Meperidine (BioDeep_00000002033)
Secondary id: BioDeep_00000397857, BioDeep_00000867698
human metabolite blood metabolite
代谢物信息卡片
ethyl 1-methyl-4-phenylpiperidine-4-carboxylate
化学式: C15H21NO2 (247.15722060000002)
中文名称: 哌替啶
谱图信息:
最多检出来源 Homo sapiens(blood) 91.76%
分子结构信息
SMILES: CCOC(=O)C1(c2ccccc2)CCN(C)CC1
InChI: InChI=1S/C15H21NO2/c1-3-18-14(17)15(9-11-16(2)12-10-15)13-7-5-4-6-8-13/h4-8H,3,9-12H2,1-2H3
描述信息
A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. [PubChem]
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
N - Nervous system > N02 - Analgesics > N02A - Opioids > N02AB - Phenylpiperidine derivatives
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:6754
- KEGG: C07128
- KEGGdrug: D08343
- PubChem: 4058
- HMDB: HMDB0014597
- Metlin: METLIN1127
- DrugBank: DB00454
- ChEMBL: CHEMBL607
- Wikipedia: Pethidine
- MeSH: Meperidine
- chemspider: 3918
- CAS: 53484-75-6
- CAS: 57-42-1
- PMhub: MS000001711
- PubChem: 9338
- NIKKAJI: J4.578K
- RefMet: Meperidine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiangjing Wang, Shunyi Wei, Yingfang Ao, Yuping Yang. [Comparison of the early analgesic efficacy of three different drugs after anterior cruciate ligament reconstruction].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2024 Apr; 56(2):293-298. doi:
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Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2022 Mar; 35(3):511-516. doi:
10.1080/08941939.2021.1880671. [PMID: 33550855] - Zeynab Khorablou, Faezeh Shahdost-Fard, Habib Razmi. Voltammetric determination of pethidine in biofluids at a carbon cloth electrode modified by carbon selenide nanofilm.
Talanta.
2022 Mar; 239(?):123131. doi:
10.1016/j.talanta.2021.123131. [PMID: 34920261] - Amanda L Hanafi, Rachel A Reed, Heather N Trenholme, Daniel M Sakai, Clare A Ryan, Michele Barletta, Jane E Quandt, Heather K Knych. Pharmacokinetics and pharmacodynamics of meperidine after intramuscular and subcutaneous administration in horses.
Veterinary surgery : VS.
2021 Feb; 50(2):410-417. doi:
10.1111/vsu.13545. [PMID: 33242227] - Briana D Hamamoto-Hardman, Eugene P Steffey, Daniel S McKemie, Philip H Kass, Heather K Knych. Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses.
BMC veterinary research.
2020 Oct; 16(1):368. doi:
10.1186/s12917-020-02564-4. [PMID: 32998730] - Aykut Kul, Murat Ozdemir, Olcay Sagirli. Determination of pethidine of abuse and relevant metabolite norpethidine in urine by ultra-performance liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2020 Jul; 186(?):113320. doi:
10.1016/j.jpba.2020.113320. [PMID: 32387748] - Abdelwahab Hashem, Fady K Ghobrial, M A Elbaset, Ahmed M Atwa, Mohamed Fadallah, Mahmoud Laymon, Ahmed El-Assmy, Khaled Z Sheir, Hassan Abol-Enein. Efficacy of pethidine, ketorolac, and lidocaine gel as analgesics for pain control in shockwave lithotripsy: A single-blinded randomized controlled trial.
Investigative and clinical urology.
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10.1074/jbc.m113.491431. [PMID: 23801329] - Chengliang Zhang, Xiping Li, Yanjiao Xu, Tao Wu, Xiuhua Ren, Dong Liu. Simultaneous determination of pethidine and norpethidine in mouse plasma by liquid chromatography-electrospray ionization source-mass spectrometry.
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2013 Jul; 37(6):351-6. doi:
10.1093/jat/bkt043. [PMID: 23719316] - John Lewis, Ronald Shimmon, Shanlin Fu. Pethidinic acid: corroboration of a doctor's denial of pethidine re-use.
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2013 Apr; 37(3):179-81. doi:
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BMC pharmacology.
2010 Jan; 10(?):1. doi:
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Critical care (London, England).
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Hepatitis monthly.
2010; 10(2):110-5. doi:
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Urologia internationalis.
2010; 85(1):42-6. doi:
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Emerging infectious diseases.
2009 Nov; 15(11):1809-11. doi:
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European journal of medicinal chemistry.
2009 Nov; 44(11):4455-60. doi:
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Journal of experimental & clinical assisted reproduction.
2009 Oct; 6(?):5. doi:
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The international journal of neuropsychopharmacology.
2009 Sep; 12(8):1055-65. doi:
10.1017/s146114570900011x. [PMID: 19275775] - Dilipkumar Pal, Santanu Dutta, Abhijit Sarkar. Evaluation of CNS activities of ethanol extract of roots and rhizomes of Cyperus rotundus in mice.
Acta poloniae pharmaceutica.
2009 Sep; 66(5):535-41. doi:
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Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
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European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2009 Aug; 28(8):935-43. doi:
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Indian journal of anaesthesia.
2009 Aug; 53(4):434-41. doi:
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European journal of anaesthesiology.
2009 May; 26(5):421-9. doi:
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Forensic science international.
2009 Apr; 186(1-3):36-43. doi:
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Acta veterinaria Scandinavica.
2009 Mar; 51(?):10. doi:
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The Annals of pharmacotherapy.
2009 Mar; 43(3):430-5. doi:
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Journal of chromatography. A.
2009 Feb; 1216(9):1496-502. doi:
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Journal of endourology.
2009 Feb; 23(2):323-8. doi:
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BMC family practice.
2008 Dec; 9(?):64. doi:
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Korean journal of radiology.
2008 Nov; 9(6):526-33. doi:
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Clinical toxicology (Philadelphia, Pa.).
2008 Nov; 46(9):885-9. doi:
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BMC infectious diseases.
2008 Oct; 8(?):146. doi:
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Theoretical biology & medical modelling.
2008 Aug; 5(?):19. doi:
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Saudi medical journal.
2008 Aug; 29(8):1180-3. doi:
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Analytica chimica acta.
2008 Jul; 621(2):185-92. doi:
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Journal of endourology.
2008 Jul; 22(7):1441-6. doi:
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Surgical endoscopy.
2008 Jul; 22(7):1701-7. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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BMC infectious diseases.
2008 Jun; 8(?):78. doi:
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Journal of chromatography. A.
2008 May; 1189(1-2):514-22. doi:
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Therapeutics and clinical risk management.
2008 Apr; 4(2):393-407. doi:
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Acta poloniae pharmaceutica.
2008 Jan; 65(1):37-43. doi:
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