Meperidine (BioDeep_00000002033)
Secondary id: BioDeep_00000397857, BioDeep_00000867698
human metabolite blood metabolite
代谢物信息卡片
ethyl 1-methyl-4-phenylpiperidine-4-carboxylate
化学式: C15H21NO2 (247.1572)
中文名称: 哌替啶
谱图信息:
最多检出来源 Homo sapiens(blood) 9.67%
分子结构信息
SMILES: CCOC(=O)C1(c2ccccc2)CCN(C)CC1
InChI: InChI=1S/C15H21NO2/c1-3-18-14(17)15(9-11-16(2)12-10-15)13-7-5-4-6-8-13/h4-8H,3,9-12H2,1-2H3
描述信息
A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. [PubChem]
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
N - Nervous system > N02 - Analgesics > N02A - Opioids > N02AB - Phenylpiperidine derivatives
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:6754
- KEGG: C07128
- KEGGdrug: D08343
- PubChem: 4058
- HMDB: HMDB0014597
- Metlin: METLIN1127
- DrugBank: DB00454
- ChEMBL: CHEMBL607
- Wikipedia: Pethidine
- MeSH: Meperidine
- chemspider: 3918
- CAS: 53484-75-6
- CAS: 57-42-1
- PMhub: MS000001711
- PubChem: 9338
- NIKKAJI: J4.578K
- RefMet: Meperidine
- KNApSAcK: 6754
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiangjing Wang, Shunyi Wei, Yingfang Ao, Yuping Yang. [Comparison of the early analgesic efficacy of three different drugs after anterior cruciate ligament reconstruction].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2024 Apr; 56(2):293-298. doi:
". [PMID: 38595247] - Osman Akyüz, Bahriye Kılıç, Sertan Gündoğan, Müslüm Ergün, Mehmet Nuri Bodakçı, Soner Çoban, Ahmet Hamdi Tefekli, Kamil Çam. The Effectiveness of Caudal Block with Low Doses of Dexmedetomidine and Pethidine in Transrectal Prostate Biopsy: Preliminary Results.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2022 Mar; 35(3):511-516. doi:
10.1080/08941939.2021.1880671. [PMID: 33550855] - Zeynab Khorablou, Faezeh Shahdost-Fard, Habib Razmi. Voltammetric determination of pethidine in biofluids at a carbon cloth electrode modified by carbon selenide nanofilm.
Talanta.
2022 Mar; 239(?):123131. doi:
10.1016/j.talanta.2021.123131. [PMID: 34920261] - Amanda L Hanafi, Rachel A Reed, Heather N Trenholme, Daniel M Sakai, Clare A Ryan, Michele Barletta, Jane E Quandt, Heather K Knych. Pharmacokinetics and pharmacodynamics of meperidine after intramuscular and subcutaneous administration in horses.
Veterinary surgery : VS.
2021 Feb; 50(2):410-417. doi:
10.1111/vsu.13545. [PMID: 33242227] - Briana D Hamamoto-Hardman, Eugene P Steffey, Daniel S McKemie, Philip H Kass, Heather K Knych. Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses.
BMC veterinary research.
2020 Oct; 16(1):368. doi:
10.1186/s12917-020-02564-4. [PMID: 32998730] - Aykut Kul, Murat Ozdemir, Olcay Sagirli. Determination of pethidine of abuse and relevant metabolite norpethidine in urine by ultra-performance liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2020 Jul; 186(?):113320. doi:
10.1016/j.jpba.2020.113320. [PMID: 32387748] - Abdelwahab Hashem, Fady K Ghobrial, M A Elbaset, Ahmed M Atwa, Mohamed Fadallah, Mahmoud Laymon, Ahmed El-Assmy, Khaled Z Sheir, Hassan Abol-Enein. Efficacy of pethidine, ketorolac, and lidocaine gel as analgesics for pain control in shockwave lithotripsy: A single-blinded randomized controlled trial.
Investigative and clinical urology.
2019 07; 60(4):251-257. doi:
10.4111/icu.2019.60.4.251. [PMID: 31294134] - Xiao-Long Guo, Ling-Zhen Liu, Qi-Quan Wang, Jin-Yang Liang, Wen-Hui Lee, Yang Xiang, Sheng-An Li, Yun Zhang. Endogenous pore-forming protein complex targets acidic glycosphingolipids in lipid rafts to initiate endolysosome regulation.
Communications biology.
2019; 2(?):59. doi:
10.1038/s42003-019-0304-y. [PMID: 30775460] - Jie Cao, Yan Du, Yu-Jin Wang, Bin Wu, Juan Jia, Zhi-Wen Wei, Ke-Ming Yun, Wu Liang, Ying-Yuan Wang, Jun-Hong Sun. Pharmacokinetics of meperidine (pethidine) in rabbit oral fluid: correlation with plasma concentrations after controlled administration.
