(S)-3-Butyl-1(3H)-isobenzofuranone (BioDeep_00000000089)
human metabolite PANOMIX_OTCML-2023
代谢物信息卡片
3-Butylphthalide pound>>3-n-Butylphthalide
化学式: C12H14O2 (190.0994)
中文名称: 正丁基苯酞, 3-丁基-1(3H)-异苯并呋喃酮, 丁基苯酞, 丁苯酚, 3-丁基苯酞, 正丁基苯肽
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 54.73%
分子结构信息
SMILES: CCCCC1C2=CC=CC=C2C(=O)O1
InChI: InChI=1S/C12H14O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h4-7,11H,2-3,8H2,1H3
描述信息
Butylphthalide is a member of benzofurans.
Butylphthalide has been used in trials studying the prevention of Restenosis.
Butylphthalide is a natural product found in Ligusticum striatum, Angelica sinensis, and other organisms with data available.
See also: Celery Seed (part of); Angelica sinensis root oil (part of).
Potential nutriceutical. 3-Butyl-1(3H)-isobenzofuranone is found in many foods, some of which are dill, parsley, lovage, and wild celery.
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
3-Butyl-1(3H)-isobenzofuranone is found in dill. Potential nutriceutical.
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D020011 - Protective Agents
Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models.
Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models.
同义名列表
35 个代谢物同义名
3-Butylphthalide pound>>3-n-Butylphthalide; 3-butyl-1,3-dihydro-2-benzofuran-1-one; 3-n-Butylphthalide;3-Butylphthalide; (S)-3-Butyl-1(3H)-isobenzofuranone; 3-N-Butylphthalide, >=98\\% (HPLC); 1(3H)-Isobenzofuranone, 3-butyl-; 3-Butyl-1(3H)-isobenzofuranone; 3-Butyl-2-benzofuran-1(3H)-one; 3-butyl-3H-isobenzofuran-1-one; 3-butylisobenzofuran-1(3H)-one; 3-butyl-3H-2-benzofuran-1-one; 3-butyl-3H-2-benzouran-1-one; 3-N-BUTYLPHTHALIDE [FHFI]; dibutyl2,2-thiobisacetate; (S)-(-)-3-butylphthalide; BUTYLPHTHALIDE [WHO-DD]; Rac-3-n-butylphthalide; (+/-)-3-BUTYLPHTHALIDE; dl-3-n-butylphthalide; (+/-)-butylphthalide; Butylphthalide [INN]; Phthalide, 3-butyl-; 3-n-butylphthalide; 3-n-Butylphathlide; N-butylphthalide; 3-BUTYLPHTHALIDE; butylphthalidum; Butylphthalide; butilftalida; colforsin; l-NBP cpd; Forskolin; DL-NBP; Butylphthalide; Butylphthalide
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:177504
- KEGG: C17854
- PubChem: 61361
- HMDB: HMDB0032064
- DrugBank: DB12749
- ChEMBL: CHEMBL248594
- Wikipedia: Butylphthalide
- MeSH: 3-n-butylphthalide
- ChemIDplus: 0006066495
- foodb: FDB011862
- chemspider: 55293
- CAS: 6066-49-5
- CAS: 3413-15-8
- medchemexpress: HY-B0647
- PMhub: MS000026151
- PubChem: 163311856
- KNApSAcK: 177504
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
16 个相关的物种来源信息
- 55605 - Angelica acutiloba:
- 85712 - Angelica gigas:
- 265806 - Angelica japonica: -
- 165353 - Angelica sinensis:
- 4045 - Apium graveolens:
- 28498 - Asarum canadense: 10.1021/JF00065A004
- 9606 - Homo sapiens: -
- 48042 - Levisticum officinale: 10.1248/CPB.11.1317
- 2689076 - Ligusticum chuanxiong:
- 2689076 - Ligusticum chuanxiong Hort.: -
- 1508160 - Ligusticum striatum:
- 4043 - Petroselinum crispum: 10.1021/JF00018A025
- 33090 - Plants: -
- 65409 - Scutellaria baicalensis: 10.1271/BBB1961.51.1449
- 33090 - 当归: -
- 33090 - 藁本: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bao Nie, Xueqing Chen, Zhuangwei Hou, Miaoxian Guo, Cheng Li, Wenkai Sun, Jiaojiao Ji, Lanlan Zang, Song Yang, Pengxiang Fan, Wenhao Zhang, Hang Li, Yuzhu Tan, Wei Li, Li Wang. Haplotype-phased genome unveils the butylphthalide biosynthesis and homoploid hybrid origin of Ligusticum chuanxiong.
Science advances.
2024 Feb; 10(6):eadj6547. doi:
10.1126/sciadv.adj6547. [PMID: 38324681] - Guangjun Yu, Yichun Shi, Shiqin Cong, Chengxun Wu, Jing Liu, Yanghui Zhang, Hongyan Liu, Xiuxiu Liu, Haixing Deng, Zhenghuai Tan, Yong Deng. Synthesis and evaluation of butylphthalide-scutellarein hybrids as multifunctional agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2024 Feb; 265(?):116099. doi:
10.1016/j.ejmech.2023.116099. [PMID: 38160618] - Xueqing Chen, Xiaopeng Zhang, Wenkai Sun, Zhuangwei Hou, Bao Nie, Fengjiao Wang, Song Yang, Shourui Feng, Wei Li, Li Wang. LcSAO1, an Unconventional DOXB Clade 2OGD Enzyme from Ligusticum chuanxiong Catalyzes the Biosynthesis of Plant-Derived Natural Medicine Butylphthalide.
