Pioglitazone (BioDeep_00000002072)

 

Secondary id: BioDeep_00000397572

human metabolite blood metabolite


代谢物信息卡片


(+-)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione

化学式: C19H20N2O3S (356.1195)
中文名称: 匹格列酮, 吡格列酮
谱图信息: 最多检出来源 Homo sapiens(blood) 8.61%

分子结构信息

SMILES: CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
InChI: InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)

描述信息

Pioglitazone is used for the treatment of diabetes mellitus type 2. Pioglitazone selectively stimulates nuclear receptor peroxisone proliferator-activated receptor gamma (PPAR-gamma). It modulates the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the lipidic, muscular tissues and in the liver.
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BG - Thiazolidinediones
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98241 - Thiazolidinedione Antidiabetic Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D007004 - Hypoglycemic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Pioglitazone (U 72107) is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone can be used in diabetes research[2][3][4].

同义名列表

14 个代谢物同义名

(+-)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione; 5-({4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione; 5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione; 5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione; Pioglitazone Hydrochloride; Poglitazone hydrochloride; Pioglitazone HCl; Pioglitazonum; Pioglitazona; Pioglitazone; Actos; U 72107; Pioglitazone; Pioglitazone



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ACE, ADIG, CD36, CYP2C9, CYP3A4, IRS1, RELA, TLR4
Peripheral membrane protein 1 CYP1B1
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 3 CYP1B1, CYP2C9, CYP3A4
Nucleus 3 ADIG, IRS1, RELA
cytosol 3 IRS1, RELA, SLC2A4
phagocytic vesicle 1 CD36
trans-Golgi network 1 SLC2A4
nucleoplasm 2 IRS1, RELA
Cell membrane 9 ACE, AGTR1, AGTR2, CD36, DPP4, GLP1R, SLC2A4, SLC5A2, TLR4
lamellipodium 1 DPP4
Multi-pass membrane protein 6 AGTR1, AGTR2, CD36, GLP1R, SLC2A4, SLC5A2
cell junction 1 DPP4
cell surface 4 ADIPOQ, CD36, DPP4, TLR4
glutamatergic synapse 1 RELA
Golgi apparatus 1 CD36
lysosomal membrane 2 DPP4, GAA
sarcolemma 1 SLC2A4
Lysosome 2 ACE, GAA
Presynapse 1 SLC2A4
endosome 1 ACE
plasma membrane 13 ACE, AGTR1, AGTR2, CD36, CYP2C9, DPP4, GAA, GCG, GLP1R, IRS1, SLC2A4, SLC5A2, TLR4
Membrane 12 ACE, ADIG, AGTR1, CD36, CYP1B1, CYP3A4, DPP4, GAA, GLP1R, SLC2A4, SLC5A2, TLR4
apical plasma membrane 3 CD36, DPP4, SLC5A2
caveola 2 CD36, IRS1
extracellular exosome 5 ACE, DPP4, GAA, SLC2A4, SLC5A2
Lysosome membrane 1 GAA
endoplasmic reticulum 1 ADIPOQ
extracellular space 6 ACE, ADIPOQ, CD36, CRP, GCG, IL10
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 SLC2A4, TLR4
intercellular canaliculus 1 DPP4
mitochondrion 1 CYP1B1
intracellular membrane-bounded organelle 5 CYP1B1, CYP2C9, CYP3A4, GAA, IRS1
Microsome membrane 3 CYP1B1, CYP2C9, CYP3A4
Single-pass type I membrane protein 2 ACE, TLR4
Secreted 8 ACE, ADIG, ADIPOQ, CRP, DPP4, GAA, GCG, IL10
extracellular region 8 ACE, ADIG, ADIPOQ, CRP, DPP4, GAA, GCG, IL10
Single-pass membrane protein 2 ADIG, DPP4
anchoring junction 1 DPP4
transcription regulator complex 1 RELA
external side of plasma membrane 4 ACE, CD36, SLC2A4, TLR4
multivesicular body 1 SLC2A4
T-tubule 1 SLC2A4
Early endosome 1 TLR4
clathrin-coated pit 1 SLC2A4
Single-pass type II membrane protein 1 DPP4
Apical cell membrane 3 CD36, DPP4, SLC5A2
Cytoplasm, perinuclear region 1 SLC2A4
Membrane raft 3 CD36, DPP4, SLC2A4
focal adhesion 1 DPP4
collagen trimer 2 ADIPOQ, CD36
sarcoplasmic reticulum 1 SLC2A4
collagen-containing extracellular matrix 1 ADIPOQ
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 CD36, TLR4
chromatin 1 RELA
phagocytic cup 1 TLR4
cell periphery 1 CD36
brush border membrane 2 ACE, CD36
sperm midpiece 1 ACE
Endomembrane system 2 DPP4, SLC2A4
Lipid droplet 1 ADIG
Cytoplasmic vesicle membrane 1 SLC2A4
specific granule membrane 1 CD36
tertiary granule membrane 1 GAA
basal plasma membrane 1 ACE
clathrin-coated vesicle 1 SLC2A4
trans-Golgi network transport vesicle 1 SLC2A4
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 1 GCG
endoplasmic reticulum lumen 1 GCG
endocytic vesicle membrane 1 CD36
endocytic vesicle 1 DPP4
azurophil granule membrane 1 GAA
vesicle membrane 1 SLC2A4
ficolin-1-rich granule membrane 1 GAA
platelet alpha granule membrane 1 CD36
lamellipodium membrane 1 DPP4
[Glucagon-like peptide 1]: Secreted 1 GCG
Cell projection, lamellipodium membrane 1 DPP4
Cell projection, invadopodium membrane 1 DPP4
insulin receptor complex 1 IRS1
autolysosome lumen 1 GAA
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
insulin-responsive compartment 1 SLC2A4
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
[Dipeptidyl peptidase 4 soluble form]: Secreted 1 DPP4


