Morin (BioDeep_00000002489)

 

Secondary id: BioDeep_00000398503

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 9CI

化学式: C15H10O7 (302.042651)
中文名称: 桑黄素, 桑色素, 桑黄素
谱图信息: 最多检出来源 Viridiplantae(plant) 0.78%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(c(c2=O)O)c1ccc(cc1O)O)O)O
InChI: InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H

描述信息

Morin is a pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2 4 and 5. It has a role as an antioxidant, a metabolite, an antihypertensive agent, a hepatoprotective agent, a neuroprotective agent, an anti-inflammatory agent, an antineoplastic agent, an antibacterial agent, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an angiogenesis modulating agent. It is a pentahydroxyflavone and a 7-hydroxyflavonol.
Morin is a natural product found in Lotus ucrainicus, Psidium guajava, and other organisms with data available.
Constituent of various woods, e.g. Morus alba (white mulberry). First isol. in 1830. Morin is found in many foods, some of which are blackcurrant, european cranberry, bilberry, and fruits.
Morin is found in bilberry. Morin is a constituent of various woods, e.g. Morus alba (white mulberry). First isolated in 1830
A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2 4 and 5.
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
D020011 - Protective Agents > D000975 - Antioxidants
Morin, a plant-derived flavonoid, possesses low antioxidant activity. Morin is a fluorescing chelating agent used in aluminum speciation[1][2].
Morin, a plant-derived flavonoid, possesses low antioxidant activity. Morin is a fluorescing chelating agent used in aluminum speciation[1][2].

同义名列表

76 个代谢物同义名

2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 9CI; 4H-1-Benzopyran-4-one, 2-2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-; 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-; 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one; 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one; 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one #; 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopyran-4-one; 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one; Aluminum Ionophore I, Selectophore(TM), function tested; 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one; 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one; 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone; 5-18-05-00492 (Beilstein Handbook Reference); 91A9D69E-FAB0-45CD-90E5-DEEFBADE86C1; 2,4,5, 7-Tetrahydroxyflavan-3-ol; Flavone, 2,3,4,5,7-pentahydroxy-; 2,4,5,7-Tetrahydroxyflavan-3-ol; 3,5,7,2,4-Pentahydroxyflavonol; 2,3,4,5,7-pentahydroxy flavone; 2,3,4,5,7-Pentahydroxy-Flavone; 3,5,7,2,4-Pentahydroxyflavone; 3,2,4,5,7-pentahydroxyflavone; Flavone,3,4,5,7-pentahydroxy-; 2,5,7-Tetrahydroxyflavan-3-ol; 2,4,3,5,7-Pentahydroxyflavone; 3,5 7 2 4-Pentahydroxyflavone; 2,3,4,5,7-pentahydroxyflavone; 2-Hydroxypelargidenolon 1522; 2,4,5,7-Tetrahydroxyflavonol; 2,3,5,7-Pentahydroxyflavone; 2,4,5,7-Pentahydroxyflavone; 3,7,2,4-Pentahydroxyflavone; YXOLAZRVSSWPPT-UHFFFAOYSA-N; Zlut prirodni 11 [Czech]; C.I. Natural Yellow 11; C.I. Natural Yellow 8; Osage Orange Crystals; C.I.Natural Yellow 8; Osage orange extract; Aluminum Ionophore I; Morin, p.a., 97.0\\%; Bois darc [French]; Toxylon Pomiferum; Spectrum5_000737; Zlut prirodni 11; Spectrum4_001924; Spectrum2_000715; Spectrum3_001941; UNII-8NFQ3F76WR; Morin anhydrous; Calico Yellow; DivK1c_000958; MEGxp0_001864; Lopac0_000776; morin hydrate; Osage orange; KBio2_006850; NCI60_001647; ACon1_000260; KBio2_004282; KBio1_000958; KBio3_002824; KBio2_001714; Tox21_500776; SMP1_000199; IDI1_000958; MORIN, REAG; 8NFQ3F76WR; Bois d,Arc; C.I. 75660; MORIN [MI]; Aurantica; Bois darc; AI3-38057; Al-Morin; Morin



