JSTX-3 (BioDeep_00000009663)

   


代谢物信息卡片


Joro spider toxin

化学式: C27H47N7O6 (565.3588)
中文名称: 乳铁蛋白
谱图信息: 最多检出来源 Homo sapiens(not specific) 49.24%

分子结构信息

SMILES: C1=CC(=C(C=C1O)O)CC(=O)NC(CC(=O)N)C(=O)NCCCCCNC(=O)CCNCCCCNCCCN
InChI: InChI=1S/C27H47N7O6/c28-10-6-13-30-11-4-5-12-31-16-9-25(38)32-14-2-1-3-15-33-27(40)22(19-24(29)37)34-26(39)17-20-7-8-21(35)18-23(20)36/h7-8,18,22,30-31,35-36H,1-6,9-17,19,28H2,(H2,29,37)(H,32,38)(H,33,40)(H,34,39)/t22-/m0/s1

描述信息

D009676 - Noxae > D011042 - Poisons > D014688 - Venoms

同义名列表

3 个代谢物同义名

Joro spider toxin; JSTX-3; JSTX-3



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ADARB1, ANXA6, BDNF, CA1, CA3, CALR, GTPBP4, ITPR3, RBFOX3
Peripheral membrane protein 1 ANXA6
Endoplasmic reticulum membrane 4 CALR, GRIA1, ITPR3, SLC7A11
Nucleus 5 ADARB1, CALR, GRM1, GTPBP4, RBFOX3
cytosol 6 ADARB1, CA1, CA3, CALR, GRIA1, GTPBP4
dendrite 5 BDNF, GRIA1, GRIA2, GRIA4, GRM1
nucleoplasm 4 ADARB1, GRIK2, GTPBP4, ITPR3
Cell membrane 9 GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIK2, GRM1, SLC7A11
Early endosome membrane 1 GRIA1
Multi-pass membrane protein 10 GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIK2, GRM1, ITPR3, SLC7A11
Synapse 2 ADARB1, GRIA1
cell surface 3 CALR, GRIA1, SLC7A11
dendritic shaft 1 GRIA1
glutamatergic synapse 5 CALR, GRIA1, GRID1, GRIK2, GRM1
Golgi membrane 1 INS
lysosomal membrane 2 ANXA6, AP5B1
neuromuscular junction 1 GRIA1
neuronal cell body 4 GRIA1, GRIA2, GRIA4, ITPR3
postsynapse 2 CALR, GRIA2
presynaptic membrane 2 GRIK1, GRIK2
sarcolemma 1 ANXA6
smooth endoplasmic reticulum 1 CALR
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 CALR
Presynapse 1 GRIA1
acrosomal vesicle 1 CALR
plasma membrane 10 GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIK2, GRM1, ITPR3, SLC7A11
synaptic vesicle membrane 1 GRIA1
terminal bouton 1 GRIK2
Membrane 10 ANXA6, BDNF, CALR, GRIA1, GRIA2, GRIA4, GRIK2, GTPBP4, ITPR3, SLC7A11
axon 1 BDNF
basolateral plasma membrane 1 SLC7A11
brush border 1 ITPR3
extracellular exosome 4 ANXA6, CA1, CALR, GRID1
endoplasmic reticulum 3 CALR, GRIK2, ITPR3
extracellular space 3 BDNF, CALR, INS
perinuclear region of cytoplasm 4 ANXA6, BDNF, CALR, GTPBP4
Schaffer collateral - CA1 synapse 1 GRM1
mitochondrion 1 ANXA6
intracellular membrane-bounded organelle 1 GRIK1
postsynaptic density 3 GRIA1, GRIA2, GRIK2
Single-pass type I membrane protein 1 SLC7A11
Secreted 2 BDNF, INS
extracellular region 3 BDNF, CALR, INS
excitatory synapse 2 GRIA1, GRIA2
hippocampal mossy fiber to CA3 synapse 1 GRIK2
neuronal cell body membrane 1 GRIA1
nuclear membrane 1 GTPBP4
external side of plasma membrane 3 CALR, GRIA1, GRIA2
Extracellular vesicle 1 GRIA4
Secreted, extracellular space, extracellular matrix 1 CALR
dendritic spine 4 GRIA1, GRIA2, GRIA3, GRIA4
perikaryon 2 GRIK2, RBFOX3
nucleolus 3 ADARB1, GTPBP4, ITPR3
neuron spine 1 GRIA1
apical part of cell 2 ITPR3, SLC7A11
cell-cell junction 1 GRIA1
recycling endosome 1 GRIA1
postsynaptic membrane 7 GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIK2
presynaptic active zone membrane 1 GRIA1
focal adhesion 2 ANXA6, CALR
GABA-ergic synapse 1 GRID1
sarcoplasmic reticulum 1 ITPR3
Cell projection, dendritic spine 1 GRIA1
collagen-containing extracellular matrix 2 ANXA6, CALR
lateral plasma membrane 1 SLC7A11
nuclear outer membrane 1 ITPR3
Postsynaptic cell membrane 8 GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIK2, GRM1
dendrite cytoplasm 1 GRIK2
kainate selective glutamate receptor complex 2 GRIK1, GRIK2
mossy fiber rosette 1 GRIK2
Late endosome 1 AP5B1
receptor complex 1 ITPR3
Zymogen granule membrane 1 ANXA6
Late endosome membrane 1 ANXA6
cell projection 1 GRIK2
phagocytic vesicle membrane 1 CALR
brush border membrane 1 SLC7A11
Nucleus, nucleolus 2 ADARB1, GTPBP4
postsynaptic density, intracellular component 1 GRIA1
Basolateral cell membrane 1 SLC7A11
Cell projection, microvillus membrane 1 SLC7A11
microvillus membrane 1 SLC7A11
nuclear envelope 1 CALR
Recycling endosome membrane 1 GRIA1
endosome lumen 1 INS
AMPA glutamate receptor complex 4 GRIA1, GRIA2, GRIA3, GRIA4
Cell projection, dendrite 2 GRIA1, GRIA4
Melanosome 1 ANXA6
Presynaptic cell membrane 1 GRIK2
synaptic membrane 1 GRIA1
secretory granule lumen 1 INS
endoplasmic reticulum quality control compartment 1 CALR
secretory granule membrane 1 ITPR3
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 BDNF, CALR, INS
endocytic vesicle membrane 4 GRIA1, GRIA2, GRIA3, GRIA4
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 3 CALR, GRIA1, INS
postsynaptic density membrane 8 GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRIK1, GRIK2, GRM1
postsynaptic endocytic zone 1 GRIA2
ER to Golgi transport vesicle membrane 1 GRIA1
parallel fiber to Purkinje cell synapse 1 GRIA3
vesicle membrane 1 ANXA6
Sarcoplasmic reticulum lumen 1 CALR
platelet dense tubular network membrane 1 ITPR3
[Isoform 2]: Nucleus 1 ADARB1
[Isoform 1]: Nucleus 1 ADARB1
lumenal side of endoplasmic reticulum membrane 1 CALR
MHC class I peptide loading complex 1 CALR
AP-5 adaptor complex 1 AP5B1
AP-type membrane coat adaptor complex 1 AP5B1
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
dendritic spine membrane 1 GRIA1
astrocyte projection 1 SLC7A11
endocytic vesicle lumen 1 CALR
ribosome 1 CALR
transport vesicle membrane 1 ITPR3
Cytoplasmic vesicle, secretory vesicle, Cortical granule 1 CALR
cortical granule 1 CALR
asymmetric synapse 1 GRIA2
Cytolytic granule 1 CALR
proximal dendrite 1 GRIA1
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
axonal spine 1 GRIA1
perisynaptic space 1 GRIA1
G protein-coupled receptor dimeric complex 1 GRM1
G protein-coupled receptor homodimeric complex 1 GRM1


