Phenobarbital (BioDeep_00000002387)
Secondary id: BioDeep_00000408850
human metabolite Endogenous blood metabolite Chemicals and Drugs
代谢物信息卡片
5-Ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
化学式: C12H12N2O3 (232.0848)
中文名称: 苯巴比妥
谱图信息:
最多检出来源 Homo sapiens(blood) 29.68%
Reviewed
Last reviewed on 2024-09-14.
Cite this Page
Phenobarbital. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/phenobarbital (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000002387). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CCC1(C(=O)NC(=O)NC1=O)C1=CC=CC=C1
InChI: InChI=1S/C12H12N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h3-7H,2H2,1H3,(H2,13,14,15,16,17)
描述信息
Phenobarbital is only found in individuals that have used or taken this drug. It is a barbituric acid derivative that acts as a nonselective central nervous system depressant.Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbital may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of phenobarbital are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal.
Phenobarbital appears as odorless white crystalline powder or colorless crystals. A saturated aqueous solution is acid to litmus (approximately pH 5). Slightly bitter taste. (NTP, 1992)
Phenobarbital is a member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups. It has a role as an anticonvulsant, a sedative, an excitatory amino acid antagonist and a drug allergen.
Phenobarbital is a DEA Schedule IV controlled substance. Substances in the DEA Schedule IV have a low potential for abuse relative to substances in Schedule III. It is a Depressants substance.
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Phenobarbital is a barbiturate that is widely used as a sedative and an antiseizure medication. Phenobarbital has been linked to rare instances of idiosyncratic liver injury that can be severe and even fatal.
Phenobarbital is a long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization.
Phenobarbital is only found in individuals that have used or taken this drug. It is a barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. [PubChem] Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbital may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of phenobarbital are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal.
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
同义名列表
35 个代谢物同义名
5-Ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione; 5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione; 5-Ethyl-5-phenyl-pyrimidine-2,4,6-trione; 5-Ethyl-5-phenylbarbituric acid; 5-Phenyl-5-ethylbarbituric acid; Phenobarbital, monosodium salt; 5-Ethyl-5-phenylbarbitic acid; Monosodium salt phenobarbital; 5-Phenyl-5-ethylbarbitic acid; Acid, phenylethylbarbituric; Phenylethylbarbituric acid; Phenylaethylbarbitursaeure; 5-Ethyl-5-phenylbarbitate; Phenylethylbarbitursaeure; 5-Phenyl-5-ethylbarbitate; Phenylethylbarbitic acid; PHENYLETHYLMALONYLUREA; Phenylethylbarbiturate; Sodium, phenobarbital; Phenobarbituric acid; Phenylethylbarbitate; phenobarbital sodium; Phenobarbitic acid; Phenylbarbital; Phenobarbitate; Phenobarbitone; phenobarbital; Phenobarbitol; Fenobarbital; Gardenal; Phenemal; Luminal; Hysteps; Phenobarbital
数据库引用编号
40 个数据库交叉引用编号
- ChEBI: CHEBI:8069
- KEGG: C07434
- KEGGdrug: D00506
- PubChem: 4763
- HMDB: HMDB0015305
- Metlin: METLIN1817
- DrugBank: DB01174
- ChEMBL: CHEMBL40
- Wikipedia: Phenobarbital
- MeSH: Phenobarbital
- chemspider: 4599
- CAS: 50-06-6
- MoNA: LU104605
- MoNA: EQ362455
- MoNA: EQ362407
- MoNA: EQ362402
- MoNA: LU104602
- MoNA: EQ362452
- MoNA: EQ362454
- MoNA: EQ362406
- MoNA: LU104604
- MoNA: LU104652
- MoNA: EQ362453
- MoNA: LU104601
- MoNA: EQ362401
- MoNA: EQ362404
- MoNA: LU104603
- MoNA: EQ362409
- MoNA: LU104651
- MoNA: EQ362408
- MoNA: EQ362451
- MoNA: EQ362405
- MoNA: EQ362403
- MoNA: LU104606
- PMhub: MS000002501
- PubChem: 9638
- PDB-CCD: UQA
- NIKKAJI: J4.499G
- RefMet: Phenobarbital
- KNApSAcK: 8069
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zahra Jamali, Mohammad Hosein Molaei-Farsangi, Habibeh Ahmadipour, Bahareh Bahmanbijari, Fatemeh Sabzevari, Zahra Daei Parizi. Comparison of the effect of phenobarbital & levetiracetam in the treatment of neonatal abstinence syndrome (NAS) as adjuvant treatment in neonates admitted to the neonatal intensive care unit: a randomized clinical trial.
BMC pregnancy and childbirth.
2024 Apr; 24(1):242. doi:
10.1186/s12884-024-06433-y. [PMID: 38580935] - Poorvi Shah, Kati L Stegner-Smith, Mohamad Rachid, Tabassum Hanif, Kenneth W Dodd. Front-Loaded Versus Low-Intermittent Phenobarbital Dosing for Benzodiazepine-Resistant Severe Alcohol Withdrawal Syndrome.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2022 07; 18(3):198-204. doi:
10.1007/s13181-022-00900-8. [PMID: 35668289] - Michelle Hermans, Marios Charalambous, Akos Pakozdy, Ursula Eisl-Glantschnigg, Jasmin Neßler, Sofie Ae Van Meervenne, Gonçalo Serrano, Ine Cornelis, Luc Van Ham, Dominique Paepe, Bart Jg Broeckx, Sofie Fm Bhatti. Evaluation of the effect of phenobarbital administration on the biochemistry profile, with a focus on serum liver values, in epileptic cats.
