Ginsenoside B2 (BioDeep_00000000025)

 

Secondary id: BioDeep_00000311365, BioDeep_00001867458

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


2-[(2-{[5,16-dihydroxy-2,6,6,10,11-pentamethyl-14-(6-methyl-2-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hept-5-en-2-yl)tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-8-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl)oxy]-6-methyloxane-3,4,5-triol

化学式: C48H82O18 (946.5500872)
中文名称: 人参皂苷 Re, 人参皂甙 Re, 人参皂甙Re
谱图信息: 最多检出来源 Viridiplantae(plant) 1.29%

分子结构信息

SMILES: C1C[C@H](O)C(C)(C)[C@]2([H])[C@@H](O[C@H]3[C@H](O[C@H]4[C@H](O)[C@@H]([C@@H](O)[C@H](C)O4)O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C[C@@]3(C)[C@]4(C)CC[C@@]([C@](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)(C)CC/C=C(\C)/C)([H])[C@@]4([H])[C@H](O)C[C@]3([H])[C@@]12C
InChI: InChI=1S/C48H82O18/c1-21(2)11-10-14-48(9,66-42-38(60)35(57)32(54)26(19-49)63-42)23-12-16-46(7)30(23)24(51)17-28-45(6)15-13-29(52)44(4,5)40(45)25(18-47(28,46)8)62-43-39(36(58)33(55)27(20-50)64-43)65-41-37(59)34(56)31(53)22(3)61-41/h11,22-43,49-60H,10,12-20H2,1-9H3

描述信息

Ginsenoside Re is a ginsenoside found in Panax ginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite, an antioxidant, a neuroprotective agent, an anti-inflammatory agent, an antineoplastic agent and a nephroprotective agent. It is a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a beta-D-glucoside, a ginsenoside, a tetracyclic triterpenoid, a disaccharide derivative and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.
Ginsenoside B2 is under investigation in clinical trial NCT00781534 (A Clinical Trial of Ginseng in Diabetes).
Ginsenoside Re is a natural product found in Panax vietnamensis, Luffa aegyptiaca, and other organisms with data available.
See also: Asian Ginseng (part of); American Ginseng (part of); Panax notoginseng root (part of).
Ginsenoside B2 is found in tea. Ginsenoside B2 is a constituent of Panax ginseng (ginseng) and Panax japonicum (Japanese ginseng)
Constituent of Panax ginseng (ginseng) and Panax japonicum (Japanese ginseng). Ginsenoside B2 is found in tea.
Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.
Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.

同义名列表

26 个代谢物同义名

2-[(2-{[5,16-dihydroxy-2,6,6,10,11-pentamethyl-14-(6-methyl-2-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hept-5-en-2-yl)tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-8-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl)oxy]-6-methyloxane-3,4,5-triol; .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,12.BETA.)-20-(.BETA.-D-GLUCOPYRANOSYLOXY)-3,12-DIHYDROXYDAMMAR-24-EN-6-YL 2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-; beta-D-Glucopyranoside, (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-; (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside; 2-O-(6-Deoxy-alpha-L-mannopyranosyl)-(3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl-beta-D-glucopyranoside; (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside; 20-(beta-D-glucopyranosyloxy)-3beta,6alpha,12beta,20-trihydroxydammar-24-en-6-yl 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside; b-D-Glucopyranoside,(3b,6a,12b)-20-(b-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-(6-deoxy-a-L-mannopyranosyl)-; GINSENOSIDE RE (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]; GINSENOSIDE RE (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG); Ginsenoside B2; PWAOOJDMFUQOKB-WCZZMFLVSA-N; Chikusetsusaponin IVc; GINSENOSIDE RE [INCI]; (20S)-ginsenoside Re; UNII-46F3R0BL3I; Sanchinoside Re; Ginsenoside B2; ginsenoside Re; ginsenoside-Re; Panaxoside RE; Ginsenoside; NSC 308877; 46F3R0BL3I; Sanchinoside Re; Panaxoside Re



