Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxo-, ethyl ester (BioDeep_00000009561)
Secondary id: BioDeep_00001877034
human metabolite blood metabolite
代谢物信息卡片
化学式: C18H17F2NO5 (365.1075)
中文名称:
谱图信息:
最多检出来源 Mentha canadensis(plant) 50%
分子结构信息
SMILES: CCOC(=O)C1=C(C)NC2=C(C(=O)OC2)C1c1ccccc1OC(F)F
InChI: InChI=1S/C18H17F2NO5/c1-3-24-16(22)13-9(2)21-11-8-25-17(23)15(11)14(13)10-6-4-5-7-12(10)26-18(19)20/h4-7,14,18,21H,3,8H2,1-2H3
描述信息
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents > D002120 - Calcium Channel Agonists
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
同义名列表
10 个代谢物同义名
Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxo-, ethyl ester; Furo(3,4-b)pyridine-3-carboxylate, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)phenyl)-2-methyl-5-oxo-, ethyl ester; Ethyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5-oxo-1H,4H,5H,7H-furo[3,4-b]pyridine-3-carboxylic acid; 2-Methyl-3-methoxycarbonyl-4-(2-difluoromethoxyphenyl)-5-oxo-1,4,5,7-tetrahydrofuro(3,4-b)pyridine; ethyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5-oxo-1H,4H,5H,7H-furo[3,4-b]pyridine-3-carboxylate; ethyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5-oxo-1H,4H,7H-furo[3,4-b]pyridine-3-carboxylate; CGP 28392, (+-)-Isomer; Ciba 28392; CGP 28-392; CGP 28 392
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:34600
- KEGG: C13761
- PubChem: 123861
- HMDB: HMDB0250227
- Metlin: METLIN69690
- ChEMBL: CHEMBL2151429
- chemspider: 110399
- CAS: 89289-93-0
- PMhub: MS000023354
- PubChem: 586347
- NIKKAJI: J22.092B
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- May Simaan, Chanterelle Cadorette, Matthieu Poterek, Jean St-Louis, Michèle Brochu. Calcium channels contribute to the decrease in blood pressure of pregnant rats.
American journal of physiology. Heart and circulatory physiology.
2002 Feb; 282(2):H665-71. doi:
10.1152/ajpheart.01183.2000. [PMID: 11788416] - T D Plant. Ion channels in pancreatic B cells.
Journal of protein chemistry.
1989 Jun; 8(3):399-402. doi:
10.1007/bf01674299. [PMID: 2477019] - T D Plant. Properties and calcium-dependent inactivation of calcium currents in cultured mouse pancreatic B-cells.
The Journal of physiology.
1988 Oct; 404(?):731-47. doi:
10.1113/jphysiol.1988.sp017316. [PMID: 2855352] - P Erne, J Wardle, K Sanders, S M Lewis, A Maseri. Mean platelet volume and size distribution and their sensitivity to agonists in patients with coronary artery disease and congestive heart failure.
Thrombosis and haemostasis.
1988 Apr; 59(2):259-63. doi:
. [PMID: 3388297] - Y Matsumura, T Uriu, H Shinyama, Y Sasaki, S Morimoto. Inhibitory effects of calcium channel agonists on renin release from rat kidney cortical slices.
The Journal of pharmacology and experimental therapeutics.
1987 Jun; 241(3):1000-5. doi:
. [PMID: 2439680] - C Korstanje, F A Jonkman, J E Van Kemenade, P A Van Zwieten. Bay k 8644, a calcium entry promoter, as an antidote in verapamil intoxication in rabbits.
Archives internationales de pharmacodynamie et de therapie.
1987 May; 287(1):109-19. doi:
. [PMID: 2443093]