Journal of feline medicine and surgery.
2022 06; 24(6):530-538. doi:
10.1177/1098612x211037431. [PMID: 34387120] - Ramzi Shawahna, Lina Zaid. Concentrations of antiseizure medications in breast milk of lactating women with epilepsy: A systematic review with qualitative synthesis.
Seizure.
2022 May; 98(?):57-70. doi:
10.1016/j.seizure.2022.03.017. [PMID: 35427849] - Pavla Pokorná, Danica Michaličková, Swantje Völler, Karolina Hronová, Dick Tibboel, Ondřej Slanař, Elke H Krekels. Severity parameters for asphyxia or hypoxic-ischemic encephalopathy do not explain inter-individual variability in the pharmacokinetics of phenobarbital in newborns treated with therapeutic hypothermia.
Minerva pediatrics.
2022 04; 74(2):107-115. doi:
10.23736/s2724-5276.20.05740-0. [PMID: 33107271] - James R Reed, Jessie J Guidry, Wayne L Backes. Proteomic and Bioinformatics Analysis of Membrane Lipid Domains after Brij 98 Solubilization of Uninduced and Phenobarbital-Induced Rat Liver Microsomes: Defining the Membrane Localization of the P450 Enzyme System.
Drug metabolism and disposition: the biological fate of chemicals.
2022 04; 50(4):374-385. doi:
10.1124/dmd.121.000752. [PMID: 35094979] - Yuan Jiang, Lin Qin, Anjing Lu, Juan Chen, Jianmei Wang, Qianru Zhang, Yanliu Lu, Qihai Gong, Jianmei Gao, Hong Ma, Daopeng Tan, Yuqi He. CYP3A1 metabolism-based neurotoxicity of strychnine in rat.
Toxicology.
2022 Mar; 471(?):153156. doi:
10.1016/j.tox.2022.153156. [PMID: 35358606] - Mirosław Zagaja, Anna Zagaja, Joanna Szala-Rycaj, Aleksandra Szewczyk, Marta Kinga Lemieszek, Grzegorz Raszewski, Marta Andres-Mach. Influence of Umbelliferone on the Anticonvulsant and Neuroprotective Activity of Selected Antiepileptic Drugs: An In Vivo and In Vitro Study.
International journal of molecular sciences.
2022 Mar; 23(7):. doi:
10.3390/ijms23073492. [PMID: 35408852] - Ashish Kumar, Manisha Naithani, Nitesh Kumar, Neha Singh, Shruti Agrawal, Ambika Sharma, Surabhi Thapliyal, Jagjit Singh, Shailendra Handu. Piperlongumine inhibits diethylnitrosamine induced hepatocellular carcinoma in rats.
Human & experimental toxicology.
2022 Jan; 41(?):9603271211073593. doi:
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2022; 15(1):29-35. doi:
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CPT: pharmacometrics & systems pharmacology.
2022 01; 11(1):104-115. doi:
10.1002/psp4.12737. [PMID: 34730282] - Shanshan Li, Yang Li, Hongjian Sun, Yang Jiang, Keming Pan, Yue Su, Nan Bu. Mulberry fruit polysaccharides alleviate diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in vivo: the roles of cell apoptosis and inflammation.
Bioengineered.
2021 12; 12(2):11599-11611. doi:
10.1080/21655979.2021.1993716. [PMID: 34866538] - Oktay Perk, Tanıl Kendirli, Handan Dinçaslan, Ebru Azapağası, Gokcen Meral. Overlap Stevens Johnson Syndrome/Toxic Epidermal Necrolysis developed due to the use of toxic-dose vinblastine in case of Langerhans Cell Histiocytosis(Letterer-Siwe).
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2021 Oct; 60(5):103173. doi:
10.1016/j.transci.2021.103173. [PMID: 34215518] - Antoine Kavaye Kandeda, Germain Sotoing Taiwe, Rigobert Espoir Mbomo Ayissi, Clémentine Moutchida. An aqueous extract of Canarium schweinfurthii attenuates seizures and potentiates sleep in mice: Evidence for involvement of GABA Pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Oct; 142(?):111973. doi:
10.1016/j.biopha.2021.111973. [PMID: 34343898] - J J García-Peñas, A Gil Nagel-Rein, R Sánchez-Carpintero, V Villanueva-Haba. Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain.
Revista de neurologia.
2021 09; 73(S01):S1-S8. doi:
10.33588/rn.73s01.2021250. [PMID: 34486101] - Ingrid F Metzger, Anna E Thomas, Cindy A Evrard, David R Jones, Andrea R Masters, David M Haas, Laura S Haneline, Sara K Quinney. Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome.
American journal of perinatology.
