Ansamitocin P3 (BioDeep_00000009059)

 

Secondary id: BioDeep_00000659520

Chemicals and Drugs


代谢物信息卡片


2-De(acetylmethylamino)-2-methylmaytansine

化学式: C32H43ClN2O9 (634.2656938)
中文名称: 安丝菌素P3
谱图信息: 最多检出来源 Macaca mulatta(otcml) 9.83%

分子结构信息

SMILES: CC(C)C(=O)O[C@H]1CC(=O)N(C)c2cc(C/C(=C/C=C/[C@H]([C@]3(C[C@@H]([C@@H](C)[C@H]4[C@@]1(C)O4)OC(=O)N3)O)OC)/C)cc(c2Cl)OC
InChI: InChI=1S/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10+/t19-,23+,24-,25+,28+,31+,32+/m1/s1

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.

同义名列表

9 个代谢物同义名

2-De(acetylmethylamino)-2-methylmaytansine; Maytansinol isobutyrate; Antibiotic C15003P3; Ansamitocin P-3; Ansamitosin P-3; C15003P3; Ansamitocin P3; Ansamitocin P 3; Antibiotic C 15003P3



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Juan Li, Siyu Guo, Qiang Hua, Fengxian Hu. Improved AP-3 production through combined ARTP mutagenesis, fermentation optimization, and subsequent genome shuffling. Biotechnology letters. 2021 Jun; 43(6):1143-1154. doi: 10.1007/s10529-020-03034-5. [PMID: 33751317]
  • Yong-Guang Zhang, Qing Liu, Hong-Fei Wang, Dong-Jin Park, Jian-Wei Guo, Chang-Jin Kim, Yuan-Ming Zhang, Wen-Jun Li. Nocardiopsis ansamitocini sp. nov., a new producer of ansamitocin P-3 of the genus Nocardiopsis. International journal of systematic and evolutionary microbiology. 2016 Jan; 66(1):230-235. doi: 10.1099/ijsem.0.000703. [PMID: 26486850]
  • Guo-Zhu Wei, Lin-Quan Bai, Tao Yang, Juan Ma, Ying Zeng, Yue-Mao Shen, Pei-Ji Zhao. A new antitumour ansamitocin from Actinosynnema pretiosum. Natural product research. 2010 Jul; 24(12):1146-50. doi: 10.1080/14786410902916552. [PMID: 20582809]
  • Peiji Zhao, Linquan Bai, Juan Ma, Ying Zeng, Lei Li, Yirong Zhang, Chunhua Lu, Huanqin Dai, Zhaoxian Wu, Yaoyao Li, Xuan Wu, Gang Chen, Xiaojiang Hao, Yuemao Shen, Zixin Deng, Heinz G Floss. Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins. Chemistry & biology. 2008 Aug; 15(8):863-74. doi: 10.1016/j.chembiol.2008.06.007. [PMID: 18721757]
  • Juan Ma, Pei-Ji Zhao, Yue-Mao Shen. New amide N-glycosides of ansamitocins identified from Actinosynnema pretiosum. Archives of pharmacal research. 2007 Jun; 30(6):670-3. doi: 10.1007/bf02977625. [PMID: 17679541]
  • Zhongfa Liu, Heinz G Floss, John M Cassady, Kenneth K Chan. Metabolism studies of the anti-tumor agent maytansine and its analog ansamitocin P-3 using liquid chromatography/tandem mass spectrometry. Journal of mass spectrometry : JMS. 2005 Mar; 40(3):389-99. doi: 10.1002/jms.800. [PMID: 15674857]
  • Zhongfa Liu, Heinz G Floss, John M Cassady, Jim Xiao, Kenneth K Chan. An API LC/MS/MS quantitation method for ansamitocin P-3 (AP3) and its preclinical pharmacokinetics. Journal of pharmaceutical and biomedical analysis. 2004 Nov; 36(4):815-21. doi: 10.1016/j.jpba.2004.07.045. [PMID: 15533675]
  • Chunhua Lu, Linquan Bai, Yuemao Shen. A novel amide N-glycoside of ansamitocins from Actinosynnema pretiosum. The Journal of antibiotics. 2004 May; 57(5):348-50. doi: 10.7164/antibiotics.57.348. [PMID: 15303496]