Fexofenadine (BioDeep_00000002312)
Secondary id: BioDeep_00000229713, BioDeep_00000873153
human metabolite Endogenous blood metabolite Chemicals and Drugs natural product
代谢物信息卡片
4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid
化学式: C32H39NO4 (501.28789340000003)
中文名称: 非索非那定
谱图信息:
最多检出来源 Homo sapiens(feces) 0.83%
分子结构信息
SMILES: CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1
InChI: InChI=1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36)
描述信息
Fexofenadine is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine, an antihistamine with potentially fatal contraindications. Fexofenadine, like other second-generation antihistamines, does not readily enter the brain from the blood, and so causes less drowsiness than first generation histamine receptor antagonists; Fexofenadine hydrochloride (brand names include Allegra and Telfast) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine, an antihistamine with potentially fatal contraindications. Fexofenadine, like other second generation antihistamines, does not readily enter the brain from the blood, and so causes less drowsiness than first-generation histamine-receptor antagonists.
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018926 - Anti-Allergic Agents
Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3].
同义名列表
24 个代谢物同义名
4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetate; 2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-α,α-dimethylbenzeneacetic acid; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-a,a-dimethylbenzeneacetic acid; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-a,a-dimethylbenzeneacetate; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-α,α-dimethylbenzeneacetate; alpha-(4-(1-Carboxy-1-methylethyl)phenyl)-4-hydroxydiphenylmethyl-1-piperidinebutanol; Aventis behring brand OF fexofenadine hydrochloride; Aventis pharma brand OF fexofenadine hydrochloride; Hoechst brand OF fexofenadine hydrochloride; Aventis brand OF fexofenadine hydrochloride; Terfenadine carboxylic acid; Terfenadine acid metabolite; Fexofenadine hydrochloride; Terfenadine carboxylate; Carboxyterfenadine; Terfenadine-COOH; fexofenadine; MDL 16,455a; Allegra; Telfast; MDL-16455; Fexofenadine
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:5050
- KEGG: C06999
- KEGGdrug: D07958
- PubChem: 3348
- HMDB: HMDB0005030
- Metlin: METLIN2766
- DrugBank: DB00950
- ChEMBL: CHEMBL914
- Wikipedia: Fexofenadine
- chemspider: 3231
- CAS: 1319714-86-7
- CAS: 138452-21-8
- CAS: 83799-24-0
- PMhub: MS000002326
- PubChem: 9212
- NIKKAJI: J413.164I
- RefMet: Fexofenadine
- medchemexpress: HY-B0801
- KNApSAcK: 5050
- LOTUS: LTS0029785
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 2 - Bacteria: LTS0029785
- 9606 - Homo sapiens: -
- 1883 - Streptomyces: LTS0029785
- 58346 - Streptomyces platensis: 10.1016/J.ABB.2011.01.008
- 58346 - Streptomyces platensis: LTS0029785
- 2062 - Streptomycetaceae: LTS0029785
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Myriam El Biali, Michael Wölfl-Duchek, Matthias Jackwerth, Severin Mairinger, Maria Weber, Karsten Bamminger, Stefan Poschner, Ivo Rausch, Natalie Schindler, Irene Hernández Lozano, Walter Jäger, Lukas Nics, Nicolas Tournier, Marcus Hacker, Markus Zeitlinger, Martin Bauer, Oliver Langer. St. John's wort extract with a high hyperforin content does not induce P-glycoprotein activity at the human blood-brain barrier.
Clinical and translational science.
2024 May; 17(5):e13804. doi:
10.1111/cts.13804. [PMID: 38700454] - Walaa A El-Dakroury, Moataz B Zewail, Gihan F Asaad, Heba M I Abdallah, Marwa E Shabana, Abdelrahman R Said, Ahmed S Doghish, Hadeer A Azab, Dalia H Amer, Ahmed E Hassan, Alaa S Sayed, Ghada M Samra, Al-Aliaa M Sallam. Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for ulcerative colitis.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2024 Mar; 196(?):114205. doi:
10.1016/j.ejpb.2024.114205. [PMID: 38311187] - Shingen Misaka, Yuko Ono, R Verena Taudte, Eva Hoier, Hiroshi Ogata, Tomoyuki Ono, Jörg König, Hiroshi Watanabe, Martin F Fromm, Kenju Shimomura. Exposure of Fexofenadine, but Not Pseudoephedrine, Is Markedly Decreased by Green Tea Extract in Healthy Volunteers.
Clinical pharmacology and therapeutics.
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Clinical and experimental dermatology.
2022 Apr; 47(4):724-729. doi:
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