2021 07; 38(9):968-975. doi:
10.1055/s-0040-1701505. [PMID: 32052397] - Claudia Ottka, Corinna Weber, Elisabeth Müller, Hannes Lohi. Serum NMR metabolomics uncovers multiple metabolic changes in phenobarbital-treated dogs.
Metabolomics : Official journal of the Metabolomic Society.
2021 06; 17(6):54. doi:
10.1007/s11306-021-01803-5. [PMID: 34076758] - Morteza Tavasolizadeh, Kazem Hasanpour, Milad Nazarzadeh, Davood Mahdian, Omid Gholami. The effect of acidic beverage versus mineral water on the change in serum phenobarbital concentrations: a randomized clinical trial on children with seizure.
The International journal of neuroscience.
2021 May; 131(5):478-481. doi:
10.1080/00207454.2020.1748619. [PMID: 32216594] - Fatoumata Dite Nènè Konipo, Housseini Dolo, Mariam Daou, Yaya Ibrahim Coulibaly, Hassane Diallo, Moussa Sangare, Siaka Yamoussa Coulibaly, Modibo Sangare, Seydou Doumbia, Youssoufa M Maiga. Using community health workers as an alternative approach for epidemiological research on epilepsy in six health districts in Mali.
Epilepsy & behavior : E&B.
2021 04; 117(?):107842. doi:
10.1016/j.yebeh.2021.107842. [PMID: 33631436] - Soha A Hassan, Amira A H Ali, Mona Yassine, Dennis Sohn, Martina Pfeffer, Reiner U Jänicke, Horst-Werner Korf, Charlotte von Gall. Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model.
Journal of pineal research.
2021 Apr; 70(3):e12724. doi:
10.1111/jpi.12724. [PMID: 33615553] - Philip Hampel, Kerstin Römermann, Björn Gailus, Marie Johne, Birthe Gericke, Edith Kaczmarek, Wolfgang Löscher. Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice.
Neuropharmacology.
2021 03; 185(?):108449. doi:
10.1016/j.neuropharm.2021.108449. [PMID: 33450274] - Luca Zombori, Melody Bacon, Hannah Wood, Fiona Chatterjee, Ramesh Venkateswaran, Simona Lampariello, Michael Yoong. Severe cortical damage associated with COVID-19 case report.
Seizure.
2021 Jan; 84(?):66-68. doi:
10.1016/j.seizure.2020.11.014. [PMID: 33285362] - Yoshiaki Yamamoto, Yuka Shiratani, Shoko Asai, Naotaka Usui, Takuji Nishida, Katsumi Imai, Yoshiyuki Kagawa, Yukitoshi Takahashi. Pharmacokinetics, tolerability, and clinical effectiveness of perampanel in Japanese patients with epilepsy.
Seizure.
2020 Dec; 83(?):181-186. doi:
10.1016/j.seizure.2020.10.017. [PMID: 33171342] - Li-Na Zhu, Deng Chen, Ying Deng, Jun He, Yu-Jin He, Dong Zhou, Ling Liu. Long-term seizure, comorbidity and socioeconomic outcomes of patients with convulsive epilepsy in rural West China.
Epilepsy research.
2020 12; 168(?):106480. doi:
10.1016/j.eplepsyres.2020.106480. [PMID: 33120304] - Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue.
Archives of toxicology.
2020 12; 94(12):4037-4041. doi:
10.1007/s00204-020-02869-1. [PMID: 32808185] - Ryota Shizu, Yuta Otsuka, Kanako Ezaki, Chizuru Ishii, Shingo Arakawa, Yuto Amaike, Taiki Abe, Takuomi Hosaka, Takamitsu Sasaki, Yuichiro Kanno, Masaaki Miyata, Yasushi Yamazoe, Kouichi Yoshinari. Antiepileptic Drug-Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator-Activated Receptor α and Peroxisome Proliferator-Activated Receptor γ Coactivator 1α-Dependent Gene Expression to Increase Blood Triglyceride Levels.
Molecular pharmacology.
2020 11; 98(5):634-647. doi:
10.1124/molpharm.120.000103. [PMID: 32892155] - Krzysztof Łukawski, Grzegorz Raszewski, Stanisław J Czuczwar. Effect of aliskiren on the anticonvulsant activity of antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice.
Epilepsy research.
2020 11; 167(?):106435. doi:
10.1016/j.eplepsyres.2020.106435. [PMID: 32784064] - Paulo Teixeira-da-Silva, Dolores Santos-Buelga, María José Otero, María José García. Population pharmacokinetics of phenobarbital in Caucasian patients with epilepsy.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Oct; 153(?):105484. doi:
10.1016/j.ejps.2020.105484. [PMID: 32707172] - Yoshiaki Yamamoto, Kiyohito Terada, Yasukiyo Araki, Yutaro Fukushima, Katsumi Imai, Yoshiyuki Kagawa, Yukitoshi Takahashi. Therapeutic Monitoring of Lacosamide in Japanese Patients With Epilepsy: Clinical Response, Tolerability, and Optimal Therapeutic Range.
Therapeutic drug monitoring.
