Fexofenadine (BioDeep_00000002312)
Secondary id: BioDeep_00000229713, BioDeep_00000873153
human metabolite Endogenous blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C32H39NO4 (501.28789340000003)
中文名称: 非索非那定
谱图信息:
最多检出来源 Homo sapiens(feces) 0.84%
分子结构信息
SMILES: CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1
InChI: InChI=1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36)
描述信息
Fexofenadine is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine, an antihistamine with potentially fatal contraindications. Fexofenadine, like other second-generation antihistamines, does not readily enter the brain from the blood, and so causes less drowsiness than first generation histamine receptor antagonists; Fexofenadine hydrochloride (brand names include Allegra and Telfast) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine, an antihistamine with potentially fatal contraindications. Fexofenadine, like other second generation antihistamines, does not readily enter the brain from the blood, and so causes less drowsiness than first-generation histamine-receptor antagonists.
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018926 - Anti-Allergic Agents
Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3].
同义名列表
23 个代谢物同义名
4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetate; 2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-α,α-dimethylbenzeneacetic acid; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-a,a-dimethylbenzeneacetic acid; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-a,a-dimethylbenzeneacetate; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-α,α-dimethylbenzeneacetate; alpha-(4-(1-Carboxy-1-methylethyl)phenyl)-4-hydroxydiphenylmethyl-1-piperidinebutanol; Aventis behring brand OF fexofenadine hydrochloride; Aventis pharma brand OF fexofenadine hydrochloride; Hoechst brand OF fexofenadine hydrochloride; Aventis brand OF fexofenadine hydrochloride; Terfenadine carboxylic acid; Terfenadine acid metabolite; Fexofenadine hydrochloride; Terfenadine carboxylate; Carboxyterfenadine; Terfenadine-COOH; fexofenadine; MDL 16,455a; Allegra; Telfast; MDL-16455
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:5050
- KEGG: C06999
- KEGGdrug: D07958
- PubChem: 3348
- HMDB: HMDB0005030
- Metlin: METLIN2766
- DrugBank: DB00950
- ChEMBL: CHEMBL914
- Wikipedia: Fexofenadine
- chemspider: 3231
- CAS: 1319714-86-7
- CAS: 138452-21-8
- CAS: 83799-24-0
- PMhub: MS000002326
- PubChem: 9212
- NIKKAJI: J413.164I
- RefMet: Fexofenadine
- medchemexpress: HY-B0801
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Myriam El Biali, Michael Wölfl-Duchek, Matthias Jackwerth, Severin Mairinger, Maria Weber, Karsten Bamminger, Stefan Poschner, Ivo Rausch, Natalie Schindler, Irene Hernández Lozano, Walter Jäger, Lukas Nics, Nicolas Tournier, Marcus Hacker, Markus Zeitlinger, Martin Bauer, Oliver Langer. St. John's wort extract with a high hyperforin content does not induce P-glycoprotein activity at the human blood-brain barrier.
Clinical and translational science.
2024 May; 17(5):e13804. doi:
10.1111/cts.13804
. [PMID: 38700454] - Walaa A El-Dakroury, Moataz B Zewail, Gihan F Asaad, Heba M I Abdallah, Marwa E Shabana, Abdelrahman R Said, Ahmed S Doghish, Hadeer A Azab, Dalia H Amer, Ahmed E Hassan, Alaa S Sayed, Ghada M Samra, Al-Aliaa M Sallam. Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for ulcerative colitis.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2024 Mar; 196(?):114205. doi:
10.1016/j.ejpb.2024.114205
. [PMID: 38311187] - Shingen Misaka, Yuko Ono, R Verena Taudte, Eva Hoier, Hiroshi Ogata, Tomoyuki Ono, Jörg König, Hiroshi Watanabe, Martin F Fromm, Kenju Shimomura. Exposure of Fexofenadine, but Not Pseudoephedrine, Is Markedly Decreased by Green Tea Extract in Healthy Volunteers.
Clinical pharmacology and therapeutics.
2022 09; 112(3):627-634. doi:
10.1002/cpt.2682
. [PMID: 35678032] - A Ningombam, S Handa, N Srivastava, R Mahajan, D De. Addition of oral fexofenadine to topical therapy leads to a significantly greater reduction in the serum interleukin-31 levels in mild to moderate paediatric atopic dermatitis.
Clinical and experimental dermatology.
2022 Apr; 47(4):724-729. doi:
10.1111/ced.15032
. [PMID: 34826148] - Amal A Sultan, Nourhan F El Nashar, Shimaa M Ashmawy, Gamal M El Maghraby. Cubosomes for Enhancing Intestinal Absorption of Fexofenadine Hydrochloride: In situ and in vivo Investigation.
International journal of nanomedicine.
2022; 17(?):3543-3560. doi:
10.2147/ijn.s370235
. [PMID: 35983479] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Qiu-Shi Xie, Jia-Xin Zhang, Ming Liu, Pei-Hua Liu, Zhong-Jian Wang, Liang Zhu, Ling Jiang, Meng-Meng Jin, Xiao-Nan Liu, Li Liu, Xiao-Dong Liu. Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine.
