Rilmenidine (BioDeep_00000002538)

 

Secondary id: BioDeep_00000858839

human metabolite blood metabolite


代谢物信息卡片


2-(N-(Dicyclopropylmethyl)amino)oxazoline phosphate salt

化学式: C10H16N2O (180.1263)
中文名称: 利美尼啶
谱图信息: 最多检出来源 Homo sapiens(blood) 99.34%

分子结构信息

SMILES: C1CC1C(C1CC1)NC1=NCCO1
InChI: InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)

描述信息

C - Cardiovascular system > C02 - Antihypertensives > C02A - Antiadrenergic agents, centrally acting > C02AC - Imidazoline receptor agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Same as: D08482

同义名列表

8 个代谢物同义名

2-(N-(Dicyclopropylmethyl)amino)oxazoline phosphate salt; N-(Dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine; 2-(N-(Dicyclopropylmethyl)amino)oxazoline; Rilmenidine phosphate; Oxaminozoline; Rilmenidine; Hyperium; Rilmenidine



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ABCB1, ACE, ADRA2A, AKT1, CASP3, CYP3A4, TFDP3
Peripheral membrane protein 2 ACHE, CYP1B1
Endoplasmic reticulum membrane 3 CYP1A2, CYP1B1, CYP3A4
Nucleus 6 ACHE, AKT1, CASP3, MPO, PARP1, TFDP3
cytosol 4 AKT1, CASP3, GPT, PARP1
nuclear body 1 PARP1
nucleoplasm 4 AKT1, CASP3, MPO, PARP1
Cell membrane 6 ABCB1, ACE, ACHE, ADRA2A, AKT1, TNF
lamellipodium 1 AKT1
Multi-pass membrane protein 2 ABCB1, ADRA2A
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 3 ABCB1, ACHE, TNF
glutamatergic synapse 3 ADRA2A, AKT1, CASP3
Golgi apparatus 1 ACHE
Golgi membrane 1 INS
lysosomal membrane 1 GAA
neuromuscular junction 1 ACHE
neuronal cell body 3 ADRA2A, CASP3, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 PARP1
Lysosome 3 ACE, GAA, MPO
endosome 1 ACE
plasma membrane 9 ABCB1, ACE, ACHE, ADRA2A, AKT1, BCHE, GAA, REN, TNF
Membrane 9 ABCB1, ACE, ACHE, AKT1, CYP1B1, CYP3A4, GAA, PARP1, REN
apical plasma membrane 1 ABCB1
basolateral plasma membrane 1 ADRA2A
extracellular exosome 5 ABCB1, ACE, GAA, GPT, MPO
Lysosome membrane 1 GAA
extracellular space 9 ACE, ACHE, BCHE, IL10, IL6, INS, MPO, REN, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 ACHE
mitochondrion 2 CYP1B1, PARP1
protein-containing complex 2 AKT1, PARP1
intracellular membrane-bounded organelle 5 CYP1A2, CYP1B1, CYP3A4, GAA, MPO
Microsome membrane 3 CYP1A2, CYP1B1, CYP3A4
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 ACE
Secreted 8 ACE, ACHE, BCHE, GAA, IL10, IL6, INS, REN
extracellular region 10 ACE, ACHE, BCHE, GAA, IL10, IL6, INS, MPO, REN, TNF
Extracellular side 1 ACHE
transcription regulator complex 2 PARP1, TFDP3
external side of plasma membrane 2 ACE, TNF
microtubule cytoskeleton 1 AKT1
nucleolus 1 PARP1
apical part of cell 1 REN
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
presynaptic active zone membrane 1 ADRA2A
Apical cell membrane 1 ABCB1
Membrane raft 1 TNF
spindle 1 AKT1
GABA-ergic synapse 1 ADRA2A
basement membrane 1 ACHE
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 MPO
receptor complex 1 ADRA2A
ciliary basal body 1 AKT1
chromatin 2 PARP1, TFDP3
phagocytic cup 1 TNF
Chromosome 1 PARP1
brush border membrane 1 ACE
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
blood microparticle 1 BCHE
sperm midpiece 1 ACE
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
endosome lumen 1 INS
tertiary granule membrane 1 GAA
side of membrane 1 ACHE
basal plasma membrane 1 ACE
azurophil granule 1 MPO
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 BCHE, IL6, INS
axon terminus 1 ADRA2A
transport vesicle 1 INS
azurophil granule membrane 1 GAA
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 ADRA2A
nuclear envelope lumen 1 BCHE
phagocytic vesicle lumen 1 MPO
synaptic cleft 1 ACHE
protein-DNA complex 1 PARP1
ficolin-1-rich granule membrane 1 GAA
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
dopaminergic synapse 1 ADRA2A
site of DNA damage 1 PARP1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
autolysosome lumen 1 GAA
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Isoform H]: Cell membrane 1 ACHE
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Andressa Manfredini, Larissa Constantino, Milton Castro Pinto, Monique Michels, Henrique Burger, Luiza W Kist, Milena Carvalho Silva, Lara Mezzari Gomes, Diogo Dominguini, Amanda Steckert, Carmen Simioni, Mauricio Bogo, Emílio Streck, Tatiana Barichello, João de Quevedo, Mervyn Singer, Cristiane Ritter, Felipe Dal-Pizzol. Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model. Clinical science (London, England : 1979). 2019 09; 133(18):1993-2004. doi: 10.1042/cs20190351. [PMID: 31527095]