2020 10; 42(5):754-759. doi:
10.1097/ftd.0000000000000764. [PMID: 32941398] - Surajit Pathak, Roberto Catanzaro, Dharani Vasan, Francesco Marotta, Yashna Chabria, Ganesan Jothimani, Rama Shanker Verma, Murugesan Ramachandran, Anisur Rahman Khuda-Bukhsh, Antara Banerjee. Benefits of aged garlic extract in modulating toxicity biomarkers against p-dimethylaminoazobenzene and phenobarbital induced liver damage in Rattus norvegicus.
Drug and chemical toxicology.
2020 Sep; 43(5):454-467. doi:
10.1080/01480545.2018.1499773. [PMID: 30207178] - Kamal K Jinadasa, Elena Peña-Vázquez, Pilar Bermejo-Barrera, Antonio Moreda-Piñeiro. A phenobarbital containing polymer/ silica coated quantum dot composite for the selective recognition of mercury species in fish samples using a room temperature phosphorescence quenching assay.
Talanta.
2020 Aug; 216(?):120959. doi:
10.1016/j.talanta.2020.120959. [PMID: 32456893] - Sofie Velghe, Lisa Delahaye, Rodney Ogwang, An Hotterbeekx, Robert Colebunders, Michel Mandro, Richard Idro, Christophe P Stove. Dried Blood Microsampling-Based Therapeutic Drug Monitoring of Antiepileptic Drugs in Children With Nodding Syndrome and Epilepsy in Uganda and the Democratic Republic of the Congo.
Therapeutic drug monitoring.
2020 06; 42(3):481-490. doi:
10.1097/ftd.0000000000000720. [PMID: 31834012] - Anne Hagemann, Dennis Klimpel, Christian G Bien, Christian Brandt, Theodor W May. Influence of dose and antiepileptic comedication on brivaracetam serum concentrations in patients with epilepsy.
Epilepsia.
2020 05; 61(5):e43-e48. doi:
10.1111/epi.16500. [PMID: 32304097] - Hiroshi Tsutsumi, Kosei Yonemitsu, Ako Sasao, Yuki Ohtsu, Shota Furukawa, Yoko Nishitani. Cerebrospinal fluid neurotransmitter levels and central nervous system depression in a rat drug overdose model.
Toxicology mechanisms and methods.
2020 Feb; 30(2):139-145. doi:
10.1080/15376516.2019.1672122. [PMID: 31550965] - Yan-Ying Wang, Wei-Wei Ma, I-Feng Peng. Screening of sleep assisting drug candidates with a Drosophila model.
PloS one.
2020; 15(7):e0236318. doi:
10.1371/journal.pone.0236318. [PMID: 32726319] - Sang-June Sohn, So-Young Jeung, Hyung-Kyu Chae, Hee-Seon Cho, Ju-Hyun An, Qiang Li, Woo-Jin Song, Hwa-Young Youn. Phenobarbital-induced anticonvulsant hypersensitivity syndrome in a cat.
The Journal of veterinary medical science.
2019 Dec; 81(12):1850-1852. doi:
10.1292/jvms.19-0388. [PMID: 31685729] - Heidi L Barnes Heller, Lauren A Trepanier, Michelle Robertson, Chaoqun Mei. Prospective crossover clinical trial comparing transdermal with oral phenobarbital administration in epileptic cats.
Journal of feline medicine and surgery.
2019 12; 21(12):1181-1187. doi:
10.1177/1098612x18823577. [PMID: 30688552] - Georgia Koukou, Sandra Niendorf, Britt Hornei, Jan-U Schlump, Andreas C Jenke, Sonja Jacobsen. Human astrovirus infection associated with encephalitis in an immunocompetent child: a case report.
Journal of medical case reports.
2019 Nov; 13(1):341. doi:
10.1186/s13256-019-2302-6. [PMID: 31757225] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
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Molecular genetics and metabolism.
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BMC pediatrics.
2019 11; 19(1):399. doi:
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Pediatric nephrology (Berlin, Germany).
2019 10; 34(10):1727-1728. doi:
10.1007/s00467-019-04231-9. [PMID: 30903373] - Yuka Ogata, Ayuko Imaoka, Takeshi Akiyoshi, Hisakazu Ohtani. Effects of food type on the extent of drug-drug interactions between activated charcoal and phenobarbital in rats.
Drug metabolism and pharmacokinetics.
2019 Aug; 34(4):287-291. doi:
10.1016/j.dmpk.2019.05.002. [PMID: 31255507] - Chunhuan Jin, Zijun Wu, Lili Wang, Yoshikatsu Kanai, Xin He. CYP450s-Activity Relations of Celastrol to Interact with Triptolide Reveal the Reasons of Hepatotoxicity of Tripterygium wilfordii.
Molecules (Basel, Switzerland).
2019 Jun; 24(11):. doi:
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Therapeutic drug monitoring.
2019 06; 41(3):257-260. doi:
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Human molecular genetics.
2019 06; 28(11):1755-1767. doi:
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Journal of molecular and cellular cardiology.
2019 06; 131(?):91-100. doi:
10.1016/j.yjmcc.2019.04.021. [PMID: 31022374] - Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Ikari. Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11.
Chemico-biological interactions.
2019 May; 305(?):12-20. doi:
10.1016/j.cbi.2019.03.026. [PMID: 30926317] - Nobutsune Ishikawa, Yuichi Tateishi, Hiroo Tani, Yoshiyuki Kobayashi, Masao Kobayashi. Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy.