文献列表

  • Soo Lim, Seung-Hwan Lee, Kyung-Wan Min, Chang Beom Lee, Sang Yong Kim, Hye Jin Yoo, Nan Hee Kim, Jae Hyeon Kim, Seungjoon Oh, Jong Chul Won, Hyuk Sang Kwon, Mi Kyung Kim, Jung Hwan Park, In-Kyung Jeong, Sungrae Kim. A multicentre, double-blind, placebo-controlled, randomized, parallel comparison, phase 3 trial to evaluate the efficacy and safety of pioglitazone add-on therapy in type 2 diabetic patients treated with metformin and dapagliflozin. Diabetes, obesity & metabolism. 2024 Jun; 26(6):2188-2198. doi: 10.1111/dom.15526. [PMID: 38425186]
  • Fatemeh Amin, Arghavan Memarzia, Hamideh Kazemi Rad, Hamid Reza Kazerani, Seyedeh Zahra Ghasemi, Mohammad Hossein Boskabady. Inhaled paraquat-induced lung injury in rat, improved by the extract of Zataria multiflora boiss and PPARγ agonist, pioglitazone. Legal medicine (Tokyo, Japan). 2024 Mar; 67(?):102335. doi: 10.1016/j.legalmed.2023.102335. [PMID: 37951808]
  • Lim Shern Kwok, Shim Siang Yian, Layla Qasim Ismael, Yvonne Tee Get Bee, Gam Lay Harn, Khoo Boon Yin. Vimentin protein is a factor for decreasing breast cancer cell proliferation co-culture with human bone marrow-derived mesenchymal stem cells pre-treated with thiazolidinedione solutions. Molecular biology reports. 2024 Feb; 51(1):317. doi: 10.1007/s11033-024-09269-z. [PMID: 38381204]
  • Yang Shaojun, M A Yanhua, Bai Zhouxia, Y U Ye, Fang Buwu, Zhang Li, Wang Li. Intervention effect of Cigu Xiaozhi prescription on ceramide lipoapoptosis in non-alcoholic fatty liver disease. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Feb; 44(1):63-69. doi: 10.19852/j.cnki.jtcm.20231215.002. [PMID: 38213240]
  • Kwazi Gabuza, Thendo I Mabuda, Oelfah Patel, Noxolo Khuboni, Ruzayda van Aarde, Sylvia Riedel, Nonhlakanipho F Sangweni, Shantal Windvogel, Rabia Johnson, Christo J F Muller. Afriplex GRTTM extract attenuates hepatic steatosis in an in vitro model of NAFLD. PloS one. 2024; 19(4):e0297572. doi: 10.1371/journal.pone.0297572. [PMID: 38630788]
  • Laya Hooshmand Gharabagh, Ali Shargh, Mohammad Reza Mohammad Hosseini Azar, Ayda Esmaeili. Comparison between the effect of Empagliflozin and Pioglitazone added to metformin in patients with type 2 diabetes and nonalcoholic fatty liver disease. Clinics and research in hepatology and gastroenterology. 2023 Dec; 48(3):102279. doi: 10.1016/j.clinre.2023.102279. [PMID: 38159676]
  • Shankar Gupta, Gurkaran Singh Baweja, Shamsher Singh, Mehdi Irani, Rajveer Singh, Vivek Asati. Integrated fragment-based drug design and virtual screening techniques for exploring the antidiabetic potential of thiazolidine-2,4-diones: Design, synthesis and in vivo studies. European journal of medicinal chemistry. 2023 Dec; 261(?):115826. doi: 10.1016/j.ejmech.2023.115826. [PMID: 37793328]
