MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0) (BioDeep_00000002524)

 

Secondary id: BioDeep_00000229696

human metabolite Endogenous blood metabolite LipidSearch


代谢物信息卡片


(5Z,8Z,11Z,14Z)-2-Hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-eicosatetraenoic acid

化学式: C23H38O4 (378.277)
中文名称: 2-花生酰基甘油
谱图信息: 最多检出来源 Homo sapiens(blood) 37.09%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0). BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/2-arachidonoylglycerol_(20:4) (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000002524). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCCCCC=CCC=CCC=CCC=CCCCC(=O)OC(CO)CO
InChI: InChI=1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-22(20-24)21-25/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-

描述信息

MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0), also known as 2-arachidonoylglycerol (2-AG), is a unique molecular species of monoacylglycerol isolated in 1995 from rat brain and canine gut as an endogenous ligand for the cannabinoid receptors. 2-AG is rapidly formed from arachidonic acid-containing phospholipids through increased phospholipid metabolism, such as enhanced inositol phospholipid turnover, in various tissues and cells upon stimulation. 2-AG binds to the cannabinoid receptors CB1 and CB2 and exhibits a variety of cannabimimetic activities in vitro and in vivo. 2-AG is an endogenous cannabinoid (endocannabinoid). Endocannabinoids are a class of fatty acid derivatives defined by their ability to interact with the specific cannabinoid receptors that were originally identified as the targets of delta9-tetrahydocannabinol (delta9-THC), the psychoactive component of cannabis. Endocannabinoids have been implicated in a growing number of important physiological and behavioral events. Endocannabinoids are amides, esters, and ethers of long-chain polyunsaturated fatty acids, which act as new lipidic mediators. 2-AG is one of the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of delta9-THC, the active principle of Cannabis sativa preparations like hashish and marijuana. The activity of AEA and 2-AG at their receptors is limited by cellular uptake through an anandamide membrane transporter (AMT), followed by intracellular degradation. A fatty acid amide hydrolase (FAAH) is the main AEA hydrolase, whereas a monoacylglycerol lipase (MAGL) is critical in degrading 2-AG (PMID: 16515464, 16278487, 16678907).
2-Arachidonoylglycerol (2-AG) is a unique molecular species of monoacylglycerol isolated in 1995 from rat brain and canine gut as an endogenous ligand for the cannabinoid receptors. 2-AG is rapidly formed from arachidonic acid-containing phospholipids through increased phospholipid metabolism, such as enhanced inositol phospholipid turnover, in various tissues and cells upon stimulation. 2-AG binds to the cannabinoid receptors (CB1 and CB2) and exhibits a variety of cannabimimetic activities in vitro and in vivo. 2-Arachidonylglycerol is an endogenous cannabinoid (endocannabinoid). Endocannabinoids are a class of fatty acid derivatives defined by their ability to interact with the specific cannabinoid receptors that were originally identified as the targets of Delta9-tetrahydocannabinol (Delta9-THC), the psychoactive component of cannabis. Endocannabinoids have been implicated in a growing number of important physiological and behavioral events. Endocannabinoids are amides, esters and ethers of long chain polyunsaturated fatty acids, which act as new lipidic mediators. 2-AG is one of the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of (-)-Delta9-tetrahydrocannabinol (THC), the active principle of Cannabis sativa preparations like hashish and marijuana. The activity of AEA and 2-AG at their receptors is limited by cellular uptake through an anandamide membrane transporter (AMT), followed by intracellular degradation. A fatty acid amide hydrolase (FAAH) is the main AEA hydrolase, whereas a monoacylglycerol lipase (MAGL) is critical in degrading 2-AG. (PMID: 16515464, 16278487, 16678907)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D063385 - Cannabinoid Receptor Modulators
D018377 - Neurotransmitter Agents > D063385 - Cannabinoid Receptor Modulators > D063386 - Cannabinoid Receptor Agonists

同义名列表

39 个代谢物同义名

(5Z,8Z,11Z,14Z)-2-Hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-eicosatetraenoic acid; (5Z,8Z,11Z,14Z)-2-Hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-eicosatetraenoate; (all-Z)-2-Hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-eicosatetraenoic acid; (all-Z)-2-Hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-eicosatetraenoate; 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate; eicosa-5,8,11,14-tetraenoic acid 1,3-dihydroxypropan-2-yl ester; 2-(5Z,8Z,11Z,14Z-Eicosatetraenoyl)-rac-glycerol; 2-Monoarachidonoylglycerolbeta-monoacylglycerol; 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol; 2-(5Z,8Z,11Z,14Z-Eicosatetraenoyl)-glycerol; MAG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0); MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0); 2-Monoarachidonoylglycerol; 2-Arachidonoyl-sn-glycerol; MAG(20:4(5Z,8Z,11Z,14Z)); MG(20:4(5Z,8Z,11Z,14Z)); Glyceryl 2-arachidonate; 2-Arachidonoyl-glycerol; 2-arachidonoylglycerol; 2-Arachidonyl glycerol; 2-Arachidonyl-glycerol; 2-Arachidonylglycerol; beta-Monoacylglycerol; MAG(0:0/20:4n6/0:0); 1-Monoacylglyceride; MAG(0:0/20:4W6/0:0); b-Monoacylglycerol; MG(0:0/20:4n6/0:0); MG(0:0/20:4W6/0:0); 1-Monoacylglycerol; MAG(20:4W6); MAG(20:4n6); MG(20:4W6); MG(20:4n6); MAG(20:4); 2-Ara-GL; MG(20:4); 2-AG; 2-Arachidonoylglycerol