Die Pharmazie.
2018 06; 73(6):324-328. doi:
10.1691/ph.2018.8014. [PMID: 29880084] - Joo-Hyun Jun, Gaab-Soo Kim, Jeong Jin Lee, Justin S Ko, Sung Joo Kim, Pil Hyun Jeon. Comparison of intrathecal morphine and surgical-site infusion of ropivacaine as adjuncts to intravenous patient-controlled analgesia in living-donor kidney transplant recipients.
Singapore medical journal.
2017 Nov; 58(11):666-673. doi:
10.11622/smedj.2017077. [PMID: 28805236] - Nicolás Fernández, Nancy Mónica Olivera, Guillermo Alberto Keller, Roberto Alberto Diez, Guillermo Di Girolamo, Patricia Noemí Quiroga. Simultaneous quantitation of meperidine, normeperidine, tramadol, propoxyphene and norpropoxyphene in human plasma using solid-phase extraction and gas chromatography/mass spectrometry: Method validation and application to cardiovascular safety of therapeutic doses.
Rapid communications in mass spectrometry : RCM.
2017 Sep; 31(18):1519-1533. doi:
10.1002/rcm.7933. [PMID: 28686794] - Fang Wu, Matthew H Slawson, Kamisha L Johnson-Davis. Metabolic Patterns of Fentanyl, Meperidine, Methylphenidate, Tapentadol and Tramadol Observed in Urine, Serum or Plasma.
Journal of analytical toxicology.
2017 May; 41(4):289-299. doi:
10.1093/jat/bkx003. [PMID: 28119437] - Guillermo Alberto Keller, María Cecilia Villa Etchegoyen, Nicolás Fernández, Nancy Mónica Olivera, Patricia Noemi Quiroga, Roberto Alejandro Diez, Guillermo Di Girolamo. Meperidine-induced QTc-interval prolongation: prevalence, risk factors, and correlation to plasma drug and metabolite concentrations
.
International journal of clinical pharmacology and therapeutics.
2017 Mar; 55(3):275-285. doi:
10.5414/cp202612. [PMID: 27509828] - Yuuki Sandhu, Katsutoshi Ando, Hidenori Takekawa, Haruhi Takagi, Michihiro Hirama, Kenji Kido, Kazuhisa Takahashi. Safety of Bronchoscopy for Patients Undergoing Hemodialysis.
Respiratory investigation.
2017 03; 55(2):173-175. doi:
10.1016/j.resinv.2016.10.007. [PMID: 28274534] - Brandon Stamper, Waseem Gul, Murrell Godfrey, Shahbaz W Gul, Mahmoud A ElSohly. LC-MS-MS Method for the Analysis of Miscellaneous Drugs in Wastewater During Football Games III.
Journal of analytical toxicology.
2016 Oct; 40(8):694-699. doi:
10.1093/jat/bkw081. [PMID: 27562966] - M Barann, U M Stamer, M Lyutenska, F Stüber, H Bönisch, B Urban. Effects of opioids on human serotonin transporters.
Naunyn-Schmiedeberg's archives of pharmacology.
2015 Jan; 388(1):43-9. doi:
10.1007/s00210-014-1056-3. [PMID: 25332055] - Domingo Lombao Iglesias, Joan Bagó Granell, Teresa Vilor Rivero. Validity of creatine kinase as an indicator of muscle injury in spine surgery and its relation with postoperative pain.
Acta orthopaedica Belgica.
2014 Dec; 80(4):545-50. doi:
. [PMID: 26280728] - Marina C Evangelista, Rodrigo A Silva, Larissa B Cardozo, Marcia A P Kahvegian, Thais C Rossetto, Julia M Matera, Denise T Fantoni. Comparison of preoperative tramadol and pethidine on postoperative pain in cats undergoing ovariohysterectomy.
BMC veterinary research.
2014 Oct; 10(?):252. doi:
10.1186/s12917-014-0252-1. [PMID: 25310968] - Che-Hao Hsu, Tso-Chou Lin, Chih-Cherng Lu, Shih-Hua Lin, Shung-Tai Ho. Clearance of meperidine and its metabolite normeperidine in hemodialysis patients with chronic noncancer pain.
Journal of pain and symptom management.
2014 Apr; 47(4):801-5. doi:
10.1016/j.jpainsymman.2013.05.007. [PMID: 23870842] - Robab Maghsoudi, Meghdad Tabatabai, Mohammad Hadi Radfar, Gholamreza Movasagi, Masoud Etemadian, Mohsen Shati, Mohsen Amjadi. Opioid-sparing effect of intravenous paracetamol after percutaneous nephrolithotomy: a double-blind randomized controlled trial.
