Proteinase inhibitor E 64 (BioDeep_00000003377)

 

Secondary id: BioDeep_00001868978


代谢物信息卡片


3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-(2S,3S)-oxiranecarboxylic acid

化学式: C15H27N5O5 (357.2012092)
中文名称: E-64
谱图信息: 最多检出来源 Viridiplantae(plant) 50%

分子结构信息

SMILES: CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O
InChI: InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
KEIO_ID E015; [MS2] KO008950
KEIO_ID E015

同义名列表

4 个代谢物同义名

3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-(2S,3S)-oxiranecarboxylic acid; Proteinase inhibitor E 64; CID 4641099; e-64



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Eman D Elkerdany, Suzanne M Elnassery, Fadwa M Arafa, Sahar Abdel-Fattah Zaki, Rasha F Mady. In vitro effect of a novel protease inhibitor cocktail on Toxoplasma gondii tachyzoites. Experimental parasitology. 2020 Dec; 219(?):108010. doi: 10.1016/j.exppara.2020.108010. [PMID: 33007297]
  • Mohamed Azarkan, Erik Maquoi, François Delbrassine, Raphael Herman, Nasiha M'Rabet, Rafaèle Calvo Esposito, Paulette Charlier, Frédéric Kerff. Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. Scientific reports. 2020 11; 10(1):19570. doi: 10.1038/s41598-020-76172-5. [PMID: 33177555]
  • Qiangni Liu, Inna Sabirzhanova, Murali K Yanda, Emily A S Bergbower, Clément Boinot, William B Guggino, Liudmila Cebotaru. Rescue of CFTR NBD2 mutants N1303K and S1235R is influenced by the functioning of the autophagosome. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2018 09; 17(5):582-594. doi: 10.1016/j.jcf.2018.05.016. [PMID: 29936070]
  • Myrna Sabanero López, Lérida L Flores Villavicencio, Karla Soto Arredondo, Gloria Barbosa Sabanero, Julio César Villagómez-Castro, Gustavo Cruz Jiménez, Gerardo Sandoval Bernal, Haydee Torres Guerrero. Proteases of Sporothrix schenckii: Cytopathological effects on a host-cell model. Revista iberoamericana de micologia. 2018 Jan; 35(1):32-38. doi: 10.1016/j.riam.2017.05.003. [PMID: 29221633]
  • C M Kershaw, G Evans, R Rodney, W M C Maxwell. Papain and its inhibitor E-64 reduce camelid semen viscosity without impairing sperm function and improve post-thaw motility rates. Reproduction, fertility, and development. 2017 Jun; 29(6):1107-1114. doi: 10.1071/rd15261. [PMID: 27156102]
  • Gregory Blass, Vladislav Levchenko, Daria V Ilatovskaya, Alexander Staruschenko. Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats. Physiological reports. 2016 09; 4(17):. doi: 10.14814/phy2.12950. [PMID: 27597769]
  • Michael W Risør, Line R Thomsen, Kristian W Sanggaard, Tania A Nielsen, Ida B Thøgersen, Marie V Lukassen, Litten Rossen, Irene Garcia-Ferrer, Tibisay Guevara, Carsten Scavenius, Ernst Meinjohanns, F Xavier Gomis-Rüth, Jan J Enghild. Enzymatic and Structural Characterization of the Major Endopeptidase in the Venus Flytrap Digestion Fluid. The Journal of biological chemistry. 2016 Jan; 291(5):2271-87. doi: 10.1074/jbc.m115.672550. [PMID: 26627834]
  • Pei Yin, Jinpeng Jia, Jijun Li, Yan Song, Yiyan Zhang, Fengkun Chen. ABT-737, a Bcl-2 Selective Inhibitor, and Chloroquine Synergistically Kill Renal Cancer Cells. Oncology research. 2016; 24(1):65-72. doi: 10.3727/096504016x14587366983838. [PMID: 27178823]
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  • Amaia Zulet, Miriam Gil-Monreal, Joji Grace Villamor, Ana Zabalza, Renier A L van der Hoorn, Mercedes Royuela. Proteolytic pathways induced by herbicides that inhibit amino acid biosynthesis. PloS one. 2013; 8(9):e73847. doi: 10.1371/journal.pone.0073847. [PMID: 24040092]
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  • Katia Gindro, Valentine Berger, Sophie Godard, Francine Voinesco, Sylvain Schnee, Olivier Viret, Virginia Alonso-Villaverde. Protease inhibitors decrease the resistance of Vitaceae to Plasmopara viticola. Plant physiology and biochemistry : PPB. 2012 Nov; 60(?):74-80. doi: 10.1016/j.plaphy.2012.07.028. [PMID: 22906813]
