Dihydrofolic acid (BioDeep_00000001333)

 

Secondary id: BioDeep_00000413236, BioDeep_00001868416

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs BioNovoGene_Lab2019 natural product


代谢物信息卡片


(2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid

化学式: C19H21N7O6 (443.1553)
中文名称: 二氢叶酸, 二氢叶酸二水合物
谱图信息: 最多检出来源 Homo sapiens(plant) 21.63%

分子结构信息

SMILES: C1C(=NC2=C(N1)N=C(NC2=O)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)

描述信息

Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division. It can be targeted with drug analogs to prevent nucleic acid synthesis. Dihydrofolic acid is also known by the name Dihydrofolate - more commonly Vitamin B9. [HMDB]
Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division. It can be targeted with drug analogs to prevent nucleic acid synthesis. Dihydrofolic acid is also known by the name Dihydrofolate - more commonly Vitamin B9.
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Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid.

同义名列表

25 个代谢物同义名

(2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid; 2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid; N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid; N-[4-[[(2-Amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid; N-(4-(((2-Amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid; N-(4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid; L-N-[p-[[(2-Amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-glutamic acid; N-(7,8-Dihydropteroyl)-L-glutamic acid; 7,8-Dihydropteroyl-L-glutamic acid; N-(7,8-Dihydropteroyl)-L-glutamate; 7,8-Dihydropteroylglutamic acid; Dihydropteroyl-L-glutamic acid; 7,8-Dihydropteroylglutamate; Dihydrofolate, (D)-isomer; 7,8-Dihydro-L-folic acid; 7,8-Dihydrofolic acid; 7,8-Dihydrofolate; Dihydrofolic acid; Dihydrofolate; Vitamin B9; H2PteGlu1; H2PteGlu; FAH2; Dihydrofolic acid; Dihydrofolate



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(5)

PlantCyc(1)

代谢反应

1150 个相关的代谢反应过程信息。

Reactome(12)

BioCyc(12)

WikiPathways(6)

Plant Reactome(320)

INOH(2)

PlantCyc(760)

COVID-19 Disease Map(1)