International journal of molecular sciences.
2023 Dec; 24(24):. doi:
10.3390/ijms242417417. [PMID: 38139246] - Yi Jia, Haiyan Xiao, Xiaolin Wang, Ying Liu, Jiaxin Wang, Haochen Xie, Hai Shang, Guibo Sun, Yu Tian. Design, synthesis, and evaluation of n-butylphthalide and ligustrazine hybrids as potent neuroprotective agents for the treatment of ischemic stroke in vitro and in vivo.
Bioorganic chemistry.
2023 Nov; 142(?):106961. doi:
10.1016/j.bioorg.2023.106961. [PMID: 37956636] - Xinghua Wang, Xinchi Luan, Zhigang Yang. The effect of butylphthalide on improving the neurological function of patients with acute anterior circulation cerebral infarction after mechanical thrombectomy.
Medicine.
2023 Aug; 102(34):e34616. doi:
10.1097/md.0000000000034616. [PMID: 37653792] - Yajuan Xing, Jianhui Guo, Wen Guo. Butylphthalide regulation of nerve cells in rats with cerebral infarction through jnk/p38mapk signaling pathway.
Pakistan journal of pharmaceutical sciences.
2023 Jul; 36(4(Special)):1367-1373. doi:
. [PMID: 37606030] - Anxin Wang, Baixue Jia, Xuelei Zhang, Xiaochuan Huo, Jianhuang Chen, Liqiang Gui, Yefeng Cai, Zaiyu Guo, Yuqing Han, Zhaolong Peng, Ping Jing, Yongjun Chen, Yan Liu, Yong Yang, Fengyun Wang, Zengqiang Sun, Tong Li, Hongxia Sun, Haicheng Yuan, Hongmin Shao, Lianbo Gao, Peipei Zhang, Feng Wang, Xiangyang Cao, Wanchao Shi, Changmao Li, Jianwen Yang, Hong Zhang, Feng Wang, Jianzhong Deng, Yanjie Liu, Weisheng Deng, Cunfeng Song, Huisheng Chen, Li He, Hongdong Zhao, Xianfeng Li, Hong Yang, Zhiming Zhou, Yilong Wang, Zhongrong Miao. Efficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke: A Randomized Clinical Trial.
JAMA neurology.
2023 Jun; ?(?):. doi:
10.1001/jamaneurol.2023.1871. [PMID: 37358859] - Ziying Ye, Chuna Li, Shuqiong Liu, Hongbin Liang, Jialiang Feng, Danyu Lin, Ying Chen, Sudan Peng, Lulu Bu, Enxiang Tao, Xiuna Jing, Yanran Liang. Dl-3-n-butylphthalide activates Nrf2, inhibits ferritinophagy, and protects MES23.5 dopaminergic neurons from ferroptosis.
Chemico-biological interactions.
2023 Jun; ?(?):110604. doi:
10.1016/j.cbi.2023.110604. [PMID: 37315914] - Xinxin Liu, Yingqi Ma, Yiguo Wang, Qiming Zhang. Effects of NBP injection on the inflammatory response, oxidative stress response and vascular endothelial function in patients with ACI: A systematic review and meta-analysis.
Medicine.
2023 Mar; 102(10):e33226. doi:
10.1097/md.0000000000033226. [PMID: 36897673] - Yajuan Xing, Jianhui Guo, Wen Guo. Butylphthalide regulation of nerve cells in rats with cerebral infarction through jnk/p38mapk signaling pathway15.
Pakistan journal of pharmaceutical sciences.
2023 Mar; 36(2(Special)):665-671. doi:
. [PMID: 37548207] - Zhenguo G Wang, Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Hongyun Huang, Lin Chen, Igor Manzhulo, Lars Wiklund, Hari Shanker Sharma. Co-administration of dl-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with mild traumatic brain injury.
International review of neurobiology.
2023; 172(?):145-185. doi:
10.1016/bs.irn.2023.06.006. [PMID: 37833011] - Lianyuan Feng, Aruna Sharma, Zhenguo Wang, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Cong Li, Ziquiang Zhang, Chen Lin, Hongyun Huang, Igor Manzhulo, Lars Wiklund, Hari Shanker Sharma. Nanowired delivery of dl-3-n-butylphthalide with antibodies to alpha synuclein potentiated neuroprotection in Parkinson's disease with emotional stress.
International review of neurobiology.
2023; 171(?):47-82. doi:
10.1016/bs.irn.2023.06.005. [PMID: 37783563] - Shengtao Tang, Kunyu Wang, Xiaokun Qi. Neuro-protective effects of n-butylphthalide on carbon monoxide poisoning rats by modulating IL-2, AKT and BCL-2.
The Journal of toxicological sciences.
2023; 48(9):495-505. doi:
10.2131/jts.48.495. [PMID: 37661366] - Jian Jia, Jianbing Wu, Duorui Ji, Weijie Jiao, Xiaoli Wang, Zhangjian Huang, Yihua Zhang. Synthesis and biological evaluation of hybrids from optically active ring-opened 3-N-butylphthalide derivatives and 4-fluro-edaravone as potential anti-acute ischemic stroke agents.
Bioorganic & medicinal chemistry.
2022 09; 69(?):116891. doi:
10.1016/j.bmc.2022.116891. [PMID: 35764031] - Zhichao Zhong, Xingrui He, Jiamin Ge, Junlong Zhu, Chuansheng Yao, Hong Cai, Xiang-Yang Ye, Tian Xie, Renren Bai. Discovery of small-molecule compounds and natural products against Parkinson's disease: Pathological mechanism and structural modification.
