DIDS (BioDeep_00000008744)
代谢物信息卡片
Benzenesulfonic acid, 2,2-(1,2-ethenediyl)bis[5-isothiocyanato-
化学式: C16H10N2O6S4 (453.9422)
中文名称: 4,4′-二异硫氰酰-2,2′-基二磺酸二钠盐, 4,4'-二异硫氰基二苯乙烯-2,2'-二磺酸
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: C(=C\c1ccc(cc1S(=O)(=O)O)N=C=S)/c1ccc(cc1S(=O)(=O)O)N=C=S
InChI: InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:36511
- ChEBI: CHEBI:4286
- KEGG: C11591
- PubChem: 5281951
- PubChem: 40600
- Metlin: METLIN53233
- ChEMBL: CHEMBL1162148
- LipidMAPS: LMPK13090003
- MeSH: 4,4-Diisothiocyanostilbene-2,2-Disulfonic Acid
- CAS: 53005-05-3
- PMhub: MS000022427
- PubChem: 13756
- PDB-CCD: 4DS
- NIKKAJI: J228.028K
- RefMet: DIDS
- KNApSAcK: 4286
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Erica de Sousa, Marília Inês Móvio, Théo Henrique de Lima-Vasconcellos, Gabrieli Bovi Dos Santos, Talita Dos Santos Gomes, Lais Takata Walter, Daniela Almeida da Silva, Tiago Rodrigues, Giselle Cerchiaro, Alexandre Hiroaki Kihara. VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway.
Cell death & disease.
2022 04; 13(4):393. doi:
10.1038/s41419-022-04755-3. [PMID: 35449127] - Samer Al-Samir, Maximilian Prill, Claudiu T Supuran, Gerolf Gros, Volker Endeward. CO2 permeability of the rat erythrocyte membrane and its inhibition.
Journal of enzyme inhibition and medicinal chemistry.
2021 Dec; 36(1):1602-1606. doi:
10.1080/14756366.2021.1952194. [PMID: 34261373] - Yoshinori Tsuji, George Kusi-Appiah, Noriko Kozai, Yuri Fukuda, Takashi Yamano, Hideya Fukuzawa. Characterization of a CO2-Concentrating Mechanism with Low Sodium Dependency in the Centric Diatom Chaetoceros gracilis.
Marine biotechnology (New York, N.Y.).
2021 Jun; 23(3):456-462. doi:
10.1007/s10126-021-10037-4. [PMID: 34109463] - Julia Yago-Ibáñez, Coral García-Pastor, Francisco J Lucio-Cazaña, Ana B Fernández-Martínez. Retinoic acid receptor-beta prevents cisplatin-induced proximal tubular cell death.
Biochimica et biophysica acta. Molecular basis of disease.
2020 07; 1866(7):165795. doi:
10.1016/j.bbadis.2020.165795. [PMID: 32278009] - Kiran George, Nisha Susan Thomas, Raman Malathi. 4,4'-Diisothiocyanatostilbene-2,2'-disulfonate modulates voltage-gated K+ current and influences cell cycle arrest in androgen sensitive and insensitive human prostate cancer cell lines.
Toxicology mechanisms and methods.
2020 Jun; 30(5):358-369. doi:
10.1080/15376516.2020.1745343. [PMID: 32193973] - M J Murray, N I Bonilla-Medrano, Q L Lee, S J Oxenford, R Angell, D P Depledge, M B Reeves. Evasion of a Human Cytomegalovirus Entry Inhibitor with Potent Cysteine Reactivity Is Concomitant with the Utilization of a Heparan Sulfate Proteoglycan-Independent Route of Entry.
Journal of virology.
2020 03; 94(7):. doi:
10.1128/jvi.02012-19. [PMID: 31941787] - Denis Velic, Cathy Charlier, Milena Popova, Titouan Jaunet-Lahary, Zakaria Bouchouireb, Sébastien Henry, Pierre Weigel, Jean-Yves Masson, Adèle Laurent, Igor Nabiev, Fabrice Fleury. Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches.
Biochimie.
2019 Dec; 167(?):187-197. doi:
10.1016/j.biochi.2019.09.016. [PMID: 31562898] - Hiromi Koma, Yasuhiro Yamamoto, Hiroaki Kumagai, Tatsurou Yagami. 4,4-Diisothiocyanatostilbene Disulfonic Acid Enhanced 15-Deoxy-Δ12,14-prostaglandin J2-Induced Neuronal Apoptosis.
Biological & pharmaceutical bulletin.