Epilepsy & behavior : E&B.
2019 05; 94(?):82-86. doi:
10.1016/j.yebeh.2019.02.004. [PMID: 30897534] - Rana Shariati, Behzad Rezaei, Hamid Reza Jamei, Ali Asghar Ensafi. Application of coated green source carbon dots with silica molecularly imprinted polymers as a fluorescence probe for selective and sensitive determination of phenobarbital.
Talanta.
2019 Mar; 194(?):143-149. doi:
10.1016/j.talanta.2018.09.069. [PMID: 30609514] - Naoki Yoshikawa, Tomoya Tazaki, Mari Hatanaka, Yasuharu Oda, Nobuhiro Matsumoto, Junichiro Sonoda, Ryuji Ikeda. Drug-drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report.
Journal of clinical pharmacy and therapeutics.
2019 Feb; 44(1):119-121. doi:
10.1111/jcpt.12764. [PMID: 30311244] - Daniel P Krull, Stephanie Ann Thomovsky, Annie Vivian Chen, Katrina L Mealey, Mark G Papich. Evaluation of Transdermal Administration of Phenobarbital in Healthy Cats.
Journal of the American Animal Hospital Association.
2019 Jan; 55(1):1-7. doi:
10.5326/jaaha-ms-6670. [PMID: 30427717] - Shafinaz Abd Gani, Suleiman Alhaji Muhammad, Aminu Umar Kura, Farahnaz Barahuie, Mohd Zobir Hussein, Sharida Fakurazi. Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice.
PloS one.
2019; 14(5):e0217009. doi:
10.1371/journal.pone.0217009. [PMID: 31141523] - Atsuyoshi Okada, Keiichiro Suzuki, Keisuke Hara, Moeko Kojina, Tetsuya Aiba. In Vivo Study on Mechanism Underlying Increased Pharmacological Effects of Phenobarbital in Rats with Glycerol-Induced Acute Renal Failure.
Biological & pharmaceutical bulletin.
2019; 42(3):501-506. doi:
10.1248/bpb.b18-00659. [PMID: 30828081] - Michael McMahon, Shaohong Ding, Lourdes Acosta Jimenez, Remi Terranova, Marie-Apolline Gerard, Antonio Vitobello, Jonathan Moggs, Colin J Henderson, C Roland Wolf. Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes.
Molecular pharmacology.
2019 01; 95(1):97-105. doi:
10.1124/mol.118.113555. [PMID: 30361333] - Wanbing Sun, Jianhong Wang, Ding Ding, Qing Zhang, Taiping Wang, Zhen Hong. Blood concentration, efficacy, and adverse events of phenobarbital: A prospective study in rural China.
Epilepsy & behavior : E&B.
2019 01; 90(?):247-251. doi:
10.1016/j.yebeh.2018.10.014. [PMID: 30563756] - Laurent M A Favié, Floris Groenendaal, Marcel P H van den Broek, Carin M A Rademaker, Timo R de Haan, Henrica L M van Straaten, Peter H Dijk, Arno van Heijst, Sinno H P Simons, Koen P Dijkman, Monique Rijken, Inge A Zonnenberg, Filip Cools, Alexandra Zecic, Johanna H van der Lee, Debbie H G M Nuytemans, Frank van Bel, Toine C G Egberts, Alwin D R Huitema. Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia.
Neonatology.
2019; 116(2):154-162. doi:
10.1159/000499330. [PMID: 31256150] - Moisés Hamoy, Luiz Dos Santos Batista, Vanessa Joia de Mello, Walace Gomes-Leal, Rômulo Augusto Feio Farias, Pedro Dos Santos Batista, José Luiz Martins do Nascimento, Helcio Casemiro Marcondes, Jason G Taylor, William D Hutchison, Marcelo Ferreira Torres, Luis André L Barbas. Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses.
Toxicology and applied pharmacology.
2018 12; 360(?):193-200. doi:
10.1016/j.taap.2018.10.008. [PMID: 30296455] - Yoshiaki Yamamoto, Yukitoshi Takahashi, Asako Horino, Naotaka Usui, Takuji Nishida, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue. Influence of Inflammation on the Pharmacokinetics of Perampanel.
Therapeutic drug monitoring.
2018 12; 40(6):725-729. doi:
10.1097/ftd.0000000000000556. [PMID: 30086086] - Sheng-Nan Wang, Chun-Ping Gu, Guang-Hui Liu, Zhen-Zhou Lin, Ping Zheng, Su-Yue Pan, Shi-Ting Liu. The effectiveness of phenobarbital in patients with refractory status epilepticus undergoing therapeutic plasma exchange.
Neuroreport.
2018 11; 29(16):1360-1364. doi:
10.1097/wnr.0000000000001119. [PMID: 30216211] - Jiahua Guo, Shohei Ito, Hoa Thanh Nguyen, Kimika Yamamoto, Hisato Iwata. Effects on the hepatic transcriptome of chicken embryos in ovo exposed to phenobarbital.
Ecotoxicology and environmental safety.