Acta pharmacologica Sinica.
2021 Mar; 42(3):470-481. doi:
10.1038/s41401-020-0402-x
. [PMID: 32555444] - Yingying Zhao, Zhimin Miao, Mingzhao Jiang, Xuan Zhou, Yong Lai. Effects of breviscapine and C3435T MDR1 gene polymorphism on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Mar; 51(3):366-372. doi:
10.1080/00498254.2020.1857467
. [PMID: 33256506] - Alexey V Shchulkin, Yulia V Abalenikhina, Pelageya D Erokhina, Ivan V Chernykh, Elena N Yakusheva. The Role of P-Glycoprotein in Decreasing Cell Membranes Permeability during Oxidative Stress.
Biochemistry. Biokhimiia.
2021 Feb; 86(2):197-206. doi:
10.1134/s0006297921020085
. [PMID: 33832418] - Piñeyro-Garza Everardo, Gómez-Silva Magdalena, Gamino-Peña Maria Elena, Cohen-Muñoz Vanessa, Sánchez-Casado Gabriela. Bioavailability assessment of fexofenadine and montelukast in a fixed-dose combination tablet versus the components administered simultaneously.
Allergologia et immunopathologia.
2021; 49(4):15-25. doi:
10.15586/aei.v49i4.89
. [PMID: 34224214] - Erlend Johannessen Egeland, Bartlomiej J Witczak, Hasse Khiabani Zaré, Hege Christensen, Anders Åsberg, Ida Robertsen. Chronic Inhibition of CYP3A is Temporarily Reduced by Each Hemodialysis Session in Patients With End-Stage Renal Disease.
Clinical pharmacology and therapeutics.
2020 10; 108(4):866-873. doi:
10.1002/cpt.1875
. [PMID: 32356565] - Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
Drug metabolism and pharmacokinetics.
2020 Aug; 35(4):389-396. doi:
10.1016/j.dmpk.2020.05.004
. [PMID: 32690433] - Khalid Hassan. Urticaria and angioedema as a prodromal cutaneous manifestation of SARS-CoV-2 (COVID-19) infection.
BMJ case reports.
2020 Jul; 13(7):. doi:
10.1136/bcr-2020-236981
. [PMID: 32641443] - Ling Zou, Peter Spanogiannopoulos, Lindsey M Pieper, Huan-Chieh Chien, Wenlong Cai, Natalia Khuri, Joshua Pottel, Bianca Vora, Zhanglin Ni, Eleftheria Tsakalozou, Wenjun Zhang, Brian K Shoichet, Kathleen M Giacomini, Peter J Turnbaugh. Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives.
Proceedings of the National Academy of Sciences of the United States of America.
2020 07; 117(27):16009-16018. doi:
10.1073/pnas.1920483117
. [PMID: 32571913] - Leonardo Pinto, Fernanda de Lima Moreira, Glauco Henrique Balthazar Nardotto, Ricardo Carvalho Cavalli, Elaine Christine Dantas Moisés, Geraldo Duarte, Vera Lucia Lanchote. Chiral Discrimination of P-glycoprotein in Parturient Women: Effect of Fluoxetine on Maternal-Fetal Fexofenadine Pharmacokinetics.
Pharmaceutical research.
2020 Jun; 37(7):131. doi:
10.1007/s11095-020-02854-4
. [PMID: 32557079] - Leonardo Santos Ribeiro Pinto, Gabriel Tavares do Vale, Fernanda de Lima Moreira, Maria Paula Marques, Eduardo Barbosa Coelho, Ricardo Carvalho Cavalli, Vera Lucia Lanchote. Direct chiral LC-MS/MS analysis of fexofenadine enantiomers in plasma and urine with application in a maternal-fetal pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 May; 1145(?):122094. doi:
10.1016/j.jchromb.2020.122094
. [PMID: 32311673] - Sara Batista do Nascimento, Mariana de Lima Nascimento, Laís Lobato de Araújo, Flávio Martins de Oliveira, Maria do Carmo Vieira, Joaquim Maurício Duarte-Almeida, João Máximo Siqueira, Isabela da Costa César, Hartmut Derendorf, Whocely Victor de Castro. Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-glycoprotein.
Current drug metabolism.
2020; 21(4):281-290. doi:
10.2174/1389200221666200512112718
. [PMID: 32394829] - Diego A C Cusinato, Edson Z Martinez, Mônica T C Cintra, Gabriela C O Filgueira, Andresa A Berretta, Vera L Lanchote, Eduardo B Coelho. Evaluation of potential herbal-drug interactions of a standardized propolis extract (EPP-AF®) using an in vivo cocktail approach.
Journal of ethnopharmacology.
2019 Dec; 245(?):112174. doi:
10.1016/j.jep.2019.112174
. [PMID: 31442620] - Cheng-Zhi Huang, Zhi-Hui Jiang, Jian Wang, Yue Luo, Hua Peng. Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials.
BMC pharmacology & toxicology.
