3-(4-hydroxyphenyl)lactate (BioDeep_00000002903)

 

Secondary id: BioDeep_00000229657, BioDeep_00000400459

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


2-Hydroxy-3-(4-hydroxyphenyl)propanoic acid

化学式: C9H10O4 (182.0579)
中文名称: 3-(4-羟基苯基)乳酸, DL-对羟基苯乳酸, 4-羟苯乳酸, 2-羟基-3-（4-羟基苯基）丙酸, DL-4-羟基苯乳酸
谱图信息: 最多检出来源 Homo sapiens(blood) 12.01%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

3-(4-hydroxyphenyl)lactate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/3-(4-hydroxyphenyl)lactate (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000002903). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=CC(=CC=C1CC(C(=O)O)O)O
InChI: InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)

描述信息

Hydroxyphenyllactic acid or 4-hydroxyphenyllactate (the L-form) is a tyrosine metabolite. The level of L-hydroxyphenyllactic acid is elevated in patients with a deficiency of the enzyme p-hydroxyphenylpyruvate oxidase (EC 1.14.2.2) (PMID: 4720815). L-hydroxyphenyllactate is present in relatively higher concentrations in the cerebrospinal fluid and urine of patients with phenylketonuria (PKU) and tyrosinemia (PMID: 3126358). However, the D-form of hydroxyphenyllactate is of bacterial origin and is also found in individuals with bacterial overgrowth or unusual gut microflora (PMID: 3126358). Microbial hydroxyphenyllactate is likely derived from phenolic or polyphenolic compounds in the diet. Bifidobacteria and lactobacilli produce considerable amounts of phenyllactic and p-hydroxyphenyllactic acids (PMID: 23061754). It has also been shown that hydroxyphenyllactate decreases ROS (reactive oxygen species) production in both mitochondria and neutrophils and so hydroxyphenyllactate may function as a natural anti-oxidant (PMID: 23061754). Hydroxyphenyllactic acid is a microbial metabolite found in Acinetobacter, Bacteroides, Bifidobacteria, Bifidobacterium, Clostridium, Enterococcus, Escherichia, Eubacterium, Klebsiella, Lactobacillus, Pseudomonas and Staphylococcus (PMID: 19961416).
Acquisition and generation of the data is financially supported in part by CREST/JST.
Hydroxyphenyllactic acid is an antifungal metabolite.

同义名列表

50 个代谢物同义名

2-Hydroxy-3-(4-hydroxyphenyl)propanoic acid; 2-Hydroxy-3-(p-hydroxyphenyl)propionic acid; 4-Hydroxyphenyllactic acid, (DL)-isomer; 2-Hydroxy-3-(p-hydroxyphenyl)propionate; 2-Hydroxy-3-(4-hydroxyphenyl)propanoate; beta-(p-Hydroxyphenyl)-DL-lactic acid; (RS)-3-(4-Hydroxyphenyl)lactic acid; b-(p-Hydroxyphenyl)-DL-lactic acid; a,4-Dihydroxybenzenepropanoic acid; 3-(4-Hydroxyphenyl)-DL-lactic acid; beta-(p-Hydroxyphenyl)lactic acid; DL-3-(4-Hydroxyphenyl)lactic acid; beta-(4-Hydroxyphenyl)lactic acid; beta-(p-Hydroxyphenyl)-DL-lactate; (RS)-3-(4-Hydroxyphenyl)lactate; 3-(p-Hydroxyphenyl)-lactic acid; 3-(4-Hydroxyphenyl)-DL-lactate; a,4-Dihydroxybenzenepropanoate; 3-(4-Hydroxyphenyl)lactic acid; b-(4-Hydroxyphenyl)lactic acid; Β-(4-hydroxyphenyl)lactic acid; b-(p-Hydroxyphenyl)-DL-lactate; b-(p-Hydroxyphenyl)lactic acid; Β-(p-hydroxyphenyl)lactic acid; DL-p-Hydroxyphenyllactic acid; beta-(p-Hydroxyphenyl)lactate; dl-4-hydroxyphenyllactic acid; Para-hydroxyphenyllactic acid; DL-3-(4-Hydroxyphenyl)lactate; beta-(4-Hydroxyphenyl)lactate; 3-(p-Hydroxyphenyl)-lactate; p-Hydroxyphenyl lactic acid; p-Hydroxyphenyllactic acid; Β-(p-hydroxyphenyl)lactate; Β-(4-hydroxyphenyl)lactate; b-(p-Hydroxyphenyl)lactate; b-(4-Hydroxyphenyl)lactate; 3-(4-Hydroxyphenyl)lactate; 4-Hydroxyphenyllactic acid; DL-p-Hydroxyphenyllactate; Hydroxyphenyllactic acid; p-Hydroxyphenyl lactate; p-Hydroxyphenyllactate; 4-Hydroxyphenyllactate; Hydroxyphenyllactate; 2-Hydroxyphloretate; DL-p-Hydroxy; HPLA; 2-Hydroxy-3-(4-hydroxyphenyl)propanoic acid; Hydroxyphenyllactic acid