PathBank(37)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 DHFR, DHPS, GCH1, HDGFL2, ODC1, PMP2, SP1, TUBB4B, TYMS
Peripheral membrane protein 1 HSD17B6
Nucleus 7 GCH1, GGH, HDGFL2, PMP2, SP1, TUBB4B, TYMS
cytosol 12 DHFR, DHFR2, DHPS, GART, GCH1, KRT83, MTHFR, ODC1, PMP2, PPAT, TUBB4B, TYMS
nucleoplasm 2 GCH1, SP1
Cell membrane 1 TNF
Early endosome membrane 1 HSD17B6
cell surface 1 TNF
mitochondrial inner membrane 2 DHFR2, TYMS
neuronal cell body 1 TNF
Lysosome 1 GGH
plasma membrane 2 F2, TNF
extracellular exosome 6 EPX, F2, GART, GGH, PMP2, TUBB4B
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 6 EPX, F2, GGH, KRT83, SP1, TNF
mitochondrion 4 DHFR, DHFR2, GCH1, TYMS
protein-containing complex 1 GCH1
intracellular membrane-bounded organelle 1 HSD17B6
Microsome membrane 1 HSD17B6
Secreted 2 F2, SP1
extracellular region 6 EPX, F2, GGH, SP1, TNF, TUBB4B
Mitochondrion matrix 2 DHFR2, TYMS
mitochondrial matrix 2 DHFR2, TYMS
nuclear membrane 1 GCH1
external side of plasma membrane 1 TNF
Extracellular vesicle 1 TUBB4B
cytoplasmic vesicle 1 GCH1
microtubule cytoskeleton 1 TUBB4B
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 2 DHFR2, TYMS
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 TUBB4B
microtubule 1 TUBB4B
collagen-containing extracellular matrix 1 F2
chromatin 1 SP1
phagocytic cup 1 TNF
mitotic spindle 1 TUBB4B
cytoskeleton 1 TUBB4B
Secreted, extracellular space 1 GGH
blood microparticle 1 F2
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
axonemal microtubule 1 TUBB4B
Melanosome 1 GGH
euchromatin 1 SP1
myelin sheath 1 PMP2
secretory granule lumen 1 EPX
Golgi lumen 1 F2
endoplasmic reticulum lumen 1 F2
transcription repressor complex 1 SP1
specific granule lumen 1 GGH
tertiary granule lumen 1 GGH
azurophil granule lumen 2 GGH, TUBB4B
Vacuole 1 GGH
protein-DNA complex 1 SP1
keratin filament 1 KRT83
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
neuron projection terminus 1 GCH1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Bharadwaja Vadloori, A K Sharath, N Prakash Prabhu, Radheshyam Maurya. Homology modelling, molecular docking, and molecular dynamics simulations reveal the inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase enzyme by Withaferin-A. BMC research notes. 2018 Apr; 11(1):246. doi: 10.1186/s13104-018-3354-1. [PMID: 29661206]
  • Mohamed Badr, Christian Kopp, Sandra Theison, Jennifer Meyer, Wolfgang E Trommer. Methotrexate-gelonin conjugate - an inhibitor of MCF-7 cells expressing the dihydrofolate receptor. Biological chemistry. 2014 Dec; 395(12):1461-6. doi: 10.1515/hsz-2013-0270. [PMID: 25205711]
  • Sandy Shuo Zhao, Mathilde A Bichelberger, Damien Y Colin, Robert Robitaille, Joelle N Pelletier, Jean-François Masson. Monitoring methotrexate in clinical samples from cancer patients during chemotherapy with a LSPR-based competitive sensor. The Analyst. 2012 Oct; 137(20):4742-50. doi: 10.1039/c2an35839e. [PMID: 22943049]
  • M Joerger, A D R Huitema, G Illerhaus, A J M Ferreri. Rational administration schedule for high-dose methotrexate in patients with primary central nervous system lymphoma. Leukemia & lymphoma. 2012 Oct; 53(10):1867-75. doi: 10.3109/10428194.2012.676177. [PMID: 22530664]
  • Thommey P Thomas, Baohua Huang, Seok Ki Choi, Justin E Silpe, Alina Kotlyar, Ankur M Desai, Hong Zong, Jeremy Gam, Melvin Joice, James R Baker. Polyvalent dendrimer-methotrexate as a folate receptor-targeted cancer therapeutic. Molecular pharmaceutics. 2012 Sep; 9(9):2669-2676. doi: 10.1021/mp3002232. [PMID: 22827500]
  • Susanne H Kirsch, Wolfgang Herrmann, Jürgen Geisel, Rima Obeid. Assay of whole blood (6S)-5-CH3-H4folate using ultra performance liquid chromatography tandem mass spectrometry. Analytical and bioanalytical chemistry. 2012 Aug; 404(3):895-902. doi: 10.1007/s00216-012-6180-7. [PMID: 22729356]
  • Valentina Citton, Alberto Burlina, Claudio Baracchini, Massimo Gallucci, Alessia Catalucci, Sandro Dal Pos, Alessandro Burlina, Renzo Manara. Apparent diffusion coefficient restriction in the white matter: going beyond acute brain territorial ischemia. Insights into imaging. 2012 Apr; 3(2):155-64. doi: 10.1007/s13244-011-0114-3. [PMID: 22696041]
  • Ann Sarah Koshy, S Jaya Kumari, Vageesh Ayyar, Prasanna Kumar. Evaluation of serum vitamin B12 levels in type 1 diabetics attending a tertiary care hospital: A preliminary cross - sectional study. Indian journal of endocrinology and metabolism. 2012 Mar; 16 Suppl 1(?):S79-82. doi: 10.4103/2230-8210.94270. [PMID: 22701852]