Journal of endourology.
2014 Jan; 28(1):23-7. doi:
10.1089/end.2013.0267. [PMID: 23952097] - Chengliang Zhang, Zaoqin Yu, Xiping Li, Yanjiao Xu, Dong Liu. Chronopharmacodynamics and chronopharmacokinetics of pethidine in mice.
PloS one.
2014; 9(7):e102054. doi:
10.1371/journal.pone.0102054. [PMID: 25025283] - Katie V Moy, Joseph D Ma, Brookie M Best, Rabia S Atayee. Factors impacting variability of the urinary normeperidine-to-meperidine metabolic ratio in patients with chronic pain.
Journal of analytical toxicology.
2014 Jan; 38(1):1-7. doi:
10.1093/jat/bkt087. [PMID: 24133175] - J H Foreman, R Ruemmler. Efficacy of intramuscular meperidine hydrochloride versus placebo in experimental foot lameness in horses.
Equine veterinary journal. Supplement.
2013 Dec; ?(45):48-53. doi:
10.1111/evj.12168. [PMID: 24304404] - Hulin Li, Kai Xu, Bingkun Li, Binshen Chen, Abai Xu, Yuanbo Chen, Yawen Xu, Yong Wen, Shaobo Zheng, Chunxiao Liu. Percutaneous nephrolithotomy under local infiltration anesthesia: a single-center experience of 2000 Chinese cases.
Urology.
2013 Nov; 82(5):1020-5. doi:
10.1016/j.urology.2013.07.007. [PMID: 23992963] - Hiroyuki Nakamura, Yuta Moriyama, Tomohiko Makiyama, Shunsuke Emori, Hisahiro Yamashita, Risa Yamazaki, Toshihiko Murayama. Lactosylceramide interacts with and activates cytosolic phospholipase A2α.
The Journal of biological chemistry.
2013 Aug; 288(32):23264-72. doi:
10.1074/jbc.m113.491431. [PMID: 23801329] - Chengliang Zhang, Xiping Li, Yanjiao Xu, Tao Wu, Xiuhua Ren, Dong Liu. Simultaneous determination of pethidine and norpethidine in mouse plasma by liquid chromatography-electrospray ionization source-mass spectrometry.
Journal of analytical toxicology.
2013 Jul; 37(6):351-6. doi:
10.1093/jat/bkt043. [PMID: 23719316] - John Lewis, Ronald Shimmon, Shanlin Fu. Pethidinic acid: corroboration of a doctor's denial of pethidine re-use.
Journal of analytical toxicology.
2013 Apr; 37(3):179-81. doi:
10.1093/jat/bkt003. [PMID: 23386323] - Hazem M Abu-Shawish, Ayoub A Dalou, Nasser Abu Ghalwa, Ghada I Khraish, Jehad Hammad, Abdel-Hakem Basheer. Determination of pethidine hydrochloride using potentiometric coated graphite and carbon paste electrodes.
Drug testing and analysis.
2013 Apr; 5(4):213-21. doi:
10.1002/dta.287. [PMID: 21538999] - Ping Yan, Guangzhao Huang, Daoquan Li, Ling Li. Homicide due to intravenous metallic mercury injection followed by sodium cyanide injection.
The American journal of forensic medicine and pathology.
2012 Sep; 33(3):273-5. doi:
10.1097/paf.0b013e318221b693. [PMID: 21646904] - Lubna Samad, Zafar Zaidi. Tubed vs tubeless PCNL in children.
JPMA. The Journal of the Pakistan Medical Association.
2012 Sep; 62(9):892-6. doi:
NULL. [PMID: 23139970] - Marija Bosilkovska, Bernhard Walder, Marie Besson, Youssef Daali, Jules Desmeules. Analgesics in patients with hepatic impairment: pharmacology and clinical implications.
Drugs.
2012 Aug; 72(12):1645-69. doi:
10.2165/11635500-000000000-00000. [PMID: 22867045] - Pamela S Hair, Charlene G Echague, Reuben D Rohn, Neel K Krishna, Julius O Nyalwidhe, Kenji M Cunnion. Hyperglycemic conditions inhibit C3-mediated immunologic control of Staphylococcus aureus.
Journal of translational medicine.
2012 Mar; 10(?):35. doi:
10.1186/1479-5876-10-35. [PMID: 22390383] - Ruth Verplaetse, Jan Tytgat. Development and validation of a sensitive UPLC-MS/MS method for the analysis of narcotic analgesics in urine and whole blood in forensic context.
Forensic science international.
