Fumonisin B2 (BioDeep_00000001868)

 

Secondary id: BioDeep_00000408560

human metabolite Endogenous natural product


代谢物信息卡片


2-[2-({19-amino-6-[(3,4-dicarboxybutanoyl)oxy]-16,18-dihydroxy-5,9-dimethylicosan-7-yl}oxy)-2-oxoethyl]butanedioic acid

化学式: C34H59NO14 (705.3935)
中文名称: 伏马菌素 B2
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: CCCCC(C)C(C(CC(C)CCCCCCC(CC(C(C)N)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O
InChI: InChI=1S/C34H59NO14/c1-5-6-12-21(3)32(49-31(43)18-24(34(46)47)16-29(40)41)27(48-30(42)17-23(33(44)45)15-28(38)39)14-20(2)11-9-7-8-10-13-25(36)19-26(37)22(4)35/h20-27,32,36-37H,5-19,35H2,1-4H3,(H,38,39)(H,40,41)(H,44,45)(H,46,47)

描述信息

Fumonisin B2 is from Fusarium moniliforme Fumonisin B2 is a fumonisin mycotoxin produced by the fungi Fusarium verticillioides and Fusarium moniliforme. It is a structural analog of fumonisin B1. Fumonisin B2 is more cytotoxic than fumonisin B1. Fumonisin B2 inhibits sphingosine acyltransferase
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
D009676 - Noxae > D011042 - Poisons > D037341 - Fumonisins
D009676 - Noxae > D002273 - Carcinogens
From Fusarium moniliforme

同义名列表

8 个代谢物同义名

2-[2-({19-amino-6-[(3,4-dicarboxybutanoyl)oxy]-16,18-dihydroxy-5,9-dimethylicosan-7-yl}oxy)-2-oxoethyl]butanedioic acid; 2-[2-({19-amino-6-[(3,4-dicarboxybutanoyl)oxy]-16,18-dihydroxy-5,9-dimethylicosan-7-yl}oxy)-2-oxoethyl]butanedioate; Fumonisin b2 from fusarium moniliforme; Fumonisin B2, Fusarium moniliforme; Fumonisin-b2; fumonisin B2; Ccris 4434; Fumonisin B2