  • Thomas Gobbetti, Nicolas Cenac, Jean-Paul Motta, Corinne Rolland, Laurence Martin, Patricia Andrade-Gordon, Martin Steinhoff, Elisabetta Barocelli, Nathalie Vergnolle. Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine. The American journal of pathology. 2012 Jan; 180(1):141-52. doi: 10.1016/j.ajpath.2011.09.031. [PMID: 22067907]
  • Runqiang Yang, Jiaojiao Song, Zhenxin Gu, Cuijuan Li. Partial purification and characterisation of cysteine protease in wheat germ. Journal of the science of food and agriculture. 2011 Oct; 91(13):2437-42. doi: 10.1002/jsfa.4484. [PMID: 21702054]
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  • Sadaf Khan, Giti Verma, Samir Sharma. A novel Ca2+-activated protease from germinating Vigna radiata seeds and its role in storage protein mobilization. Journal of plant physiology. 2010 Jul; 167(11):855-61. doi: 10.1016/j.jplph.2010.01.010. [PMID: 20149479]
  • Marco Túlio R Gomes, Andréia P Turchetti, Miriam T P Lopes, Carlos E Salas. Stimulation of fibroblast proliferation by the plant cysteine protease CMS2MS2 is independent of its proteolytic activity and requires ERK activation. Biological chemistry. 2009 Dec; 390(12):1285-91. doi: 10.1515/bc.2009.137. [PMID: 19747075]
  • Zheming Wang, Christian Gu, Tom Colby, Takayuki Shindo, Rengarajan Balamurugan, Herbert Waldmann, Markus Kaiser, Renier A L van der Hoorn. Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana. Nature chemical biology. 2008 Sep; 4(9):557-63. doi: 10.1038/nchembio.104. [PMID: 18660805]
  • Iu A Smirnova, L V Kordiukova, M V Serebriakova, I Iu Filippova, E N Lysogorskaia, L A Baratova. [Flu virion as a substrate for proteolytic enzymes]. Bioorganicheskaia khimiia. 2008 May; 34(3):409-15. doi: 10.1134/s1068162008030205. [PMID: 18672693]
  • Hendra Gunawan, Toshiro Takai, Shigaku Ikeda, Ko Okumura, Hideoki Ogawa. Protease activity of allergenic pollen of cedar, cypress, juniper, birch and ragweed. Allergology international : official journal of the Japanese Society of Allergology. 2008 Mar; 57(1):83-91. doi: 10.2332/allergolint.o-07-507. [PMID: 18209508]
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  • Jian J Duan, Joseph Huesing, Debra Teixeira. Development of tier-I toxicity assays for Orius insidiosus (Heteroptera: Anthocoridae) for assessing the risk of plant-incorporated protectants to nontarget heteropterans. Environmental entomology. 2007 Aug; 36(4):982-8. doi: 10.1603/0046-225x(2007)36[982:dottaf]2.0.co;2. [PMID: 17716490]
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  • Ji Young Kim, Hyun Jong Yang, Kwang Sig Kim, Young Bae Chung. Partial characterization of a 29 kDa cysteine protease purified from Taenia solium metacestodes. The Korean journal of parasitology. 2005 Dec; 43(4):157-60. doi: 10.3347/kjp.2005.43.4.157. [PMID: 16340305]
  • Henrietta C E Rooney, John W Van't Klooster, Renier A L van der Hoorn, Matthieu H A J Joosten, Jonathan D G Jones, Pierre J G M de Wit. Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance. Science (New York, N.Y.). 2005 Jun; 308(5729):1783-6. doi: 10.1126/science.1111404. [PMID: 15845874]
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  • G Stepek, D J Buttle, I R Duce, A Lowe, J M Behnke. Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro. Parasitology. 2005 Feb; 130(Pt 2):203-11. doi: 10.1017/s0031182004006225. [PMID: 15727070]
  • André Luis Souza Dos Santos, Rosangela Maria de Araújo Soares. Candida guilliermondii isolated from HIV-infected human secretes a 50 kDa serine proteinase that cleaves a broad spectrum of proteinaceous substrates. FEMS immunology and medical microbiology. 2005 Jan; 43(1):13-20. doi: 10.1016/j.femsim.2004.06.022. [PMID: 15607631]
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