2012 Feb; 215(1-3):136-45. doi:
10.1016/j.forsciint.2011.01.047. [PMID: 21356580] - Shulan Su, Yongqing Hua, Yanyan Wang, Wei Gu, Wei Zhou, Jin-ao Duan, Haifeng Jiang, Ting Chen, Yuping Tang. Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii.
Journal of ethnopharmacology.
2012 Jan; 139(2):649-56. doi:
10.1016/j.jep.2011.12.013. [PMID: 22178177] - Janina Thunig, Linda Flø, Stig Pedersen-Bjergaard, Steen Honoré Hansen, Christian Janfelt. Liquid-phase microextraction and desorption electrospray ionization mass spectrometry for identification and quantification of basic drugs in human urine.
Rapid communications in mass spectrometry : RCM.
2012 Jan; 26(2):133-40. doi:
10.1002/rcm.5315. [PMID: 22173801] - Lars Erik Eng Eibak, Astrid Gjelstad, Knut Einar Rasmussen, Stig Pedersen-Bjergaard. Exhaustive electromembrane extraction of some basic drugs from human plasma followed by liquid chromatography-mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2012 Jan; 57(?):33-8. doi:
10.1016/j.jpba.2011.08.026. [PMID: 21906901] - Luming Shen, Xizhao Sun, Xiaoming Cong, Ying Wang, Huaijun Zhu, Lei He. Comparison of efficacy of German and Chinese electromagnetic shock wave lithotripters: Dornier Compact S vs Huikang MZ-SWL-V.
Urology.
2011 Dec; 78(6):1240-3. doi:
10.1016/j.urology.2011.04.061. [PMID: 21777956] - Jong Yeon Lee, Young Tae Moon. Evaluation of the optimal frequency of and pretreatment with shock waves in patients with renal stones.
Korean journal of urology.
2011 Nov; 52(11):776-81. doi:
10.4111/kju.2011.52.11.776. [PMID: 22195268] - Yu Zhang, Qin Li, Minghua Lu, Lan Zhang, Guonan Chen, Zongwei Cai. [Analysis of nine narcotics in urine by microemulsion electrokinetic chromatography-field samplified sample injection].
Se pu = Chinese journal of chromatography.
2011 Aug; 29(8):791-7. doi:
. [PMID: 22128745] - Jin Soo Kim, Hyuk Hur, Byung Soh Min, Kang Young Lee, Hyun Cheol Chung, Nam Kyu Kim. Inflammatory and tumor stimulating responses after laparoscopic sigmoidectomy.
Yonsei medical journal.
2011 Jul; 52(4):635-42. doi:
10.3349/ymj.2011.52.4.635. [PMID: 21623607] - Xianqin Wang, Zheng Xiang, Xiaojun Cai, Haiya Wu, Xuebao Wang, Junwei Li, Meiling Zhang. Determination of pethidine in human plasma by LC-MS/MS.
Biomedical chromatography : BMC.
2011 Jul; 25(7):833-7. doi:
10.1002/bmc.1524. [PMID: 20872940] - J Künzel, K Geisler, I Hoffmann, A Müller, M W Beckmann, R Dittrich. Myometrial response to neurotropic and musculotropic spasmolytic drugs in an extracorporeal perfusion model of swine uteri.
Reproductive biomedicine online.
2011 Jul; 23(1):132-40. doi:
10.1016/j.rbmo.2011.03.026. [PMID: 21757131] - Surajudeen A Junaid, Chijioke Umeh, Atanda O Olabode, Jim M Banda. Incidence of rotavirus infection in children with gastroenteritis attending Jos university teaching hospital, Nigeria.
Virology journal.
2011 May; 8(?):233. doi:
10.1186/1743-422x-8-233. [PMID: 21575246] - Khaled Madbouly, Saad Alshahrani, Tariq Al-Omair, Hamoud Al Matrafi, Mostafa Mansi. Efficacy of local subcutaneous anesthesia versus intramuscular opioid sedation in extracorporeal shockwave lithotripsy: a randomized study.
Journal of endourology.
2011 May; 25(5):845-9. doi:
10.1089/end.2010.0427. [PMID: 21417936] - Y Al-Tamimi, K F Ilett, M J Paech, S J O'Halloran, P E Hartmann. Estimation of infant dose and exposure to pethidine and norpethidine via breast milk following patient-controlled epidural pethidine for analgesia post caesarean delivery.
International journal of obstetric anesthesia.
2011 Apr; 20(2):128-34. doi:
10.1016/j.ijoa.2010.12.004. [PMID: 21398109] - Shulan Su, Tuanjie Wang, Jin-Ao Duan, Wei Zhou, Yong-Qing Hua, Yu-Ping Tang, Li Yu, Da-Wei Qian. Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha.
Journal of ethnopharmacology.