2019 11; 20(1):72. doi:
10.1186/s40360-019-0363-1
. [PMID: 31783781] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964
. [PMID: 31515284] - Samantha Medwid, Mandy M J Li, Michael J Knauer, Kathleen Lin, Sara E Mansell, Crystal L Schmerk, Catherine Zhu, Katelyn E Griffin, Mohamed D Yousif, George K Dresser, Ute I Schwarz, Richard B Kim, Rommel G Tirona. Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1.
Drug metabolism and disposition: the biological fate of chemicals.
2019 08; 47(8):832-842. doi:
10.1124/dmd.119.087619
. [PMID: 31123035] - Emiliano Calvo, Jong-Seok Lee, Sang-We Kim, Victor Moreno, Javier deCastro Carpeno, Doris Weilert, Gianluca Laus, Helen Mann, Karthick Vishwanathan. Modulation of Fexofenadine Pharmacokinetics by Osimertinib in Patients With Advanced EGFR-Mutated Non-Small Cell Lung Cancer.
Journal of clinical pharmacology.
2019 08; 59(8):1099-1109. doi:
10.1002/jcph.1403
. [PMID: 30875094] - Natalia Karolina Kordulewska, Elżbieta Kostyra, Barbara Chwała, Małgorzata Moszyńska, Anna Cieślińska, Ewa Fiedorowicz, Beata Jarmołowska. A novel concept of immunological and allergy interactions in autism spectrum disorders: Molecular, anti-inflammatory effect of osthole.
International immunopharmacology.
2019 Jul; 72(?):1-11. doi:
10.1016/j.intimp.2019.01.058
. [PMID: 30953868] - Diego Alberto Ciscato Cusinato, Gabriela Campos de Oliveira Filgueira, Adriana Rocha, Monica Akissue C T Cintra, Vera Lucia Lanchote, Eduardo Barbosa Coelho. LC-MS/MS analysis of the plasma concentrations of a cocktail of 5 cytochrome P450 and P-glycoprotein probe substrates and their metabolites using subtherapeutic doses.
Journal of pharmaceutical and biomedical analysis.
2019 Feb; 164(?):430-441. doi:
10.1016/j.jpba.2018.10.029
. [PMID: 30445356] - Alireza Derakhshan, Mahmood Khodadoost, Mostafa Ghanei, Latif Gachkar, Homa Hajimahdipour, Ali Taghipour, Jaleh Yousefi, Maryam Khoshkhui, Farahzad J Azad. Effects of a Novel Barley-Based Formulation on Allergic Rhinitis: A Randomized Controlled Trial.
Endocrine, metabolic & immune disorders drug targets.
2019; 19(8):1224-1231. doi:
10.2174/1871530319666190306100611
. [PMID: 30843497] - Michael J Myers, Marilyn Martinez, Fei Li, Karyn Howard, Haile F Yancy, Lisa Troutman, Michele Sharkey. Impact of ABCB1 genotype in Collies on the pharmacokinetics of R- and S-fexofenadine.
Journal of veterinary pharmacology and therapeutics.
2018 Dec; 41(6):805-814. doi:
10.1111/jvp.12696
. [PMID: 30020547] - Tsuyoshi Karibe, Tomoki Imaoka, Koji Abe, Osamu Ando. Curcumin as an In Vivo Selective Intestinal Breast Cancer Resistance Protein Inhibitor in Cynomolgus Monkeys.
Drug metabolism and disposition: the biological fate of chemicals.
2018 05; 46(5):667-679. doi:
10.1124/dmd.117.078931
. [PMID: 29358184] - Cecilie Hurup Munkboel, Stine Bjerregaard Hasselstrøm, David Møbjerg Kristensen, Bjarne Styrishave. Effects of antihistamines on the H295R steroidogenesis - Autocrine up-regulation following 3β-HSD inhibition.
Toxicology in vitro : an international journal published in association with BIBRA.
2018 Apr; 48(?):302-309. doi:
10.1016/j.tiv.2018.01.026
. [PMID: 29409762] - Yumiko Akamine, Masatomo Miura. An update on the clinical pharmacokinetics of fexofenadine enantiomers.
Expert opinion on drug metabolism & toxicology.
2018 Apr; 14(4):429-434. doi:
10.1080/17425255.2018.1459565
. [PMID: 29635947] - Kentaro Ando, Yuji Nakamura, Mihoko Hagiwara-Nagasawa, Hiroyuki Harada, Hiroyoshi Miyamoto, Naoki Inamura, Kan Takagi, Ai Goto, Koki Chiba, Nur Jaharat Lubna, Hiroko Izumi-Nakaseko, Atsuhiko T Naito, Atsushi Sugiyama. Comparison of electropharmacological effects between terfenadine and its active derivative fexofenadine using a cross-over study in halothane-anesthetized dogs to analyze variability of pharmacodynamic and pharmacokinetic profiles of terfenadine and torsadogenic risk of fexofenadine.
The Journal of toxicological sciences.
2018; 43(3):183-192. doi:
10.2131/jts.43.183
. [PMID: 29540652] - T Vanhove, T Bouillon, H de Loor, P Annaert, Drj Kuypers. Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients.
Clinical pharmacology and therapeutics.
