1,3-Dichloro-2-propanol (BioDeep_00000009883)
Secondary id: BioDeep_00001873576
human metabolite blood metabolite
代谢物信息卡片
1,3-Dichloro-1,3-dideoxyglycerol
化学式: C3H6Cl2O (127.9796)
中文名称: 1,3-二氯丙醇, 1,3-二氯-2-丙醇
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: C(C(CCl)O)Cl
InChI: InChI=1S/C3H6Cl2O/c4-1-3(6)2-5/h3,6H,1-2H2
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D003432 - Cross-Linking Reagents
D009676 - Noxae > D009153 - Mutagens
同义名列表
21 个代谢物同义名
1,3-Dichloro-1,3-dideoxyglycerol; 2-Chloro-1-(chloromethyl)ethanol; 1,3-Dichloroisopropyl alcohol; Sym-dichloroisopropyl alcohol; 1,3-Dichloro-2-hydroxypropane; Glycerol 1,3-dichlorohydrin; Sym-glycerol dichlorohydrin; alpha,gamma-Dichlorohydrin; 1,3-Dichloropropan-2-ol; 1,3-DICHLORO-2-PROPANOL; 1,3-Dichloroisopropanol; alpha-Dichlorohydrin; Α,γ-dichlorohydrin; 1,3-Dichlorohydrin; a,g-Dichlorohydrin; Α-dichlorohydrin; a-Dichlorohydrin; HOCH(CH2CL)2; 1,3-DCP; 1,3-Dichloro-2-propanol; 1,3-Dichloro-2-propanol
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:18917
- KEGG: C14399
- PubChem: 7289
- HMDB: HMDB0244163
- Metlin: METLIN70030
- ChEMBL: CHEMBL468581
- Wikipedia: 1,3-Dichloropropan-2-ol
- chemspider: 21106535
- CAS: 96-23-1
- PMhub: MS000023703
- PubChem: 17395399
- NIKKAJI: J3.964K
- KNApSAcK: 18917
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yong Fan, Jing Lu, Jinghui Fan, Shuang Guan. 1,3-dichloro-2-propanol caused lipid droplets accumulation by suppressing neutral lipases via BMAL1 in hepatocytes.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2023 Feb; 174(?):113670. doi:
10.1016/j.fct.2023.113670. [PMID: 36805544] - Shuang Guan, Ranran Zhang, Yanan Zhao, Zhuoqun Meng, Jing Lu. 1,3-Dichloro-2-propanol induced ferroptosis through Nrf2/ARE signaling pathway in hepatocytes.
Environmental toxicology.
2022 Oct; 37(10):2515-2528. doi:
10.1002/tox.23615. [PMID: 35870111] - Yong Fan, Jing Lu, Jinhua Liu, Ranran Zhang, Zelin Yu, Shuang Guan. 1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Nov; 157(?):112578. doi:
10.1016/j.fct.2021.112578. [PMID: 34560177] - Kohei Matsushita, Shinji Takasu, Yuji Ishii, Takeshi Toyoda, Takanori Yamada, Tomomi Morikawa, Kumiko Ogawa. In vivo mutagenicity and tumor-promoting activity of 1,3-dichloro-2-propanol in the liver and kidneys of gpt delta rats.
Archives of toxicology.
2021 09; 95(9):3117-3131. doi:
10.1007/s00204-021-03120-1. [PMID: 34269859] - Jing Lu, Yong Fan, Meitong Liu, Qian Zhang, Shuang Guan. 1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells.
Toxicology.
2021 04; 454(?):152716. doi:
10.1016/j.tox.2021.152716. [PMID: 33581215] - T O Ajiboye, R A Ajala-Lawal, A B Adeyiga. Caffeic acid abrogates 1,3-dichloro-2-propanol-induced hepatotoxicity by upregulating nuclear erythroid-related factor 2 and downregulating nuclear factor-kappa B.