2011 Mar; 134(2):251-8. doi:
10.1016/j.jep.2010.12.003. [PMID: 21167270] - Dilipkumar Pal, Abhijit Sarkar, Sumanta Gain, Sandip Jana, Soumit Mandal. CNS depressant activities of roots of Coccos nucifera in mice.
Acta poloniae pharmaceutica.
2011 Mar; 68(2):249-54. doi:
". [PMID: 21485298] - Minghua Lu, Qin Li, Yongquan Lai, Lan Zhang, Bin Qiu, Guonan Chen, Zongwei Cai. Determination of stimulants and narcotics as well as their in vitro metabolites by online CE-ESI-MS.
Electrophoresis.
2011 Feb; 32(3-4):472-8. doi:
10.1002/elps.201000453. [PMID: 21254133] - Dilipkumar Pal, Krishanu Samanta. CNS activities of ethanol extract of aerial parts of Hygrophila difformis in mice.
Acta poloniae pharmaceutica.
2011 Jan; 68(1):75-81. doi:
". [PMID: 21485704] - Nickolaj Jacob Petersen, Sunniva Taule Foss, Henrik Jensen, Steen Honoré Hansen, Christian Skonberg, Detlef Snakenborg, Jörg P Kutter, Stig Pedersen-Bjergaard. On-chip electro membrane extraction with online ultraviolet and mass spectrometric detection.
Analytical chemistry.
2011 Jan; 83(1):44-51. doi:
10.1021/ac1027148. [PMID: 21142026] - S B Chandrasekar, Kalyani Divakar, A T Pawar, Divakar Goli, R Harisha, M Bhanumathy, G Sushma, H N Shivaprasad. Involvement of opioid, adenosine and 5-HT(3) receptors in antinociceptive effects of an ayurvedic polyherbal formulation.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre.
2011; 20(1):66-70. doi:
10.1159/000319763. [PMID: 21160217] - Xiaobo Gu, Sari Izenwasser, Dean Wade, Amy Housman, Gerard Gulasey, Jill B Rhoden, Christopher D Savoie, David L Mobley, Stacey A Lomenzo, Mark L Trudell. Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands.
Bioorganic & medicinal chemistry.
2010 Dec; 18(23):8356-64. doi:
10.1016/j.bmc.2010.09.060. [PMID: 20980153] - Asuman Sengoz Inan, Nurgul Ceran, Ilknur Erdem, Derya O Engin, Seniha Senbayrak, Seyfi C Ozyurek, Pasa Goktas. Neurobrucellosis with transient ischemic attack, vasculopathic changes, intracerebral granulomas and basal ganglia infarction: a case report.
Journal of medical case reports.
2010 Oct; 4(?):340. doi:
10.1186/1752-1947-4-340. [PMID: 20973948] - Jitka Fricova, Martin Vejražka, Pavel Stopka, Jana Krizova, Jaromír Běláček, Richard Rokyta. The influence of pre-emptive analgesia on postoperative analgesia and its objective evaluation.
Archives of medical science : AMS.
2010 Oct; 6(5):764-71. doi:
10.5114/aoms.2010.17093. [PMID: 22419937] - Johanna Ristimaa, Merja Gergov, Anna Pelander, Erja Halmesmäki, Ilkka Ojanperä. Broad-spectrum drug screening of meconium by liquid chromatography with tandem mass spectrometry and time-of-flight mass spectrometry.
Analytical and bioanalytical chemistry.
2010 Sep; 398(2):925-35. doi:
10.1007/s00216-010-3942-y. [PMID: 20617307] - Hark Rim, Gyoo-Sik Jung, Yeon Soon Jung. Transcatheter arterial embolization using ethanol in a dialysis patient for contracting enlarged polycystic kidneys.
Korean journal of radiology.
2010 Sep; 11(5):574-8. doi:
10.3348/kjr.2010.11.5.574. [PMID: 20808704] - Sasa Stefanić, Cornelia Spycher, Laura Morf, Gemma Fabriàs, Josefina Casas, Elisabeth Schraner, Peter Wild, Adrian B Hehl, Sabrina Sonda. Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia.
Journal of lipid research.
2010 Sep; 51(9):2527-45. doi:
10.1194/jlr.m003392. [PMID: 20335568] - Cynthia A Wong. Advances in labor analgesia.
International journal of women's health.
2010 Aug; 1(?):139-54. doi:
10.2147/ijwh.s4553. [PMID: 21072284] - Chang-Seop Lee, In-Suk Min, Jeong-Hwan Hwang, Keun-Sang Kwon, Heung-Bum Lee. Clinical significance of hypoalbuminemia in outcome of patients with scrub typhus.
BMC infectious diseases.