2017 Dec; 102(6):989-996. doi:
10.1002/cpt.718
. [PMID: 28437851] - Jingjing Yu, Zhu Zhou, Jessica Tay-Sontheimer, René H Levy, Isabelle Ragueneau-Majlessi. Intestinal Drug Interactions Mediated by OATPs: A Systematic Review of Preclinical and Clinical Findings.
Journal of pharmaceutical sciences.
2017 09; 106(9):2312-2325. doi:
10.1016/j.xphs.2017.04.004
. [PMID: 28414144] - Meng Yan, Lifang Feng, Yanhui Shi, Junnan Wang, Yan Liu, Fengmei Li, Baoxin Li. Mechanism of As2O3-Induced Action Potential Prolongation and Using hiPS-CMs to Evaluate the Rescue Efficacy of Drugs With Different Rescue Mechanism.
Toxicological sciences : an official journal of the Society of Toxicology.
2017 08; 158(2):379-390. doi:
10.1093/toxsci/kfx098
. [PMID: 28521025] - Satish Kumar Bedada, Ramgopal Appani, Praveen Kumar Boga. Capsaicin pretreatment enhanced the bioavailability of fexofenadine in rats by P-glycoprotein modulation: in vitro, in situ and in vivo evaluation.
Drug development and industrial pharmacy.
2017 Jun; 43(6):932-938. doi:
10.1080/03639045.2017.1285310
. [PMID: 28102715] - Laxmi N Jattinagoudar, Sharanappa T Nandibewoor, Shivamurti A Chimatadar. Binding of fexofenadine hydrochloride to bovine serum albumin: structural considerations by spectroscopic techniques and molecular docking.
Journal of biomolecular structure & dynamics.
2017 May; 35(6):1200-1214. doi:
10.1080/07391102.2016.1183229
. [PMID: 27109454] - Jasmina Turkanovic, Michael B Ward, Jacobus P Gerber, Robert W Milne. Effect of Garlic, Gingko, and St. John's Wort Extracts on the Pharmacokinetics of Fexofenadine: A Mechanistic Study.
Drug metabolism and disposition: the biological fate of chemicals.
2017 05; 45(5):569-575. doi:
10.1124/dmd.116.073528
. [PMID: 28188296] - Fei Li, Karyn D Howard, Michael J Myers. Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers.
The Journal of pharmacy and pharmacology.
2017 Mar; 69(3):274-284. doi:
10.1111/jphp.12687
. [PMID: 28090646] - Satish Kumar Bedada, Praveen Kumar Boga. The influence of piperine on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers.
European journal of clinical pharmacology.
2017 Mar; 73(3):343-349. doi:
10.1007/s00228-016-2173-3
. [PMID: 27981349] - Satish Kumar Bedada, Praveen Kumar Boga, Harish Kaushik Kotakonda. The effect of diosmin on the pharmacokinetics of fexofenadine in healthy human volunteers.
Xenobiotica; the fate of foreign compounds in biological systems.
2017 Mar; 47(3):230-235. doi:
10.1080/00498254.2016.1180564
. [PMID: 27151911] - Min-Gul Kim, Yunjeong Kim, Ji-Young Jeon, Dal-Sik Kim. Effect of fermented red ginseng on cytochrome P450 and P-glycoprotein activity in healthy subjects, as evaluated using the cocktail approach.
British journal of clinical pharmacology.
2016 12; 82(6):1580-1590. doi:
10.1111/bcp.13080
. [PMID: 27495955] - Natalia Karolina Kordulewska, Elżbieta Kostyra, Anna Cieślińska, Ewa Fiedorowicz, Beata Jarmołowska. Cytokine production by PBMC and serum from allergic and non-allergic subjects following in vitro histamine stimulation to test fexofenadine and osthole anti-allergic properties.
European journal of pharmacology.
2016 Nov; 791(?):763-772. doi:
10.1016/j.ejphar.2016.10.020
. [PMID: 27756601] - Natsumi Hama, Yutaka Shimomura, Hiroshi Arinami, Ryoko Maruyama, Riichiro Abe. Localized heat urticaria: Positive reaction of preheated autologous serum skin test.
The Journal of dermatology.
2016 Sep; 43(9):1099-100. doi:
10.1111/1346-8138.13356
. [PMID: 26970386] - S A Helmy, H M El Bedaiwy. HPLC Determination of Fexofenadine in Human Plasma For Therapeutic Drug Monitoring and Pharmacokinetic Studies.
Biomedical chromatography : BMC.
2016 Jul; 30(7):1059-1064. doi:
10.1002/bmc.3650
. [PMID: 26577375] - Satish Kumar Bedada, Narsimha Reddy Yellu, Prasad Neerati. Effect of resveratrol on the pharmacokinetics of fexofenadine in rats: Involvement of P-glycoprotein inhibition.
Pharmacological reports : PR.
2016 Apr; 68(2):338-43. doi:
10.1016/j.pharep.2015.08.018
. [PMID: 26922536] - Yumiko Akamine, Masatomo Miura, Hisakazu Komori, Ikumi Tamai, Ichiro Ieiri, Norio Yasui-Furukori, Tsukasa Uno. The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion.
Drug metabolism and pharmacokinetics.