European journal of medicinal chemistry.
2022 Jul; 237(?):114378. doi:
10.1016/j.ejmech.2022.114378. [PMID: 35462165] - Hai-Yan Xiao, Shu-Xian Yang, Wen Han, Li Cao, Gui-Bo Sun. [Research progress on pharmacology of butylphthalide and its derivatives].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Jul; 47(13):3425-3431. doi:
10.19540/j.cnki.cjcmm.20220117.701. [PMID: 35850792] - Beibei Fu, Shuqing Meng, Genshan Gao. A combination of tetramethylpyrazine hydrochloride and butylphthalide on serum S100B, CRP, Hcy levels and NIHSS score in patients with acute cerebral infarction: A retrospective study.
Pakistan journal of pharmaceutical sciences.
2022 May; 35(3(Special)):945-951. doi:
. [PMID: 35791592] - Zhuoling Liu, Yichun Shi, Xiaoyu Zhang, Guangjun Yu, Jingjing Li, Shiqin Cong, Yong Deng. Discovery of novel 3-butyl-6-benzyloxyphthalide Mannich base derivatives as multifunctional agents against Alzheimer's disease.
Bioorganic & medicinal chemistry.
2022 03; 58(?):116660. doi:
10.1016/j.bmc.2022.116660. [PMID: 35183029] - Yanli Guo, Huaiqiang Hu, Guigang Xu, Yang Liu, Jinbo Yan, Hui Liu. Cerebral hemodynamic changes assessment by transcranial doppler ultrasound in patients with acute cerebral infarction before and after treatment with butylphthalide.
Pakistan journal of pharmaceutical sciences.
2022 Mar; 35(2(Special)):613-618. doi:
. [PMID: 35668561] - Chaoqun Lin, Shiying Huang, Jianfeng Zhang, Huaitao Yuan, Tuchao Yao, Lukui Chen. Dl-3-N-Butylphthalide Attenuates Hypoxic Injury of Neural Stem Cells by Increasing Hypoxia-Inducible Factor-1alpha.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2022 Feb; 31(2):106221. doi:
10.1016/j.jstrokecerebrovasdis.2021.106221. [PMID: 34837757] - Jing Qian, Qing Pei, Runting Jing, Lixi Xue, Xiaoying Dong, Guojin Ren, Lijuan Feng, Feng Che. Effects of butylphthalide on the levels of serum C-reactive protein, Parkinson disease protein 7 and neurotrophin-3 and neurological function in patients with acute cerebral infarction.
Pakistan journal of pharmaceutical sciences.
2022 Jan; 35(1(Special)):349-354. doi:
. [PMID: 35236646] - Keliang Li, Qiting Zhang, Xuesheng Lu, Shengqi Yao. Effects of Butylphthalide Sodium Chloride Injection Combined with Edaravone Dexborneol on Neurological Function and Serum Inflammatory Factor Levels in Sufferers Having Acute Ischemic Stroke.
Journal of healthcare engineering.
2022; 2022(?):1509407. doi:
10.1155/2022/1509407. [PMID: 35463675] - Zhengqian Wang, Junshuang Che. Effectiveness of alteplase intravenous thrombolysis combined with butylphthalide in patients with acute severe cerebral infarction.
Folia neuropathologica.
2022; 60(4):421-426. doi:
10.5114/fn.2022.118787. [PMID: 36734384] - Li-Shu Lin, Li-Ling Lin, Tao Lin, Yan-An Wu. Simultaneous determination of 3-n-butylphthalide and its metabolite 10-hydroxy-butylphthalide in rat plasma using liquid chromatography-tandem mass spectrometry and application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2021 Nov; 35(11):e5184. doi:
10.1002/bmc.5184. [PMID: 34060121] - Junjun Tian, Peng Lei, Yifei He, Ning Zhang, Xinyu Ge, Liqiang Luo, Shu Yan, Xingxing Diao. Absorption, distribution, metabolism, and excretion of [14C]NBP (3-n-butylphthalide) in rats.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Sep; 1181(?):122915. doi:
10.1016/j.jchromb.2021.122915. [PMID: 34500404] - Honglin Xiang, Qiang Zhang, Yikun Han, Lan Yang, Yan Zhang, Qiang Liu, Zhirong Zhang, Ling Zhang. Novel brain-targeting 3-n-butylphthalide prodrugs for ischemic stroke treatment.
Journal of controlled release : official journal of the Controlled Release Society.
2021 07; 335(?):498-514. doi:
10.1016/j.jconrel.2021.05.045. [PMID: 34087248] - Wanjun Li, Song Cang, Zheng Sun, Kaishun Bi, Qing Li, Zuojing Li, Ran Liu. Development of an LC-MS/MS method for simultaneous quantitative analysis of macromolecular pharmaceutical adjuvant 2-hydroxypropyl-β-cyclodextrin and active pharmaceutical ingredients butylphthalide in rat plasma.
Journal of separation science.
2021 Jul; 44(14):2680-2692. doi:
10.1002/jssc.202100141. [PMID: 33971083] - Kang-Yun Lu, Shinn-Zong Lin, Kingsley Theras Primus Dass, Wei-Ju Lin, Shih-Ping Liu, Horng-Jyh Harn. 3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jul; 139(?):111687. doi:
10.1016/j.biopha.2021.111687. [PMID: 34243611] - Yijing Guo, Idriss Ali Abdoulaye, Fei Liu, Jiamin Wang, Xiuxiu Tian, Dafan Yu, Kai Le. N-Butylphthalide vs. Human Urinary Kallidinogenase for the Treatment of Acute Ischemic Stroke: Functional Outcome and Impact on Serum VEGF and TNF-α Expressions.