2010 Jul; 10(?):216. doi:
10.1186/1471-2334-10-216. [PMID: 20646323] - Shanmugasundaram Rajaian, Santosh Kumar, Ganesh Gopalakrishnan, Ninan K Chacko, Antony Devasia, Nitin S Kekre. Outcome of shock wave lithotripsy as monotherapy for large solitary renal stones (>2 cm in size) without stenting.
Indian journal of urology : IJU : journal of the Urological Society of India.
2010 Jul; 26(3):359-63. doi:
10.4103/0970-1591.70568. [PMID: 21116354] - Pilar Fernández, Adrian Trenholme, Katia Abarca, M Pamela Griffin, Micki Hultquist, Brian Harris, Genevieve A Losonsky. A phase 2, randomized, double-blind safety and pharmacokinetic assessment of respiratory syncytial virus (RSV) prophylaxis with motavizumab and palivizumab administered in the same season.
BMC pediatrics.
2010 Jun; 10(?):38. doi:
10.1186/1471-2431-10-38. [PMID: 20525274] - Qing-bo Shao, Xiong Zhang, Xue-lian Chen, Yan Liu, Qin Zhang, Zhen-jiang Liao. [Protective effect of early application of lytic cocktail on small intestine of severely scalded rats].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2010 Jun; 26(3):180-4. doi:
. [PMID: 20723419] - Rajan F Ezzat, Taha A Karboli, Kalandar A Kasnazani, Adnan Mh Hamawandi. Endoscopic management of biliary fascioliasis: a case report.
Journal of medical case reports.
2010 Mar; 4(?):83. doi:
10.1186/1752-1947-4-83. [PMID: 20205932] - B Pradhan. Spinal anesthesia for cesarean section: comparison of 5.0\% lignocaine and 0.5\% bupivacaine.
Nepal Medical College journal : NMCJ.
2010 Mar; 12(1):30-3. doi:
. [PMID: 20677606] - Ingela Sundström, Joris Arts, Douglas Westerlund, Per E Andrén. In vivo investigation of brain and systemic ketobemidone metabolism.
The Analyst.
2010 Feb; 135(2):405-13. doi:
10.1039/b917940b. [PMID: 20098777] - Rong Qi, Douglas G Mullen, James R Baker, Mark M Banaszak Holl. The mechanism of polyplex internalization into cells: testing the GM1/caveolin-1 lipid raft mediated endocytosis pathway.
Molecular pharmaceutics.
2010 Feb; 7(1):267-79. doi:
10.1021/mp900241t. [PMID: 20025295] - Tiina Sikanen, Stig Pedersen-Bjergaard, Henrik Jensen, Risto Kostiainen, Knut Einar Rasmussen, Tapio Kotiaho. Implementation of droplet-membrane-droplet liquid-phase microextraction under stagnant conditions for lab-on-a-chip applications.
Analytica chimica acta.
2010 Jan; 658(2):133-40. doi:
10.1016/j.aca.2009.11.002. [PMID: 20103086] - Humberto M Spindola, Leila Servat, Carina Denny, Rodney A F Rodrigues, Marcos N Eberlin, Elaine Cabral, Ilza M O Sousa, Jorge Y Tamashiro, João E Carvalho, Mary A Foglio. Antinociceptive effect of geranylgeraniol and 6alpha,7beta-dihydroxyvouacapan-17beta-oate methyl ester isolated from Pterodon pubescens Benth.
BMC pharmacology.
2010 Jan; 10(?):1. doi:
10.1186/1471-2210-10-1. [PMID: 20055987] - Fabio Silvio Taccone, Pierre-François Laterre, Herbert Spapen, Thierry Dugernier, Isabelle Delattre, Brice Layeux, Daniel De Backer, Xavier Wittebole, Pierre Wallemacq, Jean-Louis Vincent, Frédérique Jacobs. Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock.
Critical care (London, England).
2010; 14(2):R53. doi:
10.1186/cc8945. [PMID: 20370907] - Sirus Jedary Seifi, Masoud Sabouri Ghannad. A study of HDV in HBsAg positive patients in Tabriz, Northwestern Iran.
Hepatitis monthly.
2010; 10(2):110-5. doi:
NULL. [PMID: 22312383] - B Lojanapiwat. Does previous open nephrolithotomy affect the efficacy and safety of tubeless percutaneous nephrolithotomy?.
Urologia internationalis.
2010; 85(1):42-6. doi:
10.1159/000318188. [PMID: 20606406] - Avivit Cahn, Benjamin Koslowsky, Ran Nir-Paz, Violeta Temper, Nurit Hiller, Alla Karlinsky, Itzhak Gur, Carlos Hidalgo-Grass, Samuel N Heyman, Allon E Moses, Colin Block. Imported melioidosis, Israel, 2008.