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

145 个相关的代谢反应过程信息。

Reactome(144)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AKT1, CA1, CNR2, DAGLA, NAPEPLD, PIK3CA, PPARG, PTGS1, PTGS2
Peripheral membrane protein 4 MGLL, NAPEPLD, PTGS1, PTGS2
Endoplasmic reticulum membrane 4 FAAH, MGLL, PTGS1, PTGS2
Mitochondrion membrane 1 ABHD6
Nucleus 4 AKT1, PLCZ1, PPARA, PPARG
cytosol 7 AKT1, CA1, LEP, MGLL, PIK3CA, PLCZ1, PPARG
dendrite 1 CNR2
mitochondrial membrane 1 ABHD6
nucleoplasm 6 AKT1, DAGLB, NAPEPLD, PLCZ1, PPARA, PPARG
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 5 AKT1, DAGLA, DAGLB, TNF, TRPV1
lamellipodium 2 AKT1, PIK3CA
Early endosome membrane 2 DAGLA, NAPEPLD
Multi-pass membrane protein 4 DAGLA, DAGLB, FAAH, TRPV1
Golgi apparatus membrane 1 NAPEPLD
cell cortex 1 AKT1
cell surface 1 TNF
glutamatergic synapse 3 ABHD6, AKT1, FAAH
Golgi apparatus 2 NAPEPLD, PTGS1
Golgi membrane 2 INS, NAPEPLD
lysosomal membrane 2 ABHD6, DAGLB
neuronal cell body 2 TNF, TRPV1
postsynapse 2 AKT1, FAAH
presynaptic membrane 1 NAPEPLD
Cytoplasm, cytosol 1 MGLL
Presynapse 1 FAAH
plasma membrane 9 ABHD6, AKT1, CNR2, DAGLA, DAGLB, MGLL, PIK3CA, TNF, TRPV1
Membrane 7 ABHD6, AKT1, DAGLA, DAGLB, FAAH, MGLL, TRPV1
caveola 1 PTGS2
extracellular exosome 3 CA1, NAPEPLD, PTGS1
Lysosome membrane 1 ABHD6
endoplasmic reticulum 3 CNR2, FAAH, PTGS2
extracellular space 4 IL6, INS, LEP, TNF
perinuclear region of cytoplasm 3 PIK3CA, PLCZ1, PPARG
intercalated disc 1 PIK3CA
mitochondrion 1 ABHD6
protein-containing complex 2 AKT1, PTGS2
intracellular membrane-bounded organelle 2 PPARG, PTGS1
Microsome membrane 3 FAAH, PTGS1, PTGS2
pronucleus 1 PLCZ1
Secreted 3 IL6, INS, LEP
extracellular region 4 IL6, INS, LEP, TNF
Single-pass membrane protein 1 FAAH
hippocampal mossy fiber to CA3 synapse 1 NAPEPLD
photoreceptor outer segment 1 PTGS1
external side of plasma membrane 2 TNF, TRPV1
varicosity 1 DAGLA
perikaryon 1 CNR2
microtubule cytoskeleton 1 AKT1
nucleolus 1 PLCZ1
Early endosome 1 NAPEPLD
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 2 ABHD6, TNF
vesicle 1 AKT1
postsynaptic membrane 5 ABHD6, CNR2, DAGLA, NAPEPLD, TRPV1
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 FAAH
spindle 1 AKT1
GABA-ergic synapse 2 ABHD6, TRPV1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 TRPV1
receptor complex 1 PPARG
Cell projection, neuron projection 1 TRPV1
neuron projection 2 PTGS1, PTGS2
ciliary basal body 1 AKT1
chromatin 2 PPARA, PPARG
Late endosome membrane 1 ABHD6
phagocytic cup 1 TNF
cytoskeleton 1 FAAH
organelle membrane 1 FAAH
nuclear envelope 1 NAPEPLD
Nucleus envelope 1 NAPEPLD
Endomembrane system 2 FAAH, PTGS1
endosome lumen 1 INS
AMPA glutamate receptor complex 1 ABHD6
Nucleus, nucleoplasm 1 NAPEPLD
Cell projection, dendrite 1 CNR2
Smooth endoplasmic reticulum membrane 1 NAPEPLD
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 DAGLA
extrinsic component of cytoplasmic side of plasma membrane 1 CNR2
photoreceptor outer segment membrane 1 NAPEPLD
dendrite membrane 1 DAGLA
Cell projection, dendritic spine membrane 2 DAGLA, TRPV1
dendritic spine membrane 2 DAGLA, TRPV1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
sperm head 1 PLCZ1
interleukin-6 receptor complex 1 IL6
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Chu Chen. Inhibiting degradation of 2-arachidonoylglycerol as a therapeutic strategy for neurodegenerative diseases. Pharmacology & therapeutics. 2023 Apr; 244(?):108394. doi: 10.1016/j.pharmthera.2023.108394. [PMID: 36966972]
  • Joanna Kowalczyk, Barbara Budzyńska, Łukasz Kurach, Daniele Pellegata, Nesrine S El Sayed, Jürg Gertsch, Krystyna Skalicka-Woźniak. Neuropsychopharmacological profiling of scoparone in mice. Scientific reports. 2022 01; 12(1):822. doi: 10.1038/s41598-021-04741-3. [PMID: 35039558]
  • Anne-Sophie Archambault, Julyanne Brassard, Émilie Bernatchez, Cyril Martin, Vincenzo Di Marzo, Michel Laviolette, Louis-Philippe Boulet, Marie-Renée Blanchet, Nicolas Flamand. Human and Mouse Eosinophils Differ in Their Ability to Biosynthesize Eicosanoids, Docosanoids, the Endocannabinoid 2-Arachidonoyl-glycerol and Its Congeners. Cells. 2022 01; 11(1):. doi: 10.3390/cells11010141. [PMID: 35011703]
  • Isabel van Ackern, Angela Kuhla, Björn Kuhla. A Role for Peripheral Anandamide and 2-Arachidonoylglycerol in Short-Term Food Intake and Orexigenic Hypothalamic Responses in a Species with Continuous Nutrient Delivery. Nutrients. 2021 Oct; 13(10):. doi: 10.3390/nu13103587. [PMID: 34684588]