Annals of clinical and laboratory science.
2021 Jul; 51(4):503-511. doi:
NULL. [PMID: 34452888] - Yang Dong, Jianyong Yin, Teng Chen, Jiejun Wen, Qunzi Zhang, Xiaomei Li, Wenjun Lin, Feng Liu, Ying Fan, Niansong Wang. Dl-3-n-butylphthalide pretreatment attenuates renal ischemia/reperfusion injury.
Biochemical and biophysical research communications.
2021 06; 557(?):166-173. doi:
10.1016/j.bbrc.2021.04.006. [PMID: 33865225] - Zhongcheng Cao, Qing Song, Guangjun Yu, Zhuoling Liu, Shiqing Cong, Zhenghuai Tan, Yong Deng. Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry.
2021 04; 35(?):116074. doi:
10.1016/j.bmc.2021.116074. [PMID: 33640707] - Mengyao Qu, Jingjie Zhao, Yingying Zhao, Jinmei Sun, Liping Liu, Ling Wei, Yongbo Zhang. Vascular protection and regenerative effects of intranasal DL-3-N-butylphthalide treatment after ischaemic stroke in mice.
Stroke and vascular neurology.
2021 03; 6(1):74-79. doi:
10.1136/svn-2020-000364. [PMID: 32958696] - Xi Liu, Runzhe Liu, Dongxu Fu, Hao Wu, Xin Zhao, Yi Sun, Meng Wang, Xiaoping Pu. Dl-3-n-butylphthalide inhibits neuroinflammation by stimulating foxp3 and Ki-67 in an ischemic stroke model.
Aging.
2021 01; 13(3):3763-3778. doi:
10.18632/aging.202338. [PMID: 33461169] - Wenqin Zou, Yanqing Deng, Guanghui Chen, Shouqin Shangguan, Faming Zhou, Wenxin Jiang, Xiaoli Li. Influence of butyphthalide combined with urinary kallikrein in ACI treatment on neuro-cytokines and vascular endothelial function and its clinical effect.
The International journal of neuroscience.
2021 Jan; 131(1):25-30. doi:
10.1080/00207454.2020.1732972. [PMID: 32075474] - Jie Yin, Hong Chang, Dongmei Wang, Haifei Li, Aibing Yin. Fuzzy C-Means Clustering Algorithm-Based Magnetic Resonance Imaging Image Segmentation for Analyzing the Effect of Edaravone on the Vascular Endothelial Function in Patients with Acute Cerebral Infarction.
Contrast media & molecular imaging.
2021; 2021(?):4080305. doi:
10.1155/2021/4080305. [PMID: 34354551] - Kai Xie, Shuzhi Zhao, Xiaoning Li. Efficacy and Mechanism of Butylphthalide Combined with Atorvastatin Calcium Tablets in the Diagnosis of Cerebral Infarction Using Iodol/Fe₃O₄ Nanometric Contrast Agent.
Journal of nanoscience and nanotechnology.
2020 12; 20(12):7356-7361. doi:
10.1166/jnn.2020.18605. [PMID: 32711601] - Weiping Wang, Pengyan Li, Mengna Fang, Xiaoting Li, Yu Zhang, Tianhong Zhang. SFC-MS/MS method for simultaneous determination of nimodipine and 3-n-butylphthalide in beagle plasma: application to pharmacokinetic interaction study.
Bioanalysis.
2020 Nov; 12(21):1509-1519. doi:
10.4155/bio-2020-0229. [PMID: 33078962] - Chunmei Geng, Guoxian Hao, Qiao Yi, Yujin Guo, Dan Chen, Wenxiu Han, Jun Zhang, Mengqi Yang, Pei Jiang. The impact of Dl-3-n-butylphthalide on the lipidomics of the hippocampus in a rat model of lipopolysaccharide-induced depression.
Prostaglandins & other lipid mediators.
2020 10; 150(?):106464. doi:
10.1016/j.prostaglandins.2020.106464. [PMID: 32464175] - Yan Ma, Wenping Sun. Effects of Dengzhan Shengmai Capsule combined with butylphthalide soft capsule on oxidative stress indexes and serum Hcy and CRP levels in patients with vascular dementia.
Cellular and molecular biology (Noisy-le-Grand, France).
2020 Sep; 66(6):8-14. doi:
. [PMID: 33040778] - Mingzhe Wang, Yu Feng, Yike Yuan, Liqing Gui, Jian Wang, Penglin Gao, Baofeng Qin, Dandan Sima, Qiudong Wang, Weidong Pan. Use of l-3-n-Butylphthalide within 24 h after intravenous thrombolysis for acute cerebral infarction.
Complementary therapies in medicine.
2020 Aug; 52(?):102442. doi:
10.1016/j.ctim.2020.102442. [PMID: 32951710] - Li Luo, Qing Song, Yan Li, Zhongcheng Cao, Xiaoming Qiang, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.
Bioorganic & medicinal chemistry.