2018 Sep; 160(?):94-103. doi:
10.1016/j.ecoenv.2018.05.033. [PMID: 29793206] - Claudia Brandt, Petra Hillmann, Andreas Noack, Kerstin Römermann, Leon A Öhler, Denise Rageot, Florent Beaufils, Anna Melone, Alexander M Sele, Matthias P Wymann, Doriano Fabbro, Wolfgang Löscher. The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy.
Neuropharmacology.
2018 09; 140(?):107-120. doi:
10.1016/j.neuropharm.2018.08.002. [PMID: 30081001] - Karen R Muñana, Arturo J Otamendi, Julie A Nettifee, Mark G Papich. Population pharmacokinetics of extended-release levetiracetam in epileptic dogs when administered alone, with phenobarbital or zonisamide.
Journal of veterinary internal medicine.
2018 Sep; 32(5):1677-1683. doi:
10.1111/jvim.15298. [PMID: 30238679] - Kristine Hole, Birgit M Wollmann, Camilla Nguyen, Tore Haslemo, Espen Molden. Comparison of CYP3A4-Inducing Capacity of Enzyme-Inducing Antiepileptic Drugs Using 4β-Hydroxycholesterol as Biomarker.
Therapeutic drug monitoring.
2018 08; 40(4):463-468. doi:
10.1097/ftd.0000000000000518. [PMID: 29649093] - Brady S Moffett, Mindl M Weingarten, Marianne Galati, Jennifer L Placencia, Emily A Rodman, James J Riviello, Simon Y Kayyal. Phenobarbital population pharmacokinetics across the pediatric age spectrum.
Epilepsia.
2018 07; 59(7):1327-1333. doi:
10.1111/epi.14447. [PMID: 29897629] - Tamorah Lewis, Simisola Kuye, Ashley Sherman. Ursodeoxycholic acid versus phenobarbital for cholestasis in the Neonatal Intensive Care Unit.
BMC pediatrics.
2018 06; 18(1):197. doi:
10.1186/s12887-018-1167-y. [PMID: 29925342] - Shinichi Hikasa, Akihiro Sawada, Hitomi Seino, Shota Shimabukuro, Kyoko Hideta, Noriko Uwa, Satoshi Higasa, Tazuko Tokugawa, Takeshi Kimura. A potential drug interaction between phenobarbital and dolutegravir: A case report.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2018 Jun; 24(6):476-478. doi:
10.1016/j.jiac.2017.12.022. [PMID: 29415844] - Tiantian Wang, Shiyang Dong, Xiaodong Chen, Kun Qian, Huayu Wang, Hexiu Quan, Zhongli Zhang, Yueming Zuo, Liping Huang, Dongxun Li, Ming Yang, Shilin Yang, Yi Jin, Zengtao Wang. Design, synthesis, biological evaluation, homology modeling and docking studies of (E)-3-(benzo[d][1,3]dioxol-5-ylmethylene) pyrrolidin-2-one derivatives as potent anticonvulsant agents.
Bioorganic & medicinal chemistry letters.
2018 05; 28(8):1324-1329. doi:
10.1016/j.bmcl.2018.03.015. [PMID: 29548572] - Pavla Pokorná, Martin Šíma, Václav Vobruba, Dick Tibboel, Ondřej Slanař. Phenobarbital pharmacokinetics in neonates and infants during extracorporeal membrane oxygenation.
Perfusion.
2018 05; 33(1_suppl):80-86. doi:
10.1177/0267659118766444. [PMID: 29788839] - Arezou Amiri Pebdani, Shayessteh Dadfarnia, Ali Mohammad Haji Shabani, Saeid Khodadoust, Mohammad Sharif Talebianpoor. Modified dispersive liquid-phase microextraction based on sequential injection solidified floating organic drop combined with HPLC for the determination of phenobarbital and phenytoin.
Journal of separation science.
2018 Jan; 41(2):509-517. doi:
10.1002/jssc.201701111. [PMID: 29131525] - Brahim El Hasbaoui, Saloua Boujrad, Rachid Abilkacem, Aomar Agadr. [Vomiting associated with weight stagnation and convulsions: urea cycle disorder should be suspected].
The Pan African medical journal.
2018; 31(?):103. doi:
10.11604/pamj.2018.31.103.11403. [PMID: 31037164] - Sheng-Feng Cui, Wei Li, Cheng-He Zhou. Molecular spectroscopic studies examining the interactions between phenobarbital and human serum albumin in alcohol consumption.
The American journal of drug and alcohol abuse.
2018; 44(3):321-328. doi:
10.1080/00952990.2017.1387265. [PMID: 29095046] - Shuai Wang, Canhong Wang, Deqian Peng, Xinmin Liu, Chongming Wu, Peng Guo, Jianhe Wei. Agarwood Essential Oil Displays Sedative-Hypnotic Effects through the GABAergic System.
Molecules (Basel, Switzerland).
2017 Dec; 22(12):. doi:
10.3390/molecules22122190. [PMID: 29232839] - Hala M F El Miniawy, Kawkab A Ahmed, Sameeh A Mansour, Marwa M Salah Khattab. In vivo antitumour potential of camel's milk against hepatocellular carcinoma in rats and its improvement of cisplatin renal side effects.
Pharmaceutical biology.