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jia-Yi Zhou, Wen-Wen Xie, Ting-Cai Hu, Xiao-Fan Wang, Hui-Chao Yan, Xiu-Qi Wang. Mulberry Leaf-Derived Morin Activates β-Catenin by Binding to Frizzled7 to Promote Intestinal Stem Cell Expansion upon Heat-Stable Enterotoxin b Injury. Journal of agricultural and food chemistry. 2024 May; 72(18):10366-10375. doi: 10.1021/acs.jafc.3c09909. [PMID: 38651967]
  • Ziqi Hua, Yanfei Li, Tao Chen, Di Wu, Yu Xu, Jiang-Ning Hu. Morin-Based Nanoparticles for Regulation of Blood Glucose. ACS applied materials & interfaces. 2024 May; 16(17):21400-21414. doi: 10.1021/acsami.3c17642. [PMID: 38640094]
  • Arash Bahramzadeh, Sadra Samavarchi Tehrani, Golnaz Goodarzi, ShadiSadat Seyyedebrahimi, Reza Meshkani. Combination therapy of metformin and morin attenuates insulin resistance, inflammation, and oxidative stress in skeletal muscle of high-fat diet-fed mice. Phytotherapy research : PTR. 2024 Feb; 38(2):912-924. doi: 10.1002/ptr.8086. [PMID: 38091524]
  • Rahul Kumar, Vikash Kumar, Guruswami Gurusubramanian, Saurabh Singh Rathore, Vikas Kumar Roy. Morin hydrate ameliorates heat-induced testicular impairment in a mouse model. Molecular biology reports. 2024 Jan; 51(1):103. doi: 10.1007/s11033-023-09157-y. [PMID: 38219219]
  • Mervat F Zayed, Yasser K Abdel-Monem, Abeer A Arafa, Wael H Eisa. Mass production of morin-stabilized silver nanoparticles: Characterization, antioxidant, and antimicrobial activities. Microscopy research and technique. 2024 Jan; 87(1):149-158. doi: 10.1002/jemt.24419. [PMID: 37728192]
  • Mahima Singh, Ajay Guru, Raman Pachaiappan, Bader O Almutairi, Selvaraj Arokiyaraj, Muthukaruppan Gopi, Jesu Arockiaraj. Impact of butylparaben on β-cell damage and insulin/PEPCK expression in zebrafish larvae: Protective effects of morin. Journal of biochemical and molecular toxicology. 2024 Jan; 38(1):e23520. doi: 10.1002/jbt.23520. [PMID: 37632306]
  • Ibukun Mary Folorunso, Akeem Olalekan Lawal, Olusola Olalekan Elekofehinti, Opeyemi Iwaloye. Hepatoprotective Effect of Morin Hydrate in Type 2 Diabetic Wistar Rats Exposed to Diesel Exhaust Particles. Applied biochemistry and biotechnology. 2023 Oct; 195(10):5855-5880. doi: 10.1007/s12010-023-04366-4. [PMID: 36708492]
  • Xinxiu Ren, Qinfeng Guo, Hui Jiang, Xiao Han, Xiaoshi He, Haodong Liu, Zhilong Xiu, Yuesheng Dong. Combinational application of the natural products 1-deoxynojirimycin and morin ameliorates insulin resistance and lipid accumulation in prediabetic mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155106. doi: 10.1016/j.phymed.2023.155106. [PMID: 37797432]
  • Lalrawngbawli Annie, Vanrohlu Nicy, Vanlal Rempuia, Chuckles Ch Marak, Guruswami Gurusubramanian, Vikas K Roy. Morin mitigates cadmium-induced testicular impairment by stimulating testosterone secretion and germ cell proliferation in mice. Journal of biochemical and molecular toxicology. 2023 Jun; ?(?):e23400. doi: 10.1002/jbt.23400. [PMID: 37335250]