2020 04; 28(8):115400. doi:
10.1016/j.bmc.2020.115400. [PMID: 32146060] - Min Wang, Jian-Xun Liu, Ming-Jiang Yao, Jun-Guo Ren. [Advances in research on pharmacological and neuroprotective effects of traditional Chinese medicine after cerebral ischemia].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 Feb; 45(3):513-517. doi:
10.19540/j.cnki.cjcmm.20191022.403. [PMID: 32237507] - Fan-Xing Qi, Ying Hu, Li-Juan Kang, Pan Li, Tian-Chu Gao, Xin Zhang. Effects of Butyphthalide Combined with Idebenone on Inflammatory Cytokines and Vascular Endothelial Functions of Patients with Vascular Dementia.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2020 Jan; 30(1):23-27. doi:
10.29271/jcpsp.2020.01.23. [PMID: 31931927] - Jiefang Zhang, Yuewen Guo, Wenyao Li, Guangli Li, Yankun Chen. The Efficacy of N-Butylphthalide and Dexamethasone Combined with Hyperbaric Oxygen on Delayed Encephalopathy After Acute Carbon Monoxide Poisoning.
Drug design, development and therapy.
2020; 14(?):1333-1339. doi:
10.2147/dddt.s217010. [PMID: 32308366] - Xiao-Lei Zhang, Yin-Tao Dong, Yi Liu, Yi Zhang, Ting-Ting Li, Feng-Yun Hu. Effects of dl-3-n-butylphthalide on serum lipoprotein-associated phospholipase A2 and hypersensitive C-reactive protein levels in acute cerebral infarction.
Brain and behavior.
2019 12; 9(12):e01469. doi:
10.1002/brb3.1469. [PMID: 31724337] - Zhiwang Wang, Nan Yao, Xiaoyan Fu, Lingxia Wei, Maopeng Ding, Yarong Pang, Dongling Liu, Yuan Ren, Mei Guo. Butylphthalide ameliorates airway inflammation and mucus hypersecretion via NF-κB in a murine asthma model.
International immunopharmacology.
2019 Nov; 76(?):105873. doi:
10.1016/j.intimp.2019.105873. [PMID: 31493665] - Qinhui Wang, Tao Yan, Wei Jiang, Na Hu, Song Zhang, Peng Yang, Wenjuan Zhang, Lei Shi, Linna Liu. Simultaneous quantification of ligustilide, dl-3-n-butylphthalide and senkyunolide A in rat plasma by GC-MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction.
Biomedical chromatography : BMC.
2019 Oct; 33(10):e4625. doi:
10.1002/bmc.4625. [PMID: 31222844] - Y-Y Qi, X-F Feng, L Qiu, F Yang. 3-n-butylphthalide inhibits the apoptosis of nerve cells in rats with cerebral small vessel disease via the PI3K/Akt pathway.
European review for medical and pharmacological sciences.
2019 May; 23(10):4474-4480. doi:
10.26355/eurrev_201905_17959. [PMID: 31173324] - Chun-Yan Wang, Ye Xu, Xu Wang, Chuang Guo, Tao Wang, Zhan-You Wang. Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis.
Antioxidants & redox signaling.
2019 04; 30(11):1411-1431. doi:
10.1089/ars.2017.7440. [PMID: 29634349] - P P Zhang, Y H Wang, Q L Meng, X Q Han, Y L Ge, L Wang, C Liu, Y Wang, C Huang, H Y Wang. [Effects of butylphthalide on plasma nitric oxide and endothelin-1 in severe elderly OSAHS patients].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery.
2019 Mar; 33(3):242-245. doi:
10.13201/j.issn.1001-1781.2019.03.014. [PMID: 30813694] - Yuming Zhao, Dongmei Liu, Jiang Li, XiaoJie Zhang, Xiaoliang Wang. L-NBP, a multiple growth factor activator, attenuates ischemic neuronal impairments possibly through promoting neuritogenesis.
Neurochemistry international.
2019 03; 124(?):94-105. doi:
10.1016/j.neuint.2019.01.002. [PMID: 30629983] - Xu Zhang, Zi-Ming Feng, Ya-Nan Yang, Jian-Shuang Jiang, Pei-Cheng Zhang. Bioactive butylphthalide derivatives from Ligusticum chuanxiong.
Bioorganic chemistry.
2019 03; 84(?):505-510. doi:
10.1016/j.bioorg.2018.12.032. [PMID: 30602133] - Zhe Wang, Wei Sun, Zheng-Feng Lin, Rui Sun, Cheng-Ke Huang, Wei-Jian Ye, Yao-Yao Dong, Xiao-Dan Zhang, Rui-Jie Chen. A UHPLC-MS/MS method coupled with liquid-liquid extraction for the quantitation of phenacetin, omeprazole, metoprolol, midazolam and their metabolites in rat plasma and its application to the study of four CYP450 activities.
Journal of pharmaceutical and biomedical analysis.
2019 Jan; 163(?):204-210. doi:
10.1016/j.jpba.2018.10.012. [PMID: 30317077] - Huiliang Qiu, Huanlin Wu, Jin Ma, Haiming Cao, Lihua Huang, Wencong Qiu, Ying Peng, Chunhua Ding. DL-3-n-Butylphthalide reduces atrial fibrillation susceptibility by inhibiting atrial structural remodeling in rats with heart failure.
Naunyn-Schmiedeberg's archives of pharmacology.
2018 03; 391(3):323-334. doi:
10.1007/s00210-017-1457-1. [PMID: 29290021] - Jiang Li, Shao-Feng Xu, Ying Peng, Nan Feng, Ling Wang, Xiao-Liang Wang. Conversion and pharmacokinetics profiles of a novel pro-drug of 3-n-butylphthalide, potassium 2-(1-hydroxypentyl)-benzoate, in rats and dogs.
Acta pharmacologica Sinica.
