4-Oxoproline (BioDeep_00000001642)

 

Secondary id: BioDeep_00000174493, BioDeep_00001870162


代谢物信息卡片


4-oxopyrrolidine-2-carboxylic acid

化学式: C5H7NO3 (129.0426)
中文名称: (R)-4-氧代吡咯烷-2-羧酸, 4-酮-L-脯氨酸, 4-氧代脯氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 13.65%

分子结构信息

SMILES: C1C(=O)CN[C@@H]1C(=O)O
InChI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h4,6H,1-2H2,(H,8,9)

描述信息

The 4-isomer of oxoproline.

同义名列表

6 个代谢物同义名

4-Oxoproline; 4-oxopyrrolidine-2-carboxylic acid; 4-Oxo-D-proline; 4-oxo-L-proline; 4-oxo-proline; 4-Oxoproline



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 BDH2, CDH1, CDH2, CTNNB1, PRKN, PTGS1, SNAI1, STAM2, VIM
Peripheral membrane protein 4 FDXR, PTGS1, STAM2, VHL
Endoplasmic reticulum membrane 1 PTGS1
Nucleus 7 BRD4, CDH1, CTNNB1, PRKN, SNAI1, VHL, ZEB1
cytosol 9 BDH2, CDH1, CTNNB1, PRKN, SNAI1, STAM2, VHL, VIM, ZEB1
phagocytic vesicle 1 VIM
trans-Golgi network 1 CDH1
centrosome 1 CTNNB1
nucleoplasm 7 BRD4, CDH1, CTNNB1, SNAI1, STAM2, VHL, ZEB1
Cell membrane 6 ABCC1, CDH1, CDH2, CTNNB1, VHL, VIM
Cytoplasmic side 1 STAM2
lamellipodium 3 CDH1, CDH2, CTNNB1
Early endosome membrane 1 STAM2
Multi-pass membrane protein 1 ABCC1
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 3 CDH1, CDH2, CTNNB1
cell surface 1 CDH2
glutamatergic synapse 2 CDH1, CTNNB1
Golgi apparatus 3 CDH1, PRKN, PTGS1
Golgi membrane 1 INS
mitochondrial inner membrane 1 FDXR
postsynapse 1 CDH1
presynaptic membrane 1 CTNNB1
sarcolemma 1 CDH2
Cytoplasm, cytosol 1 PRKN
Presynapse 1 PRKN
endosome 1 CDH1
plasma membrane 6 ABCC1, CDH1, CDH2, CTNNB1, VHL, VIM
Membrane 4 ABCC1, CDH1, CDH2, CTNNB1
apical plasma membrane 2 ABCC1, CDH2
axon 1 VIM
basolateral plasma membrane 3 ABCC1, CDH2, CTNNB1
extracellular exosome 7 ABCC1, BDH2, CDH1, CTNNB1, MMP7, PTGS1, VIM
endoplasmic reticulum 2 PRKN, VHL
extracellular space 2 INS, MMP7
perinuclear region of cytoplasm 3 CDH1, CTNNB1, PRKN
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 3 CDH1, CDH2, CTNNB1
apicolateral plasma membrane 2 CDH2, CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 CDH2
mitochondrion 3 FDXR, PRKN, VHL
protein-containing complex 1 CTNNB1
intracellular membrane-bounded organelle 3 PTGS1, SNAI1, STAM2
Microsome membrane 1 PTGS1
postsynaptic density 2 CDH2, PRKN
pericentric heterochromatin 1 SNAI1
Single-pass type I membrane protein 2 CDH1, CDH2
Secreted 1 INS
extracellular region 3 CDH1, INS, MMP7
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 1 PRKN
mitochondrial outer membrane 1 PRKN
mitochondrial matrix 1 FDXR
transcription regulator complex 1 CTNNB1
photoreceptor outer segment 1 PTGS1
nuclear membrane 1 CDH1
Secreted, extracellular space, extracellular matrix 1 MMP7
actin cytoskeleton 1 CDH1
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
Wnt signalosome 1 CTNNB1
apical part of cell 2 CDH2, CTNNB1
cell-cell junction 2 CDH2, CTNNB1
postsynaptic membrane 1 CTNNB1
presynaptic active zone membrane 1 CDH2
Cell membrane, sarcolemma 1 CDH2
Mitochondrion inner membrane 1 FDXR
Cytoplasm, cytoskeleton 2 CTNNB1, VIM
focal adhesion 3 CDH2, CTNNB1, VIM
Cell junction, adherens junction 3 CDH1, CDH2, CTNNB1
flotillin complex 2 CDH1, CTNNB1
extracellular matrix 1 MMP7
Peroxisome 1 VIM
collagen-containing extracellular matrix 1 CDH2
fascia adherens 2 CDH2, CTNNB1
intermediate filament 1 VIM
lateral plasma membrane 3 ABCC1, CDH1, CTNNB1
nuclear speck 1 PRKN
Cell projection, neuron projection 1 PRKN
neuron projection 4 CDH2, PRKN, PTGS1, VIM
chromatin 1 ZEB1
cell leading edge 1 VIM
cell periphery 1 CTNNB1
Chromosome 1 BRD4
cytoskeleton 1 VIM
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Golgi apparatus, trans-Golgi network 1 CDH1
spindle pole 1 CTNNB1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
fibrillar center 1 SNAI1
Endomembrane system 2 CTNNB1, PTGS1
endosome lumen 1 INS
microtubule organizing center 1 VIM
euchromatin 1 CTNNB1
intermediate filament cytoskeleton 1 VIM
ubiquitin ligase complex 1 PRKN
basal plasma membrane 1 ABCC1
[Isoform 1]: Cytoplasm 1 VHL
[Isoform 3]: Cytoplasm 1 VHL
plasma membrane raft 1 CDH2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 CDH2, INS
nuclear matrix 1 VIM
endocytic vesicle 1 STAM2
transport vesicle 1 INS
beta-catenin-TCF complex 1 CTNNB1
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
aggresome 1 PRKN
Nucleus matrix 1 VIM
condensed nuclear chromosome 1 BRD4
presynaptic active zone cytoplasmic component 1 CTNNB1
ESCRT-0 complex 1 STAM2
[Isoform 2]: Nucleus 1 CDH1
protein-DNA complex 1 CTNNB1
postsynaptic specialization membrane 1 CDH2
apical junction complex 1 CDH1
dopaminergic synapse 1 PRKN
intracellular non-membrane-bounded organelle 1 VHL
Lewy body 1 PRKN
Parkin-FBXW7-Cul1 ubiquitin ligase complex 1 PRKN
Cell junction, desmosome 2 CDH1, CDH2
desmosome 2 CDH1, CDH2
catenin complex 3 CDH1, CDH2, CTNNB1
[Isoform B]: Chromosome 1 BRD4
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1