  • Giuseppe Bersani, Francesca Pacitti, Angela Iannitelli, Eleonora Caroti, Adele Quartini, Dionysios Xenos, Michela Marconi, Valentina Cuoco, Benedetta Bigio, Nicole P Bowles, Filippo Weisz, Flaminia Fanelli, Valentina D Di Lallo, Ilaria Belluomo, Ferdinando Nicoletti, Carla Nasca. Inverse correlation between plasma 2-arachidonoylglycerol levels and subjective severity of depression. Human psychopharmacology. 2021 07; 36(4):e2779. doi: 10.1002/hup.2779. [PMID: 33559925]
  • Lian-Jie Hou, Mei-Ying Xie, Wenchu Ye, Guo-Jun Zhao. The endocannabinoid 2-arachidonoylglycerol inhibits endothelial function and repair through cannabinoid 1 (CB1) receptor. International journal of cardiology. 2021 04; 328(?):176. doi: 10.1016/j.ijcard.2020.11.027. [PMID: 33217478]
  • Emiliano Manzo, Aniello Schiano Moriello, Francesco Tinto, Roberta Verde, Marco Allarà, Luciano De Petrocellis, Ester Pagano, Angelo A Izzo, Vincenzo Di Marzo, Stefania Petrosino. A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator. Cells. 2021 02; 10(2):. doi: 10.3390/cells10020450. [PMID: 33672574]
  • Ahmad Mobed, Fereshteh Kohansal, Ali Ahmadalipour, Mohammad Hasanzadeh, Flor Zargari. Bioconjugation of 2-arachidonoyl glycerol (2-AG) biotinylated antibody with gold nano-flowers toward immunosensing of 2-AG in human plasma samples: A novel immuno-platform for the screening of immunomodulation and neuroprotection using biosensing. Analytical methods : advancing methods and applications. 2021 01; 13(3):311-321. doi: 10.1039/d0ay02135k. [PMID: 33367337]
  • Simone Grasso, Marco Santonico, Giorgio Pennazza, Alessandro Zompanti, Alessandra Piccoli, Tiziana Bisogno, Mauro Maccarrone. BIONOTE as an Innovative Biosensor for Measuring Endocannabinoid Levels. Sensors (Basel, Switzerland). 2021 Jan; 21(2):. doi: 10.3390/s21020489. [PMID: 33445599]
  • Mohammad Bashashati, Emma Leishman, Heather Bradshaw, Solmaz Sigaroodi, Eric Tatro, Tamis Bright, Richard McCallum, Irene Sarosiek. Plasma endocannabinoids and cannabimimetic fatty acid derivatives are altered in gastroparesis: A sex- and subtype-dependent observation. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2021 01; 33(1):e13961. doi: 10.1111/nmo.13961. [PMID: 32779297]
  • Melissa Ellermann, Alline R Pacheco, Angel G Jimenez, Regan M Russell, Santiago Cuesta, Aman Kumar, Wenhan Zhu, Gonçalo Vale, Sarah A Martin, Prithvi Raj, Jeffrey G McDonald, Sebastian E Winter, Vanessa Sperandio. Endocannabinoids Inhibit the Induction of Virulence in Enteric Pathogens. Cell. 2020 10; 183(3):650-665.e15. doi: 10.1016/j.cell.2020.09.022. [PMID: 33031742]
  • Sophie Castonguay-Paradis, Sébastien Lacroix, Gabrielle Rochefort, Lydiane Parent, Julie Perron, Cyril Martin, Benoît Lamarche, Frédéric Raymond, Nicolas Flamand, Vincenzo Di Marzo, Alain Veilleux. Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat. Scientific reports. 2020 09; 10(1):15975. doi: 10.1038/s41598-020-72861-3. [PMID: 32994521]
  • Aruna Kilaru, Kent D Chapman. The endocannabinoid system. Essays in biochemistry. 2020 09; 64(3):485-499. doi: 10.1042/ebc20190086. [PMID: 32648908]
  • Niclas Stensson, Björn Gerdle, Malin Ernberg, Kaisa Mannerkorpi, Eva Kosek, Bijar Ghafouri. Increased Anandamide and Decreased Pain and Depression after Exercise in Fibromyalgia. Medicine and science in sports and exercise. 2020 07; 52(7):1617-1628. doi: 10.1249/mss.0000000000002293. [PMID: 32168104]
  • Lea Tischmann, Mathijs Drummen, Peter J Joris, Blandine Gatta-Cherifi, Anne Raben, Mikael Fogelholm, Isabelle Matias, Daniela Cota, Ronald P Mensink, Margriet S Westerterp-Plantenga, Tanja C Adam. Effects of a High-Protein Diet on Cardiometabolic Health, Vascular Function, and Endocannabinoids-A PREVIEW Study. Nutrients. 2020 May; 12(5):. doi: 10.3390/nu12051512. [PMID: 32455987]
  • Jing Wang, Xiaohua Zhang, Chongmei Yang, Shulei Zhao. Effect of monoacylglycerol lipase inhibition on intestinal permeability in chronic stress model. Biochemical and biophysical research communications. 2020 05; 525(4):962-967. doi: 10.1016/j.bbrc.2020.02.173. [PMID: 32173532]
  • Dorian Forte, Flaminia Fanelli, Marco Mezzullo, Martina Barone, Giulia Corradi, Giuseppe Auteri, Daniela Bartoletti, Marina Martello, Emanuela Ottaviani, Carolina Terragna, Antonio Curti, Uberto Pagotto, Francesca Palandri, Michele Cavo, Lucia Catani. Disease-Specific Derangement of Circulating Endocannabinoids and N-Acylethanolamines in Myeloproliferative Neoplasms. International journal of molecular sciences. 2020 May; 21(9):. doi: 10.3390/ijms21093399. [PMID: 32403407]
  • Pal Pacher, Natalya M Kogan, Raphael Mechoulam. Beyond THC and Endocannabinoids. Annual review of pharmacology and toxicology. 2020 01; 60(?):637-659. doi: 10.1146/annurev-pharmtox-010818-021441. [PMID: 31580774]
  • Erin C Hanlon. Impact of circadian rhythmicity and sleep restriction on circulating endocannabinoid (eCB) N-arachidonoylethanolamine (anandamide). Psychoneuroendocrinology. 2020 01; 111(?):104471. doi: 10.1016/j.psyneuen.2019.104471. [PMID: 31610409]
  • Hamid Moradi, Christina Park, Elani Streja, Donovan A Argueta, Nicholas V DiPatrizio, Amy S You, Connie M Rhee, Nosratola D Vaziri, Kamyar Kalantar-Zadeh, Daniele Piomelli. Circulating Endocannabinoids and Mortality in Hemodialysis Patients. American journal of nephrology. 2020; 51(2):86-95. doi: 10.1159/000505444. [PMID: 31935741]