2019; 42(11):1913-1920. doi:
10.1248/bpb.b19-00536. [PMID: 31685774] - Michael E Steinmann, Remo S Schmidt, Juan P Macêdo, Christina Kunz Renggli, Peter Bütikofer, Doris Rentsch, Pascal Mäser, Erwin Sigel. Identification and characterization of the three members of the CLC family of anion transport proteins in Trypanosoma brucei.
PloS one.
2017; 12(12):e0188219. doi:
10.1371/journal.pone.0188219. [PMID: 29244877] - Makoto Kurano, Masako Nishikawa, Hiroyuki Kuma, Masahiro Jona, Yutaka Yatomi. Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes.
PloS one.
2017; 12(5):e0177543. doi:
10.1371/journal.pone.0177543. [PMID: 28494002] - Rainer Schreiber, Karl Kunzelmann. Expression of anoctamins in retinal pigment epithelium (RPE).
Pflugers Archiv : European journal of physiology.
2016 11; 468(11-12):1921-1929. doi:
10.1007/s00424-016-1898-2. [PMID: 27822608] - Katie Giger, Ibrahim Habib, Ken Ritchie, Philip S Low. Diffusion of glycophorin A in human erythrocytes.
Biochimica et biophysica acta.
2016 11; 1858(11):2839-2845. doi:
10.1016/j.bbamem.2016.08.012. [PMID: 27580023] - Xian-Chen Zhang, Hong-Jian Gao, Tian-Yuan Yang, Hong-Hong Wu, Yu-Mei Wang, Xiao-Chun Wan. Al(3+) -promoted fluoride accumulation in tea plants (Camellia sinensis) was inhibited by an anion channel inhibitor DIDS.
Journal of the science of food and agriculture.
2016 Sep; 96(12):4224-30. doi:
10.1002/jsfa.7626. [PMID: 26777729] - Reinhart A F Reithmeier, Joseph R Casey, Antreas C Kalli, Mark S P Sansom, Yilmaz Alguel, So Iwata. Band 3, the human red cell chloride/bicarbonate anion exchanger (AE1, SLC4A1), in a structural context.
Biochimica et biophysica acta.
2016 Jul; 1858(7 Pt A):1507-32. doi:
10.1016/j.bbamem.2016.03.030. [PMID: 27058983] - Miyuki Kuno, Guangshuai Li, Yoshie Moriura, Yoshiko Hino, Junko Kawawaki, Hiromu Sakai. Acid-inducible proton influx currents in the plasma membrane of murine osteoclast-like cells.
Pflugers Archiv : European journal of physiology.
2016 05; 468(5):837-47. doi:
10.1007/s00424-016-1796-7. [PMID: 26843093] - Emanuele Bernardinelli, Roberta Costa, Charity Nofziger, Markus Paulmichl, Silvia Dossena. Effect of Known Inhibitors of Ion Transport on Pendrin (SLC26A4) Activity in a Human Kidney Cell Line.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 38(5):1984-98. doi:
10.1159/000445559. [PMID: 27161422] - Masayoshi Nanami, Yoskaly Lazo-Fernandez, Vladimir Pech, Jill W Verlander, Diana Agazatian, Alan M Weinstein, Hui-Fang Bao, Douglas C Eaton, Susan M Wall. ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct. I. Stilbene-sensitive Cl- secretion.
American journal of physiology. Renal physiology.
2015 Aug; 309(3):F251-8. doi:
10.1152/ajprenal.00471.2013. [PMID: 25925258] - Zhifei Shao, Rohit Gaurav, Devendra K Agrawal. Intermediate-conductance calcium-activated potassium channel KCa3.1 and chloride channel modulate chemokine ligand (CCL19/CCL21)-induced migration of dendritic cells.
Translational research : the journal of laboratory and clinical medicine.
2015 Jul; 166(1):89-102. doi:
10.1016/j.trsl.2014.11.010. [PMID: 25583444] - Tiziana Vigliarolo, Lucrezia Guida, Enrico Millo, Chiara Fresia, Emilia Turco, Antonio De Flora, Elena Zocchi. Abscisic acid transport in human erythrocytes.
The Journal of biological chemistry.
2015 May; 290(21):13042-52. doi:
10.1074/jbc.m114.629501. [PMID: 25847240] - Zbigniew Burdach, Renata Kurtyka, Agnieszka Siemieniuk, Waldemar Karcz. Role of chloride ions in the promotion of auxin-induced growth of maize coleoptile segments.
Annals of botany.