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jingyuan Zeng, Xican Li, Rongxin Cai, Ban Chen, Chunhou Li, Qingzhong Hu, Yue Sun. Proposing anti-counterfeiting pharmacopoeia quality markers for Shenlingbaizhu granule based on UHPLC-Q-orbitrap-MS identification. Phytochemical analysis : PCA. 2023 Sep; ?(?):. doi: 10.1002/pca.3284. [PMID: 37735858]
  • Xiaoyan Xu, Meiting Jiang, Xiaohang Li, Yu Wang, Meiyu Liu, Hongda Wang, Yueguang Mi, Boxue Chen, Xiumei Gao, Wenzhi Yang. Three-dimensional characteristic chromatogram by online comprehensive two-dimensional liquid chromatography: Application to the identification and differentiation of ginseng from herbal medicines to various Chinese patent medicines. Journal of chromatography. A. 2023 Jul; 1700(?):464042. doi: 10.1016/j.chroma.2023.464042. [PMID: 37163941]
  • Jie Chang, Yujue Wang, Jing Xu, Xiaoye Du, Jingang Cui, Teng Zhang, Yu Chen. Ginsenoside Re Mitigates Photooxidative Stress-Mediated Photoreceptor Degeneration and Retinal Inflammation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023 Jun; ?(?):. doi: 10.1007/s11481-023-10073-y. [PMID: 37326907]
  • Xia Jiang, Lin Chen, Qing Fu, DanLi Ma, XueTing Liu, XiaoYi Wang. Kidney Yang Deficiency Syndrome Exacerbates Aβ25-35-Induced Pathological Changes, And Ginsenoside Re Ameliorates Synapse Lesions In Aβ25-35-Injected Rats With Kidney Yang Deficiency Syndrome. Current Alzheimer research. 2023 May; ?(?):. doi: 10.2174/1567205020666230512094230. [PMID: 37183470]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Jian Ye, Tian-Jiao Lyu, Ling-Yan Li, Ying Liu, Hong Zhang, Xu Wang, Xin Xi, Zong-Jun Liu, Jun-Qing Gao. Ginsenoside Re attenuates myocardial ischemia/reperfusion induced ferroptosis via miR-144-3p/SLC7A11. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 May; 113(?):154681. doi: 10.1016/j.phymed.2023.154681. [PMID: 36893674]
  • Yan Xu, Xue Meng, Wen-Xue Zhao, Dong-Guang Liu, Jian-Guo Zhu, Ru Yao, Jing-Chun Yao, Gui-Min Zhang. [Neuroprotective effect of ginsenoside Re on drosophila model of Parkinson's disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Apr; 48(7):1927-1935. doi: 10.19540/j.cnki.cjcmm.20230103.705. [PMID: 37282969]
  • Eun-Joo Shin, Bao Trong Nguyen, Naveen Sharma, Ngoc Kim Cuong Tran, Yen Nhi Doan Nguyen, Yeonggwang Hwang, Jung Hoon Park, Seung-Yeol Nah, Sung Kwon Ko, Jae Kyung Byun, Yi Lee, Dae-Joong Kim, Ji Hoon Jeong, Hyoung-Chun Kim. Ginsenoside Re mitigates memory impairments in aged GPx-1 KO mice by inhibiting the interplay between PAFR, NFκB, and microgliosis in the hippocampus. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Mar; 173(?):113627. doi: 10.1016/j.fct.2023.113627. [PMID: 36682417]
  • Linwei Chen, Nina Wei, Yong Jiang, Chengye Yuan, Luwei Xu, Jindong Li, Min Kong, Yan Chen, Qin Wang. Comparative pharmacokinetics of seven bioactive components after oral administration of crude and processed Qixue Shuangbu Prescription in chronic heart failure rats by microdialysis combined with UPLC-MS/MS. Journal of ethnopharmacology. 2023 Mar; 303(?):116035. doi: 10.1016/j.jep.2022.116035. [PMID: 36513265]
  • Eun-Joo Shin, Ji Hoon Jeong, Bao-Trong Nguyen, Naveen Sharma, Cuong Ngoc Kim Tran, Seung-Yeol Nah, Yi Lee, Jae Kyung Byun, Sung Kwon Ko, Hyoung-Chun Kim. Ginsenoside Re attenuates 8-OH-DPAT-induced serotonergic behaviors in mice via interactive modulation between PKCδ gene and Nrf2. Drug and chemical toxicology. 2023 Mar; 46(2):281-296. doi: 10.1080/01480545.2021.2022689. [PMID: 35707918]