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  • Po-Sheng Yang, Hung-Tsung Wu, Hsien-Hui Chung, Chun-Ta Chen, Chin-Wen Chi, Ching-Hua Yeh, Juei-Tang Cheng. Rilmenidine improves hepatic steatosis through p38-dependent pathway to higher the expression of farnesoid X receptor. Naunyn-Schmiedeberg's archives of pharmacology. 2012 Jan; 385(1):51-6. doi: 10.1007/s00210-011-0691-1. [PMID: 21947253]
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  • Lukáš Chytil, Josef Cvačka, Věra Marešová, Branislav Štrauch, Jiří Widimský, Martin Štícha, Ondřej Slanař. Development of a fast LC-MS/MS method for quantification of rilmenidine in human serum: elucidation of fragmentation pathways by HRMS. Journal of mass spectrometry : JMS. 2010 Oct; 45(10):1179-85. doi: 10.1002/jms.1809. [PMID: 20815039]
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  • Kalina Kawecka-Jaszcz, Danuta Czarnecka, Marek Klocek, Michał Zabojszcz, Marta Kucharska, Rafał Jaworski, Robert Pachocki. Rilmenidine--its antihypertensive efficacy, safety and impact on quality of life in perimenopausal women with mild to moderate essential hypertension. Blood pressure. 2006; 15(1):51-8. doi: 10.1080/08037050600565969. [PMID: 16492616]
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  • Łukasz Nowak, Marcin Adamczak, Andrzej Wiecek. Blockade of sympathetic nervous system activity by rilmenidine increases plasma adiponectin concentration in patients with essential hypertension. American journal of hypertension. 2005 Nov; 18(11):1470-5. doi: 10.1016/j.amjhyper.2005.05.026. [PMID: 16280284]
  • Dmitrii A Anichkov, Nadezhda A Shostak, Olga V Schastnaya. Comparison of rilmenidine and lisinopril on ambulatory blood pressure and plasma lipid and glucose levels in hypertensive women with metabolic syndrome. Current medical research and opinion. 2005 Jan; 21(1):113-9. doi: 10.1185/030079904x20277. [PMID: 15881482]
  • Murray Esler, Alan Lux, Garry Jennings, Jacqui Hastings, Flora Socratous, Gavin Lambert. Rilmenidine sympatholytic activity preserves mental stress, orthostatic sympathetic responses and adrenaline secretion. Journal of hypertension. 2004 Aug; 22(8):1529-34. doi: 10.1097/01.hjh.0000125453.28861.b8. [PMID: 15257176]
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  • Laurent Monassier, Hugues Greney, Lionel Thomas, Pascal Bousquet. Chronic treatment with rilmenidine in spontaneously hypertensive rats: differences between two schedules of administration. Journal of cardiovascular pharmacology. 2004 Mar; 43(3):394-401. doi: 10.1097/00005344-200403000-00010. [PMID: 15076223]
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  • Peera Buranakitjaroen, Peerapong Kittipawong, Banhan Koanantakul, Chumpol Piamsomboon, Nattanun Prasassarakich, Songkwan Silaraks, Apichard Sukonthasarn, Assada Tiyapant. Efficacy and safety of rilmenidine, a selective imidazoline I1 receptor binding ligand, in mild-to-moderate Thai hypertensive patients. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2003 Oct; 86(10):903-10. doi: NULL. [PMID: 14650701]
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  • Frédérique Touzeau, Axelle Arrault, Gérald Guillaumet, Elizabeth Scalbert, Bruno Pfeiffer, Marie-Claire Rettori, Pierre Renard, Jean-Yves Mérour. Synthesis and biological evaluation of new 2-(4,5-dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine derivatives. Journal of medicinal chemistry. 2003 May; 46(10):1962-79. doi: 10.1021/jm021050c. [PMID: 12723959]
  • Anna Miczke, Danuta Pupek-Musialik, Maciej Cymerys, Wiesław Bryl, Magdalena Kujawska-Łuczak, Paweł Bogdański. [The effect of analysed hypotensive drugs on certain metabolic parameters]. Polskie Archiwum Medycyny Wewnetrznej. 2003 Mar; 109(3):237-42. doi: NULL. [PMID: 12924169]
  • Saco J de Visser, Jeroen-Paul van der Post, Loyd Nanhekhan, Rik C Schoemaker, Adam F Cohen, Joop M A van Gerven. Concentration-effect relationships of two rilmenidine single-dose infusion rates in hypertensive patients. Clinical pharmacology and therapeutics. 2002 Oct; 72(4):419-28. doi: 10.1067/mcp.2002.127638. [PMID: 12386644]
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  • D N Mayorov, S L Burke, G A Head. Relative importance of rostral ventrolateral medulla in sympathoinhibitory action of rilmenidine in conscious and anesthetized rabbits. Journal of cardiovascular pharmacology. 2001 Mar; 37(3):252-61. doi: 10.1097/00005344-200103000-00003. [PMID: 11243415]
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