Tocainide (BioDeep_00000003183)
Secondary id: BioDeep_00000406042
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
AstraZeneca brand OF tocainide hydrochloride
化学式: C11H16N2O (192.12625659999998)
中文名称: 妥卡尼
谱图信息:
最多检出来源 Homo sapiens(blood) 97.62%
分子结构信息
SMILES: CC(N)C(=O)NC1=C(C)C=CC=C1C
InChI: InChI=1S/C11H16N2O/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12/h4-6,9H,12H2,1-3H3,(H,13,14)
描述信息
Tocainide is only found in individuals that have used or taken this drug. It is an antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels. [PubChem]Tocainide acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. Tocainide binds preferentially to the inactive state of the sodium channels.The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.
C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BB - Antiarrhythmics, class ib
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
20 个代谢物同义名
AstraZeneca brand OF tocainide hydrochloride; 2-Amino-N-(2,6-dimethylphenyl)propanamide; 2-Amino-N-(2,6-dimethylphenyl)propionamid; Tocainide monohydrochloride, (+-)-isomer; Tocainide monohdyrochloride, (R)-isomer; Tocainide monohydrochloride, (S)-isomer; Tocainide monohydrobromide, (R)-isomer; 2-Amino-2,6-propionoxylidide; Tocainide monohydrochloride; Hydrochloride, tocainide; Tocainide hydrochloride; Tocainide, (+-)-isomer; Tocainide, (S)-isomer; Tocainide, (R)-isomer; Alanyl-2,6-xylidide; Tocainidum; Xylotocan; Tocainida; tocainide; Tonocard
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:9611
- KEGG: C07142
- KEGGdrug: D06172
- PubChem: 38945
- HMDB: HMDB0015189
- Metlin: METLIN2864
- DrugBank: DB01056
- ChEMBL: CHEMBL1762
- Wikipedia: Tocainide
- MeSH: Tocainide
- chemspider: 35632
- CAS: 41708-72-9
- CAS: 53984-26-2
- CAS: 76213-25-7
- PMhub: MS000008422
- PubChem: 9351
- NIKKAJI: J16.873D
- RefMet: Tocainide
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Marco Pistolozzi, Cecilia Fortugno, Carlo Franchini, Filomena Corbo, Marilena Muraglia, Myriam Roy, Guy Félix, Carlo Bertucci. Species-dependent binding of tocainide analogues to albumin: affinity chromatography and circular dichroism study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Neuroscience.
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1987 Sep; 32(5):1440-6. doi:
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1987 Jun; 33(6):1069. doi:
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1987 Feb; 10(2):155-62. doi:
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1986 Jul; 32(7):1311-7. doi:
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1986 Jun; 39(3):452-63. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
1981 Apr; 11(4):259-65. doi:
10.3109/00498258109045300. [PMID: 6795837] - R A Winkle, J W Mason, D C Harrison. Tocainide for drug-resistant ventricular arrhythmias: efficacy, side effects, and lidocaine responsiveness for predicting tocainide success.
American heart journal.
1980 Dec; 100(6 Pt 2):1031-6. doi:
10.1016/0002-8703(80)90209-4. [PMID: 6778191] - B C Bastian, P W Macfarlane, J H McLauchlan, D Ballantyne, P Clark, W S Hillis, A P Rae, I Hutton. A prospective randomized trial of tocainide in patients following myocardial infarction.
American heart journal.
1980 Dec; 100(6 Pt 2):1017-22. doi:
10.1016/0002-8703(80)90207-0. [PMID: 6778189] - A T Elvin, D Lalka, K Stoeckel, P du Souich, J E Axelson, L H Golden, A J McLean. Tocainide kinetics and metabolism: effects of phenobarbital and substrates of glucuronyl transferase.
Clinical pharmacology and therapeutics.
1980 Nov; 28(5):652-8. doi:
10.1038/clpt.1980.217. [PMID: 6777107] - R Venkataramanan, J E Axelson. The effect of phenobarbital and SKF 525A on tocainide pharmacokinetics in the rat.
The Journal of pharmacology and experimental therapeutics.
1980 Oct; 215(1):235-9. doi:
. [PMID: 6778991] - R Venkataramanan, J E Axelson. Dose-dependent pharmacokinetics of tocainide in the rat.
The Journal of pharmacology and experimental therapeutics.
1980 Oct; 215(1):231-4. doi:
. [PMID: 6778990] - P A Reece, P E Stanley. High-performance liquid chromatographic assay for tocainide in human plasma: comparison with gas--liquid chromatographic assay.
Journal of chromatography.
1980 Jul; 183(1):109-14. doi:
10.1016/s0378-4347(00)81407-3. [PMID: 6772656] - D M Roden, D M Roden, S B Reele, S B Reele, S B Higgins, S B Higgins, R K Carr, R K Carr, R F Smith, R F Smith, J A Oates, J A Oates, R L Woosley, R L Woosley. Tocainide therapy for refractory ventricular arrhythmias.
American heart journal.
1980 Jul; 100(1):15-22. doi:
10.1016/0002-8703(80)90274-4. [PMID: 6770666] - M D Klein, P A Levine, T J Ryan. Antiarrhythmic efficacy, pharmacokinetics and clinical safety of tocainide in convalescent myocardial infarction patients.
Chest.
1980 Jun; 77(6):726-30. doi:
10.1378/chest.77.6.726. [PMID: 6772381] - G J Stewart, L C Knight, B W Arbogast, H S Stern. Inhibition of leukocyte locomotion by tocainide, a primary amine analog of lidocaine: at study with 111indium-labeled leukocytes and scanning electron microscopy.
Laboratory investigation; a journal of technical methods and pathology.
1980 Mar; 42(3):302-9. doi:
NULL. [PMID: 6767137]