2014 Oct; 114(5):1023-34. doi:
10.1093/aob/mcu170. [PMID: 25129632] - Xiqian Lan, Aakash Jhaveri, Kang Cheng, Hongxiu Wen, Moin A Saleem, Peter W Mathieson, Joanna Mikulak, Sharon Aviram, Ashwani Malhotra, Karl Skorecki, Pravin C Singhal. APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability.
American journal of physiology. Renal physiology.
2014 Aug; 307(3):F326-36. doi:
10.1152/ajprenal.00647.2013. [PMID: 24899058] - S B Liao, K H Cheung, M P L Cheung, P F Wong, W S O, F Tang. Adrenomedullin increases the short-circuit current in the rat prostate: Receptors, chloride channels, the effects of cAMP and calcium ions and implications on fluid secretion.
Andrology.
2014 May; 2(3):474-80. doi:
10.1111/j.2047-2927.2014.00189.x. [PMID: 24711244] - Takayuki Suzuki, Jun Suzuki, Shigekazu Nagata. Functional swapping between transmembrane proteins TMEM16A and TMEM16F.
The Journal of biological chemistry.
2014 Mar; 289(11):7438-47. doi:
10.1074/jbc.m113.542324. [PMID: 24478309] - Min-hua Zhang, Xiao-dong Zhuang, Jing-ning Weng. [The effects of chloride channel inhibitor on bFGF-induced proliferation of lens epithelial cells].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology.
2013 Nov; 49(11):1014-9. doi:
NULL. [PMID: 24513004] - Violetta Siyanov, Jay M Baltz. NHE1 is the sodium-hydrogen exchanger active in acute intracellular pH regulation in preimplantation mouse embryos.
Biology of reproduction.
2013 Jun; 88(6):157. doi:
10.1095/biolreprod.113.109033. [PMID: 23677982] - Seong-Ki Lee, Walter F Boron, Mark D Parker. Substrate specificity of the electrogenic sodium/bicarbonate cotransporter NBCe1-A (SLC4A4, variant A) from humans and rabbits.
American journal of physiology. Renal physiology.
2013 Apr; 304(7):F883-99. doi:
10.1152/ajprenal.00612.2012. [PMID: 23324180] - Kensuke Nakajima, Atsuko Tanaka, Yusuke Matsuda. SLC4 family transporters in a marine diatom directly pump bicarbonate from seawater.
Proceedings of the National Academy of Sciences of the United States of America.
2013 Jan; 110(5):1767-72. doi:
10.1073/pnas.1216234110. [PMID: 23297242] - Matthew E Pamenter, Guy A Perkins, Xiang Q Gu, Mark H Ellisman, Gabriel G Haddad. DIDS (4,4-diisothiocyanatostilbenedisulphonic acid) induces apoptotic cell death in a hippocampal neuronal cell line and is not neuroprotective against ischemic stress.
PloS one.
2013; 8(4):e60804. doi:
10.1371/journal.pone.0060804. [PMID: 23577164] - Chiara Rigato, Nina Swinnen, Roeland Buckinx, Isabelle Couillin, Jean-Marie Mangin, Jean-Michel Rigo, Pascal Legendre, Hervé Le Corronc. Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Aug; 32(34):11559-73. doi:
10.1523/jneurosci.1042-12.2012. [PMID: 22915101] - M Ashrafpour, J Fahanik Babaei, R Saghiri, H Sepehri, H Sharifi. Modulation of the hepatocyte rough endoplasmic reticulum single chloride channel by nucleotide-Mg2+ interaction.
Pflugers Archiv : European journal of physiology.
2012 Aug; 464(2):175-82. doi:
10.1007/s00424-012-1121-z. [PMID: 22684478] - Michael Lu, Chuanqing Ding. CFTR-mediated Cl(-) transport in the acinar and duct cells of rabbit lacrimal gland.
Current eye research.
2012 Aug; 37(8):671-7. doi:
10.3109/02713683.2012.675613. [PMID: 22578307] - Xuan Zhang, Xiao-Na Du, Guo-Hong Zhang, Zhan-Feng Jia, Xing-Juan Chen, Dong-Yang Huang, Bo-Yi Liu, Hai-Lin Zhang. Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives.
Molecular pharmacology.
2012 May; 81(5):689-700. doi:
10.1124/mol.111.076000. [PMID: 22328719] - Dongmei Di, Zongchun Wang, Yang Liu, Guanghua Luo, Yuanping Shi, Maria Berggren-Söderlund, Peter Nilsson-Ehle, Xiaoying Zhang, Ning Xu. ABCA1 upregulating apolipoproein M expression mediates via the RXR/LXR pathway in HepG2 cells.