  • Sadra Samavarchi Tehrani, Golnaz Goodarzi, Ghodratollah Panahi, Fahimeh Zamani-Garmsiri, Reza Meshkani. The combination of metformin with morin alleviates hepatic steatosis via modulating hepatic lipid metabolism, hepatic inflammation, brown adipose tissue thermogenesis, and white adipose tissue browning in high-fat diet-fed mice. Life sciences. 2023 Jun; 323(?):121706. doi: 10.1016/j.lfs.2023.121706. [PMID: 37075944]
  • Ziying Wang, Jinshuai Cui, Dongni Li, Shuzhen Ran, Junqing Huang, Gang Chen. Morin exhibits a neuroprotective effect in MPTP-induced Parkinson's disease model via TFEB/AMPK-mediated mitophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 May; 116(?):154866. doi: 10.1016/j.phymed.2023.154866. [PMID: 37209604]
  • Ola E Mohamed, Dalaal M Abdallah, Ahmed M Fayez, Reem A Mohamed, Hanan S El-Abhar. Morin post-treatment surpassed calpeptin in ameliorating 3-NP-induced cortical neurotoxicity via modulation of glutamate/calpain axis, Kidins220, and BDNF/TrkB/AKT/CREB trajectory. International immunopharmacology. 2023 Feb; 116(?):109771. doi: 10.1016/j.intimp.2023.109771. [PMID: 36736222]
  • Ravi Gor, Linkon Saha, Sparsh Agarwal, Urekha Karri, Advait Sohani, Thirumurthy Madhavan, Raman Pachaiappan, Satish Ramalingam. Morin inhibits colon cancer stem cells by inhibiting PUM1 expression in vitro. Medical oncology (Northwood, London, England). 2022 Oct; 39(12):251. doi: 10.1007/s12032-022-01851-4. [PMID: 36224472]
  • I O Ishola, I O Awogbindin, T G Olubodun-Obadun, O A Oluwafemi, J E Onuelu, O O Adeyemi. Morin ameliorates rotenone-induced Parkinson disease in mice through antioxidation and anti-neuroinflammation: gut-brain axis involvement. Brain research. 2022 08; 1789(?):147958. doi: 10.1016/j.brainres.2022.147958. [PMID: 35654119]
  • Anamika Gupta, Rumana Ahmad, Sahabjada Siddiqui, Kusum Yadav, Aditi Srivastava, Anchal Trivedi, Bilal Ahmad, Mohsin Ali Khan, Amit Kumar Shrivastava, Girish Kumar Singh. Flavonol morin targets host ACE2, IMP-α, PARP-1 and viral proteins of SARS-CoV-2, SARS-CoV and MERS-CoV critical for infection and survival: a computational analysis. Journal of biomolecular structure & dynamics. 2022 08; 40(12):5515-5546. doi: 10.1080/07391102.2021.1871863. [PMID: 33526003]
  • Selim Çomaklı, Fatih Mehmet Kandemir, Sefa Küçükler, Selçuk Özdemir. Morin mitigates ifosfamide induced nephrotoxicity by regulation of NF-kappaB/p53 and Bcl-2 expression. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2022 Aug; 97(6):423-432. doi: 10.1080/10520295.2021.2021449. [PMID: 35037524]
  • Praveen Kumar Issac, Manikandan Velayutham, Ajay Guru, Gokul Sudhakaran, Raman Pachaiappan, Jesu Arockiaraj. Protective effect of morin by targeting mitochondrial reactive oxygen species induced by hydrogen peroxide demonstrated at a molecular level in MDCK epithelial cells. Molecular biology reports. 2022 Jun; 49(6):4269-4279. doi: 10.1007/s11033-022-07261-z. [PMID: 35182324]
  • R L Shyma, S Mini. Neuroprotective effect of Morin via TrkB/Akt pathway against diabetes mediated oxidative stress and apoptosis in neuronal cells. Toxicology mechanisms and methods. 2022 May; ?(?):1-10. doi: 10.1080/15376516.2022.2065225. [PMID: 35414346]
  • Xichuan Li, Ce Wang, Jinqian Chen, Xia Hu, Hao Zhang, Zhiying Li, Bei Lan, Wei Zhang, Yanjun Su, Chunze Zhang. Potential interactions among myricetin and dietary flavonols through the inhibition of human UDP-glucuronosyltransferase in vitro. Toxicology letters. 2022 Apr; 358(?):40-47. doi: 10.1016/j.toxlet.2022.01.007. [PMID: 35063619]