  • Björn Kuhla, Volkhard Kaever, Armin Tuchscherer, Angela Kuhla. Involvement of Plasma Endocannabinoids and the Hypothalamic Endocannabinoid System in Increasing Feed Intake after Parturition of Dairy Cows. Neuroendocrinology. 2020; 110(3-4):246-257. doi: 10.1159/000501208. [PMID: 31141804]
  • Vinicius R Acquaro Junior, Germán Augusto Goméz-Ríos, Marcos Tascon, Maria Eugênia Costa Queiroz, Janusz Pawliszyn. Analysis of endocannabinoids in plasma samples by biocompatible solid-phase microextraction devices coupled to mass spectrometry. Analytica chimica acta. 2019 Dec; 1091(?):135-145. doi: 10.1016/j.aca.2019.09.002. [PMID: 31679567]
  • Patrick Heilman, Matthew N Hill, Mary Coussons-Read, Lena Brundin, Emil F Coccaro. Role of the kynurenine pathway and the endocannabinoid system as modulators of inflammation and personality traits. Psychoneuroendocrinology. 2019 12; 110(?):104434. doi: 10.1016/j.psyneuen.2019.104434. [PMID: 31525567]
  • Stefano Vanni, Laura Riccardi, Giulia Palermo, Marco De Vivo. Structure and Dynamics of the Acyl Chains in the Membrane Trafficking and Enzymatic Processing of Lipids. Accounts of chemical research. 2019 11; 52(11):3087-3096. doi: 10.1021/acs.accounts.9b00134. [PMID: 31364837]
  • R Gurke, D Thomas, Y Schreiber, S M G Schäfer, S C Fleck, G Geisslinger, N Ferreirós. Determination of endocannabinoids and endocannabinoid-like substances in human K3EDTA plasma - LC-MS/MS method validation and pre-analytical characteristics. Talanta. 2019 Nov; 204(?):386-394. doi: 10.1016/j.talanta.2019.06.004. [PMID: 31357310]
  • Aurélien Laguerre, Sebastian Hauke, Jian Qiu, Martin J Kelly, Carsten Schultz. Photorelease of 2-Arachidonoylglycerol in Live Cells. Journal of the American Chemical Society. 2019 10; 141(42):16544-16547. doi: 10.1021/jacs.9b05978. [PMID: 31560527]
  • Amanda J Page, George Hatzinikolas, Andrew D Vincent, Paul Cavuoto, Gary A Wittert. The TRPV1 channel regulates glucose metabolism. American journal of physiology. Endocrinology and metabolism. 2019 10; 317(4):E667-E676. doi: 10.1152/ajpendo.00102.2019. [PMID: 31408376]
  • Julia Fernández de Luco, Gastón Prez, Bruno Hernández Cravero, Diego de Mendoza, Guillermo R Labadie. Synthesis of a Deuterated Standard for the Quantification of 2-Arachidonoylglycerol in Caenorhabditis elegans. Journal of visualized experiments : JoVE. 2019 09; ?(151):. doi: 10.3791/59882. [PMID: 31589209]
  • Jacob D Meyer, Kevin M Crombie, Dane B Cook, Cecilia J Hillard, Kelli F Koltyn. Serum Endocannabinoid and Mood Changes after Exercise in Major Depressive Disorder. Medicine and science in sports and exercise. 2019 09; 51(9):1909-1917. doi: 10.1249/mss.0000000000002006. [PMID: 30973483]
  • Myungsun Shin, Andrew Buckner, Jessica Prince, Timothy N J Bullock, Ku-Lung Hsu. Diacylglycerol Lipase-β Is Required for TNF-α Response but Not CD8+ T Cell Priming Capacity of Dendritic Cells. Cell chemical biology. 2019 07; 26(7):1036-1041.e3. doi: 10.1016/j.chembiol.2019.04.002. [PMID: 31105063]
  • Chongyang Qiu, Lei Yang, Botao Wang, Lihua Cui, Caixia Li, Yuzhen Zhuo, Lanqiu Zhang, Shukun Zhang, Qi Zhang, Ximo Wang. The role of 2-arachidonoylglycerol in the regulation of the tumor-immune microenvironment in murine models of pancreatic cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jul; 115(?):108952. doi: 10.1016/j.biopha.2019.108952. [PMID: 31078044]
  • Cristina Miralpeix, Anna Fosch, Josefina Casas, Miguel Baena, Laura Herrero, Dolors Serra, Rosalía Rodríguez-Rodríguez, Núria Casals. Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice. Journal of lipid research. 2019 07; 60(7):1260-1269. doi: 10.1194/jlr.m092742. [PMID: 31138606]
  • Pauline Bottemanne, Adrien Paquot, Hafsa Ameraoui, Mireille Alhouayek, Giulio G Muccioli. The α/β-hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 06; 33(6):7635-7646. doi: 10.1096/fj.201802259r. [PMID: 30896979]
  • Liqing Chen, Yan Yan, Tinggui Chen, Liwei Zhang, Xiaoxia Gao, Chenhui Du, Huizhi Du. Forsythiaside prevents β-amyloid-induced hippocampal slice injury by upregulating 2-arachidonoylglycerol via cannabinoid receptor 1-dependent NF-κB pathway. Neurochemistry international. 2019 05; 125(?):57-66. doi: 10.1016/j.neuint.2019.02.008. [PMID: 30769029]
  • Qing-Rong Liu, Nicholas S Huang, Hong Qu, Jennifer F O'Connell, Isabel Gonzalez-Mariscal, Sara Santa-Cruz-Calvo, Maire E Doyle, Zheng-Xiong Xi, Yun Wang, Emmanuel S Onaivi, Josephine M Egan. Identification of novel mouse and rat CB1R isoforms and in silico modeling of human CB1R for peripheral cannabinoid therapeutics. Acta pharmacologica Sinica. 2019 Mar; 40(3):387-397. doi: 10.1038/s41401-018-0152-1. [PMID: 30202012]
  • Maximilian J Schloss, Michael Horckmans, Raquel Guillamat-Prats, Daniel Hering, Estelle Lauer, Sebastien Lenglet, Christian Weber, Aurelien Thomas, Sabine Steffens. 2-Arachidonoylglycerol mobilizes myeloid cells and worsens heart function after acute myocardial infarction. Cardiovascular research. 2019 03; 115(3):602-613. doi: 10.1093/cvr/cvy242. [PMID: 30295758]