2017 Dec; 55(1):1513-1520. doi:
10.1080/13880209.2017.1309553. [PMID: 28372475] - Swantje Völler, Robert B Flint, Leo M Stolk, Pieter L J Degraeuwe, Sinno H P Simons, Paula Pokorna, David M Burger, Ronald de Groot, Dick Tibboel, Catherijne A J Knibbe. Model-based clinical dose optimization for phenobarbital in neonates: An illustration of the importance of data sharing and external validation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Nov; 109S(?):S90-S97. doi:
10.1016/j.ejps.2017.05.026. [PMID: 28506869] - Shino Kuramoto, Motohiro Kato, Hidetoshi Shindoh, Akihisa Kaneko, Masaki Ishigai, Seiji Miyauchi. Simple Evaluation Method for CYP3A4 Induction from Human Hepatocytes: The Relative Factor Approach with an Induction Detection Limit Concentration Based on the Emax Model.
Drug metabolism and disposition: the biological fate of chemicals.
2017 11; 45(11):1139-1145. doi:
10.1124/dmd.117.076349. [PMID: 28821485] - Ashlee J Conway, Fiona C Brown, Robert O Fullinfaw, Benjamin T Kile, Stephen M Jane, David J Curtis. A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen.
Disease models & mechanisms.
2017 08; 10(8):1005-1013. doi:
10.1242/dmm.029116. [PMID: 28600349] - Philip Marx-Stoelting, Katrin Ganzenberg, Constanze Knebel, Flavia Schmidt, Svenja Rieke, Helen Hammer, Felix Schmidt, Oliver Pötz, Michael Schwarz, Albert Braeuning. Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice.
Archives of toxicology.
2017 Aug; 91(8):2895-2907. doi:
10.1007/s00204-016-1925-2. [PMID: 28058446] - Rik Schoemaker, Janet R Wade, Armel Stockis. Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years.
European journal of clinical pharmacology.
2017 Jun; 73(6):727-733. doi:
10.1007/s00228-017-2230-6. [PMID: 28280887] - Hirokazu Nakayama, Hirotoshi Echizen, Ryuichi Ogawa, Atsuya Akabane, Toshiaki Kato, Takao Orii. Induration at Injection or Infusion Site May Reduce Bioavailability of Parenteral Phenobarbital Administration.
Therapeutic drug monitoring.
2017 06; 39(3):297-302. doi:
10.1097/ftd.0000000000000391. [PMID: 28328763] - Rodrigo Campos Dos Santos, Adriana Kaori Kakazu, Mariane Gonçalves Santos, Fábio Antônio Belinelli Silva, Eduardo Costa Figueiredo. Characterization and application of restricted access carbon nanotubes in online extraction of anticonvulsant drugs from plasma samples followed by liquid chromatography analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Jun; 1054(?):50-56. doi:
10.1016/j.jchromb.2017.02.025. [PMID: 28419925] - Ayman M Mahmoud, Amr R Zaki, Manal E Hassan, Gomaa Mostafa-Hedeab. Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling.
Chemico-biological interactions.
2017 May; 270(?):41-50. doi:
10.1016/j.cbi.2017.04.012. [PMID: 28414157] - Tahira Assad, Rafeeq Alam Khan. Effect of methanol extract of Trigonella foenum-graecum L. seeds on anxiety, sedation and motor coordination.
Metabolic brain disease.
2017 04; 32(2):343-349. doi:
10.1007/s11011-016-9914-y. [PMID: 27639708] - Abdur Rauf, Taibi Ben Hadda, Ghias Uddin, José P Cerón-Carrasco, Jorge Peña-García, Horacio Pérez-Sánchez, Haroon Khan, Saud Bawazeer, Seema Patel, Mohammad S Mubarak, Tareq Abu-Izneid, Yahia Nasser Mabkhot. Sedative-hypnotic-like effect and molecular docking of di-naphthodiospyrol from Diospyros lotus in an animal model.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Apr; 88(?):109-113. doi:
10.1016/j.biopha.2017.01.043. [PMID: 28103503] - Juthamas Khamseekaew, Sirinart Kumfu, Suwakon Wongjaikam, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Somdet Srichairatanakool, Suthat Fucharoen, Siriporn C Chattipakorn, Nipon Chattipakorn. Effects of iron overload, an iron chelator and a T-Type calcium channel blocker on cardiac mitochondrial biogenesis and mitochondrial dynamics in thalassemic mice.
European journal of pharmacology.
2017 Mar; 799(?):118-127. doi:
10.1016/j.ejphar.2017.02.015. [PMID: 28192097] - F Stabile, C R Barnett, L De Risio. Phenobarbital administration every eight hours: improvement of seizure management in idiopathic epileptic dogs with decreased phenobarbital elimination half-life.
The Veterinary record.
2017 Feb; 180(7):178. doi:
10.1136/vr.104051. [PMID: 28062844] - Ravali Alagandula, Xiang Zhou, Baochuan Guo. A dilute-and-shoot flow-injection tandem mass spectrometry method for quantification of phenobarbital in urine.
Rapid communications in mass spectrometry : RCM.
