Mannitol 1-phosphate (BioDeep_00000001738)

 

Secondary id: BioDeep_00001869073

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


{[(2R,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]oxy}phosphonic acid

化学式: C6H15O9P (262.0454)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(natural_products) 10.83%

分子结构信息

SMILES: C(C(C(C(C(COP(=O)(O)O)O)O)O)O)O
InChI: InChI=1S/C6H15O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h3-11H,1-2H2,(H2,12,13,14)/t3-,4-,5-,6-/m1/s1

描述信息

Mannitol-1-phosphate is a sugar alcohol. Mannitol-1-phosphate dehydrogenase, (EC 1.1.1.17) reduces fructose 6-phosphate into mannitol 1-phosphate, in the mannitol cycle of organisms such as Lactobacillus plantarum, a lactic acid bacterium found in many fermented food products and in the gastrointestinal tract of mammals. Mannitol-1-phosphate is also produced in many organisms that have a range of biological interactions with humans: parasitic, mutualism, or commensalism (Examples. A. niger; A. parasiticus; B. subtilis; C. difficile; E. faecalis; E. coli; K. pneumoniae; L. salivarius; M. hyopneumoniae; M. mycoides; M. pneumoniae; P. multocida; S. typhi; S. typhimurium; S. aureus; S. pneumoniae; V. cholerae; V. parahaemolyticus; Y. pestis). [HMDB]
Mannitol 1-phosphate is a sugar alcohol. Mannitol 1-phosphate dehydrogenase (EC 1.1.1.17) reduces fructose 6-phosphate into mannitol 1-phosphate in the gastrointestinal tract of mammals and the mannitol cycle of organisms such as Lactobacillus plantarum, a lactic acid bacterium found in many fermented food products. Mannitol 1-phosphate is also produced in many organisms that have a range of biological interactions with humans (e.g. A. niger, A. parasiticus, B. subtilis, C. difficile, E. faecalis, E. coli, K. pneumoniae, L. salivarius, M. hyopneumoniae, M. mycoides, M. pneumoniae, P. multocida, S. typhi, S. typhimurium, S. aureus, S. pneumoniae, V. cholerae, V. parahaemolyticus, Y. pestis).
KEIO_ID M011

同义名列表

10 个代谢物同义名

{[(2R,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]oxy}phosphonic acid; Mannitol 1-phosphoric acid; D-Mannitol 6-phosphate; D-Mannitol-1-phosphate; D-Mannitol 1-phosphate; Mannitol 1-phosphate; Mannitol-1-phosphate; Alditol 6-phosphate; Mannitol-1-P; D-Mannitol 1-phosphate



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 G6PD, GCK, GK, GPD1, GPI, ITPR3, MDH1, MVD, PMM1, PMM2
Peripheral membrane protein 3 G6PD, GCK, SORD
Endoplasmic reticulum membrane 4 ALG1, CDIPT, DPM1, ITPR3
Mitochondrion membrane 1 SORD
Nucleus 6 DPM1, GCK, GK, MYCT1, SNU13, TCEA1
cytosol 10 G6PD, GCK, GK, GPD1, GPI, MDH1, MVD, PMM1, PMM2, SORD
mitochondrial membrane 1 SORD
nuclear body 1 MYCT1
centrosome 1 MDH1
nucleoplasm 6 GCK, ITPR3, MYCT1, PMM2, SNU13, TCEA1
Cell membrane 1 CDIPT
Multi-pass membrane protein 2 CDIPT, ITPR3
Golgi apparatus membrane 2 GCK, GCNT7
Golgi apparatus 1 CDIPT
Golgi membrane 2 GCK, GCNT7
mitochondrial inner membrane 1 LDHD
neuronal cell body 3 ITPR3, PMM1, PMM2
Cytoplasm, cytosol 3 G6PD, GK, MDH1
plasma membrane 2 CDIPT, ITPR3
Membrane 8 ALG1, CDIPT, DPM1, G6PD, GPI, ITPR3, MYCT1, SORD
basolateral plasma membrane 1 GCK
brush border 1 ITPR3
extracellular exosome 6 G6PD, GK, GPD1, GPI, MDH1, SORD
endoplasmic reticulum 3 ALG1, DPM1, ITPR3
extracellular space 3 GPI, MDH1, SORD
mitochondrion 4 GATC, GCK, GK, LDHD
protein-containing complex 1 SNU13
intracellular membrane-bounded organelle 2 G6PD, MYCT1
Secreted 1 GPI
extracellular region 1 GPI
cytoplasmic side of plasma membrane 1 G6PD
Mitochondrion outer membrane 1 GK
Single-pass membrane protein 2 ALG1, GK
mitochondrial outer membrane 1 GK
centriolar satellite 1 G6PD
ciliary membrane 1 GPI
motile cilium 1 SORD
nucleolus 3 ITPR3, SNU13, TCEA1
apical part of cell 1 ITPR3
Single-pass type II membrane protein 1 GCNT7
sarcoplasmic reticulum 1 ITPR3
nuclear outer membrane 1 ITPR3
receptor complex 1 ITPR3
Nucleus, nucleolus 1 SNU13
Cell projection, cilium, flagellum 1 SORD
Basolateral cell membrane 1 GCK
spliceosomal complex 1 SNU13
[Isoform 4]: Cytoplasm, cytosol 1 GK
ficolin-1-rich granule lumen 1 GPI
secretory granule lumen 1 GPI
secretory granule membrane 1 ITPR3
transcription factor TFIID complex 1 TCEA1
small-subunit processome 1 SNU13
box C/D methylation guide snoRNP complex 1 SNU13
ribonucleoprotein complex 1 SNU13
platelet dense tubular network membrane 1 ITPR3
U2-type precatalytic spliceosome 1 SNU13
U4/U6 x U5 tri-snRNP complex 1 SNU13
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
glutamyl-tRNA(Gln) amidotransferase complex 1 GATC
dolichol-phosphate-mannose synthase complex 1 DPM1
precatalytic spliceosome 1 SNU13
transport vesicle membrane 1 ITPR3
cytoplasmic side of endoplasmic reticulum membrane 2 ALG1, ITPR3
[Isoform 3]: Mitochondrion outer membrane 1 GK
dense fibrillar component 1 SNU13
U4atac snRNP 1 SNU13