Biochemical and biophysical research communications.
2012 Apr; 421(1):152-6. doi:
10.1016/j.bbrc.2012.04.022. [PMID: 22516753] - Min-Hwang Chang, Consuelo Plata, Yukihiro Kurita, Akira Kato, Shigehisa Hirose, Michael F Romero. Euryhaline pufferfish NBCe1 differs from nonmarine species NBCe1 physiology.
American journal of physiology. Cell physiology.
2012 Apr; 302(8):C1083-95. doi:
10.1152/ajpcell.00233.2011. [PMID: 22159080] - A H Henkin, A M Ortegon, S Cho, W-J Shen, A Falcon, F B Kraemer, S-J Lee, A Stahl. Evidence for protein-mediated fatty acid efflux by adipocytes.
Acta physiologica (Oxford, England).
2012 Apr; 204(4):562-70. doi:
10.1111/j.1748-1716.2011.02367.x. [PMID: 21951599] - Li-Ming Chen, Xue Qin, Fraser J Moss, Ying Liu, Walter F Boron. Effect of simultaneously replacing putative TM6 and TM12 of human NBCe1-A with those from NBCn1 on surface abundance in Xenopus oocytes.
The Journal of membrane biology.
2012 Mar; 245(3):131-40. doi:
10.1007/s00232-012-9421-y. [PMID: 22383045] - Bing Shen, Xiang Li, Fei Wang, Xiaoqiang Yao, Dan Yang. A synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells.
PloS one.
2012; 7(4):e34694. doi:
10.1371/journal.pone.0034694. [PMID: 22514656] - Jinseok Heo, Frederick Sachs, Jianbin Wang, Susan Z Hua. Shear-induced volume decrease in MDCK cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2012; 30(2):395-406. doi:
10.1159/000339033. [PMID: 22759987] - Matthew E Pamenter, Julie Ryu, Serena T Hua, Guy A Perkins, Vincent L Mendiola, Xiang Q Gu, Mark H Ellisman, Gabriel G Haddad. DIDS prevents ischemic membrane degradation in cultured hippocampal neurons by inhibiting matrix metalloproteinase release.
PloS one.
2012; 7(8):e43995. doi:
10.1371/journal.pone.0043995. [PMID: 22937143] - Bridget L Morse, Melanie A Felmlee, Marilyn E Morris. γ-Hydroxybutyrate blood/plasma partitioning: effect of physiologic pH on transport by monocarboxylate transporters.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jan; 40(1):64-9. doi:
10.1124/dmd.111.041285. [PMID: 21976619] - Chien-Yu Chen, Song-Kun Shyue, Li-Chieh Ching, Kuo-Hui Su, Yu-Lin Wu, Yu Ru Kou, An-Na Chiang, Ching-Chian Pan, Tzong-Shyuan Lee. Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages.
The Journal of nutritional biochemistry.
2011 Nov; 22(11):1015-21. doi:
10.1016/j.jnutbio.2010.08.014. [PMID: 21190831] - Patthara Kongsuphol, Rainer Schreiber, Kamonshanok Kraidith, Karl Kunzelmann. CFTR induces extracellular acid sensing in Xenopus oocytes which activates endogenous Ca²⁺-activated Cl⁻ conductance.
Pflugers Archiv : European journal of physiology.
2011 Sep; 462(3):479-87. doi:
10.1007/s00424-011-0983-9. [PMID: 21647592] - Luigi Catacuzzeno, Francesco Aiello, Bernard Fioretti, Luigi Sforna, Emilia Castigli, Paola Ruggieri, Ada Maria Tata, Antonella Calogero, Fabio Franciolini. Serum-activated K and Cl currents underlay U87-MG glioblastoma cell migration.
Journal of cellular physiology.
2011 Jul; 226(7):1926-33. doi:
10.1002/jcp.22523. [PMID: 21506123] - K Suffrian, K G Schulz, M A Gutowska, U Riebesell, M Bleich. Cellular pH measurements in Emiliania huxleyi reveal pronounced membrane proton permeability.
The New phytologist.
2011 May; 190(3):595-608. doi:
10.1111/j.1469-8137.2010.03633.x. [PMID: 21294736] - Jörg D Schulzke, Susanne Andres, Maren Amasheh, Anja Fromm, Dorothee Günzel. Anti-diarrheal mechanism of the traditional remedy Uzara via reduction of active chloride secretion.
PloS one.