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

32 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ADIG, CASP3, DCTN4, FANCC, PINK1, PPARG, TFPT
Nucleus 11 ADIG, CASP3, DCTN4, FANCB, FANCC, GABPA, PINK1, PPARG, SERF1A, SIRT3, TFPT
cytosol 9 CASP3, DCTN4, FANCB, FANCC, GPT, LONP1, PINK1, PPARG, SERF1A
centrosome 1 DCTN4
nucleoplasm 8 CASP3, FANCB, FANCC, GABPA, LONP1, PPARG, SIRT3, TFPT
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 1 TNF
Multi-pass membrane protein 1 MT-CYB
cell cortex 1 DCTN4
cell surface 1 TNF
glutamatergic synapse 1 CASP3
growth cone 1 PINK1
mitochondrial inner membrane 2 MT-CYB, PINK1
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 2 PINK1, SERF1A
Lysosome 1 SGSH
plasma membrane 2 CSF2, TNF
Membrane 5 ADIG, LONP1, MT-CYB, PINK1, SERF1A
axon 1 PINK1
extracellular exosome 2 GPT, SGSH
endoplasmic reticulum 1 PINK1
extracellular space 3 CSF2, IL10, TNF
lysosomal lumen 1 SGSH
perinuclear region of cytoplasm 2 PINK1, PPARG
mitochondrion 4 LONP1, MT-CYB, PINK1, SIRT3
protein-containing complex 2 SERF1A, SIRT3
intracellular membrane-bounded organelle 2 CSF2, PPARG
postsynaptic density 1 CASP3
Secreted 3 ADIG, CSF2, IL10
extracellular region 4 ADIG, CSF2, IL10, TNF
Mitochondrion outer membrane 1 PINK1
Single-pass membrane protein 2 ADIG, PINK1
mitochondrial outer membrane 1 PINK1
Mitochondrion matrix 2 LONP1, SIRT3
mitochondrial matrix 2 LONP1, SIRT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 DCTN4
external side of plasma membrane 1 TNF
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 2 MT-CYB, PINK1
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 DCTN4
focal adhesion 1 DCTN4
mitochondrial nucleoid 1 LONP1
mitochondrial intermembrane space 1 PINK1
Cytoplasm, myofibril, sarcomere 1 DCTN4
sarcomere 1 DCTN4
receptor complex 1 PPARG
chromatin 5 FANCB, FANCC, GABPA, PINK1, PPARG
phagocytic cup 1 TNF
cytoskeleton 1 PINK1
spindle pole 1 DCTN4
Cytoplasm, cell cortex 1 DCTN4
actin filament 1 TFPT
Lipid droplet 1 ADIG
Fanconi anaemia nuclear complex 2 FANCB, FANCC
cell body 1 PINK1
stress fiber 1 DCTN4
dynactin complex 1 DCTN4
kinetochore 1 DCTN4
cytoplasmic dynein complex 1 DCTN4
respiratory chain complex III 1 MT-CYB
Cytoplasm, cytoskeleton, stress fiber 1 DCTN4
death-inducing signaling complex 1 CASP3
Lewy body 1 PINK1
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
astrocyte projection 1 PINK1
Ino80 complex 1 TFPT
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Z A Chalyy, M G Kiseleva, I B Sedova, V A Tutelyan. [Mycotoxins in spices consumed in Russia]. Voprosy pitaniia. 2023; 92(2):26-34. doi: 10.33029/0042-8833-2023-92-2-26-34. [PMID: 37346017]
  • Raquel Torrijos, Tiago de Melo Nazareth, Pilar Vila-Donat, Jordi Mañes, Giuseppe Meca. Use of Mustard Extracts Fermented by Lactic Acid Bacteria to Mitigate the Production of Fumonisin B1 and B2 by Fusarium verticillioides in Corn Ears. Toxins. 2022 01; 14(2):. doi: 10.3390/toxins14020080. [PMID: 35202108]
  • Julia Laurain, Didier Tardieu, Maria Matard-Mann, Maria Angeles Rodriguez, Philippe Guerre. Fumonisin B1 Accumulates in Chicken Tissues over Time and This Accumulation Was Reduced by Feeding Algo-Clay. Toxins. 2021 10; 13(10):. doi: 10.3390/toxins13100701. [PMID: 34678994]
  • Ewa Tomaszewska, Halyna Rudyk, Piotr Dobrowolski, Janine Donaldson, Izabela Świetlicka, Iwona Puzio, Daniel Kamiński, Dariusz Wiącek, Volodymyr Kushnir, Oksana Brezvyn, Viktor Muzyka, Renata Doraczyńska, Siemowit Muszyński, Ihor Kotsyumbas. Changes in the Intestinal Histomorphometry, the Expression of Intestinal Tight Junction Proteins, and the Bone Structure and Liver of Pre-Laying Hens Following Oral Administration of Fumonisins for 21 Days. Toxins. 2021 05; 13(6):. doi: 10.3390/toxins13060375. [PMID: 34070555]
  • András Szabó, Szabolcs Nagy, Omeralfaroug Ali, Zsolt Gerencsér, Miklós Mézes, Krisztián Milán Balogh, Tibor Bartók, Levente Horváth, Aziz Mouhanna, Melinda Kovács. A 65-Day Fumonisin B Exposure at High Dietary Levels Has Negligible Effects on the Testicular and Spermatological Parameters of Adult Rabbit Bucks. Toxins. 2021 03; 13(4):. doi: 10.3390/toxins13040237. [PMID: 33806221]