  • Yi Yang, Jiuying Liu, Weiwei Xu. Naringenin and morin reduces insulin resistance and endometrial hyperplasia in the rat model of polycystic ovarian syndrome through enhancement of inflammation and autophagic apoptosis. Acta biochimica Polonica. 2022 Feb; 69(1):91-100. doi: 10.18388/abp.2020_5722. [PMID: 35143137]
  • Xinxin Gao, Jingnan Xu, Liqiang Jiang, Wei Liu, Hongrong Hong, Yuxiao Qian, Shurou Li, Wenlong Huang, Haiguang Zhao, Zhengtao Yang, Quan Liu, Zhengkai Wei. Morin alleviates aflatoxin B1-induced liver and kidney injury by inhibiting heterophil extracellular traps release, oxidative stress and inflammatory responses in chicks. Poultry science. 2021 Dec; 100(12):101513. doi: 10.1016/j.psj.2021.101513. [PMID: 34731740]
  • Praveen Kumar Issac, Ajay Guru, Manikandan Velayutham, Raman Pachaiappan, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Ki Choon Choi, Ramasamy Harikrishnan, Jesu Arockiaraj. Oxidative stress induced antioxidant and neurotoxicity demonstrated in vivo zebrafish embryo or larval model and their normalization due to morin showing therapeutic implications. Life sciences. 2021 Oct; 283(?):119864. doi: 10.1016/j.lfs.2021.119864. [PMID: 34358548]
  • Ling Yang, Na Cao, Yumeng Miao, Yue Dai, Zhifeng Wei. Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes in a 'Prickle1-mTORC2' Dependent Manner. Molecular nutrition & food research. 2021 10; 65(19):e2100367. doi: 10.1002/mnfr.202100367. [PMID: 34331380]
  • Praveen Kumar Issac, Rupmanjari Karan, Ajay Guru, R Pachaiappan, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Ki Choon Choi, Ramasamy Harikrishnan, Jesu Arockia Raj. Insulin signaling pathway assessment by enhancing antioxidant activity due to morin using in vitro rat skeletal muscle L6 myotubes cells. Molecular biology reports. 2021 Aug; 48(8):5857-5872. doi: 10.1007/s11033-021-06580-x. [PMID: 34302266]
  • Nausheen Nazir, Muhammad Zahoor, Mohammad Nisar, Imran Khan, Riaz Ullah, Amal Alotaibi. Antioxidants Isolated from Elaeagnus umbellata (Thunb.) Protect against Bacterial Infections and Diabetes in Streptozotocin-Induced Diabetic Rat Model. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154464. [PMID: 34361617]
  • Yanan Yan, Lin Li, Huilin Zhang, Fangfang Du, Yating Meng, Shaomin Shuang, Ruibing Wang, Shengmei Song, Chuan Dong. Carbon dots for ratiometric fluorescence detection of morin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Jul; 256(?):119751. doi: 10.1016/j.saa.2021.119751. [PMID: 33819765]
  • Hatem M Abuohashish, Abdullah F AlAsmari, Mohamed Mohany, Mohammed M Ahmed, Salim S Al-Rejaie. Supplementation of Morin Restores the Altered Bone Histomorphometry in Hyperglycemic Rodents via Regulation of Insulin/IGF-1 Signaling. Nutrients. 2021 Jul; 13(7):. doi: 10.3390/nu13072365. [PMID: 34371877]
  • Arijit Mondal, Tapan Kumar Maity. Isolation of cytotoxic monomeric protein and morin derivatives from Solena amplexicaulis (Lam.) Gandhi. Natural product research. 2021 Jun; 35(12):2086-2089. doi: 10.1080/14786419.2019.1652287. [PMID: 31429296]
  • Shahid Ali Rajput, Xiu-Qi Wang, Hui-Chao Yan. Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jun; 138(?):111511. doi: 10.1016/j.biopha.2021.111511. [PMID: 33744757]