2015 Oct; 30(5):352-7. doi:
10.1016/j.dmpk.2015.06.005
. [PMID: 26213156] - Erik Sjögren, David Dahlgren, Carl Roos, Hans Lennernäs. Human in vivo regional intestinal permeability: quantitation using site-specific drug absorption data.
Molecular pharmaceutics.
2015 Jun; 12(6):2026-39. doi:
10.1021/mp500834v
. [PMID: 25919764] - Shuwen Jiang, Weiman Zhao, Yang Chen, Zeyu Zhong, Mian Zhang, Feng Li, Ping Xu, Kaijing Zhao, Ying Li, Li Liu, Xiaodong Liu. Paroxetine decreased plasma exposure of glyburide partly via inhibiting intestinal absorption in rats.
Drug metabolism and pharmacokinetics.
2015 Jun; 30(3):240-6. doi:
10.1016/j.dmpk.2015.02.004
. [PMID: 25890690] - Prasad Neerati, Satish Kumar Bedada. Effect of diosmin on the intestinal absorption and pharmacokinetics of fexofenadine in rats.
Pharmacological reports : PR.
2015 Apr; 67(2):339-44. doi:
10.1016/j.pharep.2014.09.010
. [PMID: 25712660] - Benjamin K A Thomson, Thomas D Nolin, Thomas J Velenosi, David A Feere, Michael J Knauer, Linda J Asher, Andrew A House, Bradley L Urquhart. Effect of CKD and dialysis modality on exposure to drugs cleared by nonrenal mechanisms.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2015 Apr; 65(4):574-82. doi:
10.1053/j.ajkd.2014.09.015
. [PMID: 25453994] - Ayahisa Watanabe, Ryosuke Watari, Keiko Ogawa, Ryosuke Shimizu, Yukari Tanaka, Nozomi Takai, Ken-ichi Nezasa, Yoshitaka Yamaguchi. Using improved serial blood sampling method of mice to study pharmacokinetics and drug-drug interaction.
Journal of pharmaceutical sciences.
2015 Mar; 104(3):955-61. doi:
NULL
. [PMID: 25452230] - Kotaro Hiraoka, Manabu Tashiro, Thomas Grobosch, Marcus Maurer, Keiichi Oda, Jun Toyohara, Kenji Ishii, Kiichi Ishiwata, Kazuhiko Yanai. Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine.
Expert opinion on drug safety.
2015 Feb; 14(2):199-206. doi:
10.1517/14740338.2015.989831
. [PMID: 25466429] - Y Akamine, M Miura, N Yasui-Furukori, I Ieiri, T Uno. Effects of multiple-dose rifampicin 450 mg on the pharmacokinetics of fexofenadine enantiomers in Japanese volunteers.
Journal of clinical pharmacy and therapeutics.
2015 Feb; 40(1):98-103. doi:
10.1111/jcpt.12213
. [PMID: 25263393] - Mudalige Don Vajira Malin Gunawardena, Anura Weerasinghe, Jagath Herath, Naomali Amarasena. Myocardial infarction associated with eosinophilia and plasma extravasation at multiple sites. A variant of Kounis syndrome.
BMJ case reports.
2015 Jan; 2015(?):. doi:
10.1136/bcr-2014-207987
. [PMID: 25608982] - Soad Ali Yehia, Mohamed Shafik El-Ridi, Mina Ibrahim Tadros, Nolwa Gamal El-Sherif. Phenylalanine-free taste-masked orodispersible tablets of fexofenadine hydrochloride: development, in vitro evaluation and in vivo estimation of the drug pharmacokinetics in healthy human volunteers.
Pharmaceutical development and technology.
2015; 20(5):528-39. doi:
10.3109/10837450.2014.882942
. [PMID: 24490806] - Meng Yan, Kaiping Zhang, Yanhui Shi, Lifang Feng, Lin Lv, Baoxin Li. Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency.
Drug design, development and therapy.
2015; 9(?):5737-47. doi:
10.2147/dddt.s91561
. [PMID: 26543354] - Ellen Mueller Fox, Christopher P Morris, Marc P Hübner, Edward Mitre. Histamine 1 Receptor Blockade Enhances Eosinophil-Mediated Clearance of Adult Filarial Worms.
PLoS neglected tropical diseases.
2015; 9(7):e0003932. doi:
10.1371/journal.pntd.0003932
. [PMID: 26204515] - Takumi Tomono, Kyoma Otsuka, Kentaro Yano, Masahiko Kanagawa, Hiroshi Arakawa, Takuo Ogihara. Recommended Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of P-Glycoprotein Substrates in Rats.
Biological & pharmaceutical bulletin.
2015; 38(12):1960-3. doi:
10.1248/bpb.b15-00392
. [PMID: 26632187] - Yumiko Akamine. [Determinants of the stereoselective pharmacokinetics of fexofenadine].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2015; 135(3):473-81. doi:
10.1248/yakushi.14-00218
. [PMID: 25759055] - M Bosilkovska, C F Samer, J Déglon, M Rebsamen, C Staub, P Dayer, B Walder, J A Desmeules, Y Daali. Geneva cocktail for cytochrome p450 and P-glycoprotein activity assessment using dried blood spots.