  • Batool Zamani, Seyyed Mashaalah Tabatabizadeh, Hamidreza Gilasi, Shadi Yazdani. Effects of pioglitazone and linagliptin on glycemic control, lipid profile and hs-CRP in metformin-treated patients with type 2 diabetes: a comparative study. Hormone molecular biology and clinical investigation. 2023 Dec; 44(4):385-391. doi: 10.1515/hmbci-2022-0070. [PMID: 38143260]
  • Johanna M Melin, Maria Forslund, Simon J Alesi, Terhi Piltonen, Daniela Romualdi, Poli M Spritzer, Chau Thien Tay, Alexia S Pena, Selma F Witchel, Aya Mousa, Helena J Teede. Effects of different insulin sensitisers in the management of polycystic ovary syndrome: A systematic review and meta-analysis. Clinical endocrinology. 2023 Nov; ?(?):. doi: 10.1111/cen.14983. [PMID: 37933831]
  • Ahmad H Alhowail. Pioglitazone ameliorates DOX-induced cognitive impairment by mitigating inflammation, oxidative stress, and apoptosis of hippocampal neurons in rats. Behavioural brain research. 2023 Oct; ?(?):114714. doi: 10.1016/j.bbr.2023.114714. [PMID: 37838244]
  • Arghavan Memarzia, Seyedeh Zahra Ghasemi, Sepideh Behrouz, Mohammad Hossein Boskabady. The effects of Crocus sativus extract on inhaled paraquat-induced lung inflammation, oxidative stress, pathological changes and tracheal responsiveness in rats. Toxicon : official journal of the International Society on Toxinology. 2023 Oct; ?(?):107316. doi: 10.1016/j.toxicon.2023.107316. [PMID: 37827264]
  • F de Zegher, M Díaz, L Ibáñez. Adolescent polycystic ovary syndrome without obesity: HOTAIR rs1443512 genotype relates to fat mass and to the redistribution of fat mass on low-dose pioglitazone. Journal of endocrinological investigation. 2023 Oct; ?(?):. doi: 10.1007/s40618-023-02206-0. [PMID: 37805962]
  • Moumita Nath, Kasturi Bhattacharjee, Yashmin Choudhury. The antidiabetic drug pioglitazone ameliorates betel-nut-induced carcinogenesis in mice by restoring normal lipid metabolism, reducing oxidative stress, and inducing apoptosis. Journal of cancer research and therapeutics. 2023 Oct; 19(7):1967-1974. doi: 10.4103/jcrt.jcrt_844_22. [PMID: 38376305]
  • Rasool Haddadi, Mohammad Cheraghi-Poor. Peroxisome proliferator activated receptor-gamma (PPAR-γ) ligand, pioglitazone, increases analgesic and anti-inflammatory effects of naproxen. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Sep; ?(?):. doi: 10.1007/s00210-023-02715-y. [PMID: 37698622]
  • Y Pei, Y-Y Liu, M Sun, J Zheng, T-T Zhou, B Wang, H Hu, Z-L Wang. Beneficial effects of pioglitazone and α-lipoic acid in patients with polycystic ovaries syndrome. European review for medical and pharmacological sciences. 2023 Aug; 27(15):7118-7126. doi: 10.26355/eurrev_202308_33285. [PMID: 37606122]
  • Jieying Liu, Dongmei Wang, Ziyan Xie, Lu Ding, Shunhua Li, Xuemei Ma, Jing Liu, Jing Ren, Cheng Xiao, Chunru Yang, Xinhua Xiao. Combination of Pioglitazone and Metformin Actions on Liver Lipid Metabolism in Obese Mice. Biomolecules. 2023 07; 13(8):. doi: 10.3390/biom13081199. [PMID: 37627267]