  • Magdalena Grill, Christoph Högenauer, Andreas Blesl, Johannes Haybaeck, Nicole Golob-Schwarzl, Nerea Ferreirós, Dominique Thomas, Robert Gurke, Martin Trötzmüller, Harald C Köfeler, Birgit Gallé, Rudolf Schicho. Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer. Scientific reports. 2019 02; 9(1):2358. doi: 10.1038/s41598-019-38865-4. [PMID: 30787385]
  • Dagmar Koethe, Franziska Pahlisch, Martin Hellmich, Cathrin Rohleder, Juliane K Mueller, Andreas Meyer-Lindenberg, E Fuller Torrey, Daniele Piomelli, F Markus Leweke. Familial abnormalities of endocannabinoid signaling in schizophrenia. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2019 02; 20(2):117-125. doi: 10.1080/15622975.2018.1449966. [PMID: 29521179]
  • Laura Kind, Petri Kursula. Structural properties and role of the endocannabinoid lipases ABHD6 and ABHD12 in lipid signalling and disease. Amino acids. 2019 Feb; 51(2):151-174. doi: 10.1007/s00726-018-2682-8. [PMID: 30564946]
  • Álvaro Fernández-Ochoa, Rosa Quirantes-Piné, Isabel Borrás-Linares, David Gemperline, Marta E Alarcón Riquelme, Lorenzo Beretta, Antonio Segura-Carretero. Urinary and plasma metabolite differences detected by HPLC-ESI-QTOF-MS in systemic sclerosis patients. Journal of pharmaceutical and biomedical analysis. 2019 Jan; 162(?):82-90. doi: 10.1016/j.jpba.2018.09.021. [PMID: 30227356]
  • Dipanjan Chanda, Dietbert Neumann, Jan F C Glatz. The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target. Prostaglandins, leukotrienes, and essential fatty acids. 2019 01; 140(?):51-56. doi: 10.1016/j.plefa.2018.11.016. [PMID: 30553404]
  • Md Rahmat Ali, Suresh Kumar, Nishtha Shalmali, Obaid Afzal, Sabir Azim, Damini Chanana, Ozair Alam, Yam Nath Paudel, Manju Sharma, Sandhya Bawa. Development of Thiazole-5-carboxylate Derivatives as Selective Inhibitors of Monoacylglycerol Lipase as Target in Cancer. Mini reviews in medicinal chemistry. 2019; 19(5):410-423. doi: 10.2174/1389557518666180702103542. [PMID: 29962341]
  • Caitlin A D Jagla, Caitlin E Scott, Yaliang Tang, Changjiang Qiao, Gabriel E Mateo-Semidey, Guillermo A Yudowski, Dai Lu, Debra A Kendall. Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate β-Arrestin-Dependent Responses. Molecular pharmacology. 2019 01; 95(1):1-10. doi: 10.1124/mol.118.112854. [PMID: 30322873]
  • Brittany N Szafran, Jung Hwa Lee, Abdolsamad Borazjani, Peter Morrison, Grace Zimmerman, Kelly L Andrzejewski, Matthew K Ross, Barbara L F Kaplan. Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions. Molecules (Basel, Switzerland). 2018 Dec; 23(12):. doi: 10.3390/molecules23123167. [PMID: 30513753]
  • Tanya J Little, Nada Cvijanovic, Nicholas V DiPatrizio, Donovan A Argueta, Christopher K Rayner, Christine Feinle-Bisset, Richard L Young. Plasma endocannabinoid levels in lean, overweight, and obese humans: relationships to intestinal permeability markers, inflammation, and incretin secretion. American journal of physiology. Endocrinology and metabolism. 2018 10; 315(4):E489-E495. doi: 10.1152/ajpendo.00355.2017. [PMID: 29438631]
  • Isabel Forner-Piquer, Stefania Santangeli, Francesca Maradonna, Alessandro Rabbito, Fabiana Piscitelli, Hamid R Habibi, Vincenzo Di Marzo, Oliana Carnevali. Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate. Environmental pollution (Barking, Essex : 1987). 2018 Oct; 241(?):1-8. doi: 10.1016/j.envpol.2018.05.007. [PMID: 29793103]
  • Michał Biernacki, Barbara Malinowska, Magdalena Timoszuk, Martek Toczek, Anna Jastrząb, Patryk Remiszewski, Elżbieta Skrzydlewska. Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma. Prostaglandins & other lipid mediators. 2018 09; 138(?):54-63. doi: 10.1016/j.prostaglandins.2018.09.001. [PMID: 30201316]
  • Katja Wingenfeld, Lucia Dettenborn, Clemens Kirschbaum, Wei Gao, Christian Otte, Stefan Roepke. Reduced levels of the endocannabinoid arachidonylethanolamide (AEA) in hair in patients with borderline personality disorder - a pilot study. Stress (Amsterdam, Netherlands). 2018 07; 21(4):366-369. doi: 10.1080/10253890.2018.1451837. [PMID: 29546791]
  • Marc P Baggelaar, Mauro Maccarrone, Mario van der Stelt. 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain. Progress in lipid research. 2018 07; 71(?):1-17. doi: 10.1016/j.plipres.2018.05.002. [PMID: 29751000]
  • Lisa E Flannery, Rebecca J Henry, Daniel M Kerr, David P Finn, Michelle Roche. FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signaling in the rat, independent of sex. Journal of neuroscience research. 2018 06; 96(6):989-1001. doi: 10.1002/jnr.24120. [PMID: 28726298]
  • Avery L McIntosh, Huan Huang, Danilo Landrock, Gregory G Martin, Shengrong Li, Ann B Kier, Friedhelm Schroeder. Impact of Fabp1 Gene Ablation on Uptake and Degradation of Endocannabinoids in Mouse Hepatocytes. Lipids. 2018 06; 53(6):561-580. doi: 10.1002/lipd.12071. [PMID: 30203570]