Clinical pharmacology and therapeutics.
2014 Sep; 96(3):349-59. doi:
10.1038/clpt.2014.83
. [PMID: 24722393] - Yumiko Akamine, Masatomo Miura, Hisakazu Komori, Shun Saito, Hiroyuki Kusuhara, Ikumi Tamai, Ichiro Ieiri, Tsukasa Uno, Norio Yasui-Furukori. Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers.
European journal of clinical pharmacology.
2014 Sep; 70(9):1087-95. doi:
10.1007/s00228-014-1705-y
. [PMID: 24903351] - Rajendraprasad Muppavarapu, Swati Guttikar, Manavalan Rajappan, Kannan Kamarajan, Ramesh Mullangi. Sensitive LC-MS/MS-ESI method for simultaneous determination of montelukast and fexofenadine in human plasma: application to a bioequivalence study.
Biomedical chromatography : BMC.
2014 Aug; 28(8):1048-56. doi:
10.1002/bmc.3114
. [PMID: 24424850] - Basanth Babu Eedara, Prabhakar Reddy Veerareddy, Raju Jukanti, Suresh Bandari. Improved oral bioavailability of fexofenadine hydrochloride using lipid surfactants: ex vivo, in situ and in vivo studies.
Drug development and industrial pharmacy.
2014 Aug; 40(8):1030-43. doi:
10.3109/03639045.2013.801984
. [PMID: 23738504] - Vineesh V Raveendran, Karen M Kassel, Donald D Smith, James P Luyendyk, Kurt J Williams, Rachel Cherian, Gregory A Reed, Colleen A Flynn, Iván L Csanaky, Andrew L Lickteig, Matthew J Pratt-Hyatt, Curtis D Klaassen, Kottarappat N Dileepan. H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice.
American journal of physiology. Gastrointestinal and liver physiology.
2014 Jul; 307(2):G219-28. doi:
10.1152/ajpgi.00027.2014
. [PMID: 24852568] - Erik Sjögren, Mikael Hedeland, Ulf Bondesson, Hans Lennernäs. Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Jun; 57(?):214-23. doi:
10.1016/j.ejps.2013.09.014
. [PMID: 24075962] - André Mateus, Pär Matsson, Per Artursson. A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Journal of medicinal chemistry.
2014 Apr; 57(7):3005-10. doi:
10.1021/jm401963n
. [PMID: 24601604] - Melanie S Joy, Reginald F Frye, Thomas D Nolin, Brittney V Roberts, Mary K La, Jinzhao Wang, Kim L R Brouwer, Mary Anne Dooley, Ronald J Falk. In vivo alterations in drug metabolism and transport pathways in patients with chronic kidney diseases.
Pharmacotherapy.
2014 Feb; 34(2):114-22. doi:
10.1002/phar.1347
. [PMID: 24038489] - Marija Bosilkovska, Julien Déglon, Caroline Samer, Bernhard Walder, Jules Desmeules, Christian Staub, Youssef Daali. Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma.
Bioanalysis.
2014 Jan; 6(2):151-64. doi:
10.4155/bio.13.289
. [PMID: 24423593] - Vineesh V Raveendran, Donald D Smith, Xiaoyu Tan, Matthew E Sweeney, Gregory A Reed, Colleen A Flynn, Ossama W Tawfik, Ginger Milne, Kottarappat N Dileepan. Chronic ingestion of H1-antihistamines increase progression of atherosclerosis in apolipoprotein E-/- mice.
PloS one.
2014; 9(7):e102165. doi:
10.1371/journal.pone.0102165
. [PMID: 25020133] - Yoshiki Matsuda, Yoshihiro Konno, Takashi Hashimoto, Mika Nagai, Takayuki Taguchi, Masahiro Satsukawa, Shinji Yamashita. In vivo assessment of the impact of efflux transporter on oral drug absorption using portal vein-cannulated rats.
Drug metabolism and disposition: the biological fate of chemicals.
2013 Aug; 41(8):1514-21. doi:
10.1124/dmd.113.051680
. [PMID: 23686319] - Ichiro Ieiri, Shyohei Tsunemitsu, Kazuya Maeda, Yukie Ando, Noritomo Izumi, Miyuki Kimura, Naoe Yamane, Tsuyoshi Okuzono, Mariko Morishita, Naoki Kotani, Eri Kanda, Mariko Deguchi, Kyoko Matsuguma, Shunji Matsuki, Takeshi Hirota, Shin Irie, Hiroyuki Kusuhara, Yuichi Sugiyama. Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam (CYP3A4), fexofenadine (p-glycoprotein), and pravastatin (OATP1B1) as probe drugs.
Journal of clinical pharmacology.
2013 Jun; 53(6):654-61. doi:
10.1002/jcph.62
. [PMID: 23381882] - Nicole Schoepke, Martin K Church, Marcus Maurer. The inhibition by levocetirizine and fexofenadine of the histamine-induced wheal and flare response in healthy Caucasian and Japanese volunteers.
Acta dermato-venereologica.