Human & experimental toxicology.
2019 Sep; 38(9):1092-1101. doi:
10.1177/0960327119851257. [PMID: 31142131] - Jing Lu, Baochen Fang, Yixuan Huang, Siyu Tao, Bo Sun, Shuang Guan, Yingli Jin. Epigallocatechin-3-gallate protects against 1,3-dichloro-2-propanol-induced lipid accumulation in C57BL/6J mice.
Life sciences.
2018 Sep; 209(?):324-331. doi:
10.1016/j.lfs.2018.08.007. [PMID: 30092300] - Jing Lu, Bijun Cheng, Zhuoqun Meng, Baochen Fang, Tianjiao Li, Maocheng Sun, Meitong Liu, Shuang Guan. Alliin attenuates 1, 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway.
Life sciences.
2018 Feb; 195(?):19-24. doi:
10.1016/j.lfs.2017.12.040. [PMID: 29305303] - Jing Lu, Baochen Fang, Yiying Zheng, Xin Yu, Guoren Huang, Zhenning Wang, Xuming Deng, Shuang Guan. 1,3-dichloro-2-propanol induced lipid accumulation in HepG2 cells through cAMP/protein kinase A and AMP-activated protein kinase pathways via Gi/o-coupled receptors.
Environmental toxicology and pharmacology.
2017 Oct; 55(?):118-126. doi:
10.1016/j.etap.2017.07.013. [PMID: 28843851] - Gwang-Won Kim, Chang-Hyun Oh, Jong-Choon Kim, Woong Yoon, Yong-Yeon Jeong, Yun-Hyeon Kim, Jae-Kyu Kim, Jin-Gyoon Park, Heoung-Keun Kang, Gwang-Woo Jeong. Noninvasive biomarkers for acute hepatotoxicity induced by 1,3-dichloro-2-propanol: hyperpolarized 13C dynamic MR spectroscopy.
Magnetic resonance imaging.
2016 Feb; 34(2):159-65. doi:
10.1016/j.mri.2015.10.023. [PMID: 26523652] - In-Chul Lee, Je-Won Ko, Sang-Min Lee, Sung-Hwan Kim, In-Sik Shin, Og-Sung Moon, Won-Kee Yoon, Hyoung-Chin Kim, Jong-Choon Kim. Time-course and molecular mechanism of hepatotoxicity induced by 1,3-dichloro-2-propanol in rats.
Environmental toxicology and pharmacology.
2015 Jul; 40(1):191-8. doi:
10.1016/j.etap.2015.06.011. [PMID: 26143167] - Jing Lu, Baochen Fang, Mengrou Ren, Guoren Huang, Shuang Zhang, Yi Wang, Xuming Deng, Shuang Guan. Nonalcoholic fatty liver disease induced by 13-week oral administration of 1,3-dichloro-2-propanol in C57BL/6J mice.
Environmental toxicology and pharmacology.
2015 May; 39(3):1115-21. doi:
10.1016/j.etap.2015.04.007. [PMID: 25910858] - Suramya Waidyanatha, Norman F Gaudette, Yan Hong, Timothy R Fennell. Formation of epichlorohydrin, a known rodent carcinogen, following oral administration of 1,3-dichloro-2-propanol in rats.
Chemical research in toxicology.
2014 Oct; 27(10):1787-95. doi:
10.1021/tx500239q. [PMID: 25254956] - Jing Lu, Guoren Huang, Sizhuo Hu, Zhenning Wang, Shuang Guan. 1,3-Dichloro-2-propanol induced hyperlipidemia in C57BL/6J mice via AMPK signaling pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2014 Feb; 64(?):403-9. doi:
10.1016/j.fct.2013.11.049. [PMID: 24333398] - Jeong-Hyeon Lim, Sung-Hwan Kim, In-Chul Lee, Changjong Moon, Sung-Ho Kim, Dong-Ho Shin, Hyoung-Chin Kim, Jong-Choon Kim. Evaluation of Maternal Toxicity in Rats Exposed to Multi-Wall Carbon Nanotubes during Pregnancy.