  • Luca Navarini, Tiziana Bisogno, Pamela Mozetic, Fabiana Piscitelli, Domenico Paolo Emanuele Margiotta, Fabio Basta, Antonella Afeltra, Mauro Maccarrone. Endocannabinoid system in systemic lupus erythematosus: First evidence for a deranged 2-arachidonoylglycerol metabolism. The international journal of biochemistry & cell biology. 2018 06; 99(?):161-168. doi: 10.1016/j.biocel.2018.04.010. [PMID: 29655919]
  • Avery L McIntosh, Gregory G Martin, Huan Huang, Danilo Landrock, Ann B Kier, Friedhelm Schroeder. Δ9-Tetrahydrocannabinol induces endocannabinoid accumulation in mouse hepatocytes: antagonism by Fabp1 gene ablation. Journal of lipid research. 2018 04; 59(4):646-657. doi: 10.1194/jlr.m082644. [PMID: 29414765]
  • Samir Haj-Dahmane, Roh-Yu Shen, Matthew W Elmes, Keith Studholme, Martha P Kanjiya, Diane Bogdan, Panayotis K Thanos, Jeremy T Miyauchi, Stella E Tsirka, Dale G Deutsch, Martin Kaczocha. Fatty-acid-binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses. Proceedings of the National Academy of Sciences of the United States of America. 2018 03; 115(13):3482-3487. doi: 10.1073/pnas.1721339115. [PMID: 29531087]
  • Sascha Heinitz, Alessio Basolo, Paolo Piaggi, Daniele Piomelli, Reiner Jumpertz von Schwartzenberg, Jonathan Krakoff. Peripheral Endocannabinoids Associated With Energy Expenditure in Native Americans of Southwestern Heritage. The Journal of clinical endocrinology and metabolism. 2018 03; 103(3):1077-1087. doi: 10.1210/jc.2017-02257. [PMID: 29300902]
  • Kevin M Crombie, Angelique G Brellenthin, Cecilia J Hillard, Kelli F Koltyn. Psychobiological Responses to Aerobic Exercise in Individuals With Posttraumatic Stress Disorder. Journal of traumatic stress. 2018 02; 31(1):134-145. doi: 10.1002/jts.22253. [PMID: 29388710]
  • Huub J van Eyk, Linda D van Schinkel, Vasudev Kantae, Charlotte E A Dronkers, Jos J M Westenberg, Albert de Roos, Hildo J Lamb, J Wouter Jukema, Amy C Harms, Thomas Hankemeier, Mario van der Stelt, Ingrid M Jazet, Patrick C N Rensen, Johannes W A Smit. Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes. Nutrition & diabetes. 2018 01; 8(1):6. doi: 10.1038/s41387-017-0016-7. [PMID: 29343706]
  • Hui Deng, Mario van der Stelt. Chemical tools to modulate 2-arachidonoylglycerol biosynthesis. Biotechnology and applied biochemistry. 2018 Jan; 65(1):9-15. doi: 10.1002/bab.1568. [PMID: 28589628]
  • Sevil Köse, Fatima Aerts-Kaya, Çağla Zübeyde Köprü, Emirhan Nemutlu, Barış Kuşkonmaz, Beren Karaosmanoğlu, Ekim Zihni Taşkıran, Belgin Altun, Duygu Uçkan Çetinkaya, Petek Korkusuz. Human bone marrow mesenchymal stem cells secrete endocannabinoids that stimulate in vitro hematopoietic stem cell migration effectively comparable to beta-adrenergic stimulation. Experimental hematology. 2018 01; 57(?):30-41.e1. doi: 10.1016/j.exphem.2017.09.009. [PMID: 29030083]
  • Ruisong Pei, Diana M DiMarco, Kelley K Putt, Derek A Martin, Qinlei Gu, Chureeporn Chitchumroonchokchai, Heather M White, Cameron O Scarlett, Richard S Bruno, Bradley W Bolling. Low-fat yogurt consumption reduces biomarkers of chronic inflammation and inhibits markers of endotoxin exposure in healthy premenopausal women: a randomised controlled trial. The British journal of nutrition. 2017 Dec; 118(12):1043-1051. doi: 10.1017/s0007114517003038. [PMID: 29179781]
  • Johannes Fuss, Laura Bindila, Klaus Wiedemann, Matthias K Auer, Peer Briken, Sarah V Biedermann. Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans. The journal of sexual medicine. 2017 Nov; 14(11):1372-1379. doi: 10.1016/j.jsxm.2017.09.016. [PMID: 29110806]
  • Ana C Pascual, Virginia L Gaveglio, Norma M Giusto, Susana J Pasquaré. 2-Arachidonoylglycerol metabolism is differently modulated by oligomeric and fibrillar conformations of amyloid beta in synaptic terminals. Neuroscience. 2017 Oct; 362(?):168-180. doi: 10.1016/j.neuroscience.2017.08.042. [PMID: 28844762]
  • V M Artegoitia, A P Foote, R G Tait, L A Kuehn, R M Lewis, T L Wheeler, H C Freetly. Endocannabinoid concentrations in plasma during the finishing period are associated with feed efficiency and carcass composition of beef cattle. Journal of animal science. 2017 Oct; 95(10):4568-4574. doi: 10.2527/jas2017.1629. [PMID: 29108057]
  • Isabel Forner-Piquer, Francesca Maradonna, Giorgia Gioacchini, Stefania Santangeli, Marco Allarà, Fabiana Piscitelli, Hamid R Habibi, Vincenzo Di Marzo, Oliana Carnevali. Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish. Endocrinology. 2017 10; 158(10):3462-3476. doi: 10.1210/en.2017-00458. [PMID: 28938452]
  • Pegah Poursharifi, Sri Ramachandra Murthy Madiraju, Marc Prentki. Monoacylglycerol signalling and ABHD6 in health and disease. Diabetes, obesity & metabolism. 2017 09; 19 Suppl 1(?):76-89. doi: 10.1111/dom.13008. [PMID: 28880480]
  • Robert W Buntyn, Navatha Alugubelly, Rachel L Hybart, Afzaal N Mohammed, Carole A Nail, Greta C Parker, Matthew K Ross, Russell L Carr. Inhibition of Endocannabinoid-Metabolizing Enzymes in Peripheral Tissues Following Developmental Chlorpyrifos Exposure in Rats. International journal of toxicology. 2017 Sep; 36(5):395-402. doi: 10.1177/1091581817725272. [PMID: 28820005]