文献列表

  • Sebastian Kwiatkowski, Maria Bozko, Michal Zarod, Apolonia Witecka, Kubra Kocdemir, Adam K Jagielski, Jakub Drozak. Recharacterization of the mammalian cytosolic type 2 (R)-β-hydroxybutyrate dehydrogenase as 4-oxo-l-proline reductase (EC 1.1.1.104). The Journal of biological chemistry. 2022 03; 298(3):101708. doi: 10.1016/j.jbc.2022.101708. [PMID: 35150746]
  • Seongwon Seo, Harris A Lewin. Reconstruction of metabolic pathways for the cattle genome. BMC systems biology. 2009 Mar; 3(?):33. doi: 10.1186/1752-0509-3-33. [PMID: 19284618]
  • W J Lee, R A Hawkins, D R Peterson, J R Viña. Role of oxoproline in the regulation of neutral amino acid transport across the blood-brain barrier. The Journal of biological chemistry. 1996 Aug; 271(32):19129-33. doi: 10.1074/jbc.271.32.19129. [PMID: 8702588]
  • V Ganapathy, R A Roesel, J C Howard, F H Leibach. Interaction of proline, 5-oxoproline, and pipecolic acid for renal transport in the rabbit. The Journal of biological chemistry. 1983 Feb; 258(4):2266-72. doi: NULL. [PMID: 6822557]
  • T E SMITH, C MITOMA. Partial purification and some properties of 4-ketoproline reductase. The Journal of biological chemistry. 1962 Apr; 237(?):1177-80. doi: 10.1016/s0021-9258(18)60303-5. [PMID: 13914427]