文献列表

  • Sylvie Rousvoal, Agnès Groisillier, Simon M Dittami, Gurvan Michel, Catherine Boyen, Thierry Tonon. Mannitol-1-phosphate dehydrogenase activity in Ectocarpus siliculosus, a key role for mannitol synthesis in brown algae. Planta. 2011 Feb; 233(2):261-73. doi: 10.1007/s00425-010-1295-6. [PMID: 20981555]
  • Dezhi Wu, Long Qiu, Lulu Xu, Lingzhen Ye, Mingxian Chen, Dongfa Sun, Zhonghua Chen, Haitao Zhang, Xiaoli Jin, Fei Dai, Guoping Zhang. Genetic variation of HvCBF genes and their association with salinity tolerance in Tibetan annual wild barley. PloS one. 2011; 6(7):e22938. doi: 10.1371/journal.pone.0022938. [PMID: 21829562]
  • Yonglan Yu, Haili Zhang, Guan Zhu. Plant-type trehalose synthetic pathway in cryptosporidium and some other apicomplexans. PloS one. 2010 Sep; 5(9):e12593. doi: 10.1371/journal.pone.0012593. [PMID: 20830297]
  • Cristina Fernandez-Aunión, Thouraya Ben Hamouda, Fernando Iglesias-Guerra, Montserrat Argandoña, Mercedes Reina-Bueno, Joaquín J Nieto, M Elarbi Aouani, Carmen Vargas. Biosynthesis of compatible solutes in rhizobial strains isolated from Phaseolus vulgaris nodules in Tunisian fields. BMC microbiology. 2010 Jul; 10(?):192. doi: 10.1186/1471-2180-10-192. [PMID: 20633304]
  • Thierry Dulermo, Christine Rascle, Geneviève Billon-Grand, Elisabeth Gout, Richard Bligny, Pascale Cotton. Novel insights into mannitol metabolism in the fungal plant pathogen Botrytis cinerea. The Biochemical journal. 2010 Mar; 427(2):323-32. doi: 10.1042/bj20091813. [PMID: 20136633]
  • Jan Nadwodnik, Gertrud Lohaus. Subcellular concentrations of sugar alcohols and sugars in relation to phloem translocation in Plantago major, Plantago maritima, Prunus persica, and Apium graveolens. Planta. 2008 Apr; 227(5):1079-89. doi: 10.1007/s00425-007-0682-0. [PMID: 18188589]
  • Stephan Marzin, Robert Mihaly, Janos Pauk, Patrick Schweizer. A transient assay system for the assessment of cell-autonomous gene function in dehydration-stressed barley. Journal of experimental botany. 2008; 59(12):3359-69. doi: 10.1093/jxb/ern186. [PMID: 18641397]
  • Heriberto Vélëz, Norman J Glassbrook, Margaret E Daub. Mannitol metabolism in the phytopathogenic fungus Alternaria alternata. Fungal genetics and biology : FG & B. 2007 Apr; 44(4):258-68. doi: 10.1016/j.fgb.2006.09.008. [PMID: 17092745]
  • Peter S Solomon, Ormonde D C Waters, Cordula I Jörgens, Rohan G T Lowe, Judith Rechberger, Robert D Trengove, Richard P Oliver. Mannitol is required for asexual sporulation in the wheat pathogen Stagonospora nodorum (glume blotch). The Biochemical journal. 2006 Oct; 399(2):231-9. doi: 10.1042/bj20060891. [PMID: 16859492]
  • Lei Hu, Hai Lu, Qunlu Liu, Xuemei Chen, Xiangning Jiang. Overexpression of mtlD gene in transgenic Populus tomentosa improves salt tolerance through accumulation of mannitol. Tree physiology. 2005 Oct; 25(10):1273-81. doi: 10.1093/treephys/25.10.1273. [PMID: 16076776]
  • Wei Tang, Xuexian Peng, Ronald J Newton. Enhanced tolerance to salt stress in transgenic loblolly pine simultaneously expressing two genes encoding mannitol-1-phosphate dehydrogenase and glucitol-6-phosphate dehydrogenase. Plant physiology and biochemistry : PPB. 2005 Feb; 43(2):139-46. doi: 10.1016/j.plaphy.2005.01.009. [PMID: 15820661]
  • Koji Iwamoto, Hideaki Kawanobe, Tomoyoshi Ikawa, Yoshihiro Shiraiwa. Characterization of salt-regulated mannitol-1-phosphate dehydrogenase in the red alga Caloglossa continua. Plant physiology. 2003 Oct; 133(2):893-900. doi: 10.1104/pp.103.026906. [PMID: 12972650]
  • F F Roossien, M Blaauw, G T Robillard. Kinetics and subunit interaction of the mannitol-specific enzyme II of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system. Biochemistry. 1984 Oct; 23(21):4934-9. doi: 10.1021/bi00316a017. [PMID: 6437444]