  • Abdallah Gendy, Mohamed R Elnagar, Ayman Soubh, Asmaa Al-Mokaddem, Alaadin El-Haddad, Mohamed Kotb El-Sayed. Morin alleviates hepatic ischemia/reperfusion-induced mischief: In vivo and in silico contribution of Nrf2, TLR4, and NLRP3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jun; 138(?):111539. doi: 10.1016/j.biopha.2021.111539. [PMID: 34311537]
  • Anbu Singaravelu, Karthikkumar Venkatachalam, Richard L Jayaraj, Padma Jayabalan, Saravanan Nadanam. Morin treatment for acute ethanol exposure in rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2021 Apr; 96(3):230-241. doi: 10.1080/10520295.2020.1785548. [PMID: 32597243]
  • Shengjie Fan, Haiyan Zhang, Yahui Wang, Yuanyuan Zhao, Lingling Luo, Hongrun Wang, Gen Chen, Lianjun Xing, Peiyong Zheng, Cheng Huang. LXRα/β Antagonism Protects against Lipid Accumulation in the Liver but Increases Plasma Cholesterol in Rhesus Macaques. Chemical research in toxicology. 2021 03; 34(3):833-838. doi: 10.1021/acs.chemrestox.0c00445. [PMID: 33647205]
  • Ya-Jun Sun, Yan-Fang Zhang, Hui-Min Xu, Yong-Tao Ma, Chun Li, Chun-Hong Nie, Min Zhao. [Morin Improves Experimental Autoimmune Thyroiditis in Rats via NLRP3/Caspase-1 Pathway]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2021 Mar; 52(2):229-234. doi: 10.12182/20210160507. [PMID: 33829696]
  • Solaipriya Solairaja, Mohammad Qasim Andrabi, Nageswara Rao Dunna, Sivaramakrishnan Venkatabalasubramanian. Overview of Morin and Its Complementary Role as an Adjuvant for Anticancer Agents. Nutrition and cancer. 2021; 73(6):927-942. doi: 10.1080/01635581.2020.1778747. [PMID: 32530303]
  • Mahendra Pal Singh, Chanchal Sharma, Sun Chul Kang. Morin hydrate attenuates adenine-induced renal fibrosis via targeting cathepsin D signaling. International immunopharmacology. 2021 Jan; 90(?):107234. doi: 10.1016/j.intimp.2020.107234. [PMID: 33310295]
  • Ebenezer Tunde Olayinka, Kayode Ezekiel Adewole. Ameliorative effect of morin on dutasteride-tamsulosin-induced testicular oxidative stress in rat. Journal of complementary & integrative medicine. 2020 Dec; 18(2):327-337. doi: 10.1515/jcim-2019-0160. [PMID: 34187124]
  • Itzel Ivonn López-Tenorio, Aarón Domínguez-López, Ángel Miliar-García, Gerardo Norberto Escalona-Cardoso, Samantha Alejandra Real-Sandoval, Alejandro Gómez-Alcalá, María Eugenia Jaramillo-Flores. Modulation of the mRNA of the Nlrp3 inflammasome by Morin and PUFAs in an obesity model induced by a high-fat diet. Food research international (Ottawa, Ont.). 2020 11; 137(?):109706. doi: 10.1016/j.foodres.2020.109706. [PMID: 33233280]
  • Swathi Karamchedu, Lakshmi Tunki, Hitesh Kulhari, Deep Pooja. Morin hydrate loaded solid lipid nanoparticles: Characterization, stability, anticancer activity, and bioavailability. Chemistry and physics of lipids. 2020 11; 233(?):104988. doi: 10.1016/j.chemphyslip.2020.104988. [PMID: 33035545]
  • Hany H Arab, Muhammed A Saad, Ayman E El-Sahar, Muhammad Y Al-Shorbagy. Mechanistic perspective of morin protection against ketoprofen-induced gastric mucosal injury: Targeting HMGB1/RAGE/NF-κB, DJ-1/Nrf2/HO-1 and PI3K/mTOR pathways. Archives of biochemistry and biophysics. 2020 10; 693(?):108552. doi: 10.1016/j.abb.2020.108552. [PMID: 32860758]
  • Kiran Thakur, Yun-Yang Zhu, Jing-Yu Feng, Jian-Guo Zhang, Fei Hu, Chandan Prasad, Zhao-Jun Wei. Morin as an imminent functional food ingredient: an update on its enhanced efficacy in the treatment and prevention of metabolic syndromes. Food & function. 2020 Oct; 11(10):8424-8443. doi: 10.1039/d0fo01444c. [PMID: 33043925]