  • Anastasia Malek, Luz-Elena Núñez, Marco Magistri, Lara Brambilla, Sandra Jovic, Giuseppina M Carbone, Francisco Morís, Carlo V Catapano. Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer. PloS one. 2012; 7(4):e35130. doi: 10.1371/journal.pone.0035130. [PMID: 22545098]
  • Mohd A Mohd Ridzuan, Robert W Moon, Ellen Knuepfer, Sally Black, Anthony A Holder, Judith L Green. Subcellular location, phosphorylation and assembly into the motor complex of GAP45 during Plasmodium falciparum schizont development. PloS one. 2012; 7(3):e33845. doi: 10.1371/journal.pone.0033845. [PMID: 22479457]
  • Carolyn Tam, Deborah O'Connor, Gideon Koren. Circulating unmetabolized folic Acid: relationship to folate status and effect of supplementation. Obstetrics and gynecology international. 2012; 2012(?):485179. doi: 10.1155/2012/485179. [PMID: 22529856]
  • N A Orlova, S V Kovnir, I I Vorobiev, A S Yuriev, A G Gabibov, A I Vorobiev. Stable Expression of Recombinant Factor VIII in CHO Cells Using Methotrexate-Driven Transgene Amplification. Acta naturae. 2012 Jan; 4(1):93-100. doi: 10.32607/20758251-2012-4-1-93-100. [PMID: 22708069]
  • Andrea Marzi, Reiko Yoshida, Hiroko Miyamoto, Mari Ishijima, Yasuhiko Suzuki, Megumi Higuchi, Yukie Matsuyama, Manabu Igarashi, Eri Nakayama, Makoto Kuroda, Masayuki Saijo, Friederike Feldmann, Douglas Brining, Heinz Feldmann, Ayato Takada. Protective efficacy of neutralizing monoclonal antibodies in a nonhuman primate model of Ebola hemorrhagic fever. PloS one. 2012; 7(4):e36192. doi: 10.1371/journal.pone.0036192. [PMID: 22558378]
  • Yan Jin, Zheng Liu, Wei Cao, Xinying Ma, Yihui Fan, Yang Yu, Jing Bai, Feng Chen, Jesusa Rosales, Ki-Young Lee, Songbin Fu. Novel functional MAR elements of double minute chromosomes in human ovarian cells capable of enhancing gene expression. PloS one. 2012; 7(2):e30419. doi: 10.1371/journal.pone.0030419. [PMID: 22319568]
  • Roderick A M Williams, Terry K Smith, Benjamin Cull, Jeremy C Mottram, Graham H Coombs. ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major. PLoS pathogens. 2012; 8(5):e1002695. doi: 10.1371/journal.ppat.1002695. [PMID: 22615560]
  • Zsuzsanna Bodi, Silin Zhong, Surbhi Mehra, Jie Song, Neil Graham, Hongying Li, Sean May, Rupert George Fray. Adenosine Methylation in Arabidopsis mRNA is Associated with the 3' End and Reduced Levels Cause Developmental Defects. Frontiers in plant science. 2012; 3(?):48. doi: 10.3389/fpls.2012.00048. [PMID: 22639649]
  • Ning Xu, Yan Li, Ying-Tao Zhao, Li Guo, Yuan-Yuan Fang, Jian-Hua Zhao, Xiu-Jie Wang, Li Huang, Hui-Shan Guo. Identification and characterization of small RNAs in the hyperthermophilic archaeon Sulfolobus solfataricus. PloS one. 2012; 7(4):e35306. doi: 10.1371/journal.pone.0035306. [PMID: 22514725]
  • Lisa M Schechter, Joy C Valenta, David J Schneider, Alan Collmer, Eric Sakk. Functional and computational analysis of amino acid patterns predictive of type III secretion system substrates in Pseudomonas syringae. PloS one. 2012; 7(4):e36038. doi: 10.1371/journal.pone.0036038. [PMID: 22558318]
  • Yulin Gao, Stuart R Reitz, Qingbo Wei, Wenyan Yu, Zhongren Lei. Insecticide-mediated apparent displacement between two invasive species of leafminer fly. PloS one. 2012; 7(5):e36622. doi: 10.1371/journal.pone.0036622. [PMID: 22662122]
  • Jeffrey C Waller, Kenneth W Ellens, Sophie Alvarez, Karen Loizeau, Stéphane Ravanel, Andrew D Hanson. Mitochondrial and plastidial COG0354 proteins have folate-dependent functions in iron-sulphur cluster metabolism. Journal of experimental botany. 2012 Jan; 63(1):403-11. doi: 10.1093/jxb/err286. [PMID: 21984653]
  • John P Burand, Woojin Kim, Claudio L Afonso, Edan R Tulman, Gerald F Kutish, Zhiqiang Lu, Daniel L Rock. Analysis of the genome of the sexually transmitted insect virus Helicoverpa zea nudivirus 2. Viruses. 2012 01; 4(1):28-61. doi: 10.3390/v4010028. [PMID: 22355451]
  • Bruce C Campbell, Kathleen L Chan, Jong H Kim. Chemosensitization as a means to augment commercial antifungal agents. Frontiers in microbiology. 2012; 3(?):79. doi: 10.3389/fmicb.2012.00079. [PMID: 22393330]
  • Helen Kuokuo Kimbi, Mesame Ntoko, Nelson N Ntonifor, Emmaculate Lum, Anna L Njunda, Peter Nde Fon. Efficacy and Tolerability of Malartin and Sulphadoxine-Pyrimethamine Combination against Uncomplicated Falciparum Malaria in Dibanda, Southwest Cameroon. Journal of tropical medicine. 2012; 2012(?):372518. doi: 10.1155/2012/372518. [PMID: 22529865]
