huixia Jin, William T Harrison, Simon W White, Isabelle Doan, Shelby N Harper, Patrick D Leidig, J Todd Purves. Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats.
American journal of physiology. Renal physiology.
2020 02; 318(2):F354-F362. doi:
10.1152/ajprenal.00408.2019. [PMID: 31869244] - Asmahan Abu-Arish, Elvis Pandžić, Dusik Kim, Hsin Wei Tseng, Paul W Wiseman, John W Hanrahan. Agonists that stimulate secretion promote the recruitment of CFTR into membrane lipid microdomains.
The Journal of general physiology.
2019 06; 151(6):834-849. doi:
10.1085/jgp.201812143. [PMID: 31048413] - Negin Mahmoudi, Sahar Eftekharzadeh, Marzieh Golmohammadi, Reza Khorramirouz, Javad Hashemi, Zeinab Kashani, Maryam Alijani, Amir Ali Hamidieh, Abdol-Mohammad Kajbafzadeh. Alleviation of Cyclophosphamide-induced Hemorrhagic Cystitis by Dietary Pomegranate: A Comparative Experimental Study With Mesna.
Journal of pediatric hematology/oncology.
2018 11; 40(8):609-615. doi:
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Asia-Pacific journal of clinical oncology.
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Journal of veterinary internal medicine.
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Free radical biology & medicine.
2017 09; 110(?):54-62. doi:
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Respirology (Carlton, Vic.).
2017 08; 22(6):1084-1092. doi:
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Plant physiology and biochemistry : PPB.
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Japanese journal of clinical oncology.
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Bone marrow transplantation.
2015 Nov; 50(11):1490-2. doi:
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Toxicologic pathology.
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Amino acids.
2015 Mar; 47(3):511-23. doi:
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PloS one.
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PloS one.
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Amino acids.
2014 Feb; 46(2):429-39. doi:
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Organic letters.
2013 Mar; 15(5):1020-3. doi:
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Nanotoxicology.
2013 Mar; 7(2):192-201. doi:
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Acta neurochirurgica.
2013 Jan; 155(1):141-9; discussion 149. doi:
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2012 Aug; 48(67):8359-61. doi:
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Neurochemical research.
2012 May; 37(5):1057-62. doi:
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Journal of clinical pharmacology.
2012 Apr; 52(4):530-42. doi:
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Analytical and bioanalytical chemistry.
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Inflammation.
2012 Feb; 35(1):297-307. doi:
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Lung cancer (Amsterdam, Netherlands).
2012 Feb; 75(2):213-6. doi:
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Rare tumors.
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Case reports in oncology.
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PloS one.
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Molecular systems biology.
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Annals of hematology.
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Journal of the Korean Society of Coloproctology.
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2011 Jul; 21(3):160-5. doi:
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The Journal of surgical research.
2011 Jul; 169(1):44-50. doi:
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Free radical biology & medicine.
2011 Jun; 50(11):1630-8. doi:
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BMC cell biology.
2011 May; 12(?):20. doi:
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Biochemistry.
2011 May; 50(17):3512-6. doi:
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Pediatric nephrology (Berlin, Germany).
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Cancer chemotherapy and pharmacology.
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The Journal of biological chemistry.
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International neurourology journal.
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Cancer chemotherapy and pharmacology.
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International journal of surgical oncology.
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PloS one.
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Case reports in urology.
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Archaea (Vancouver, B.C.).
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Cancer research and treatment.
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Therapeutic advances in respiratory disease.
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The journal of physical chemistry. B.
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Cancer chemotherapy and pharmacology.
2010 Apr; 65(5):941-51. doi:
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PloS one.
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Urologia internationalis.
2010; 85(1):118-20. doi:
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Case reports in medicine.
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Mediators of inflammation.
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2009 Oct; 877(28):3300-8. doi:
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Journal of gastroenterology and hepatology.
2009 Apr; 24(4):623-32. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Apr; 877(10):857-66. doi:
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Therapeutic drug monitoring.
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Fertility and sterility.
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Blood purification.
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Analytical chemistry.
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Lung cancer (Amsterdam, Netherlands).
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International journal of molecular sciences.
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American journal of obstetrics and gynecology.
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Pediatric nephrology (Berlin, Germany).
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Military medicine.
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Cell biochemistry and function.
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Cell biology and toxicology.
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Pediatric nephrology (Berlin, Germany).
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Pediatric nephrology (Berlin, Germany).
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Gan to kagaku ryoho. Cancer & chemotherapy.
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
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The Journal of laryngology and otology.
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Hepatology research : the official journal of the Japan Society of Hepatology.
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Molecular nutrition & food research.
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Critical care (London, England).
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