  • Bao Trong Nguyen, Eun-Joo Shin, Ji Hoon Jeong, Naveen Sharma, Seung Yeol Nah, Sung Kwon Ko, Jae Kyung Byun, Yi Lee, Xin Gen Lei, Dae-Joong Kim, Toshitaka Nabeshima, Hyoung-Chun Kim. Ginsenoside Re attenuates memory impairments in aged Klotho deficient mice via interactive modulations of angiotensin II AT1 receptor, Nrf2 and GPx-1 gene. Free radical biology & medicine. 2022 08; 189(?):2-19. doi: 10.1016/j.freeradbiomed.2022.07.003. [PMID: 35840016]
  • Jiasong Cai, Kunlong Huang, Shengnan Han, Ruichan Chen, Zhijun Li, Yan Chen, Bing Chen, Shaoguang Li, Lin Xinhua, Hong Yao. A comprehensive system review of pharmacological effects and relative mechanisms of Ginsenoside Re: Recent advances and future perspectives. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 102(?):154119. doi: 10.1016/j.phymed.2022.154119. [PMID: 35617888]
  • Heyu Wang, Yaran Teng, Shinan Li, Ying Li, Hui Li, Lili Jiao, Wei Wu. UHPLC-MS-Based Serum and Urine Metabolomics Reveals the Anti-Diabetic Mechanism of Ginsenoside Re in Type 2 Diabetic Rats. Molecules (Basel, Switzerland). 2021 Nov; 26(21):. doi: 10.3390/molecules26216657. [PMID: 34771066]
  • Eun-Joo Shin, Ji Hoon Jeong, Bao-Trong Nguyen, Naveen Sharma, Seung-Yeol Nah, Yoon Hee Chung, Yi Lee, Jae Kyung Byun, Toshitaka Nabeshima, Sung Kwon Ko, Hyoung-Chun Kim. Ginsenoside Re Protects against Serotonergic Behaviors Evoked by 2,5-Dimethoxy-4-iodo-amphetamine in Mice via Inhibition of PKCδ-Mediated Mitochondrial Dysfunction. International journal of molecular sciences. 2021 Jul; 22(13):. doi: 10.3390/ijms22137219. [PMID: 34281274]
  • Xue Li, Zhifeng Yan, Longzhu Li, Tao Ma, Yang Chen. [Preparation of branched polyethyleneimine-assisted boric acid-functionalized magnetic nanoparticles and its application to selective enrichment of ginsenoside Re]. Se pu = Chinese journal of chromatography. 2021 Jun; 39(6):599-606. doi: 10.3724/sp.j.1123.2020.11005. [PMID: 34227320]
  • Ji-Hyeon Jeon, Sowon Lee, Wonpyo Lee, Sojeong Jin, Mihwa Kwon, Chul Hwi Shin, Min-Koo Choi, Im-Sook Song. Herb-Drug Interaction of Red Ginseng Extract and Ginsenoside Rc with Valsartan in Rats. Molecules (Basel, Switzerland). 2020 Jan; 25(3):. doi: 10.3390/molecules25030622. [PMID: 32023909]
  • Gyeong Hee Lee, Won Jin Lee, Jinwoo Hur, Eunsu Kim, Hyuk Gyoon Lee, Han Geuk Seo. Ginsenoside Re Mitigates 6-Hydroxydopamine-Induced Oxidative Stress through Upregulation of GPX4. Molecules (Basel, Switzerland). 2020 Jan; 25(1):. doi: 10.3390/molecules25010188. [PMID: 31906464]
  • Yonghui Yu, Jinghui Sun, Jiangang Liu, Peili Wang, Chenglong Wang. Ginsenoside Re Preserves Cardiac Function and Ameliorates Left Ventricular Remodeling in a Rat Model of Myocardial Infarction. Journal of cardiovascular pharmacology. 2020 01; 75(1):91-97. doi: 10.1097/fjc.0000000000000752. [PMID: 31599782]
  • Yang Gao, Chen-Ying Gao, Ping Zhu, Shang-Fu Xu, Yun-Mei Luo, Jiang Deng, Dan-Li Yang. Ginsenoside Re inhibits vascular neointimal hyperplasia in balloon-injured carotid arteries through activating the eNOS/NO/cGMP pathway in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Oct; 106(?):1091-1097. doi: 10.1016/j.biopha.2018.07.044. [PMID: 30119175]
  • Lei Zhang, Fei Li, Wang-Jun Qin, Chao Fu, Xiang-Lin Zhang. Changes in intestinal microbiota affect metabolism of ginsenoside Re. Biomedical chromatography : BMC. 2018 Oct; 32(10):e4284. doi: 10.1002/bmc.4284. [PMID: 29748959]