2018 Feb; 39(2):275-285. doi:
10.1038/aps.2017.90. [PMID: 28905934] - Yingda Zang, Xiuyun Song, Chuangjun Li, Jie Ma, Shifeng Chu, Dandan Liu, Qian Ren, Yan Li, Naihong Chen, Dongming Zhang. Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo.
European journal of medicinal chemistry.
2018 Jan; 143(?):438-448. doi:
10.1016/j.ejmech.2017.11.084. [PMID: 29202406] - Zhiyan Tian, Jinhua Wang, Yan Wang, Miao Zhang, Yuying Zhou. Effects of butylphthalide on cognitive decline in diabetic rats.
Molecular medicine reports.
2017 Dec; 16(6):9131-9136. doi:
10.3892/mmr.2017.7700. [PMID: 28990110] - S-C Tang, C-J Luo, K-H Zhang, K Li, X-H Fan, L-P Ning, P Xue. Effects of dl-3-n-butylphthalide on serum VEGF and bFGF levels in acute cerebral infarction.
European review for medical and pharmacological sciences.
2017 Oct; 21(19):4431-4436. doi:
. [PMID: 29077149] - Jiang Li, Xiao-Liang Wang, Ai-Ping Wang, Shao-Feng Xu, Hong-Tao Jin. Toxicokinetics and toxicity of potassium 2-(1-hydroxypentyl)-benzoate in beagle dogs.
Journal of Asian natural products research.
2017 Apr; 19(4):388-401. doi:
10.1080/10286020.2017.1302940. [PMID: 28367640] - Haiqing Yan, Zhixin Yan, Xiaolu Niu, Jianling Wang, Yongkun Gui, Ping Zhang. Dl-3-n-butylphthalide can improve the cognitive function of patients with acute ischemic stroke: a prospective intervention study.
Neurological research.
2017 Apr; 39(4):337-343. doi:
10.1080/01616412.2016.1268775. [PMID: 28145815] - Wenping Xiang, Hui Xue, Baojun Wang, Yuechun Li, Jun Zhang, Changchun Jiang, Jiangxia Pang. Efficacy of N-Butylphthalide and Hyperbaric Oxygen Therapy on Cognitive Dysfunction in Patients with Delayed Encephalopathy After Acute Carbon Monoxide Poisoning.
Medical science monitor : international medical journal of experimental and clinical research.
2017 Mar; 23(?):1501-1506. doi:
10.12659/msm.899499. [PMID: 28352069] - Xiaoming Qiang, Yan Li, Xia Yang, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Deng. DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Bioorganic & medicinal chemistry letters.
2017 02; 27(4):718-722. doi:
10.1016/j.bmcl.2017.01.050. [PMID: 28131710] - Zhi-Wang Wang, Yong-Hui Wang, Yuan Ren, Rui-Qiong Wang, Xing-Yao Lin, Hai-Jing Duan. [Preliminary pharmacodynamics study on antiasthmatic action of butylphthalide in guinea pig].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2017 Feb; 33(2):136-139. doi:
10.12047/j.cjap.5463.2017.035. [PMID: 29931921] - Danita Champakaew, Anuluck Junkum, Udom Chaithong, Atchariya Jitpakdi, Doungrat Riyong, Anchalee Wannasan, Jitrawadee Intirach, Roongtawan Muangmoon, Arpaporn Chansang, Benjawan Tuetun, Benjawan Pitasawat. Assessment of Angelica sinensis (Oliv.) Diels as a repellent for personal protection against mosquitoes under laboratory and field conditions in northern Thailand.
Parasites & vectors.
2016 06; 9(1):373. doi:
10.1186/s13071-016-1650-y. [PMID: 27357395] - Wang Zhi-Wang, F U Xiao-Yan, Ren Yuan, Duan Hai-Jing, Liu Xue-Feng, Cheng Xiao-Li. [Effects of butylphthalide on bronchial asthma in guinea pigs and involvement of endothelin].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2016 Jun; 32(6):509-513. doi:
10.13459/j.cnki.cjap.2016.06.006. [PMID: 29926617] - Hongru Zhao, Wenwei Yun, Qunying Zhang, Xiuying Cai, Xuemin Li, Guozhen Hui, Xianju Zhou, Jianqiang Ni. Mobilization of Circulating Endothelial Progenitor Cells by dl-3-n-Butylphthalide in Acute Ischemic Stroke Patients.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2016 Apr; 25(4):752-60. doi:
10.1016/j.jstrokecerebrovasdis.2015.11.018. [PMID: 26775268] - Chun-Yan Wang, Zhan-You Wang, Jing-Wei Xie, Tao Wang, Xu Wang, Ye Xu, Jian-Hui Cai. Dl-3-n-butylphthalide-induced upregulation of antioxidant defense is involved in the enhancement of cross talk between CREB and Nrf2 in an Alzheimer's disease mouse model.
Neurobiology of aging.
2016 Feb; 38(?):32-46. doi:
10.1016/j.neurobiolaging.2015.10.024. [PMID: 26827641] - Fuxu Wang, Jia Ma, Fei Han, Xiujin Guo, Li Meng, Yufeng Sun, Cheng Jin, Huijun Duan, Hang Li, Ying Peng. DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model.
Scientific reports.
2016 Jan; 6(?):19396. doi:
10.1038/srep19396. [PMID: 26759189] - Idriss Ali Abdoulaye, Yi Jing Guo. A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives.
BioMed research international.
2016; 2016(?):5012341. doi:
10.1155/2016/5012341. [PMID: 28053983] - Xing-xing Diao, Kan Zhong, Xiu-li Li, Da-fang Zhong, Xiao-yan Chen. Isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-hydroxy-NBP and 10-hydroxy-NBP, across the rat blood-brain barrier.