2017 Jan; 31(1):39-46. doi:
10.1002/rcm.7763. [PMID: 27739613] - Andrea Enrique, Sofía Goicoechea, Rocío Castaño, Facundo Taborda, Luisa Rocha, Sandra Orozco, Elena Girardi, Luis Bruno Blanch. New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice.
Epilepsy research.
2017 01; 129(?):8-16. doi:
10.1016/j.eplepsyres.2016.10.012. [PMID: 27875747] - Jarogniew J Luszczki, Pawel Patrzylas, Miroslaw Zagaja, Marta Andres-Mach, Katarzyna Zaluska, Maria W Kondrat-Wrobel, Monika Szpringer, Jaroslaw Chmielewski, Magdalena Florek-Luszczki. Effects of arachidonyl-2'-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice.
PloS one.
2017; 12(8):e0183873. doi:
10.1371/journal.pone.0183873. [PMID: 28859122] - Keaton S Smetana, Aaron M Cook, Melissa L Thompson Bastin, Douglas R Oyler. Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Journal of critical care.
2016 12; 36(?):116-124. doi:
10.1016/j.jcrc.2016.06.023. [PMID: 27546759] - Marize de Lourdes Marzo Solano, Noeme Souza Rocha, Luis Fernando Barbisan, Carla Adriene da Silva Franchi, Ana Lúcia Tozzi Spinardi-Barbisan, Maria Luiza Cotrim Sartor de Oliveira, Daisy Maria Fávero Salvadori, Lúcia Regina Ribeiro, João Lauro Viana de Camargo. Alternative Multiorgan Initiation-Promotion Assay for Chemical Carcinogenesis in the Wistar Rat.
Toxicologic pathology.
2016 12; 44(8):1146-1159. doi:
10.1177/0192623316678931. [PMID: 28245158] - Rekha Dwivedi, Meenakshi Singh, Thomas Kaleekal, Yogendra Kumar Gupta, Manjari Tripathi. Concentration of antiepileptic drugs in persons with epilepsy: a comparative study in serum and saliva.
The International journal of neuroscience.
2016 Nov; 126(11):972-8. doi:
10.3109/00207454.2015.1088848. [PMID: 26441313] - Azadeh Ashtarinezhad, Ataollah Panahyab, Shahrzad Shaterzadeh-Oskouei, Hessam Khoshniat, Baharak Mohamadzadehasl, Farshad H Shirazi. Teratogenic study of phenobarbital and levamisole on mouse fetus liver tissue using biospectroscopy.
Journal of pharmaceutical and biomedical analysis.
2016 Sep; 128(?):174-183. doi:
10.1016/j.jpba.2016.05.015. [PMID: 27262993] - Delisha A Stewart, Jason H Winnike, Susan L McRitchie, Robert F Clark, Wimal W Pathmasiri, Susan J Sumner. Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences.
Journal of proteome research.
2016 09; 15(9):3225-40. doi:
10.1021/acs.jproteome.6b00430. [PMID: 27447733] - Tomoya Takeuchi, Jun Natsume, Hiroyuki Kidokoro, Naoko Ishihara, Hiroyuki Yamamoto, Yoshiteru Azuma, Yuji Ito, Naoko Kurahashi, Takeshi Tsuji, Motomasa Suzuki, Kazuya Itomi, Keitaro Yamada, Hirokazu Kurahashi, Shinpei Abe, Akihisa Okumura, Koichi Maruyama, Tamiko Negoro, Kazuyoshi Watanabe, Seiji Kojima. The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy.
Brain & development.
2016 Sep; 38(8):723-30. doi:
10.1016/j.braindev.2016.03.004. [PMID: 27033151] - Lihua Qu, Yuanjie Fan, Wenjun Wang, Kai Ma, Zheng Yin. Development, validation and clinical application of an online-SPE-LC-HRMS/MS for simultaneous quantification of phenobarbital, phenytoin, carbamazepine, and its active metabolite carbamazepine 10,11-epoxide.
Talanta.
2016 Sep; 158(?):77-88. doi:
10.1016/j.talanta.2016.05.036. [PMID: 27343581] - Ruixin Hao, Shengzhong Su, Yinan Wan, Frank Shen, Ben Niu, Denise M Coslo, Istvan Albert, Xing Han, Curtis J Omiecinski. Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver.
Biochimica et biophysica acta.
2016 09; 1859(9):1228-1237. doi:
10.1016/j.bbagrm.2016.04.002. [PMID: 27080131] - Elizabeth A Rondini, Zofia Duniec-Dmuchowski, Daniela Cukovic, Alan A Dombkowski, Thomas A Kocarek. Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat Hepatocytes.
The Journal of pharmacology and experimental therapeutics.
2016 08; 358(2):216-29. doi:
10.1124/jpet.116.233312. [PMID: 27225895] - Alice Marmugi, Céline Lukowicz, Frederic Lasserre, Alexandra Montagner, Arnaud Polizzi, Simon Ducheix, Adeline Goron, Laurence Gamet-Payrastre, Sabine Gerbal-Chaloin, Jean Marc Pascussi, Marthe Moldes, Thierry Pineau, Hervé Guillou, Laila Mselli-Lakhal. Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.
Toxicology and applied pharmacology.
2016 07; 303(?):90-100. doi:
10.1016/j.taap.2016.05.006. [PMID: 27180240]