  • Nemanja Vujic, Melanie Korbelius, Christina Leopold, Madalina Duta-Mare, Silvia Rainer, Stefanie Schlager, Madeleine Goeritzer, Dagmar Kolb, Thomas O Eichmann, Clemens Diwoky, Andreas Zimmer, Robert Zimmermann, Achim Lass, Branislav Radovic, Dagmar Kratky. Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice. Oncotarget. 2017 May; 8(20):33122-33136. doi: 10.18632/oncotarget.16529. [PMID: 28380440]
  • Camila Marchioni, Israel Donizeti de Souza, Caroline Fernandes Grecco, José Alexandre Crippa, Vitor Tumas, Maria Eugênia Costa Queiroz. A column switching ultrahigh-performance liquid chromatography-tandem mass spectrometry method to determine anandamide and 2-arachidonoylglycerol in plasma samples. Analytical and bioanalytical chemistry. 2017 May; 409(14):3587-3596. doi: 10.1007/s00216-017-0300-3. [PMID: 28337517]
  • Flaminia Fanelli, Marco Mezzullo, Ilaria Belluomo, Valentina Diana Di Lallo, Margherita Baccini, Daniela Ibarra Gasparini, Elena Casadio, Marianna Mastroroberto, Valentina Vicennati, Alessandra Gambineri, Antonio Maria Morselli-Labate, Renato Pasquali, Uberto Pagotto. Plasma 2-arachidonoylglycerol is a biomarker of age and menopause related insulin resistance and dyslipidemia in lean but not in obese men and women. Molecular metabolism. 2017 05; 6(5):406-415. doi: 10.1016/j.molmet.2017.03.005. [PMID: 28462075]
  • Na Cui, Xiaoye Feng, Zhiming Zhao, Jie Zhang, Yueming Xu, Luning Wang, Guimin Hao. Restored Plasma Anandamide and Endometrial Expression of Fatty Acid Amide Hydrolase in Women With Polycystic Ovary Syndrome by the Combination Use of Diane-35 and Metformin. Clinical therapeutics. 2017 Apr; 39(4):751-758. doi: 10.1016/j.clinthera.2017.02.007. [PMID: 28291580]
  • Stephanie C Gantz, Bruce P Bean. Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling. Neuron. 2017 Mar; 93(6):1375-1387.e2. doi: 10.1016/j.neuron.2017.02.025. [PMID: 28262417]
  • Donovan A Argueta, Nicholas V DiPatrizio. Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity. Physiology & behavior. 2017 03; 171(?):32-39. doi: 10.1016/j.physbeh.2016.12.044. [PMID: 28065722]
  • Vasudev Kantae, Shinji Ogino, Marek Noga, Amy C Harms, Robin M van Dongen, Gerrit L J Onderwater, Arn M J M van den Maagdenberg, Gisela M Terwindt, Mario van der Stelt, Michel D Ferrari, Thomas Hankemeier. Quantitative profiling of endocannabinoids and related N-acylethanolamines in human CSF using nano LC-MS/MS. Journal of lipid research. 2017 03; 58(3):615-624. doi: 10.1194/jlr.d070433. [PMID: 27999147]
  • Zoe Thompson, Donovan Argueta, Theodore Garland, Nicholas DiPatrizio. Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes. Physiology & behavior. 2017 03; 170(?):141-150. doi: 10.1016/j.physbeh.2016.11.041. [PMID: 28017680]
  • Emmanuel Dotsey, Irina Ushach, Egest Pone, Rie Nakajima, Algis Jasinskas, Donovan A Argueta, Andrea Dillon, Nicholas DiPatrizio, Huw Davies, Albert Zlotnik, Peter D Crompton, Philip L Felgner. Transient Cannabinoid Receptor 2 Blockade during Immunization Heightens Intensity and Breadth of Antigen-specific Antibody Responses in Young and Aged mice. Scientific reports. 2017 02; 7(?):42584. doi: 10.1038/srep42584. [PMID: 28209996]
  • Marina Quartu, Laura Poddighe, Tiziana Melis, Maria Pina Serra, Marianna Boi, Sara Lisai, Gianfranca Carta, Elisabetta Murru, Laura Muredda, Maria Collu, Sebastiano Banni. Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion. Lipids in health and disease. 2017 Jan; 16(1):14. doi: 10.1186/s12944-016-0389-y. [PMID: 28103941]
  • Shira Zelber-Sagi, Shahar Azar, Alina Nemirovski, Muriel Webb, Zamir Halpern, Oren Shibolet, Joseph Tam. Serum levels of endocannabinoids are independently associated with nonalcoholic fatty liver disease. Obesity (Silver Spring, Md.). 2017 01; 25(1):94-101. doi: 10.1002/oby.21687. [PMID: 27863097]
  • A Barbonetti, T Bisogno, N Battista, F Piscitelli, A Micillo, S Francavilla, M Maccarrone, F Francavilla. 2-arachidonoylglycerol levels are increased in leukocytospermia and correlate with seminal macrophages. Andrology. 2017 01; 5(1):87-94. doi: 10.1111/andr.12283. [PMID: 27863106]
  • Anberitha T Matthews, Jung Hwa Lee, Abdolsamad Borazjani, Lee C Mangum, Xiang Hou, Matthew K Ross. Oxyradical stress increases the biosynthesis of 2-arachidonoylglycerol: involvement of NADPH oxidase. American journal of physiology. Cell physiology. 2016 Dec; 311(6):C960-C974. doi: 10.1152/ajpcell.00251.2015. [PMID: 27784678]
  • V M Artegoitia, A P Foote, R M Lewis, D A King, S D Shackelford, T L Wheeler, H C Freetly. Endocannabinoids concentrations in plasma associated with feed efficiency and carcass composition of beef steers. Journal of animal science. 2016 Dec; 94(12):5177-5181. doi: 10.2527/jas.2016-1025. [PMID: 28046144]
  • Freek J Janssen, Mario van der Stelt. Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. Bioorganic & medicinal chemistry letters. 2016 08; 26(16):3831-7. doi: 10.1016/j.bmcl.2016.06.076. [PMID: 27394666]
  • Ana Maria Sanchez, Raffaella Cioffi, Paola Viganò, Massimo Candiani, Roberta Verde, Fabiana Piscitelli, Vincenzo Di Marzo, Elisabetta Garavaglia, Paola Panina-Bordignon. Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis. Reproductive sciences (Thousand Oaks, Calif.). 2016 08; 23(8):1071-9. doi: 10.1177/1933719116630414. [PMID: 26887427]