2013 May; 93(3):286-93. doi:
10.2340/00015555-1490
. [PMID: 23147964] - Quan Zhou, Zhen Ye, Zourong Ruan, Su Zeng. Investigation on modulation of human P-gp by multiple doses of Radix Astragali extract granules using fexofenadine as a phenotyping probe.
Journal of ethnopharmacology.
2013 Apr; 146(3):744-9. doi:
10.1016/j.jep.2013.01.037
. [PMID: 23422332] - Ken Grime, Stuart W Paine. Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement.
Drug metabolism and disposition: the biological fate of chemicals.
2013 Feb; 41(2):372-8. doi:
10.1124/dmd.112.049312
. [PMID: 23139379] - Hiroyuki Kusuhara, Masatomo Miura, Norio Yasui-Furukori, Kenta Yoshida, Yumiko Akamine, Miyu Yokochi, Shinya Fukizawa, Kazuaki Ikejiri, Kayoko Kanamitsu, Tsukasa Uno, Yuichi Sugiyama. Effect of coadministration of single and multiple doses of rifampicin on the pharmacokinetics of fexofenadine enantiomers in healthy subjects.
Drug metabolism and disposition: the biological fate of chemicals.
2013 Jan; 41(1):206-13. doi:
10.1124/dmd.112.048330
. [PMID: 23115085] - Atsuko Tomaru, Mariko Takeda-Morishita, Hirokazu Banba, Kozo Takayama. Analysis of the pharmacokinetic boosting effects of ritonavir on oral bioavailability of drugs in mice.
Drug metabolism and pharmacokinetics.
2013; 28(2):144-52. doi:
10.2133/dmpk.dmpk-12-rg-057
. [PMID: 22971642] - Kayoko Ohura, Toshimitsu Soejima, Ryoichi Nogata, Yasuhisa Adachi, Shin-ichi Ninomiya, Teruko Imai. Effect of intestinal first-pass hydrolysis on the oral bioavailability of an ester prodrug of fexofenadine.
Journal of pharmaceutical sciences.
2012 Sep; 101(9):3264-74. doi:
10.1002/jps.23182
. [PMID: 22628163] - Kei Suzuki, Yoshihisa Shitara, Kousuke Fukuda, Toshiharu Horie. Long-lasting inhibition of the intestinal absorption of fexofenadine by cyclosporin A in rats.
Journal of pharmaceutical sciences.
2012 Jul; 101(7):2606-15. doi:
10.1002/jps.23174
. [PMID: 22538465] - Fu Qiang, Hyun-Jae Shin, Beom-Jin Lee, Hyo-Kyung Han. Enhanced systemic exposure of fexofenadine via the intranasal administration of chitosan-coated liposome.
International journal of pharmaceutics.
2012 Jul; 430(1-2):161-6. doi:
10.1016/j.ijpharm.2012.04.007
. [PMID: 22525082] - Christine Y Malati, Sarah M Robertson, Jennifer D Hunt, Cheryl Chairez, Raul M Alfaro, Joseph A Kovacs, Scott R Penzak. Influence of Panax ginseng on cytochrome P450 (CYP)3A and P-glycoprotein (P-gp) activity in healthy participants.
Journal of clinical pharmacology.
2012 Jun; 52(6):932-9. doi:
10.1177/0091270011407194
. [PMID: 21646440] - Sam Rebello, Sally Zhao, Sam Hariry, Marion Dahlke, Natalya Alexander, Arpine Vapurcuyan, Imad Hanna, Venkateswar Jarugula. Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects.
European journal of clinical pharmacology.
2012 May; 68(5):697-708. doi:
10.1007/s00228-011-1167-4
. [PMID: 22124880] - Marie Croft, Brendan Keely, Ian Morris, Lan Tann, Graham Lappin. Predicting drug candidate victims of drug-drug interactions, using microdosing.
Clinical pharmacokinetics.
2012 Apr; 51(4):237-46. doi:
10.2165/11597070-000000000-00000
. [PMID: 22335429] - E D Kharasch, D Whittington, D Ensign, C Hoffer, P S Bedynek, S Campbell, K Stubbert, A Crafford, A London, T Kim. Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics.
Clinical pharmacology and therapeutics.
2012 Apr; 91(4):673-84. doi:
10.1038/clpt.2011.276
. [PMID: 22398970] - Junji Saruwatari, Norio Yasui-Furukori, Takenori Niioka, Yumiko Akamine, Ayaka Takashima, Sunao Kaneko, Tsukasa Uno. Different effects of the selective serotonin reuptake inhibitors fluvoxamine, paroxetine, and sertraline on the pharmacokinetics of fexofenadine in healthy volunteers.
Journal of clinical psychopharmacology.
2012 Apr; 32(2):195-9. doi:
10.1097/jcp.0b013e318248ddb9
. [PMID: 22367658] - Samar Farha, Jacqueline Sharp, Kewal Asosingh, Margaret Park, Suzy A A Comhair, W H Wilson Tang, Jim Thomas, Carol Farver, Fred Hsieh, James E Loyd, Serpil C Erzurum. Mast cell number, phenotype, and function in human pulmonary arterial hypertension.
Pulmonary circulation.