Acta pharmacologica Sinica.
2015 Dec; 36(12):1520-7. doi:
10.1038/aps.2015.64. [PMID: 26567730] - Yihan Hu, Xiaoxu Bi, Pu Zhao, Huachuan Zheng, Xueshi Huang. Cytotoxic Activities, SAR and Anti-Invasion Effects of Butylphthalide Derivatives on Human Hepatocellular Carcinoma SMMC7721 Cells.
Molecules (Basel, Switzerland).
2015 Nov; 20(11):20312-9. doi:
10.3390/molecules201119699. [PMID: 26569212] - Ran Du, Jun Fang Teng, Yan Wang, Xin Yu Zhao, Zhao Bo Shi. Clinical study of Butylphthalide combined with Xue Shuan Tong on serum inflammatory factors and prognosis effect of patients with cerebral infarction.
Pakistan journal of pharmaceutical sciences.
2015 Sep; 28(5 Suppl):1823-7. doi:
NULL. [PMID: 26525022] - Jun Zhu, Yantao Zhang, Changhai Yang. Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats.
Molecular medicine reports.
2015 Feb; 11(2):1448-54. doi:
10.3892/mmr.2014.2791. [PMID: 25352064] - Yun Li, Longshan Zhao, Xiaoting Li, Bei Guo, Juanhang Zhao, Xianglin Wang, Tianhong Zhang. Quantification of 3-n-butylphthalide in beagle plasma samples by supercritical fluid chromatography with triple quadruple mass spectrometry and its application to an oral bioavailability study.
Journal of separation science.
2015 Feb; 38(4):697-702. doi:
10.1002/jssc.201401073. [PMID: 25446715] - Zujian Lan, Xiaoyu Xu, Wenkai Xu, Jin Li, Zengrong Liang, Xuefei Zhang, Ming Lei, Chunshun Zhao. Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent.
Drug design, development and therapy.
2015; 9(?):3377-91. doi:
10.2147/dddt.s84731. [PMID: 26170623] - Xingxing Diao, Xiaoyan Pang, Cen Xie, Zitao Guo, Dafang Zhong, Xiaoyan Chen. Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase 1A1.
Drug metabolism and disposition: the biological fate of chemicals.
2014 Apr; 42(4):774-81. doi:
10.1124/dmd.113.056218. [PMID: 24468743] - Ning Li, Zhixia Qiu, Xuliang Wang, Tingting Li, Hui Ji, Yihua Zhang, Yang Lu, Di Zhao, Xijing Chen. Pharmacokinetics in Sprague-Dawley rats and Beagle dogs and in vitro metabolism of ZJM-289, a novel nitric dioxide donor.
Xenobiotica; the fate of foreign compounds in biological systems.
2014 Jan; 44(1):59-69. doi:
10.3109/00498254.2013.805854. [PMID: 23773000] - Xingxing Diao, Zhiyu Ma, Peng Lei, Dafang Zhong, Yifan Zhang, Xiaoyan Chen. Enantioselective determination of 3-n-butylphthalide (NBP) in human plasma by liquid chromatography on a teicoplanin-based chiral column coupled with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Nov; 939(?):67-72. doi:
10.1016/j.jchromb.2013.09.014. [PMID: 24103433] - Maryam Hassanpour Moghadam, Mohsen Imenshahidi, Seyed Ahmad Mohajeri. Antihypertensive effect of celery seed on rat blood pressure in chronic administration.
Journal of medicinal food.
2013 Jun; 16(6):558-63. doi:
10.1089/jmf.2012.2664. [PMID: 23735001] - Xingxing Diao, Zhiyu Ma, Haidong Wang, Dafang Zhong, Yifan Zhang, Jing Jin, Yaxin Fan, Xiaoyan Chen. Simultaneous quantitation of 3-n-butylphthalide (NBP) and its four major metabolites in human plasma by LC-MS/MS using deuterated internal standards.
Journal of pharmaceutical and biomedical analysis.
2013 May; 78-79(?):19-26. doi:
10.1016/j.jpba.2013.01.033. [PMID: 23434525] - Xiaoli Wang, Linna Wang, Tingting Li, Zhangjian Huang, Yisheng Lai, Hui Ji, Xiaolong Wan, Jinyi Xu, Jide Tian, Yihua Zhang. Novel hybrids of optically active ring-opened 3-n-butylphthalide derivative and isosorbide as potential anti-ischemic stroke agents.
Journal of medicinal chemistry.
2013 Apr; 56(7):3078-89. doi:
10.1021/jm4001693. [PMID: 23509954] - Xingxing Diao, Pan Deng, Cen Xie, Xiuli Li, Dafang Zhong, Yifan Zhang, Xiaoyan Chen. Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation.
Drug metabolism and disposition: the biological fate of chemicals.
2013 Feb; 41(2):430-44. doi:
10.1124/dmd.112.049684. [PMID: 23169608] - Ning Li, Xuliang Wang, Tingting Li, Hui Ji, Yihua Zhang, Zhixia Qiu, Di Zhao, Xijing Chen. Identification of circulatory and excretory metabolites of a novel nitric oxide donor ZJM-289 in rat plasma, bile, urine and faeces by liquid chromatography-tandem mass spectrometry.
Xenobiotica; the fate of foreign compounds in biological systems.