  • Emma Leishman, Ben Cornett, Karl Spork, Alex Straiker, Ken Mackie, Heather B Bradshaw. Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. Pharmacological research. 2016 08; 110(?):159-172. doi: 10.1016/j.phrs.2016.04.020. [PMID: 27109320]
  • Ziliang Zou, Yongli Lu, Yunhong Zha, Hongwei Yang. Endocannabinoid 2-Arachidonoylglycerol Suppresses LPS-Induced Inhibition of A-Type Potassium Channel Currents in Caudate Nucleus Neurons Through CB1 Receptor. Journal of molecular neuroscience : MN. 2016 Aug; 59(4):493-503. doi: 10.1007/s12031-016-0761-4. [PMID: 27129498]
  • Ulrike Liisberg, Kristin Røen Fauske, Ondrej Kuda, Even Fjære, Lene Secher Myrmel, Nina Norberg, Livar Frøyland, Ingvild Eide Graff, Bjørn Liaset, Karsten Kristiansen, Jan Kopecky, Lise Madsen. Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice. The Journal of nutritional biochemistry. 2016 07; 33(?):119-27. doi: 10.1016/j.jnutbio.2016.03.014. [PMID: 27155918]
  • Buqing Yi, Igor Nichiporuk, Michel Nicolas, Stefan Schneider, Matthias Feuerecker, Galina Vassilieva, Detlef Thieme, Gustav Schelling, Alexander Choukèr. Reductions in circulating endocannabinoid 2-arachidonoylglycerol levels in healthy human subjects exposed to chronic stressors. Progress in neuro-psychopharmacology & biological psychiatry. 2016 Jun; 67(?):92-7. doi: 10.1016/j.pnpbp.2016.01.004. [PMID: 26780604]
  • Sally Miller, Emma Leishman, Sherry Shujung Hu, Alhasan Elghouche, Laura Daily, Natalia Murataeva, Heather Bradshaw, Alex Straiker. Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model. Investigative ophthalmology & visual science. 2016 Jun; 57(7):3287-96. doi: 10.1167/iovs.16-19356. [PMID: 27333182]
  • Liang Dong, Hechang Zou, Chong Yuan, Yu H Hong, Charis L Uhlson, Robert C Murphy, William L Smith. Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2. Journal of lipid research. 2016 06; 57(6):1043-50. doi: 10.1194/jlr.m067512. [PMID: 27059979]
  • A M Monteleone, V Di Marzo, P Monteleone, R Dalle Grave, T Aveta, M El Ghoch, F Piscitelli, U Volpe, S Calugi, M Maj. Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity. European journal of nutrition. 2016 Jun; 55(4):1799-805. doi: 10.1007/s00394-016-1153-9. [PMID: 26759262]
  • Emma Leishman, Ken Mackie, Serge Luquet, Heather B Bradshaw. Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain. Biochimica et biophysica acta. 2016 Jun; 1861(6):491-500. doi: 10.1016/j.bbalip.2016.03.003. [PMID: 26956082]
  • I A Reddy, J A Pino, P Weikop, N Osses, G Sørensen, T Bering, C Valle, R J Bluett, K Erreger, G Wortwein, J G Reyes, D Graham, G D Stanwood, T A Hackett, S Patel, A Fink-Jensen, G E Torres, A Galli. Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. Translational psychiatry. 2016 05; 6(?):e809. doi: 10.1038/tp.2016.86. [PMID: 27187231]
  • L Zhang, M Kolaj, L P Renaud. Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons. Neuroscience. 2016 May; 322(?):308-19. doi: 10.1016/j.neuroscience.2016.02.047. [PMID: 26924019]
  • Melissa R Miller, Nadja Mannowetz, Anthony T Iavarone, Rojin Safavi, Elena O Gracheva, James F Smith, Rose Z Hill, Diana M Bautista, Yuriy Kirichok, Polina V Lishko. Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. Science (New York, N.Y.). 2016 Apr; 352(6285):555-9. doi: 10.1126/science.aad6887. [PMID: 26989199]
  • Giovanna Morello, Roberta Imperatore, Letizia Palomba, Carmine Finelli, Giuseppe Labruna, Fabrizio Pasanisi, Lucia Sacchetti, Lorena Buono, Fabiana Piscitelli, Pierangelo Orlando, Vincenzo Di Marzo, Luigia Cristino. Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling. Proceedings of the National Academy of Sciences of the United States of America. 2016 Apr; 113(17):4759-64. doi: 10.1073/pnas.1521304113. [PMID: 27071101]
  • James Lim, Miki Igarashi, Kwang-Mook Jung, Stefania Butini, Giuseppe Campiani, Daniele Piomelli. Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2016 Apr; 41(5):1329-39. doi: 10.1038/npp.2015.284. [PMID: 26361059]
  • Fabio Arturo Iannotti, Vincenzo Di Marzo, Stefania Petrosino. Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders. Progress in lipid research. 2016 04; 62(?):107-28. doi: 10.1016/j.plipres.2016.02.002. [PMID: 26965148]
  • Stefania Petrosino, Aniello Schiano Moriello, Santiago Cerrato, Mariella Fusco, Anna Puigdemont, Luciano De Petrocellis, Vincenzo Di Marzo. The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels. British journal of pharmacology. 2016 Apr; 173(7):1154-62. doi: 10.1111/bph.13084. [PMID: 25598150]
  • Isabel González-Mariscal, Susan M Krzysik-Walker, Wook Kim, Michael Rouse, Josephine M Egan. Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice. Molecular and cellular endocrinology. 2016 Mar; 423(?):1-10. doi: 10.1016/j.mce.2015.12.015. [PMID: 26724516]
  • S V Siegmund, A Wojtalla, M Schlosser, F A Schildberg, P A Knolle, R M Nüsing, A Zimmer, C P Strassburg, M V Singer. Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells. Biochemical and biophysical research communications. 2016 Feb; 470(3):678-684. doi: 10.1016/j.bbrc.2016.01.083. [PMID: 26801558]