  • Yanmei Zhong, Yingying Xu, Yongzhen Tan, Xuanxuan Zhang, Ruolun Wang, Danmin Chen, Zhaotao Wang, Xunlong Zhong. Lipidomics of the erythrocyte membrane and network pharmacology to explore the mechanism of mangiferin from Anemarrhenae rhizoma in treating type 2 diabetes mellitus rats. Journal of pharmaceutical and biomedical analysis. 2023 Jun; 230(?):115386. doi: 10.1016/j.jpba.2023.115386. [PMID: 37044004]
  • Silvia Botrous, Ayaat Elmaghraby, Samar El-Achy, Yehia Mustafa, Effat Badr, Amany Haggag, Salah Abdel-Rahman. Inhibition of TNF-α Oncogene Expression by Artemisia Annua L. Extract Against Pioglitazone Side Effects in Male Albino Mice. Molecular biotechnology. 2023 May; ?(?):. doi: 10.1007/s12033-023-00762-7. [PMID: 37179253]
  • Azza A Ali, Eman B Saad, Rana H Abd El-Rhman, Ola M Abd El-Raouf, Amany M Gad. Impact of peroxisome proliferator activated receptor agonist drugs in a model of nephrotoxicity in rats. Journal of biochemical and molecular toxicology. 2023 Mar; ?(?):e23350. doi: 10.1002/jbt.23350. [PMID: 36988379]
  • Mohd Imran, Sahaya Mercy Jaquline Robert, Manju Sharma, Vidhu Aeri. Evaluation of Sida cordifolia and Sida rhombifolia extracts in a rat model of streptozotocin-induced diabetic nephropathy. Polimery w medycynie. 2023 Mar; ?(?):. doi: 10.17219/pim/156847. [PMID: 36975210]
  • Seyedeh Zahra Ghasemi, Sima Beigoli, Arghavan Memarzia, Sepideh Behrouz, Zahra Gholamnezhad, Majid Darroudi, Fatemeh Amin, Mohammad Hossein Boskabady. Paraquat-induced systemic inflammation and oxidative stress in rats improved by Curcuma longa ethanolic extract, curcumin and a PPAR agonist. Toxicon : official journal of the International Society on Toxinology. 2023 Mar; 227(?):107090. doi: 10.1016/j.toxicon.2023.107090. [PMID: 36965712]
  • Han Zhao, Dongxu Wang, Chuan Xing, Bo Lv, Xiaochen Wang, Bing He. Pioglitazone can improve liver sex hormone-binding globulin levels and lipid metabolism in polycystic ovary syndrome by regulating hepatocyte nuclear factor-4α. The Journal of steroid biochemistry and molecular biology. 2023 Feb; 229(?):106265. doi: 10.1016/j.jsbmb.2023.106265. [PMID: 36737028]
  • Jihyun An, Joo Hyun Sohn. Pharmacological advances in the treatment of nonalcoholic fatty liver diseases : focused on global results of randomized controlled trials. Clinical and molecular hepatology. 2023 02; 29(Suppl):S268-S275. doi: 10.3350/cmh.2022.0437. [PMID: 36537018]
  • Piseth Nhoek, Sungjin Ahn, Pisey Pel, Young-Mi Kim, Jungmoo Huh, Hyun Woo Kim, Minsoo Noh, Young-Won Chin. Alkaloids and Coumarins with Adiponectin-Secretion-Promoting Activities from the Leaves of Orixa japonica. Journal of natural products. 2023 01; 86(1):138-148. doi: 10.1021/acs.jnatprod.2c00844. [PMID: 36529937]
  • Thomas J McClelland, Alexander J Fowler, Thomas W Davies, Rupert Pearse, John Prowle, Zudin Puthucheary. Can pioglitazone be used for optimization of nutrition in critical illness? A systematic review. JPEN. Journal of parenteral and enteral nutrition. 2023 Jan; ?(?):. doi: 10.1002/jpen.2481. [PMID: 36700419]
