Altanserin (BioDeep_00000003095)
Secondary id: BioDeep_00000405751
human metabolite blood metabolite
代谢物信息卡片
3-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one
化学式: C22H22FN3O2S (411.1417)
中文名称: Altanserin 盐酸盐
谱图信息:
最多检出来源 Homo sapiens(blood) 25%
分子结构信息
SMILES: c1ccc2c(c1)c(=O)n(CCN1CCC(CC1)C(=O)c1ccc(cc1)F)c(=S)[nH]2
InChI: InChI=1S/C22H22FN3O2S/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
Altanserin can synthesize Fluorine-18 Altanserin. Fluorine-18 Altanserin binds to the brain 5HT2 receptors[1].
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:2613
- KEGG: C11734
- PubChem: 3033677
- PubChem: 54367
- HMDB: HMDB0248260
- Metlin: METLIN69185
- ChEMBL: CHEMBL62919
- Wikipedia: Altanserin
- chemspider: 2298299
- CAS: 76330-71-7
- PMhub: MS000008048
- PubChem: 13899
- NIKKAJI: J32.855C
- RefMet: Altanserin
- medchemexpress: HY-119156
- KNApSAcK: 2613
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Marie Spies, Arafat Nasser, Brice Ozenne, Peter S Jensen, Gitte M Knudsen, Patrick M Fisher. Common HTR2A variants and 5-HTTLPR are not associated with human in vivo serotonin 2A receptor levels.
Human brain mapping.
2020 11; 41(16):4518-4528. doi:
10.1002/hbm.25138. [PMID: 32697408] - Abraham Martín, Boguslaw Szczupak, Vanessa Gómez-Vallejo, Sandra Plaza, Daniel Padró, Ainhoa Cano, Jordi Llop. PET imaging of serotoninergic neurotransmission with [(11)C]DASB and [(18)F]altanserin after focal cerebral ischemia in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2013 Dec; 33(12):1967-75. doi:
10.1038/jcbfm.2013.156. [PMID: 23982048] - Hanne D Hansen, Anders Ettrup, Matthias M Herth, Agnete Dyssegaard, Cecilia Ratner, Nic Gillings, Gitte M Knudsen. Direct comparison of [(18) F]MH.MZ and [(18) F] altanserin for 5-HT2A receptor imaging with PET.
Synapse (New York, N.Y.).
2013 Jun; 67(6):328-37. doi:
10.1002/syn.21643. [PMID: 23390031] - Boris B Quednow, Valerie Treyer, Felix Hasler, Nadja Dörig, Matthias T Wyss, Cyrill Burger, Katharina M Rentsch, Gerrit Westera, Pius August Schubiger, Alfred Buck, Franz X Vollenweider. Assessment of serotonin release capacity in the human brain using dexfenfluramine challenge and [18F]altanserin positron emission tomography.
NeuroImage.
2012 Feb; 59(4):3922-32. doi:
10.1016/j.neuroimage.2011.09.045. [PMID: 21996132] - Patrick J Riss, Young T Hong, David Williamson, Daniele Caprioli, Sergey Sitnikov, Valentina Ferrari, Steve J Sawiak, Jean-Claude Baron, Jeffrey W Dalley, Tim D Fryer, Franklin I Aigbirhio. Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2011 Dec; 31(12):2334-42. doi:
10.1038/jcbfm.2011.94. [PMID: 21750562] - David Erritzoe, Vibe G Frokjaer, Klaus K Holst, Maria Christoffersen, Sys S Johansen, Claus Svarer, Jacob Madsen, Peter M Rasmussen, Thomas Ramsøy, Terry L Jernigan, Gitte M Knudsen. In vivo imaging of cerebral serotonin transporter and serotonin(2A) receptor binding in 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") and hallucinogen users.
Archives of general psychiatry.
2011 Jun; 68(6):562-76. doi:
10.1001/archgenpsychiatry.2011.56. [PMID: 21646575] - Hans Rasmussen, Bjorn H Ebdrup, David Erritzoe, Bodil Aggernaes, Bob Oranje, Jan Kalbitzer, Lars H Pinborg, William F C Baaré, Claus Svarer, Henrik Lublin, Gitte M Knudsen, Birte Glenthoj. Serotonin2A receptor blockade and clinical effect in first-episode schizophrenia patients treated with quetiapine.
Psychopharmacology.
2011 Feb; 213(2-3):583-92. doi:
10.1007/s00213-010-1941-5. [PMID: 20614105] - Anders Bue Klein, Viktorija Trajkovska, David Erritzoe, Steven Haugbol, Jacob Madsen, William Baaré, Susana Aznar, Gitte M Knudsen. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2010 Nov; 30(11):e1-7. doi:
10.1038/jcbfm.2010.114. [PMID: 20736957] - Vibe G Frokjaer, David Erritzoe, Anders Juul, Finn Arup Nielsen, Klaus Holst, Claus Svarer, Jacob Madsen, Olaf B Paulson, Gitte M Knudsen. Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding.
Psychoneuroendocrinology.