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

48 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AFP, AHR, ALB, DMRT1, HPD, LDHA, MAPK14, PAK1, ZIC1
Peripheral membrane protein 4 CYP1B1, HPD, HSD17B6, PAK1
Endoplasmic reticulum membrane 2 CYP1B1, HPD
Nucleus 7 AHR, ALB, DMRT1, LDHA, MAPK14, PAK1, ZIC1
cytosol 8 AHR, ALB, HGD, HPD, LDHA, MAPK14, PAK1, TAT
dendrite 1 PAK1
centrosome 2 ALB, PAK1
nucleoplasm 4 AHR, MAPK14, PAK1, ZIC1
Cell membrane 2 GPRC5A, PAK1
Cleavage furrow 1 PAK1
lamellipodium 1 PAK1
ruffle membrane 1 PAK1
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 3 GPRC5A, HCAR3, SLC25A13
Golgi apparatus membrane 1 HPD
cell junction 1 HCAR3
glutamatergic synapse 1 MAPK14
Golgi apparatus 1 ALB
Golgi membrane 2 HPD, INS
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 SLC25A13
Lysosome 1 GAA
endosome 1 PAK1
plasma membrane 5 GAA, GPRC5A, HCAR3, PAK1, SLC25A13
Membrane 4 CYP1B1, GAA, HCAR3, LDHA
axon 1 PAK1
extracellular exosome 6 ALB, GAA, GPRC5A, HGD, HPD, LDHA
Lysosome membrane 1 GAA
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 ALB, HSD17B6
extracellular space 5 AFP, ALB, CXCL8, IL6, INS
lysosomal lumen 1 GAA
intercalated disc 1 PAK1
mitochondrion 4 CYP1B1, LDHA, MAPK14, SLC25A13
protein-containing complex 3 AHR, ALB, PAK1
intracellular membrane-bounded organelle 4 CYP1B1, GAA, GPRC5A, HSD17B6
Microsome membrane 2 CYP1B1, HSD17B6
Secreted 6 AFP, ALB, CXCL8, GAA, IL6, INS
extracellular region 6 ALB, CXCL8, GAA, IL6, INS, MAPK14
anchoring junction 1 ALB
transcription regulator complex 1 AHR
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PAK1
nuclear membrane 1 PAK1
Z disc 1 PAK1
nucleolus 1 GPRC5A
midbody 1 PAK1
cell-cell junction 1 PAK1
vesicle 1 GPRC5A
Cell projection, lamellipodium 1 PAK1
Cell projection, ruffle membrane 1 PAK1
Mitochondrion inner membrane 1 SLC25A13
Cell junction, focal adhesion 1 PAK1
focal adhesion 1 PAK1
Mitochondrion intermembrane space 1 SLC25A13
mitochondrial intermembrane space 1 SLC25A13
nuclear speck 1 MAPK14
ruffle 1 PAK1
receptor complex 1 GPRC5A
ciliary basal body 1 ALB
chromatin 2 AHR, DMRT1
Chromosome 1 PAK1
centriole 1 ALB
spindle pole 2 ALB, MAPK14
actin filament 1 PAK1
blood microparticle 1 ALB
endosome lumen 1 INS
female germ cell nucleus 1 DMRT1
aryl hydrocarbon receptor complex 1 AHR
Cytoplasmic vesicle membrane 1 GPRC5A
Nucleus, nucleoplasm 1 PAK1
tertiary granule membrane 1 GAA
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 AFP, ALB, IL6, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ficolin-1-rich granule membrane 1 GAA
oxidoreductase complex 1 LDHA
interleukin-6 receptor complex 1 IL6
autolysosome lumen 1 GAA
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
ciliary transition fiber 1 ALB
Cell projection, invadopodium 1 PAK1


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