2011 Sep; 41(9):805-17. doi:
10.3109/00498254.2011.580385. [PMID: 21561319] - Bao Tan, Hai-lian Shi, Guang Ji, Lan Lu, Ai-Li Cao, Song-shan Shi, Jian-qun Xie. Antiproliferative effects of essential oil of a compound Chinese herbal medicine Weiqi Decoction on AGS cells.
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2011 May; 9(5):558-64. doi:
10.3736/jcim20110515. [PMID: 21565144] - Zhining Wen, Zhijun Wang, Steven Wang, Ranadheer Ravula, Lun Yang, Jun Xu, Charles Wang, Zhong Zuo, Moses S S Chow, Leming Shi, Ying Huang. Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map.
PloS one.
2011 Mar; 6(3):e18278. doi:
10.1371/journal.pone.0018278. [PMID: 21464939] - Jia Wang, Jian-Bo Yang, Ai-Guo Wang, Teng-Fei Ji, Ya-Lun Su. [Studies on the chemical constituents of Ligusticum sinense].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2011 Mar; 34(3):378-80. doi:
. [PMID: 21823452] - Mohammed Rabbani, Seyed Ebrahim Sajjadi, Masoud Sadeghi. Chemical composition of the essential oil from kelussia odoratissima Mozaff. and the evaluation of its sedative and anxiolytic effects in mice.
Clinics (Sao Paulo, Brazil).
2011; 66(5):843-8. doi:
10.1590/s1807-59322011000500022. [PMID: 21789390] - Jimei Li, Yin Li, Molly Ogle, Xin Zhou, Mingke Song, Minke Song, Shan Ping Yu, Ling Wei. DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway.
Brain research.
2010 Nov; 1359(?):216-26. doi:
10.1016/j.brainres.2010.08.061. [PMID: 20800583] - Mahesh Ramalingam, Park Yong-Ki. Free radical scavenging activities of Cnidium officinale Makino and Ligusticum chuanxiong Hort. methanolic extracts.
Pharmacognosy magazine.
2010 Oct; 6(24):323-30. doi:
10.4103/0973-1296.71794. [PMID: 21120037] - Yuping Tang, Min Zhu, Sheng Yu, Yongqing Hua, Jin-Ao Duan, Shulan Su, Xu Zhang, Yin Lu, Anwei Ding. Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong.
Molecules (Basel, Switzerland).
2010 Jan; 15(1):341-51. doi:
10.3390/molecules15010341. [PMID: 20110895] - Linlin Chen, Jin Qi, Yan-Xu Chang, Danni Zhu, Boyang Yu. Identification and determination of the major constituents in Traditional Chinese Medicinal formula Danggui-Shaoyao-San by HPLC-DAD-ESI-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2009 Sep; 50(2):127-37. doi:
10.1016/j.jpba.2009.03.039. [PMID: 19411155] - Zhi-Jun Wang, Siu-Kwan Wo, Ling Wang, Clara B S Lau, Vincent H L Lee, Moses S S Chow, Zhong Zuo. Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2009 Sep; 50(2):232-44. doi:
10.1016/j.jpba.2009.04.001. [PMID: 19423264] - Baijuan Yang, Junhui Chen, Frank Sen-Chun Lee, Xiaoru Wang. GC-MS fingerprints for discrimination of Ligusticum chuanxiong from Angelica.
Journal of separation science.
2008 Oct; 31(18):3231-7. doi:
10.1002/jssc.200800332. [PMID: 18773421] - Zhanqi Niu, Fengju Chen, Jin Sun, Xiaohong Liu, Yongjun Wang, Dawei Chen, Zhonggui He. High-performance liquid chromatography for the determination of 3-n-butylphthalide in rat plasma by tandem quadrupole mass spectrometry: application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Jul; 870(1):135-9. doi:
10.1016/j.jchromb.2008.05.044. [PMID: 18555754] - Ying Peng, Changhong Xing, Cynthia A Lemere, Guiquan Chen, Ling Wang, Yipu Feng, Xiaoliang Wang. l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells.
Neuroscience letters.
2008 Mar; 434(2):224-9. doi:
10.1016/j.neulet.2008.01.080. [PMID: 18328624] - Ying Peng, Shaofeng Xu, Guiquan Chen, Ling Wang, Yipu Feng, Xiaoliang Wang. l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats.
The Journal of pharmacology and experimental therapeutics.
2007 Jun; 321(3):902-10. doi:
10.1124/jpet.106.118760. [PMID: 17374747] - Yi Zhang, Ling Wang, Jiang Li, Xiao-Liang Wang. 2-(1-Hydroxypentyl)-benzoate increases cerebral blood flow and reduces infarct volume in rats model of transient focal cerebral ischemia.
The Journal of pharmacology and experimental therapeutics.
2006 Jun; 317(3):973-9. doi:
10.1124/jpet.105.098517. [PMID: 16527903] - Song-Lin Li, Ping Li, Liang-Hong Sheng, Rui-Yan Li, Lian-Wen Qi, Lu-Yong Zhang. Live cell extraction and HPLC-MS analysis for predicting bioactive components of traditional Chinese medicines.
Journal of pharmaceutical and biomedical analysis.
2006 May; 41(2):576-81. doi:
10.1016/j.jpba.2006.01.014. [PMID: 16488100] - Yoshiko Kurobayashi, Emi Kouno, Akira Fujita, Yasujiro Morimitsu, Kikue Kubota. Potent odorants characterize the aroma quality of leaves and stalks in raw and boiled celery.
Bioscience, biotechnology, and biochemistry.
2006 Apr; 70(4):958-65. doi:
10.1271/bbb.70.958. [PMID: 16636464]