  • Xiao-Nan Chen, Dan-Qi Li, Meng-di Zhao, Gang-Yan Yu, Shou-Ying Du, Yang Lu, Jie Bai, Peng-Yue Li, Ya-Li Wu, Zhi-Hao Tian, Yan-Ying Zeng. Pharmacokinetics of Panax notoginseng Saponins in Adhesive and Normal Preparation of Fufang Danshen. European journal of drug metabolism and pharmacokinetics. 2018 Apr; 43(2):215-225. doi: 10.1007/s13318-017-0433-y. [PMID: 28916980]
  • Eun-Joo Yang, Kyung-Chul Shin, Dae Young Lee, Deok-Kun Oh. Complete Biotransformation of Protopanaxatriol-Type Ginsenosides in Panax ginseng Leaf Extract to Aglycon Protopanaxatriol by β-Glycosidases from Dictyoglomus turgidum and Pyrococcus furiosus. Journal of microbiology and biotechnology. 2018 Feb; 28(2):255-261. doi: 10.4014/jmb.1709.09053. [PMID: 29169217]
  • Jingyuan Li, Ying Liu, Wei Li, Zhe Wang, Pan Guo, Lin Li, Naijing Li. Metabolic profiling of the effects of ginsenoside Re in an Alzheimer's disease mouse model. Behavioural brain research. 2018 Jan; 337(?):160-172. doi: 10.1016/j.bbr.2017.09.027. [PMID: 28927718]
  • Zi Wang, Yan-Fei Li, Xin-Yue Han, Yin-Shi Sun, Lian-Xue Zhang, Wei Liu, Xiang-Xiang Liu, Wei Li, Ying-Ying Liu. Kidney Protection Effect of Ginsenoside Re and Its Underlying Mechanisms on Cisplatin-Induced Kidney Injury. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 48(5):2219-2229. doi: 10.1159/000492562. [PMID: 30110677]
  • E González-Burgos, Carlos Fernández-Moriano, R Lozano, I Iglesias, M P Gómez-Serranillos. Ginsenosides Rd and Re co-treatments improve rotenone-induced oxidative stress and mitochondrial impairment in SH-SY5Y neuroblastoma cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Nov; 109(Pt 1):38-47. doi: 10.1016/j.fct.2017.08.013. [PMID: 28843595]
  • Thu-Hien Thi Tu, Naveen Sharma, Eun-Joo Shin, Hai-Quyen Tran, Yu Jeung Lee, Ji Hoon Jeong, Jung Hwan Jeong, Seung Yeol Nah, Hoang-Yen Phi Tran, Jae Kyung Byun, Sung Kwon Ko, Hyoung-Chun Kim. Ginsenoside Re Protects Trimethyltin-Induced Neurotoxicity via Activation of IL-6-Mediated Phosphoinositol 3-Kinase/Akt Signaling in Mice. Neurochemical research. 2017 Nov; 42(11):3125-3139. doi: 10.1007/s11064-017-2349-y. [PMID: 28884396]
  • Zhaoxia Jin, Lin Gao, Lin Zhang, Tianyi Liu, Fang Yu, Zongshen Zhang, Qiong Guo, Biying Wang. Antimicrobial activity of saponins produced by two novel endophytic fungi from Panax notoginseng. Natural product research. 2017 Nov; 31(22):2700-2703. doi: 10.1080/14786419.2017.1292265. [PMID: 28278662]
  • Jeniffer Silva, Yu-Jin Kim, Dexin Xiao, Johan Sukweenadhi, Tingting Hu, Woo-Saeng Kwon, Jianping Hu, Deok-Chun Yang, Dabing Zhang. Cytological analysis of ginseng carpel development. Protoplasma. 2017 Sep; 254(5):1909-1922. doi: 10.1007/s00709-017-1081-4. [PMID: 28154963]
  • Guilin Chen, Haijun Li, Yugang Gao, Lianxue Zhang, Yan Zhao. Flavored black ginseng exhibited antitumor activity via improving immune function and inducing apoptosis. Food & function. 2017 May; 8(5):1880-1889. doi: 10.1039/c6fo01870j. [PMID: 28426048]
  • L Zhang, T T Wang. Construction and transformation of expression vector containing Panax japonicus SS gene. Genetics and molecular research : GMR. 2017 Jan; 16(1):. doi: 10.4238/gmr16019341. [PMID: 28128417]
  • Guoqiong Cao, Ping Su, Shuai Zhang, Limin Guo, Haijing Zhang, Yuexia Liang, Chunxia Qin, Wensheng Zhang. Ginsenoside Re reduces Aβ production by activating PPARγ to inhibit BACE1 in N2a/APP695 cells. European journal of pharmacology. 2016 Dec; 793(?):101-108. doi: 10.1016/j.ejphar.2016.11.006. [PMID: 27840193]