  • Michael Kube, Jelena Mitrovic, Bojan Duduk, Ralf Rabus, Erich Seemüller. Current view on phytoplasma genomes and encoded metabolism. TheScientificWorldJournal. 2012; 2012(?):185942. doi: 10.1100/2012/185942. [PMID: 22550465]
  • J Enrique Salcedo-Sora, Edwin Ochong, Susan Beveridge, David Johnson, Alexis Nzila, Giancarlo A Biagini, Paul A Stocks, Paul M O'Neill, Sanjeev Krishna, Patrick G Bray, Stephen A Ward. The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters. The Journal of biological chemistry. 2011 Dec; 286(52):44659-68. doi: 10.1074/jbc.m111.286054. [PMID: 21998306]
  • Hugh J McMillan, Basil T Darras, Peter B Kang. Autoimmune neuromuscular disorders in childhood. Current treatment options in neurology. 2011 Dec; 13(6):590-607. doi: 10.1007/s11940-011-0146-5. [PMID: 21912840]
  • Jee Young Kim, Kee Duk Park, David P Richman. Treatment of myasthenia gravis based on its immunopathogenesis. Journal of clinical neurology (Seoul, Korea). 2011 Dec; 7(4):173-83. doi: 10.3988/jcn.2011.7.4.173. [PMID: 22259613]
  • Susan M Wernimont, Andrew G Clark, Patrick J Stover, Martin T Wells, Augusto A Litonjua, Scott T Weiss, J Michael Gaziano, Katherine L Tucker, Andrea Baccarelli, Joel Schwartz, Valentina Bollati, Patricia A Cassano. Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study. BMC medical genetics. 2011 Nov; 12(?):150. doi: 10.1186/1471-2350-12-150. [PMID: 22103680]
  • Swenja Schuhmacher, Matthias Oelze, Franziska Bollmann, Hartmut Kleinert, Christian Otto, Tjebo Heeren, Sebastian Steven, Michael Hausding, Maike Knorr, Andrea Pautz, Kurt Reifenberg, Eberhard Schulz, Tommaso Gori, Philip Wenzel, Thomas Münzel, Andreas Daiber. Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy. Diabetes. 2011 Oct; 60(10):2608-16. doi: 10.2337/db10-1395. [PMID: 21844097]
  • Glenn Tisman, April Garcia. Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report. Journal of medical case reports. 2011 Aug; 5(?):413. doi: 10.1186/1752-1947-5-413. [PMID: 21867542]
  • Anna Stachurska, Magdalena Kozakowska, Alicja Jozkowicz, Jozef Dulak, Agnieszka Loboda. Aristolochic acid I and ochratoxin A differentially regulate VEGF expression in porcine kidney epithelial cells--the involvement of SP-1 and HIFs transcription factors. Toxicology letters. 2011 Jul; 204(2-3):118-26. doi: 10.1016/j.toxlet.2011.04.022. [PMID: 21554934]
  • Juliana Almeida, Leandro Quadrana, Ramón Asís, Nathalia Setta, Fabiana de Godoy, Luisa Bermúdez, Santiago N Otaiza, Junia V Corrêa da Silva, Alisdair R Fernie, Fernando Carrari, Magdalena Rossi. Genetic dissection of vitamin E biosynthesis in tomato. Journal of experimental botany. 2011 Jul; 62(11):3781-98. doi: 10.1093/jxb/err055. [PMID: 21527625]
  • B P Mallikarjuna Swamy, Prashant Vikram, Shalabh Dixit, H U Ahmed, Arvind Kumar. Meta-analysis of grain yield QTL identified during agricultural drought in grasses showed consensus. BMC genomics. 2011 Jun; 12(?):319. doi: 10.1186/1471-2164-12-319. [PMID: 21679437]
  • Tatsiana Rakovich, Coilin Boland, Ilana Bernstein, Vimbai M Chikwana, Dirk Iwata-Reuyl, Vincent P Kelly. Queuosine deficiency in eukaryotes compromises tyrosine production through increased tetrahydrobiopterin oxidation. The Journal of biological chemistry. 2011 Jun; 286(22):19354-63. doi: 10.1074/jbc.m111.219576. [PMID: 21487017]
  • Kikin Mutaqin, Jana L Comer, Astri C Wayadande, Ulrich Melcher, Jacqueline Fletcher. Selection and characterization of Spiroplasma citri mutants by random transposome mutagenesis. Canadian journal of microbiology. 2011 Jun; 57(6):525-32. doi: 10.1139/w11-026. [PMID: 21635220]
  • Arvind Kumar, Soumynanda Chakraborti, Prachi Joshi, Pinak Chakrabarti, Ranadhir Chakraborty. A multiple antibiotic and serum resistant oligotrophic strain, Klebsiella pneumoniae MB45 having novel dfrA30, is sensitive to ZnO QDs. Annals of clinical microbiology and antimicrobials. 2011 May; 10(?):19. doi: 10.1186/1476-0711-10-19. [PMID: 21595893]
  • Etsuo Yokota, Haruko Ueda, Kohsuke Hashimoto, Hidefumi Orii, Tomoo Shimada, Ikuko Hara-Nishimura, Teruo Shimmen. Myosin XI-dependent formation of tubular structures from endoplasmic reticulum isolated from tobacco cultured BY-2 cells. Plant physiology. 2011 May; 156(1):129-43. doi: 10.1104/pp.111.175018. [PMID: 21427277]
