Flindokalner (BioDeep_00000009609)

   

Volatile Flavor Compounds


代谢物信息卡片


3-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)indolin-2-one

化学式: C16H10ClF4NO2 (359.0336158)
中文名称: 3-(5-氯-2-甲氧基苯基)-3-氟-1,3-二氢-6-三氟甲基-2H-吲哚-2-酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C(C=C1)Cl)C2(C3=C(C=C(C=C3)C(F)(F)F)NC2=O)F
InChI: InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)

描述信息

Same as: D04192
C26170 - Protective Agent > C1509 - Neuroprotective Agent

同义名列表

5 个代谢物同义名

Flindokalner; BMS 204352; 3-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)indolin-2-one; (+/-)-BMS 204352; BMS 204352



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Donglu Zhang, Rajesh Krishna, Lifei Wang, Jianing Zeng, James Mitroka, Renke Dai, Narayanan Narasimhan, Richard A Reeves, Nuggehally R Srinivas, Lewis J Klunk. Metabolism, pharmacokinetics, and protein covalent binding of radiolabeled MaxiPost (BMS-204352) in humans. Drug metabolism and disposition: the biological fate of chemicals. 2005 Jan; 33(1):83-93. doi: 10.1124/dmd.104.001412. [PMID: 15502007]
  • Jianing Zeng, Holly Palme, Nuggehally Srinivas, Mark Arnold. Determination of a neuroprotective agent (S)-(+)-BMS-204352 in human, rat and dog plasma by enantioselective liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Nov; 811(2):109-17. doi: 10.1016/j.jchromb.2004.08.002. [PMID: 15522709]
  • Donglu Zhang, Weiping Zhao, Vikram A Roongta, James G Mitroka, Lewis J Klunk, Mingshe Zhu. Amide N-glucuronidation of MaxiPost catalyzed by UDP-glucuronosyltransferase 2B7 in humans. Drug metabolism and disposition: the biological fate of chemicals. 2004 May; 32(5):545-51. doi: 10.1124/dmd.32.5.545. [PMID: 15100177]
  • Rikke Louise Schrøder, Dorte Strøbaek, Søren-Peter Olesen, Palle Christophersen. Voltage-independent KCNQ4 currents induced by (+/-)BMS-204352. Pflugers Archiv : European journal of physiology. 2003 Aug; 446(5):607-16. doi: 10.1007/s00424-003-1116-x. [PMID: 12851819]
  • Donglu Zhang, Marc Ogan, Richard Gedamke, Vikram Roongta, Renke Dai, Mingshe Zhu, J Kent Rinehart, Lewis Klunk, James Mitroka. Protein covalent binding of maxipost through a cytochrome P450-mediated ortho-quinone methide intermediate in rats. Drug metabolism and disposition: the biological fate of chemicals. 2003 Jul; 31(7):837-45. doi: 10.1124/dmd.31.7.837. [PMID: 12814959]
  • Rajesh Krishna, Holly Palme, Jianing Zeng, Nuggehally Srinivas. Effect of dose and input rate on the brain penetration of BMS-204352 following intravenous administration to rats. Biopharmaceutics & drug disposition. 2002 Sep; 23(6):227-31. doi: 10.1002/bdd.317. [PMID: 12214322]
  • Rajesh Krishna, Vinod R Shah, Nuggehally Srinivas. Pharmacokinetics and dose proportionality of BMS-204352 after intraarterial administration to rats. Biopharmaceutics & drug disposition. 2002 Sep; 23(6):233-7. doi: 10.1002/bdd.318. [PMID: 12214323]
  • Ming Yao, Subbarao Mantha, Vinod R Shah, Nimish N Vachharajani, Mark E Arnold, Janice M Pursley, Nuggehally R Srinivas. High performance liquid chromatographic-mass spectrometric assay for the quantitation of BMS-204352 in dog K(3)EDTA plasma. Biomedical chromatography : BMC. 2002 May; 16(3):175-82. doi: 10.1002/bmc.123. [PMID: 11920941]
  • Piyasena Hewawasam, Valentin K Gribkoff, Yadagiri Pendri, Steven I Dworetzky, Nicholas A Meanwell, Eduardo Martinez, Christopher G Boissard, Debra J Post-Munson, Joanne T Trojnacki, Krishnaswamy Yeleswaram, Lorraine M Pajor, Jay Knipe, Qi Gao, Robert Perrone, John E Starrett. The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels. Bioorganic & medicinal chemistry letters. 2002 Apr; 12(7):1023-6. doi: 10.1016/s0960-894x(02)00101-4. [PMID: 11909708]
  • Rajesh Krishna, Vinod R Shah, Subbaro Mantha, Nimish N Vachharajani, Nuggehally Srinivas. Pharmacokinetics and dose proportionality of BMS-204352 after intravenous administration to dogs. Biopharmaceutics & drug disposition. 2002 Mar; 23(2):83-6. doi: 10.1002/bdd.294. [PMID: 11932963]
  • Rajesh Krishna, Ming Yao, Nuggehally R Srinivas, Vinod Shah, Janice M Pursley, Mark Arnold, Nimish N Vachharajani. Disposition of radiolabeled BMS-204352 in rats and dogs. Biopharmaceutics & drug disposition. 2002 Jan; 23(1):41-6. doi: 10.1002/bdd.292. [PMID: 11891672]
  • R Søgaard, T Ljungstrøm, K A Pedersen, S P Olesen, B S Jensen. KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology. American journal of physiology. Cell physiology. 2001 Apr; 280(4):C859-66. doi: 10.1152/ajpcell.2001.280.4.c859. [PMID: 11245603]
  • R Krishna, M Yao, D Kaczor, N Vachharajani, N R Srinivas. In vitro protein binding studies with BMS-204352: lack of protein binding displacement interaction in human serum. Biopharmaceutics & drug disposition. 2001 Jan; 22(1):41-4. doi: 10.1002/bdd.269. [PMID: 11745906]