Emerging infectious diseases.
2009 Nov; 15(11):1809-11. doi:
10.3201/eid1511.090038. [PMID: 19891871] - Xiaofan Sui, Jin Sun, Haiyan Li, Yongjun Wang, Jianfang Liu, Xiaohong Liu, Wenping Zhang, Lijiang Chen, Zhonggui He. Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
European journal of medicinal chemistry.
2009 Nov; 44(11):4455-60. doi:
10.1016/j.ejmech.2009.06.004. [PMID: 19586686] - Grace Wing Shan Kong, Lai Ping Cheung, Christopher John Haines, Po Mui Lam. Comprehensive assessment of serum estradiol impact on selected physiologic markers observed during in-vitro fertilization and embryo transfer cycles.
Journal of experimental & clinical assisted reproduction.
2009 Oct; 6(?):5. doi:
NULL. [PMID: 20485580] - Meredith A Fox, Catherine L Jensen, Dennis L Murphy. Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice.
The international journal of neuropsychopharmacology.
2009 Sep; 12(8):1055-65. doi:
10.1017/s146114570900011x. [PMID: 19275775] - Dilipkumar Pal, Santanu Dutta, Abhijit Sarkar. Evaluation of CNS activities of ethanol extract of roots and rhizomes of Cyperus rotundus in mice.
Acta poloniae pharmaceutica.
2009 Sep; 66(5):535-41. doi:
". [PMID: 19894649] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - C Karsten, S Baumgarte, A W Friedrich, C von Eiff, K Becker, W Wosniok, A Ammon, J Bockemühl, H Karch, H-I Huppertz. Incidence and risk factors for community-acquired acute gastroenteritis in north-west Germany in 2004.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2009 Aug; 28(8):935-43. doi:
10.1007/s10096-009-0729-1. [PMID: 19319582] - Rupinder Singh, Indu Sen, Jyotsna Wig, M Minz, Ashish Sharma, Indu Bala. An acetazolamide based multimodal analgesic approach versus conventional pain management in patients undergoing laparoscopic living donor nephrectomy.
Indian journal of anaesthesia.
2009 Aug; 53(4):434-41. doi:
NULL. [PMID: 20640205] - Andrea Perniola, Anil Gupta, Kristina Crafoord, Bijan Darvish, Anders Magnuson, Kjell Axelsson. Intraabdominal local anaesthetics for postoperative pain relief following abdominal hysterectomy: a randomized, double-blind, dose-finding study.
European journal of anaesthesiology.
2009 May; 26(5):421-9. doi:
10.1097/eja.0b013e3283261b53. [PMID: 19521298] - M Gergov, P Nokua, E Vuori, I Ojanperä. Simultaneous screening and quantification of 25 opioid drugs in post-mortem blood and urine by liquid chromatography-tandem mass spectrometry.
Forensic science international.
2009 Apr; 186(1-3):36-43. doi:
10.1016/j.forsciint.2009.01.013. [PMID: 19232849] - Anna H Edner, Birgitta Essén-Gustavsson, Görel C Nyman. Metabolism during anaesthesia and recovery in colic and healthy horses: a microdialysis study.
Acta veterinaria Scandinavica.
2009 Mar; 51(?):10. doi:
10.1186/1751-0147-51-10. [PMID: 19284560] - Mohammad Reza Khajavi, Seyed Babak Mojaver Aghili, Reza Shariat Moharari, Atabak Najafi, Robab Mohtaram, Patricia Khashayar, Mojtaba Mojtahedzade. Subcutaneous tramadol infiltration at the wound site versus intravenous administration after pyelolithotomy.
The Annals of pharmacotherapy.
2009 Mar; 43(3):430-5. doi:
10.1345/aph.1l494. [PMID: 19261960] - Nickolaj Jacob Petersen, Henrik Jensen, Steen Honoré Hansen, Knut Einar Rasmussen, Stig Pedersen-Bjergaard. Drop-to-drop microextraction across a supported liquid membrane by an electrical field under stagnant conditions.
Journal of chromatography. A.
2009 Feb; 1216(9):1496-502. doi:
10.1016/j.chroma.2008.12.079. [PMID: 19135677] - Fatemeh Izadpanah, Mojtaba Mojtahedzadeh, Seyed Mohammad Kazem Aghamir, Davood Atharikia, Simin Dashti, Ali Abbasi. Effect of intravenous pentoxifylline in inflammatory response in patients undergoing nephrolithotomy.
Journal of endourology.
2009 Feb; 23(2):323-8. doi:
10.1089/end.2008.0474. [PMID: 19220089] - Bart J Knottnerus, Patrick J E Bindels, Suzanne E Geerlings, Eric P Moll van Charante, Gerben ter Riet. Optimizing the diagnostic work-up of acute uncomplicated urinary tract infections.