  • Xiqian Zhang, Rujun Ma, Xiaojuan Liu, Xuehua Jiang, Ling Wang. Simultaneous determination of ginsenoside Rg1 , Re and notoginsenoside R1 in human plasma by LC-MS/MS and its application in a pharmacokinetic study in Chinese volunteers. Biomedical chromatography : BMC. 2016 Dec; 30(12):1915-1921. doi: 10.1002/bmc.3766. [PMID: 27219100]
  • Fengxia Lin, Sanlin Lei, Jin'an Ma, Li Shi, Dan Mao, Shaofan Zhang, Jianhua Huang, Xinyi Liu, Dengfeng Ding, Yingjin Zhang, Sifang Zhang. [Inhibitory effect of jianpi-jiedu prescription-contained serum on colorectal cancer SW48 cell proliferation by mTOR-P53-P21 signalling pathway]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2016 Nov; 41(11):1128-1136. doi: 10.11817/j.issn.1672-7347.2016.11.003. [PMID: 27932756]
  • Yawei Shi, Xuesi Wan, Nan Shao, Runyi Ye, Ning Zhang, Yunjian Zhang. Protective and anti‑angiopathy effects of ginsenoside Re against diabetes mellitus via the activation of p38 MAPK, ERK1/2 and JNK signaling. Molecular medicine reports. 2016 Nov; 14(5):4849-4856. doi: 10.3892/mmr.2016.5821. [PMID: 27748921]
  • Guoliang Dai, Zhitao Jiang, Lijing Zhu, Qian Zhang, Yang Zong, Shijia Liu, Changyin Li, Wenzheng Ju. Simultaneous determination of notoginsenoside R1 and ginsenoside Re in rat plasma by ultra high performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study. Journal of separation science. 2016 Sep; 39(17):3368-74. doi: 10.1002/jssc.201600522. [PMID: 27412519]
  • Rong-Chang Chen, Jian Wang, Longpo Yang, Gui-Bo Sun, Xiao-Bo Sun. Protective effects of ginsenoside Re on lipopolysaccharide-induced cardiac dysfunction in mice. Food & function. 2016 May; 7(5):2278-87. doi: 10.1039/c5fo01357g. [PMID: 27074714]
  • Qian Zhang, Chun-sheng Li, Shuo Wang, Wei Gu. Effects of Chinese medicine shen-fu injection on the expression of inflammatory cytokines and complements during post-resuscitation immune dysfunction in a porcine model. Chinese journal of integrative medicine. 2016 Feb; 22(2):101-9. doi: 10.1007/s11655-014-1857-8. [PMID: 25253551]
  • Yunsung Nam, Myung Bok Wie, Eun-Joo Shin, Thuy-Ty Lan Nguyen, Seung-Yeol Nah, Sung Kwon Ko, Ji Hoon Jeong, Choon-Gon Jang, Hyoung-Chun Kim. Ginsenoside Re protects methamphetamine-induced mitochondrial burdens and proapoptosis via genetic inhibition of protein kinase C δ in human neuroblastoma dopaminergic SH-SY5Y cell lines. Journal of applied toxicology : JAT. 2015 Aug; 35(8):927-44. doi: 10.1002/jat.3093. [PMID: 25523949]
  • Yi-hang Chen, Meng-xuan Li, Zhao-qing Meng, Jiao-jiao Yang, Wen-zhe Huang, Zhen-zhong Wang, Yue-sheng Wang, Wei Xiao. [Traditional Chinese medicine pairs (III)--effect of extract of Ginseng Radix et Rhizoma and Puerariae Lobatae Radix on intestinal absorption in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Aug; 40(15):3094-9. doi: . [PMID: 26677717]
  • Shi Shen, Xi Chen, Ye Bi, Zhu Wang. [Uncertainty evaluation for determining ginsenosides in ginseng food by HPLC]. Wei sheng yan jiu = Journal of hygiene research. 2015 Mar; 44(2):288-93. doi: ". [PMID: 25997236]
  • Rongrong Jiang, Jiajia Dong, Xiuxue Li, Feifei Du, Weiwei Jia, Fang Xu, Fengqing Wang, Junling Yang, Wei Niu, Chuan Li. Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3. British journal of pharmacology. 2015 Feb; 172(4):1059-73. doi: 10.1111/bph.12971. [PMID: 25297453]
  • Bao Qiong Li, Jing Chen, Jiao Jiao Li, Xue Wang, Hong Lin Zhai. The application of a Tchebichef moment method to the quantitative analysis of multiple compounds based on three-dimensional HPLC fingerprint spectra. The Analyst. 2015 Jan; 140(2):630-6. doi: 10.1039/c4an01736f. [PMID: 25426727]
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