文献列表

  • S Kott, C Sager, D Tapken, M Werner, M Hollmann. Comparative analysis of the pharmacology of GluR1 in complex with transmembrane AMPA receptor regulatory proteins gamma2, gamma3, gamma4, and gamma8. Neuroscience. 2009 Jan; 158(1):78-88. doi: 10.1016/j.neuroscience.2007.12.047. [PMID: 18304748]
  • M L Leski, S L Valentine, J D Baer, J T Coyle. Insulin-like growth factor I prevents the development of sensitivity to kainate neurotoxicity in cerebellar granule cells. Journal of neurochemistry. 2000 Oct; 75(4):1548-56. doi: 10.1046/j.1471-4159.2000.0751548.x. [PMID: 10987835]
  • O Meucci, R J Miller. Dissociation between the Joro spider toxin sensitivity of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and their ability to increase intracellular calcium. Neuropharmacology. 1998 Oct; 37(10-11):1431-43. doi: 10.1016/s0028-3908(98)00147-6. [PMID: 9849678]
  • E Eber, T Uhlig, C McMenamin, P D Sly. Leflunomide, a novel immunomodulating agent, prevents the development of allergic sensitization in an animal model of allergic asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 1998 Mar; 28(3):376-84. doi: 10.1046/j.1365-2222.1998.00240.x. [PMID: 9543089]
  • K Shimazaki, M Sokabe, N Kawai. Spider toxin-binding protein: functional and immunohistochemical study. Annals of the New York Academy of Sciences. 1993 Dec; 707(?):427-30. doi: 10.1111/j.1749-6632.1993.tb38089.x. [PMID: 9137586]