  • Hong Lin, Binghai Lou, Jonathan M Glynn, Harshavardhan Doddapaneni, Edwin L Civerolo, Chuanwu Chen, Yongping Duan, Lijuan Zhou, Cheryl M Vahling. The complete genome sequence of 'Candidatus Liberibacter solanacearum', the bacterium associated with potato zebra chip disease. PloS one. 2011 Apr; 6(4):e19135. doi: 10.1371/journal.pone.0019135. [PMID: 21552483]
  • Pak Leung Ho, Wai U Lo, Man Kiu Yeung, Chi Ho Lin, Kin Hung Chow, Irene Ang, Amy Hin Yan Tong, Jessie Yun-Juan Bao, Si Lok, Janice Yee Chi Lo. Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong. PloS one. 2011 Mar; 6(3):e17989. doi: 10.1371/journal.pone.0017989. [PMID: 21445317]
  • Holger Cario, Desirée E C Smith, Henk Blom, Nenad Blau, Harald Bode, Karlheinz Holzmann, Ulrich Pannicke, Karl-Peter Hopfner, Eva-Maria Rump, Zuleya Ayric, Elisabeth Kohne, Klaus-Michael Debatin, Yvo Smulders, Klaus Schwarz. Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. American journal of human genetics. 2011 Feb; 88(2):226-31. doi: 10.1016/j.ajhg.2011.01.007. [PMID: 21310277]
  • Oztekin Algul, Janet L Paulsen, Amy C Anderson. 2,4-Diamino-5-(2'-arylpropargyl)pyrimidine derivatives as new nonclassical antifolates for human dihydrofolate reductase inhibition. Journal of molecular graphics & modelling. 2011 Feb; 29(5):608-13. doi: 10.1016/j.jmgm.2010.11.004. [PMID: 21146434]
  • M Hinken, S Halwachs, C Kneuer, W Honscha. Subcellular localization and distribution of the reduced folate carrier in normal rat tissues. European journal of histochemistry : EJH. 2011 Jan; 55(1):e3. doi: 10.4081/ejh.2011.e3. [PMID: 21556118]
  • Olav A Christophersen, Anna Haug. Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology. Lipids in health and disease. 2011 Jan; 10(?):16. doi: 10.1186/1476-511x-10-16. [PMID: 21247506]
  • Der-Yuan Chen, Hui-Min Chih, Joung-Liang Lan, Hsin-Yueh Chang, Wei-Wen Chen, En-Pei Isabel Chiang. Blood lipid profiles and peripheral blood mononuclear cell cholesterol metabolism gene expression in patients with and without methotrexate treatment. BMC medicine. 2011 Jan; 9(?):4. doi: 10.1186/1741-7015-9-4. [PMID: 21232092]
  • Ekaterina M Nestorovich, Vladimir A Karginov, Michel R Popoff, Sergey M Bezrukov, Holger Barth. Tailored ß-cyclodextrin blocks the translocation pores of binary exotoxins from C. botulinum and C. perfringens and protects cells from intoxication. PloS one. 2011; 6(8):e23927. doi: 10.1371/journal.pone.0023927. [PMID: 21887348]
  • Juliana A Moura, Claudete J Valduga, Elaine R Tavares, Iara F Kretzer, Durvanei A Maria, Raul C Maranhão. Novel formulation of a methotrexate derivative with a lipid nanoemulsion. International journal of nanomedicine. 2011; 6(?):2285-95. doi: 10.2147/ijn.s18039. [PMID: 22072866]
  • Daniel Scott, Jürgen Rohr, Younsoo Bae. Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity. International journal of nanomedicine. 2011; 6(?):2757-67. doi: 10.2147/ijn.s25427. [PMID: 22114504]
  • Louis A Lichten, Moon-Suhn Ryu, Liang Guo, Jennifer Embury, Robert J Cousins. MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction. PloS one. 2011; 6(6):e21526. doi: 10.1371/journal.pone.0021526. [PMID: 21738690]
  • Martin Roesel, Christoph Tappeiner, Arnd Heiligenhaus, Carsten Heinz. Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis. Clinical ophthalmology (Auckland, N.Z.). 2011; 5(?):1309-13. doi: 10.2147/opth.s11125. [PMID: 21966207]
  • Maddalena Rossi, Alberto Amaretti, Stefano Raimondi. Folate production by probiotic bacteria. Nutrients. 2011 01; 3(1):118-34. doi: 10.3390/nu3010118. [PMID: 22254078]
  • Enav Corem-Salkmon, Zvi Ram, Dianne Daniels, Benny Perlstein, David Last, Sharona Salomon, Gregory Tamar, Ran Shneor, David Guez, Shlomo Margel, Yael Mardor. Convection-enhanced delivery of methotrexate-loaded maghemite nanoparticles. International journal of nanomedicine. 2011; 6(?):1595-602. doi: 10.2147/ijn.s23025. [PMID: 21904449]
  • Umakhanth Venkatraman Girija, Daniel A Mitchell, Silke Roscher, Russell Wallis. Carbohydrate recognition and complement activation by rat ficolin-B. European journal of immunology. 2011 Jan; 41(1):214-23. doi: 10.1002/eji.201040612. [PMID: 21182092]
  • Alireza Soleimani, Mojtaba Usefzadeh, Elahe Mianehsaz, Fatemeh Foroozanfard, Hassan Nikoueinejad, Seyyed Alireza Moraveji, Omid Nasiri, Mohsen Rajali. Comparison of oral folic acid and folinic acid on blood homocysteine level of patients on hemodialysis. Iranian journal of kidney diseases. 2011 Jan; 5(1):45-9. doi: NULL. [PMID: 21189434]