  • L N Tamimi, Z Zakaraya, M Hailat, W Abu Dayyih, E Daoud, A Abed, M J Saadh, B Majeed, H Abumansour, A Aburumman, J M Majeed, M Hamad. Anti-diabetic effect of cotreatment with resveratrol and pioglitazone in diabetic rats. European review for medical and pharmacological sciences. 2023 01; 27(1):325-332. doi: 10.26355/eurrev_202301_30879. [PMID: 36647881]
  • Fu Jianfang, Xiao Wanxia, Gao Xiling, Xu Jing, Yang Wenjuan, Liu Jianrong, He Qingzhen, Ma Kaiyan, Lian Jingxuan, Chen Taixiong, Xu Qian, Li Mengying, Ming Jie, Ji Qiuhe. Effect and Safety of Pioglitazone-Metformin Tablets in the Treatment of Newly Diagnosed Type 2 Diabetes Patients with Nonalcoholic Fatty Liver Disease in Shaanxi Province: A Randomized, Double-Blinded, Double-Simulated Multicenter Study. Journal of diabetes research. 2023; 2023(?):2044090. doi: 10.1155/2023/2044090. [PMID: 37305429]
  • Xuehui Zhang, Xue Chen, Zhe Liang, Maoxiao Nie, Yunfeng Yan, Quanming Zhao. Pioglitazone combined with atorvastatin promotes plaque stabilization in a rabbit model. Vascular. 2022 Dec; 30(6):1205-1212. doi: 10.1177/17085381211040992. [PMID: 34470532]
  • Gary N Landis, Sebastian Ko, Oscar Peng, Brett Bognar, Michael Khmelkov, Hans S Bell, John Tower. A screen of small molecule and genetic modulators of life span in female Drosophila identifies etomoxir, RH5849 and unanticipated temperature effects. Fly. 2022 12; 16(1):397-413. doi: 10.1080/19336934.2022.2149209. [PMID: 36412257]
  • Liudan Chen, Yangu Tao, Jianjun Li, Mengru Kang. Pioglitazone use is associated with reduced risk of Parkinson's disease in patients with diabetes: A systematic review and meta-analysis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2022 Dec; 106(?):154-158. doi: 10.1016/j.jocn.2022.10.023. [PMID: 36335768]
  • Yan Zhao, Wenli Zhao, Hongwu Wang, Ye Zhao, Huaien Bu, Hirokazu Takahashi. Pioglitazone on nonalcoholic steatohepatitis: A systematic review and meta-analysis of 15 RCTs. Medicine. 2022 Nov; 101(46):e31508. doi: 10.1097/md.0000000000031508. [PMID: 36401449]
  • Hager H Shaaban, Ibrahim Alzaim, Ahmed El-Mallah, Rania G Aly, Ahmed F El-Yazbi, Ahmed Wahid. Metformin, pioglitazone, dapagliflozin and their combinations ameliorate manifestations associated with NAFLD in rats via anti-inflammatory, anti-fibrotic, anti-oxidant and anti-apoptotic mechanisms. Life sciences. 2022 Nov; 308(?):120956. doi: 10.1016/j.lfs.2022.120956. [PMID: 36103959]
  • Bruno Vergès. Intestinal lipid absorption and transport in type 2 diabetes. Diabetologia. 2022 10; 65(10):1587-1600. doi: 10.1007/s00125-022-05765-8. [PMID: 35908083]
  • Seung Hyun Lee, Nayoung Kim, Minkyu Kim, Sang-Ho Woo, Inhee Han, Jisu Park, Kyeongdae Kim, Kyu Seong Park, Kibyeong Kim, Dahee Shim, Sang-Eun Park, Jing Yu Zhang, Du-Min Go, Dae-Yong Kim, Won Kee Yoon, Seung-Pyo Lee, Jongsuk Chung, Ki-Wook Kim, Jung Hwan Park, Seung Hyun Lee, Sak Lee, Soo-Jin Ann, Sang-Hak Lee, Hyo-Suk Ahn, Seong Cheol Jeong, Tae Kyeong Kim, Goo Taeg Oh, Woong-Yang Park, Hae-Ock Lee, Jae-Hoon Choi. Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia. Nature communications. 2022 09; 13(1):5461. doi: 10.1038/s41467-022-33202-2. [PMID: 36115863]