  • Akinluyi Elizabeth, Aderibigbe Adegbuyi, Adeoluwa Olusegun, Ben-Azu Benneth, Eduviere Anthony, Ajayi Abayomi, Umukoro Solomon. Morin hydrate attenuates chronic stress-induced memory impairment and degeneration of hippocampal subfields in mice: The role of oxidative, nitrergic and neuroinflammatory pathways. Metabolic brain disease. 2020 10; 35(7):1145-1156. doi: 10.1007/s11011-020-00595-2. [PMID: 32653975]
  • Kumiko Taguchi, Ikumi Tano, Nozomu Kaneko, Takayuki Matsumoto, Tsuneo Kobayashi. Plant polyphenols Morin and Quercetin rescue nitric oxide production in diabetic mouse aorta through distinct pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Sep; 129(?):110463. doi: 10.1016/j.biopha.2020.110463. [PMID: 32768953]
  • Maryam Ghaeidamini Harouni, Soheila Rahgozar, Somayeh Rahimi Babasheikhali, Arman Safavi, Elaheh Sadat Ghodousi. Fatty acid synthase, a novel poor prognostic factor for acute lymphoblastic leukemia which can be targeted by ginger extract. Scientific reports. 2020 08; 10(1):14072. doi: 10.1038/s41598-020-70839-9. [PMID: 32826925]
  • Satchakorn Khamchai, Wijitra Chumboatong, Janejira Hata, Chainarong Tocharus, Apichart Suksamrarn, Jiraporn Tocharus. Morin protects the blood-brain barrier integrity against cerebral ischemia reperfusion through anti-inflammatory actions in rats. Scientific reports. 2020 08; 10(1):13379. doi: 10.1038/s41598-020-70214-8. [PMID: 32770144]
  • Wan Yin Tew, Chu Shan Tan, Mohd Zaini Asmawi, Mun Fei Yam. Underlying mechanism of vasorelaxant effect exerted by 3,5,7,2',4'-pentahydroxyflavone in rats aortic ring. European journal of pharmacology. 2020 Aug; 880(?):173123. doi: 10.1016/j.ejphar.2020.173123. [PMID: 32335091]
  • Erna Karalija, Adisa Parić, Sabina Dahija, Renata Bešta-Gajević, Sanja Ćavar Zeljković. Phenolic compounds and bioactive properties of Verbascum glabratum subsp. bosnense (K. Malý) Murb., an endemic plant species. Natural product research. 2020 Aug; 34(16):2407-2411. doi: 10.1080/14786419.2018.1538221. [PMID: 30580595]
  • Gyeong Han Jeong, Tae Hoon Kim. Nonthermal Plasma-Induced Degradation of Morin and Enhancement of Biological Activities. Chemistry & biodiversity. 2020 May; 17(5):e2000010. doi: 10.1002/cbdv.202000010. [PMID: 32196948]
  • Fatih Mehmet Kandemir, Serkan Yıldırım, Sefa Kucukler, Cuneyt Caglayan, Ekrem Darendelioğlu, Muhammet Bahaeddin Dortbudak. Protective effects of morin against acrylamide-induced hepatotoxicity and nephrotoxicity: A multi-biomarker approach. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Apr; 138(?):111190. doi: 10.1016/j.fct.2020.111190. [PMID: 32068001]
  • Joel Frandsen, Seoung-Ryoung Choi, Prabagaran Narayanasamy. Neural Glyoxalase Pathway Enhancement by Morin Derivatives in an Alzheimer's Disease Model. ACS chemical neuroscience. 2020 02; 11(3):356-366. doi: 10.1021/acschemneuro.9b00566. [PMID: 31909963]
  • Kyu-Shik Lee, Gi Suk Nam, Junyoung Baek, Soyoung Kim, Kyung-Soo Nam. Inhibition of TPA‑induced metastatic potential by morin hydrate in MCF‑7 human breast cancer cells via the Akt/GSK‑3β/c‑Fos signaling pathway. International journal of oncology. 2020 Feb; 56(2):630-640. doi: 10.3892/ijo.2020.4954. [PMID: 31939617]
  • Hamit Çelik, Sefa Kucukler, Selim Çomaklı, Selçuk Özdemir, Cuneyt Caglayan, Ahmet Yardım, Fatih Mehmet Kandemir. Morin attenuates ifosfamide-induced neurotoxicity in rats via suppression of oxidative stress, neuroinflammation and neuronal apoptosis. Neurotoxicology. 2020 01; 76(?):126-137. doi: 10.1016/j.neuro.2019.11.004. [PMID: 31722249]