  • Daniel Vaiman, Géraldine Gascoin-Lachambre, Farid Boubred, Françoise Mondon, Jean-Marc Feuerstein, Isabelle Ligi, Isabelle Grandvuillemin, Sandrine Barbaux, Eric Ghigo, Vincent Achard, Umberto Simeoni, Christophe Buffat. The intensity of IUGR-induced transcriptome deregulations is inversely correlated with the onset of organ function in a rat model. PloS one. 2011; 6(6):e21222. doi: 10.1371/journal.pone.0021222. [PMID: 21731679]
  • L Michel Espinoza-Fonseca, David D Thomas. Atomic-level characterization of the activation mechanism of SERCA by calcium. PloS one. 2011; 6(10):e26936. doi: 10.1371/journal.pone.0026936. [PMID: 22046418]
  • Stéphanie Cottier, Timon Mönig, Zheming Wang, Jiří Svoboda, Wilhelm Boland, Markus Kaiser, Erich Kombrink. The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells: potential and limitations. Frontiers in plant science. 2011; 2(?):101. doi: 10.3389/fpls.2011.00101. [PMID: 22639623]
  • Russell A Johnson, Geoffrey I McFadden, Christopher D Goodman. Characterization of two malaria parasite organelle translation elongation factor G proteins: the likely targets of the anti-malarial fusidic acid. PloS one. 2011; 6(6):e20633. doi: 10.1371/journal.pone.0020633. [PMID: 21695207]
  • Sahar Abubucker, John Martin, Christina M Taylor, Makedonka Mitreva. HelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritization. PloS one. 2011; 6(7):e21832. doi: 10.1371/journal.pone.0021832. [PMID: 21760913]
  • Rakhi Srivastava, Daman Saluja, Bilikere S Dwarakanath, Madhu Chopra. Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract of Boerhaavia diffusa Linn. (Punarnava) Root. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):427031. doi: 10.1093/ecam/nep223. [PMID: 21869896]
  • Mahreen Arooj, Sundarapandian Thangapandian, Shalini John, Swan Hwang, Jong Keun Park, Keun Woo Lee. 3D QSAR pharmacophore modeling, in silico screening, and density functional theory (DFT) approaches for identification of human chymase inhibitors. International journal of molecular sciences. 2011; 12(12):9236-64. doi: 10.3390/ijms12129236. [PMID: 22272131]
  • Daniel H Lewis, Dominic M Barfield, Karen R Humm, Robert A Goggs. Use of calcium folinate in the management of accidental methotrexate ingestion in two dogs. Journal of the American Veterinary Medical Association. 2010 Dec; 237(12):1450-4. doi: 10.2460/javma.237.12.1450. [PMID: 21155685]
  • John C Panetta, Alex Sparreboom, Ching-Hon Pui, Mary V Relling, William E Evans. Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells. PLoS computational biology. 2010 Dec; 6(12):e1001019. doi: 10.1371/journal.pcbi.1001019. [PMID: 21152005]
  • Karen Walker. Interscience Conference on Antimicrobial Agents and Chemotherapy - 50th Annual Meeting - Research on Promising New Agents: Part 1. IDrugs : the investigational drugs journal. 2010 Nov; 13(11):743-5. doi: NULL. [PMID: 21046515]
  • Andrea Harrer, Roland Lang, Robert Grims, Michaela Braitsch, Thomas Hawranek, Werner Aberer, Lothar Vogel, Walther Schmid, Fatima Ferreira, Martin Himly. Diclofenac hypersensitivity: antibody responses to the parent drug and relevant metabolites. PloS one. 2010 Oct; 5(10):e13707. doi: 10.1371/journal.pone.0013707. [PMID: 21060839]
  • María G Mediavilla, Gisela A Di Venanzio, Edgardo E Guibert, Claudio Tiribelli. Heterologous ferredoxin reductase and flavodoxin protect Cos-7 cells from oxidative stress. PloS one. 2010 Oct; 5(10):e13501. doi: 10.1371/journal.pone.0013501. [PMID: 20976072]
  • Leena Rajith, Krishnapillai Girish Kumar. Electroanalysis of trimethoprim on metalloporphyrin incorporated glassy carbon electrode. Drug testing and analysis. 2010 Sep; 2(9):436-41. doi: 10.1002/dta.161. [PMID: 20845390]
  • Kazuhiro Matsuoka, Hiroaki Komori, Masato Nose, Yaeta Endo, Tatsuya Sawasaki. Simple screening method for autoantigen proteins using the N-terminal biotinylated protein library produced by wheat cell-free synthesis. Journal of proteome research. 2010 Aug; 9(8):4264-73. doi: 10.1021/pr9010553. [PMID: 20575507]
  • Klaus Pietrzik, Lynn Bailey, Barry Shane. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clinical pharmacokinetics. 2010 Aug; 49(8):535-48. doi: 10.2165/11532990-000000000-00000. [PMID: 20608755]
  • Hetty Jolink, Jan den Hartigh, Leo G Visser, Cees van Nieuwkoop. Pancytopenia due to proguanil toxicity in a returning traveller with fever. European journal of clinical pharmacology. 2010 Aug; 66(8):811-2. doi: 10.1007/s00228-010-0824-3. [PMID: 20407763]