2012 Apr; 2(2):220-8. doi:
10.4103/2045-8932.97609
. [PMID: 22837863] - Yumiko Akamine, Masatomo Miura, Norio Yasui-Furukori, Midori Kojima, Tsukasa Uno. Carbamazepine differentially affects the pharmacokinetics of fexofenadine enantiomers.
British journal of clinical pharmacology.
2012 Mar; 73(3):478-81. doi:
10.1111/j.1365-2125.2011.04106.x
. [PMID: 21950458] - Fabrizio Piras, Francesca Salani, Paola Bossù, Carlo Caltagirone, Gianfranco Spalletta. High serum levels of transforming growth factor β1 are associated with increased cortical thickness in cingulate and right frontal areas in healthy subjects.
Journal of neuroinflammation.
2012 Feb; 9(?):42. doi:
10.1186/1742-2094-9-42
. [PMID: 22373370] - Evan D Kharasch, Pamela Sheffels Bedynek, Christine Hoffer, Alysa Walker, Dale Whittington. Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A).
Anesthesiology.
2012 Feb; 116(2):432-47. doi:
10.1097/aln.0b013e3182423478
. [PMID: 22273859] - Jessica Wong, Robert Phelps, Jacob Levitt. Treatment of acquired perforating dermatosis with cantharidin.
Archives of dermatology.
2012 Feb; 148(2):160-2. doi:
10.1001/archdermatol.2011.350
. [PMID: 22351815] - Daniel J McGrail, Deepraj Ghosh, Nhat D Quach, Michelle R Dawson. Differential mechanical response of mesenchymal stem cells and fibroblasts to tumor-secreted soluble factors.
PloS one.
2012; 7(3):e33248. doi:
10.1371/journal.pone.0033248
. [PMID: 22438903] - Carolyn Tam, Deborah O'Connor, Gideon Koren. Circulating unmetabolized folic Acid: relationship to folate status and effect of supplementation.
Obstetrics and gynecology international.
2012; 2012(?):485179. doi:
10.1155/2012/485179
. [PMID: 22529856] - Cristiano Longo, Lucia Leo, Antonella Leone. Carotenoids, fatty acid composition and heat stability of supercritical carbon dioxide-extracted-oleoresins.
International journal of molecular sciences.
2012; 13(4):4233-54. doi:
10.3390/ijms13044233
. [PMID: 22605975] - Yukari Tanaka, Yutaka Yoshikawa, Hiroyuki Yasui. Development of a highly sensitive methodology for quantitative determination of fexofenadine in a microdose study by multiple injection method using ultra-high performance liquid chromatography with tandem mass spectrometry.
Biological & pharmaceutical bulletin.
2012; 35(5):698-704. doi:
10.1248/bpb.35.698
. [PMID: 22687404] - Pius S Fasinu, Patrick J Bouic, Bernd Rosenkranz. An overview of the evidence and mechanisms of herb-drug interactions.
Frontiers in pharmacology.
2012; 3(?):69. doi:
10.3389/fphar.2012.00069
. [PMID: 22557968] - Daniel Eikel, Marissa Vavrek, Sheri Smith, Carol Bason, Suzie Yeh, Walter A Korfmacher, Jack D Henion. Liquid extraction surface analysis mass spectrometry (LESA-MS) as a novel profiling tool for drug distribution and metabolism analysis: the terfenadine example.
Rapid communications in mass spectrometry : RCM.
2011 Dec; 25(23):3587-96. doi:
10.1002/rcm.5274
. [PMID: 22095508] - Amin Kanani, Robert Schellenberg, Richard Warrington. Urticaria and angioedema.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology.
2011 Nov; 7 Suppl 1(?):S9. doi:
10.1186/1710-1492-7-s1-s9
. [PMID: 22165855] - Xin Ming, Beverly M Knight, Dhiren R Thakker. Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters.
Molecular pharmaceutics.
2011 Oct; 8(5):1677-86. doi:
10.1021/mp200026v
. [PMID: 21780830] - Ewa Cichocka-Jarosz, Lavanya Diwakar, Piotr Brzyski, Beata Tobiasz-Adamczyk, Grzegorz Lis, Jacek J Pietrzyk. Congruence of the current practices in Hymenoptera venom allergic patients in Poland with EAACI guidelines.
Archives of medical science : AMS.
2011 Oct; 7(5):832-9. doi:
10.5114/aoms.2011.25558
. [PMID: 22291828] - Eriko Suwa, Katsunori Yamaura, Manabu Oda, Takao Namiki, Koichi Ueno. Histamine H(4) receptor antagonist reduces dermal inflammation and pruritus in a hapten-induced experimental model.
European journal of pharmacology.
2011 Sep; 667(1-3):383-8. doi:
10.1016/j.ejphar.2011.05.037
. [PMID: 21664903] - Parul Gor, Yazen Alnouti, Gregory A Reed. Buspirone, fexofenadine, and omeprazole: quantification of probe drugs and their metabolites in human plasma.
Journal of pharmaceutical and biomedical analysis.
2011 Jul; 55(5):1127-35. doi:
10.1016/j.jpba.2011.03.043
. [PMID: 21546194]