  • Hae Jin Kim, In Kyung Jeong, Kyu Yeon Hur, Soo-Kyung Kim, Jung Hyun Noh, Sung Wan Chun, Eun Seok Kang, Eun-Jung Rhee, Sung Hee Choi. Comparison of Efficacy of Glimepiride, Alogliptin, and Alogliptin-Pioglitazone as the Initial Periods of Therapy in Patients with Poorly Controlled Type 2 Diabetes Mellitus: An Open-Label, Multicenter, Randomized, Controlled Study. Diabetes & metabolism journal. 2022 09; 46(5):689-700. doi: 10.4093/dmj.2021.0183. [PMID: 35295073]
  • Yousef Baghcheghi, Farimah Beheshti, Mahmoud Hosseini, Arezoo Gowhari-Shabgah, Mohammad Ali-Hassanzadeh, Mahdiyeh Hedayati-Moghadam. Cardiovascular protective effects of PPARγ agonists in hypothyroid rats: protection against oxidative stress. Clinical and experimental hypertension (New York, N.Y. : 1993). 2022 Aug; 44(6):539-547. doi: 10.1080/10641963.2022.2079669. [PMID: 35722928]
  • Ricardo J Samms, Christine C Cheng, Marcel Fourcaudot, Sami Heikkinen, Ahmed Khattab, John Adams, Eugenio Cersosimo, Curtis Triplitt, Curtis Puckett, Kostas Tsintzas, Andrew C Adams, Muhammad A Abdul-Ghani, Ralph A DeFronzo, Luke Norton. FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes. American journal of physiology. Endocrinology and metabolism. 2022 08; 323(2):E123-E132. doi: 10.1152/ajpendo.00050.2022. [PMID: 35723225]
  • Muneera Waheed Alfarhan, Heba Al-Hussaini, Narayana Kilarkaje. Role of PPAR-γ in diabetes-induced testicular dysfunction, oxidative DNA damage and repair in leptin receptor-deficient obese type 2 diabetic mice. Chemico-biological interactions. 2022 Jul; 361(?):109958. doi: 10.1016/j.cbi.2022.109958. [PMID: 35472412]
  • Xiran Lin, Xianmin Meng, Zhiqi Song, Jingrong Lin. Peroxisome proliferator-activator receptor γ and psoriasis, molecular and cellular biochemistry. Molecular and cellular biochemistry. 2022 Jul; 477(7):1905-1920. doi: 10.1007/s11010-022-04417-0. [PMID: 35348980]
  • Pierre-Axel Monternier, Jaspreet Singh, Parveen Parasar, Pierre Theurey, Sheila DeWitt, Vincent Jacques, Eric Klett, Navtej Kaur, Tavarekere N Nagaraja, David E Moller, Sophie Hallakou-Bozec. Therapeutic potential of deuterium-stabilized (R)-pioglitazone-PXL065-for X-linked adrenoleukodystrophy. Journal of inherited metabolic disease. 2022 07; 45(4):832-847. doi: 10.1002/jimd.12510. [PMID: 35510808]
  • Christian Setz, Maximilian Große, Janina Auth, Maria Fröba, Pia Rauch, Alexander Bausch, Matthew Wright, Ulrich Schubert. Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of Concern. International journal of molecular sciences. 2022 Jun; 23(12):. doi: 10.3390/ijms23126830. [PMID: 35743273]
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