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  • Ahmed Hamed Arisha, Mona M Ahmed, Mohamed A Kamel, Yasser A Attia, Mohamed M A Hussein. Morin ameliorates the testicular apoptosis, oxidative stress, and impact on blood-testis barrier induced by photo-extracellularly synthesized silver nanoparticles. Environmental science and pollution research international. 2019 Oct; 26(28):28749-28762. doi: 10.1007/s11356-019-06066-1. [PMID: 31376127]
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  • Bruno Dos Santos Lima, Caio de Alcântara Campos, Anna Clara Ramos da Silva Santos, Victória Caroline Nunes Santos, Gabriela das Graças Gomes Trindade, Saravanan Shanmugam, Erik Willyame Menezes Pereira, Ricardo Neves Marreto, Marcelo Cavalcante Duarte, Jackson Roberto Guedes da Silva Almeida, Jullyana de Souza Siqueira Quintans, Lucindo José Quintans, Adriano Antunes de Souza Araújo. Development of morin/hydroxypropyl-β-cyclodextrin inclusion complex: Enhancement of bioavailability, antihyperalgesic and anti-inflammatory effects. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Apr; 126(?):15-24. doi: 10.1016/j.fct.2019.01.038. [PMID: 30738132]
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  • Yuri Ikeuchi-Takahashi, Ayaka Kobayashi, Chizuko Ishihara, Takumi Matsubara, Hiroaki Matsubara, Hiraku Onishi. Influence of Polysorbate 60 on Formulation Properties and Bioavailability of Morin-Loaded Nanoemulsions with and without Low-Saponification-Degree Polyvinyl Alcohol. Biological & pharmaceutical bulletin. 2018; 41(5):754-760. doi: 10.1248/bpb.b17-00964. [PMID: 29709912]
  • Jianbo Li, Yang Yang, Likang Lu, Qiujin Ma, Jinjie Zhang. Preparation, characterization and systemic application of self-assembled hydroxyethyl starch nanoparticles-loaded flavonoid Morin for hyperuricemia therapy. International journal of nanomedicine. 2018; 13(?):2129-2141. doi: 10.2147/ijn.s158585. [PMID: 29692610]
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  • Yue Zhou, Zhan-Qi Cao, Hong-Yuan Wang, Yan-Na Cheng, Lu-Gang Yu, Xin-Ke Zhang, Yan Sun, Xiu-Li Guo. The anti-inflammatory effects of Morin hydrate in atherosclerosis is associated with autophagy induction through cAMP signaling. Molecular nutrition & food research. 2017 09; 61(9):. doi: 10.1002/mnfr.201600966. [PMID: 28421659]
  • Ting-Ting Gu, Lin Song, Tian-Yu Chen, Xing Wang, Xiao-Juan Zhao, Xiao-Qin Ding, Yan-Zi Yang, Ying Pan, Dong-Mei Zhang, Ling-Dong Kong. Fructose downregulates miR-330 to induce renal inflammatory response and insulin signaling impairment: Attenuation by morin. Molecular nutrition & food research. 2017 08; 61(8):. doi: 10.1002/mnfr.201600760. [PMID: 28205387]
  • Qianqian Wang, Yixiang Xu, Jiaqi Xu, Xudong Wang, Chen Shen, Yan Zhang, Xiufeng Liu, Boyang Yu, Jian Zhang. Molecular cloning and expression of a glycosyltransferase from Bacillus subtilis for modification of morin and related polyphenols. Biotechnology letters. 2017 Aug; 39(8):1229-1235. doi: 10.1007/s10529-017-2352-z. [PMID: 28484911]
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  • Pooja Ghosh, Jayita Patwari, Swagata Dasgupta. Complexation With Human Serum Albumin Facilitates Sustained Release of Morin From Polylactic-Co-Glycolic Acid Nanoparticles. The journal of physical chemistry. B. 2017 03; 121(8):1758-1770. doi: 10.1021/acs.jpcb.6b08559. [PMID: 28201869]