  • Kristin E Porter, Anamika Basu, Alan E Hubbard, Michael N Bates, David Kalman, Omar Rey, Allan Smith, Martyn T Smith, Craig Steinmaus, Christine F Skibola. Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism. Environmental research. 2010 Aug; 110(6):580-7. doi: 10.1016/j.envres.2010.05.001. [PMID: 20670920]
  • Sara Nannizzi, Gareth J Veal, Elisa Giovannetti, Valentina Mey, Simona Ricciardi, Christopher J Ottley, Mario Del Tacca, Romano Danesi. Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines. Cancer chemotherapy and pharmacology. 2010 Aug; 66(3):547-58. doi: 10.1007/s00280-009-1195-2. [PMID: 20020129]
  • Cristiani Cortez Mendes, Joice Matos Biselli, Bruna Lancia Zampieri, Eny Maria Goloni-Bertollo, Marcos Nogueira Eberlin, Renato Haddad, Maria Francesca Riccio, Hélio Vannucchi, Valdemir Melechco Carvalho, Erika Cristina Pavarino-Bertelli. 19-base pair deletion polymorphism of the dihydrofolate reductase (DHFR) gene: maternal risk of Down syndrome and folate metabolism. Sao Paulo medical journal = Revista paulista de medicina. 2010 Jul; 128(4):215-8. doi: 10.1590/s1516-31802010000400008. [PMID: 21120433]
  • Bee Jen Tan, Kiah Shen Quek, Man-Yi Wong, Wai Keung Chui, Gigi N C Chiu. Liposomal M-V-05: formulation development and activity testing of a novel dihydrofolate reductase inhibitor for breast cancer therapy. International journal of oncology. 2010 Jul; 37(1):211-8. doi: 10.3892/ijo_00000669. [PMID: 20514413]
  • Sally Hamour, Alan D Salama, Charles D Pusey. Management of ANCA-associated vasculitis: Current trends and future prospects. Therapeutics and clinical risk management. 2010 Jun; 6(?):253-64. doi: 10.2147/tcrm.s6112. [PMID: 20596502]
  • Tae-Jin Lee, Pete E Pascuzzi, Sharon B Settlage, Randall W Shultz, Milos Tanurdzic, Pablo D Rabinowicz, Margit Menges, Ping Zheng, Dorrie Main, James A H Murray, Bryon Sosinski, George C Allen, Robert A Martienssen, Linda Hanley-Bowdoin, Matthew W Vaughn, William F Thompson. Arabidopsis thaliana chromosome 4 replicates in two phases that correlate with chromatin state. PLoS genetics. 2010 Jun; 6(6):e1000982. doi: 10.1371/journal.pgen.1000982. [PMID: 20548960]
  • Li-Te Chin, Pei-Ru Huang, Kuang-Yu Hu, Nai-Kuei Huang, Cheng-Di Chiu, Ai-Ling Hour, Hao-Ai Shui, Chi-Hong Chu, Han-Min Chen. A proteomics-based translational approach reveals an antifolate resistance inherent in human plasma derived from blood donation. Journal of proteome research. 2010 Jun; 9(6):3091-102. doi: 10.1021/pr100005u. [PMID: 20707402]
  • Danny W Wilson, Brendan S Crabb, James G Beeson. Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays. Malaria journal. 2010 Jun; 9(?):152. doi: 10.1186/1475-2875-9-152. [PMID: 20525251]
  • Fabio Coppedè. One-carbon metabolism and Alzheimer's disease: focus on epigenetics. Current genomics. 2010 Jun; 11(4):246-60. doi: 10.2174/138920210791233090. [PMID: 21119889]
  • Bailin Tu, Robert N Ziemann, Bryan C Tieman, David J Hawksworth, Joan Tyner, James Scheffel, Mary S Pinkus, Susan E Brophy, Jeffrey M Werneke, Robin Gutierrez, Michael White. Generation and characterization of chimeric antibodies against NS3, NS4, NS5, and core antigens of hepatitis C virus. Clinical and vaccine immunology : CVI. 2010 Jun; 17(6):1040-7. doi: 10.1128/cvi.00068-10. [PMID: 20427624]
  • Anthony I Okoh, Etinosa O Igbinosa. Antibiotic susceptibility profiles of some Vibrio strains isolated from wastewater final effluents in a rural community of the Eastern Cape Province of South Africa. BMC microbiology. 2010 May; 10(?):143. doi: 10.1186/1471-2180-10-143. [PMID: 20470419]
  • Steven F Werder. Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatric disease and treatment. 2010 May; 6(?):159-95. doi: 10.2147/ndt.s6564. [PMID: 20505848]
  • Phyllis S Frisa, James W Jacobberger. Cytometry of chromatin bound Mcm6 and PCNA identifies two states in G1 that are separated functionally by the G1 restriction point. BMC cell biology. 2010 Apr; 11(?):26. doi: 10.1186/1471-2121-11-26. [PMID: 20398392]
  • Umakhanth Venkatraman Girija, Christopher Furze, Julia Toth, Wilhelm J Schwaeble, Daniel A Mitchell, Anthony H Keeble, Russell Wallis. Engineering novel complement activity into a pulmonary surfactant protein. The Journal of biological chemistry. 2010 Apr; 285(14):10546-52. doi: 10.1074/jbc.m109.097493. [PMID: 20118239]
  • G B Tactacan, M Jing, S Thiessen, J C Rodriguez-Lecompte, D L O'Connor, W Guenter, J D House. Characterization of folate-dependent enzymes and indices of folate status in laying hens supplemented with folic acid or 5-methyltetrahydrofolate. Poultry science. 2010 Apr; 89(4):688-96. doi: 10.3382/ps.2009-00417. [PMID: 20308400]