  • Zhong-Xing Rao, Mike D Tokach, Jason C Woodworth, Joel M DeRouchey, Robert D Goodband, Hilda I Calderón, Steve S Dritz. Effects of Fumonisin-Contaminated Corn on Growth Performance of 9 to 28 kg Nursery Pigs. Toxins. 2020 09; 12(9):. doi: 10.3390/toxins12090604. [PMID: 32961935]
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  • Bastien Barral, Marc Chillet, Anna Doizy, Maeva Grassi, Laetitia Ragot, Mathieu Léchaudel, Noel Durand, Lindy Joy Rose, Altus Viljoen, Sabine Schorr-Galindo. Diversity and Toxigenicity of Fungi that Cause Pineapple Fruitlet Core Rot. Toxins. 2020 05; 12(5):. doi: 10.3390/toxins12050339. [PMID: 32455651]
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  • Stephanie L Bolton, Phillip M Brannen, Anthony E Glenn. A Novel Population of Fusarium fujikuroi Isolated from Southeastern U.S. Winegrapes Reveals the Need to Re-Evaluate the Species' Fumonisin Production. Toxins. 2016 08; 8(9):. doi: 10.3390/toxins8090254. [PMID: 27589800]
  • Salama A Ouf, Abdulrahman H Basher, Abdel-Aleam H Mohamed. Inhibitory effect of double atmospheric pressure argon cold plasma on spores and mycotoxin production of Aspergillus niger contaminating date palm fruits. Journal of the science of food and agriculture. 2015 Dec; 95(15):3204-10. doi: 10.1002/jsfa.7060. [PMID: 25557283]
  • Kristian Fog Nielsen, Archard Ferdinand Ngemela, Lene Bai Jensen, Lívia Soman de Medeiros, Peter Have Rasmussen. UHPLC-MS/MS determination of ochratoxin A and fumonisins in coffee using QuEChERS extraction combined with mixed-mode SPE purification. Journal of agricultural and food chemistry. 2015 Jan; 63(3):1029-34. doi: 10.1021/jf504254q. [PMID: 25553918]
  • Meng Fu, Renjie Li, Congcong Guo, Minhao Pang, Yingchao Liu, Jingao Dong. Natural incidence of Fusarium species and fumonisins B1 and B2 associated with maize kernels from nine provinces in China in 2012. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2015; 32(4):503-11. doi: 10.1080/19440049.2014.976846. [PMID: 25315450]
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  • Johannes Gerding, Benedikt Cramer, Hans-Ulrich Humpf. Determination of mycotoxin exposure in Germany using an LC-MS/MS multibiomarker approach. Molecular nutrition & food research. 2014 Dec; 58(12):2358-68. doi: 10.1002/mnfr.201400406. [PMID: 25243722]
  • Fernando Carlos Sousa, Christiano Rodrigues Schamber, Sandra Sheila Seron Amorin, Maria Raquel Marçal Natali. Effect of fumonisin-containing diet on the myenteric plexus of the jejunum in rats. Autonomic neuroscience : basic & clinical. 2014 Oct; 185(?):93-9. doi: 10.1016/j.autneu.2014.08.001. [PMID: 25183308]
  • Olga Torres, Jorge Matute, Janee Gelineau-van Waes, Joyce R Maddox, Simon G Gregory, Allison E Ashley-Koch, Jency L Showker, Nicholas C Zitomer, Kenneth A Voss, Ronald T Riley. Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala. Molecular nutrition & food research. 2014 May; 58(5):973-83. doi: 10.1002/mnfr.201300481. [PMID: 24375966]
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  • Weijun Kong, Tingting Xie, Junyuan Li, Jianhe Wei, Feng Qiu, Aidi Qi, Yuguo Zheng, Meihua Yang. Analysis of fumonisins B1 and B2 in spices and aromatic and medicinal herbs by HPLC-FLD with on-line post-column derivatization and positive confirmation by LC-MS/MS. The Analyst. 2012 Jul; 137(13):3166-74. doi: 10.1039/c2an35164a. [PMID: 22627776]
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  • M Qiu, X Liu, Y Wang, C Zhang. [Survey on the fumonisins intake and the urinary Sa/So ratio of people suffered from a high incidence of esophageal cancer]. Wei sheng yan jiu = Journal of hygiene research. 2001 Nov; 30(6):365-7. doi: NULL. [PMID: 12561623]
  • L van der Westhuizen, G S Shephard, D J van Schalkwyk. The effect of a single gavage dose of fumonisin B(2) on the sphinganine and sphingosine concentrations in vervet monkeys. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2001 May; 39(5):455-9. doi: 10.1016/s0278-6915(00)00154-x. [PMID: 11313111]
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