  • Moon Hee Lee, Hee-Jae Cha, Eun Ok Choi, Min Ho Han, Sung Ok Kim, Gi-Young Kim, Su Hyun Hong, Cheol Park, Sung-Kwon Moon, Soon-Jeong Jeong, Moon-Jin Jeong, Wun-Jae Kim, Yung Hyun Choi. Antioxidant and cytoprotective effects of morin against hydrogen peroxide-induced oxidative stress are associated with the induction of Nrf-2‑mediated HO-1 expression in V79-4 Chinese hamster lung fibroblasts. International journal of molecular medicine. 2017 Mar; 39(3):672-680. doi: 10.3892/ijmm.2017.2871. [PMID: 28204816]
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  • Yanrong Chen, Yanke Li, Huali Xu, Gang Li, Yunxia Ma, Yu Jun Pang. MORIN MITIGATES OXIDATIVE STRESS, APOPTOSIS AND INFLAMMATION IN CEREBRAL ISCHEMIC RATS. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2017; 14(2):348-355. doi: 10.21010/ajtcam.v14i2.36. [PMID: 28573251]
  • Athira K V, Rajaram Mohanrao Madhana, Eshvendar Reddy Kasala, Pavan Kumar Samudrala, Mangala Lahkar, Ranadeep Gogoi. Morin Hydrate Mitigates Cisplatin-Induced Renal and Hepatic Injury by Impeding Oxidative/Nitrosative Stress and Inflammation in Mice. Journal of biochemical and molecular toxicology. 2016 Dec; 30(12):571-579. doi: 10.1002/jbt.21817. [PMID: 27111570]
  • Chitra Dhanasekar, Mahaboobkhan Rasool. Morin, a dietary bioflavonol suppresses monosodium urate crystal-induced inflammation in an animal model of acute gouty arthritis with reference to NLRP3 inflammasome, hypo-xanthine phospho-ribosyl transferase, and inflammatory mediators. European journal of pharmacology. 2016 Sep; 786(?):116-127. doi: 10.1016/j.ejphar.2016.06.005. [PMID: 27268719]
  • Kaan Kaltalioglu, Sule Coskun-Cevher. Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity. Renal failure. 2016 Sep; 38(8):1291-9. doi: 10.1080/0886022x.2016.1209383. [PMID: 27425870]
  • Yuri Ikeuchi-Takahashi, Chizuko Ishihara, Hiraku Onishi. Formulation and Evaluation of Morin-Loaded Solid Lipid Nanoparticles. Biological & pharmaceutical bulletin. 2016 Sep; 39(9):1514-22. doi: 10.1248/bpb.b16-00300. [PMID: 27320782]
  • Atanu Singha Roy, Sintu Kumar Samanta, Pooja Ghosh, Debi Ranjan Tripathy, Sudip Kumar Ghosh, Swagata Dasgupta. Cell cytotoxicity and serum albumin binding capacity of the morin-Cu(ii) complex and its effect on deoxyribonucleic acid. Molecular bioSystems. 2016 08; 12(9):2818-33. doi: 10.1039/c6mb00344c. [PMID: 27345944]
  • Sona Franova, Ivana Kazimierova, Lenka Pappova, Marta Joskova, Lukas Plank, Martina Sutovska. Bronchodilatory, antitussive and anti-inflammatory effect of morin in the setting of experimentally induced allergic asthma. The Journal of pharmacy and pharmacology. 2016 Aug; 68(8):1064-72. doi: 10.1111/jphp.12576. [PMID: 27283356]
  • Jarinyaporn Naowaboot, Supaporn Wannasiri, Patchareewan Pannangpetch. Morin attenuates hepatic insulin resistance in high-fat-diet-induced obese mice. Journal of physiology and biochemistry. 2016 Jun; 72(2):269-80. doi: 10.1007/s13105-016-0477-5. [PMID: 26976296]
  • Alpana Mathur, Fatima Rizvi, Poonam Kakkar. PHLPP2 down regulation influences nuclear Nrf2 stability via Akt-1/Gsk3β/Fyn kinase axis in acetaminophen induced oxidative renal toxicity: Protection accorded by morin. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2016 Mar; 89(?):19-31. doi: 10.1016/j.fct.2016.01.001. [PMID: 26767949]