BMC family practice.
2008 Dec; 9(?):64. doi:
10.1186/1471-2296-9-64. [PMID: 19063737] - Hyo Sung Kwak, Young Min Han. Percutaneous transportal sclerotherapy with N-butyl-2-cyanoacrylate for gastric varices: technique and clinical efficacy.
Korean journal of radiology.
2008 Nov; 9(6):526-33. doi:
10.3348/kjr.2008.9.6.526. [PMID: 19039269] - Fábio Bucaretchi, Sueli Moreira Mello, Ronan José Vieira, Ronei Luciano Mamoni, Maria Heloísa Souza Lima Blotta, Edson Antunes, Stephen Hyslop. Systemic envenomation caused by the wandering spider Phoneutria nigriventer, with quantification of circulating venom.
Clinical toxicology (Philadelphia, Pa.).
2008 Nov; 46(9):885-9. doi:
10.1080/15563650802258524. [PMID: 18788004] - Jonna Idh, Anna Westman, Daniel Elias, Feleke Moges, Assefa Getachew, Aschalew Gelaw, Tommy Sundqvist, Tony Forslund, Addis Alemu, Belete Ayele, Ermias Diro, Endalkachew Melese, Yared Wondmikun, Sven Britton, Olle Stendahl, Thomas Schön. Nitric oxide production in the exhaled air of patients with pulmonary tuberculosis in relation to HIV co-infection.
BMC infectious diseases.
2008 Oct; 8(?):146. doi:
10.1186/1471-2334-8-146. [PMID: 18950489] - Hirotaka Ando, Shigeru Izawa, Wataru Hori, Ippei Nakagawa. Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling.
Theoretical biology & medical modelling.
2008 Aug; 5(?):19. doi:
10.1186/1742-4682-5-19. [PMID: 18687151] - Abdulmalik M Tayib, Hisham A Mosli, Hasan M Farsi, Mahmoud A Atwa, Hisham A Saada. Shock wave lithotripsy in patients with renal calculi.
Saudi medical journal.
2008 Aug; 29(8):1180-3. doi:
NULL. [PMID: 18690315] - Zhaohui Zhang, Chenggong Zhang, Xiaoli Su, Ming Ma, Bo Chen, Shouzhuo Yao. Carrier-mediated liquid phase microextraction coupled with high performance liquid chromatography for determination of illicit drugs in human urine.
Analytica chimica acta.
2008 Jul; 621(2):185-92. doi:
10.1016/j.aca.2008.05.016. [PMID: 18573383] - N P Gupta, Saurabh Mishra, Manav Suryawanshi, Amlesh Seth, Rajeev Kumar. Comparison of standard with tubeless percutaneous nephrolithotomy.
Journal of endourology.
2008 Jul; 22(7):1441-6. doi:
10.1089/end.2007.0338. [PMID: 18690810] - A Eickhoff, D Hartmann, J C Eickhoff, J F Riemann, M D Enderle. Pain sensation and neuromuscular stimulation during argon plasma coagulation in gastrointestinal endoscopy.
Surgical endoscopy.
2008 Jul; 22(7):1701-7. doi:
10.1007/s00464-007-9700-3. [PMID: 18071803] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Vaomalala Raharimanga, Jean-François Carod, Charles-Emile Ramarokoto, Jean-Baptiste Chrétien, Fanjasoa Rakotomanana, Antoine Talarmin, Vincent Richard. Age-specific seroprevalence of hepatitis A in Antananarivo (Madagascar).
BMC infectious diseases.
2008 Jun; 8(?):78. doi:
10.1186/1471-2334-8-78. [PMID: 18538023] - Alvaro J Santos-Neto, Jonas Bergquist, Fernando M Lanças, Per J R Sjöberg. Simultaneous analysis of five antidepressant drugs using direct injection of biofluids in a capillary restricted-access media-liquid chromatography-tandem mass spectrometry system.
Journal of chromatography. A.
2008 May; 1189(1-2):514-22. doi:
10.1016/j.chroma.2008.02.107. [PMID: 18355831] - Amirali Masoumi, Berenice Reed-Gitomer, Catherine Kelleher, Mir Reza Bekheirnia, Robert W Schrier. Developments in the management of autosomal dominant polycystic kidney disease.
Therapeutics and clinical risk management.
2008 Apr; 4(2):393-407. doi:
10.2147/tcrm.s1617. [PMID: 18728845] - Dilipkumar Pal. Evaluation of CNS activities of aerial parts of Cynodon dactylon Pers. in mice.
Acta poloniae pharmaceutica.
2008 Jan; 65(1):37-43. doi:
". [PMID: 18536171]