  • Pattakorn Buppan, Chaturong Putaporntip, Urassaya Pattanawong, Sunee Seethamchai, Somchai Jongwutiwes. Comparative detection of Plasmodium vivax and Plasmodium falciparum DNA in saliva and urine samples from symptomatic malaria patients in a low endemic area. Malaria journal. 2010 Mar; 9(?):72. doi: 10.1186/1475-2875-9-72. [PMID: 20214828]
  • Alexander Semmler, Susan Farmand, Susanna Moskau, Birgit Stoffel-Wagner, Michael Linnebank. The G allele of transcobalamin 2 c.776C→G is associated with an unfavorable lipoprotein profile. Annals of nutrition & metabolism. 2010; 57(2):112-5. doi: 10.1159/000320418. [PMID: 20948192]
  • Cullen K T Pang, Joshua H Hunter, Ramesh Gujjar, Ramulu Podutoori, Julie Bowman, Devaraja G Mudeppa, Pradipsinh K Rathod. Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase. Molecular and biochemical parasitology. 2009 Nov; 168(1):74-83. doi: 10.1016/j.molbiopara.2009.06.011. [PMID: 19591883]
  • Roberta Alfieri, Matteo Barberis, Ferdinando Chiaradonna, Daniela Gaglio, Luciano Milanesi, Marco Vanoni, Edda Klipp, Lilia Alberghina. Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation. BMC bioinformatics. 2009 Oct; 10 Suppl 12(?):S16. doi: 10.1186/1471-2105-10-s12-s16. [PMID: 19828076]
  • William M Pardridge, Ruben J Boado. Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery. Pharmaceutical research. 2009 Oct; 26(10):2227-36. doi: 10.1007/s11095-009-9939-6. [PMID: 19609743]
  • Neeloo Singh, Jaspreet Kaur, Pranav Kumar, Swati Gupta, Nasib Singh, Angana Ghosal, Avijit Dutta, Ashutosh Kumar, Ramapati Tripathi, Mohammad Imran Siddiqi, Chitra Mandal, Anuradha Dube. An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1. Parasitology research. 2009 Oct; 105(5):1317-25. doi: 10.1007/s00436-009-1557-z. [PMID: 19621245]
  • Alan G Mathew, Sumalee Liamthong, Jun Lin, Yingying Hong. Evidence of class 1 integron transfer between Escherichia coli and Salmonella spp. on livestock farms. Foodborne pathogens and disease. 2009 Oct; 6(8):959-64. doi: 10.1089/fpd.2009.0263. [PMID: 19630513]
  • Aner Gurvitz. The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2. Molecular genetics and genomics : MGG. 2009 Oct; 282(4):407-16. doi: 10.1007/s00438-009-0474-2. [PMID: 19685079]
  • K Augustin, J Frank, S Augustin, P Langguth, V Ohrvik, C M Witthoft, G Rimbach, S Wolffram. Greeen tea extracts lower serum folates in rats at very high dietary concentrations only and do not affect plasma folates in a human pilot study. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2009 Sep; 60(3):103-8. doi: NULL. [PMID: 19826188]
  • Mary R Sweeney, Anthony Staines, Leslie Daly, Aisling Traynor, Sean Daly, Steven W Bailey, Patricia B Alverson, June E Ayling, John M Scott. Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?. BMC public health. 2009 Aug; 9(?):295. doi: 10.1186/1471-2458-9-295. [PMID: 19689788]
  • Ashraf M Ahmed, Emad E A Younis, Yojiro Ishida, Tadashi Shimamoto. Genetic basis of multidrug resistance in Salmonella enterica serovars Enteritidis and Typhimurium isolated from diarrheic calves in Egypt. Acta tropica. 2009 Aug; 111(2):144-9. doi: 10.1016/j.actatropica.2009.04.004. [PMID: 19375408]
  • Jae-Sook Park, Sarah K Steinbach, Michel Desautels, Sean M Hemmingsen. Essential role for Schizosaccharomyces pombe pik1 in septation. PloS one. 2009 Jul; 4(7):e6179. doi: 10.1371/journal.pone.0006179. [PMID: 19587793]
  • Mizuki Mizukawa, Koji Ohmori, Ayumi Obayashi, Yasuhiro Ishihara, Junji Yoshida, Takahisa Noma, Kazushi Yukiiri, Hiroaki Kosaka, Masakazu Kohno. Effects of combined olmesartan and pravastatin on glucose intolerance and cardiovascular remodeling in a metabolic-syndrome model. Hypertension research : official journal of the Japanese Society of Hypertension. 2009 Jul; 32(7):617-24. doi: 10.1038/hr.2009.63. [PMID: 19461650]
  • Sindhu Issac, K Girish Kumar. Voltammetric determination of sulfamethoxazole at a multiwalled carbon nanotube modified glassy carbon sensor and its application studies. Drug testing and analysis. 2009 Jul; 1(7):350-4. doi: 10.1002/dta.69. [PMID: 20355213]
  • Antonina Joanna Mazur, Dorota Nowak, Hans Georg Mannherz, Maria Malicka-Błaszkiewicz. Methotrexate induces apoptosis in CaSki and NRK cells and influences the organization of their actin cytoskeleton. European journal of pharmacology. 2009 Jun; 613(1-3):24-33. doi: 10.1016/j.ejphar.2009.04.020. [PMID: 19383496]