Classification Term: 169928

Sphingoid base analogs (ontology term: 8b019aa35530624ea3ae362adc6b5a28)

found 67 associated metabolites at sub_class metabolite taxonomy ontology rank level.

Child Taxonomies: There is no child term of current ontology term.

Fumonisin B1

1,2,3-propanetricarboxylic acid, 1,-1-[1-(12-amino-4,9,11-trihydroxy-2-methyltridecyl)-2-(1-methylpentyl)-1,2-ethanediyl] ester

C34H59NO15 (721.3884504)

Fumonisin B1 is from Fusarium moniliforme Fumonisin B1 is an inhibitor of ceramide synthase D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins D009676 - Noxae > D011042 - Poisons > D037341 - Fumonisins D009676 - Noxae > D002273 - Carcinogens D009676 - Noxae > D013723 - Teratogens D004791 - Enzyme Inhibitors From Fusarium moniliforme

Fumonisin B2

2-[2-({19-amino-6-[(3,4-dicarboxybutanoyl)oxy]-16,18-dihydroxy-5,9-dimethylicosan-7-yl}oxy)-2-oxoethyl]butanedioic acid

C34H59NO14 (705.3935354)

Fumonisin B2 is from Fusarium moniliforme Fumonisin B2 is a fumonisin mycotoxin produced by the fungi Fusarium verticillioides and Fusarium moniliforme. It is a structural analog of fumonisin B1. Fumonisin B2 is more cytotoxic than fumonisin B1. Fumonisin B2 inhibits sphingosine acyltransferase D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins D009676 - Noxae > D011042 - Poisons > D037341 - Fumonisins D009676 - Noxae > D002273 - Carcinogens From Fusarium moniliforme

N,N-Dimethylsphingosine

(S-(R,S-(e)))-2-(dimethylamino)-4-Octadecene-1,3-diol

C20H41NO2 (327.31371260000003)

N,N-Dimethylsphingosine is an inhibitor of sphingosine kinase. It is a natural metabolite of sphingosine in some cancer cell lines and tissues. N,N-Dimethylsphingosine inhibited U937 cell sphingosine kinase with a Ki value of 3.1 ¬µM. N,N-Dimethylsphingosine induces apoptosis, but it is not an inhibitor of protein kinase C. N,N-Dimethylsphingosine (DMS) has recently been identified as an inducer of pain in a rat model of chronic pain. (PMID: 22267119) It has properties similar to capsaicin (PMID: 16740613). Other studies have indicated that DMS inhibits airway inflammation in asthma (PMID: 18359884) and is cardioprotective (PMID: 16831409). N,N-Dimethylsphingosine is an inhibitor of sphingosine kinase. It is a natural metabolite of sphingosine in some cancer cell lines and tissues.1 N,N-Dimethylsphingosine inhibited U937 cell sphingosine kinase with a Ki value of 3.1 ?M.2 N,N-Dimethylsphingosine induces apoptosis, but it is not an inhibitor of protein kinase C. [HMDB] D004791 - Enzyme Inhibitors

Psychosine sulfate

{[(2S,4R,5S,6S)-6-{[(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methoxy}sulphonic acid

C24H47NO10S (541.2920522000001)

psychosine sulfate is a intermediate in the biosynthesis of cerebrosides. It is one of the products involved in the reaction of 3-phosphoadenylyl sulfate with galactosylsphingosine catalyzed by psychosine sulfotransferase, and the other product is ADP respectively. psychosine sulfate is a intermediate in the biosynthesis of cerebrosides.

C16 Sphinganine

2-aminohexadecane-1,3-diol

C16H35NO2 (273.266765)

Fumonisin B4

2-[2-({19-amino-6-[(3,4-dicarboxybutanoyl)oxy]-18-hydroxy-5,9-dimethylicosan-7-yl}oxy)-2-oxoethyl]butanedioic acid

C34H59NO13 (689.3986204)

Fumonisin B4 is from Fusarium moniliforme. From Fusarium moniliforme

Fumonisin A1

2-[2-({6-[(3,4-dicarboxybutanoyl)oxy]-11,16,18-trihydroxy-19-[(Z)-(1-hydroxyethylidene)amino]-5,9-dimethylicosan-7-yl}oxy)-2-oxoethyl]butanedioic acid

C36H61NO16 (763.3990146)

Fumonisin A1 is produced by Fusarium moniliform Production by Fusarium moniliforme

Spisulosine

2-aminooctadecan-3-ol

C18H39NO (285.3031484)

Xestoaminol C

(2S, 3R)-2-Amino-3-tetradecanol

C14H31NO (229.24055159999997)

Leucettamol A

(2S,3R,5Z,8Z,11Z,14Z,17Z,20Z,28R,29S)-2,29-diaminotriaconta-5,8,11,14,17,20-hexaene-3,28-diol

C30H52N2O2 (472.40285719999997)

Halaminol A

1-deoxy-tetradecasphing-13-enine

C14H29NO (227.2249024)

Psychosine

1-beta-galactosyl-sphing-4-enine

C24H47NO7 (461.3352352)

A glycosylsphingoid consisting of sphingosine having a beta-D-galactosyl residue attached at the 1-position.

Aplidiasphingosine

2S-amino-5,9,13,17-tetramethyl-8E,16-octadecadiene-1,3R,14-triol

C22H43NO3 (369.3242768)

An amino alcohol that is 2-aminooctadeca-8,16-diene-1,3,14-triol substituted by methyl groups at positions 5, 9, 13 and 17 (the 2S,3R,8E stereoisomer).

termitomycesphin A

N-(2R-hydroxy-hexadecanoyl)-1-beta-glucosyl-8-hydroxy,9-methylene-sphing-4E-enine

C41H77NO10 (743.5547182)

plakoside A

C57H105NO9 (947.778892)

fumonisin b1

C34H59NO15 (721.3884504)

A diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol. D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins D009676 - Noxae > D011042 - Poisons > D037341 - Fumonisins D009676 - Noxae > D002273 - Carcinogens D009676 - Noxae > D013723 - Teratogens D004791 - Enzyme Inhibitors CONFIDENCE Reference Standard (Level 1)

fumonisin B2

1,1-[(1S,2R)-1-[(2S,9R,11S,12S)-12-amino-9,11-dihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl]ester-1,2,3-propanetricarboxylic acid

C34H59NO14 (705.3935354)

A fumonisin that is (2S,3S,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,14,15-triol in which the hydroxy groups at positions 14 and 15 have each been esterified by condensation with the 1-carboxy group of 3-carboxyglutaric acid (giving a 3-carboxyglutarate ester group with R configuration in each case). D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins D009676 - Noxae > D011042 - Poisons > D037341 - Fumonisins D009676 - Noxae > D002273 - Carcinogens CONFIDENCE standard compound; INTERNAL_ID 5969 CONFIDENCE Reference Standard (Level 1)

Fumonisin B4

C34H59NO13 (689.3986204)

A fumonisin that is fumonisin B2 that is lacking hydroxy group located gamma- to the amino substituent. D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins D009676 - Noxae > D011042 - Poisons > D037341 - Fumonisins CONFIDENCE isolated standard

C17 Sphingosine

2S-amino-4E-heptadecene-1,3R-diol

C17H35NO2 (285.266765)

Sphingosine (d17:1) is a 17-carbon sphingosine found in human skin. Sphingosine (d17:1) can be phosphorylated by sphingosine kinases to produce C-17 sphingosine-1-phosphate. Sphingosine C-17 was used as an internal standard for spectral analysis of sphingoid compounds[1][2][3].