Environmental health and toxicology.
2011; 26(?):e2011006. doi:
10.5620/eht.2011.26.e2011006. [PMID: 22125767] - Mohd Suhail, Shridhar Patil, Salma Khan, Sana Siddiqui. Antioxidant Vitamins and Lipoperoxidation in Non-pregnant, Pregnant, and Gestational Diabetic Women: Erythrocytes Osmotic Fragility Profiles.
Journal of clinical medicine research.
2010 Dec; 2(6):266-73. doi:
10.4021/jocmr454w. [PMID: 22043260] - Gary Williams, Jean-Charles Leblanc, R Woodrow Setzer. Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: (CAS No. 96-23-1) 1,3-dichloro-2-propanol (DCP).
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2010 Jan; 48 Suppl 1(?):S57-62. doi:
10.1016/j.fct.2009.10.038. [PMID: 20113855] - Hyeon-Yeong Kim, Sung-Bae Lee, Kyung-Taek Lim, Moo-Kang Kim, Jong-Choon Kim. subchronic inhalation toxicity study of 1,3-dichloro-2-propanol in rats.
The Annals of occupational hygiene.
2007 Oct; 51(7):633-43. doi:
10.1093/annhyg/mem041. [PMID: 17921239] - Xiaomin Xu, Yiping Ren, Pinggu Wu, Jianlong Han, Xianghong Shen. The simultaneous separation and determination of chloropropanols in soy sauce and other flavoring with gas chromatography-mass spectrometry in negative chemical and electron impact ionization modes.
Food additives and contaminants.
2006 Feb; 23(2):110-9. doi:
10.1080/02652030500391929. [PMID: 16449052] - Ihsan Ergün, M Cenk Akbostanci, Başol Canbakan, Bilge Koçer, Arzu Ensari, Gökhan Nergizoglu, Kenan Keven. Minimal change nephrotic syndrome with stiff-person syndrome: is there a link?.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2005 Jul; 46(1):e11-4. doi:
10.1053/j.ajkd.2005.03.009. [PMID: 15983949] - Yoshiki Kuroda, Yukiko Fueta, Kiyotaka Kohshi, Hiroyuki Nakao, Hirohisa Imai, Takahiko Katoh. [Toxicity of dichloropropanols].
Journal of UOEH.
2002 Sep; 24(3):271-80. doi:
10.7888/juoeh.24.271. [PMID: 12235957] - T Shiozaki, Y Mizobata, H Sugimoto, T Yoshioka, T Sugimoto. Fulminant hepatitis following exposure to dichlorohydrin--report of two cases.
Human & experimental toxicology.
1994 Apr; 13(4):267-70. doi:
10.1177/096032719401300408. [PMID: 8204313] - J Haratake, A Furuta, T Iwasa, C Wakasugi, K Imazu. Submassive hepatic necrosis induced by dichloropropanol.
Liver.
1993 Jun; 13(3):123-9. doi:
10.1111/j.1600-0676.1993.tb00618.x. [PMID: 8336524] - J Wienecke. 1,3-Dichloropropanol-(2) as an indicator of exposure to epichlorohydrine.
Clinical chemistry.
1993 Feb; 39(2):365. doi:
10.1093/clinchem/39.2.365. [PMID: 8432031] - M Koga, N Inoue, K Imazu, N Yamada, Y Shinoki. Identification and quantitative analysis of urinary metabolites of dichloropropanols in rats.
Journal of UOEH.
1992 Mar; 14(1):13-22. doi:
10.7888/juoeh.14.13. [PMID: 1509208] - K Imazu, K Fujishiro, N Inoue, M Koga, T Iwasa. [Toxicity of dichloropropanols--changes in hematological findings and serum chemistry].
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