2010 Oct; 35(9):1311-20. doi:
10.1016/j.psyneuen.2010.03.002. [PMID: 20356681] - David Erritzoe, Klaus Holst, Vibe G Frokjaer, Cecilie L Licht, Jan Kalbitzer, Finn A Nielsen, Claus Svarer, Jacob Madsen, Gitte Knudsen. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010 Mar; 30(9):3391-7. doi:
10.1523/jneurosci.2852-09.2010. [PMID: 20203198] - Lekshmi Santhosh, Kristina M Estok, Rebecca S Vogel, Gilles D Tamagnan, Ronald M Baldwin, Effie M Mitsis, Martha G Macavoy, Julie K Staley, Christopher H van Dyck. Regional distribution and behavioral correlates of 5-HT(2A) receptors in Alzheimer's disease with [(18)F]deuteroaltanserin and PET.
Psychiatry research.
2009 Sep; 173(3):212-7. doi:
10.1016/j.pscychresns.2009.03.007. [PMID: 19682865] - F Hasler, O F Kuznetsova, R N Krasikova, T Cservenyak, B B Quednow, F X Vollenweider, S M Ametamey, G Westera. GMP-compliant radiosynthesis of [18F]altanserin and human plasma metabolite studies.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2009 Apr; 67(4):598-601. doi:
10.1016/j.apradiso.2008.12.007. [PMID: 19162492] - René Hurlemann, Thomas E Schlaepfer, Andreas Matusch, Harald Reich, Nadim J Shah, Karl Zilles, Wolfgang Maier, Andreas Bauer. Reduced 5-HT(2A) receptor signaling following selective bilateral amygdala damage.
Social cognitive and affective neuroscience.
2009 Mar; 4(1):79-84. doi:
10.1093/scan/nsn039. [PMID: 19015089] - A Matusch, R Hurlemann, E Rota Kops, O H Winz, D Elmenhorst, H Herzog, K Zilles, A Bauer. Acute S-ketamine application does not alter cerebral [18F]altanserin binding: a pilot PET study in humans.
Journal of neural transmission (Vienna, Austria : 1996).
2007; 114(11):1433-42. doi:
10.1007/s00702-007-0751-3. [PMID: 17541696] - Lars H Pinborg, Karen H Adams, Stig Yndgaard, Steen G Hasselbalch, Søren Holm, Heidi Kristiansen, Olaf B Paulson, Gitte M Knudsen. [18F]altanserin binding to human 5HT2A receptors is unaltered after citalopram and pindolol challenge.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2004 Sep; 24(9):1037-45. doi:
10.1097/01.wcb.0000126233.08565.e7. [PMID: 15356424] - Lars H Pinborg, Karen H Adams, Claus Svarer, Søren Holm, Steen G Hasselbalch, Steven Haugbøl, Jacob Madsen, Gitte M Knudsen. Quantification of 5-HT2A receptors in the human brain using [18F]altanserin-PET and the bolus/infusion approach.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2003 Aug; 23(8):985-96. doi:
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The American journal of psychiatry.
2003 Aug; 160(8):1522-4. doi:
10.1176/appi.ajp.160.8.1522. [PMID: 12900319] - J C Price, B J Lopresti, C C Meltzer, G S Smith, N S Mason, Y Huang, D P Holt, R N Gunn, C A Mathis. Analyses of [(18)F]altanserin bolus injection PET data. II: consideration of radiolabeled metabolites in humans.
Synapse (New York, N.Y.).
2001 Jul; 41(1):11-21. doi:
10.1002/syn.1055. [PMID: 11354009] - C H van Dyck, J C Soares, P Z Tan, J K Staley, R M Baldwin, L A Amici, X Fu, P K Garg, J P Seibyl, D S Charney, R B Innis. Equilibrium modeling of 5-HT(2A) receptors with [18F]deuteroaltanserin and PET: feasibility of a constant infusion paradigm.
Nuclear medicine and biology.
2000 Nov; 27(8):715-22. doi:
10.1016/s0969-8051(00)00160-8. [PMID: 11150702] - C H van Dyck, P Z Tan, R M Baldwin, L A Amici, P K Garg, C K Ng, R Soufer, D S Charney, R B Innis. PET quantification of 5-HT2A receptors in the human brain: a constant infusion paradigm with [18F]altanserin.
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Nuclear medicine and biology.
1999 Aug; 26(6):601-8. doi:
10.1016/s0969-8051(99)00022-0. [PMID: 10587097] - G S Smith, J C Price, B J Lopresti, Y Huang, N Simpson, D Holt, N S Mason, C C Meltzer, R A Sweet, T Nichols, D Sashin, C A Mathis. Test-retest variability of serotonin 5-HT2A receptor binding measured with positron emission tomography and [18F]altanserin in the human brain.
Synapse (New York, N.Y.).
1998 Dec; 30(4):380-92. doi:
10.1002/(sici)1098-2396(199812)30:4<380::aid-syn5>3.0.co;2-u. [PMID: 9826230] - B Sadzot, C Lemaire, P Maquet, E Salmon, A Plenevaux, C Degueldre, J P Hermanne, M Guillaume, R Cantineau, D Comar. Serotonin 5HT2 receptor imaging in the human brain using positron emission tomography and a new radioligand, [18F]altanserin: results in young normal controls.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1995 Sep; 15(5):787-97. doi:
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