2011 Mar; 6(3):e18107. doi:
10.1371/journal.pone.0018107. [PMID: 21479205] - Karolina Matkovic, Izabela Koszela-Piotrowska, Wieslawa Jarmuszkiewicz, Adam Szewczyk. Ion conductance pathways in potato tuber (Solanum tuberosum) inner mitochondrial membrane.
Biochimica et biophysica acta.
2011 Mar; 1807(3):275-85. doi:
10.1016/j.bbabio.2010.12.001. [PMID: 21167126] - Carolina D Duarte, Ruth Greferath, Claude Nicolau, Jean-Marie Lehn. myo-Inositol trispyrophosphate: a novel allosteric effector of hemoglobin with high permeation selectivity across the red blood cell plasma membrane.
Chembiochem : a European journal of chemical biology.
2010 Dec; 11(18):2543-8. doi:
10.1002/cbic.201000499. [PMID: 21086482] - Rashmi P Rao, J Prakasa Rao. Evidence for functional interaction of plasma membrane electron transport, voltage-dependent anion channel and volume-regulated anion channel in frog aorta.
Journal of biosciences.
2010 Dec; 35(4):519-24. doi:
10.1007/s12038-010-0059-6. [PMID: 21289433] - M B da Silva, V M A Costa, V R A Pereira, G J B de Albertim, E B B de Melo, D P Bezerra, R P da Silva, C G Rodrigues, C M M Carneiro, L N Yuldasheva, O V Krasilnikov. Ion channels in volume regulation of clonal kidney cells.
Cell proliferation.
2010 Dec; 43(6):529-41. doi:
10.1111/j.1365-2184.2010.00702.x. [PMID: 21039991] - Claudia Sagheddu, Anna Boccaccio, Michele Dibattista, Giorgia Montani, Roberto Tirindelli, Anna Menini. Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells.
The Journal of physiology.
2010 Nov; 588(Pt 21):4189-204. doi:
10.1113/jphysiol.2010.194407. [PMID: 20837642] - Soojung Lee, Hye Jeong Lee, Han Soo Yang, Ian M Thornell, Mark O Bevensee, Inyeong Choi. Sodium-bicarbonate cotransporter NBCn1 in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport.
Experimental physiology.
2010 Sep; 95(9):926-37. doi:
10.1113/expphysiol.2010.053967. [PMID: 20591978] - Roselani I Henry, Simon A Cobbold, Richard J W Allen, Asif Khan, Rhys Hayward, Adele M Lehane, Patrick G Bray, Susan M Howitt, Giancarlo A Biagini, Kevin J Saliba, Kiaran Kirk. An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum.
The Journal of biological chemistry.
2010 Jun; 285(24):18615-26. doi:
10.1074/jbc.m110.120980. [PMID: 20332090] - Lina Wang, Guanghong Ding, Quanbao Gu, Wolfgang Schwarz. Single-channel properties of a stretch-sensitive chloride channel in the human mast cell line HMC-1.
European biophysics journal : EBJ.
2010 Apr; 39(5):757-67. doi:
10.1007/s00249-009-0542-x. [PMID: 19823818] - Gloria Celedón, Gustavo González, Eduardo Lissi, Tania Cerda, Diana Martinez, Carmen Soto, Mario Pupo, Fabiola Pazos, Maria E Lanio, Carlos Alvarez. Effect of calcium on the hemolytic activity of Stichodactyla helianthus toxin sticholysin II on human erythrocytes.
Toxicon : official journal of the International Society on Toxinology.
2009 Nov; 54(6):845-50. doi:
10.1016/j.toxicon.2009.06.017. [PMID: 19559039] - Long Xu, Ting-Lou, Nonghua Lv, Xuan Zhu, Youxiang Chen, Jing Yang. Emodin augments calcium activated chloride channel in colonic smooth muscle cells by Gi/Go protein.
European journal of pharmacology.
2009 Aug; 615(1-3):171-6. doi:
10.1016/j.ejphar.2009.04.045. [PMID: 19409890] - Marieangela C Wilson, David Meredith, Chotirote Bunnun, Richard B Sessions, Andrew P Halestrap. Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle.
The Journal of biological chemistry.
2009 Jul; 284(30):20011-21. doi:
10.1074/jbc.m109.014217. [PMID: 19473976] - A K Stewart, A Yamamoto, M Nakakuki, T Kondo, S L Alper, H Ishiguro. Functional coupling of apical Cl-/HCO3- exchange with CFTR in stimulated HCO3- secretion by guinea pig interlobular pancreatic duct.
American journal of physiology. Gastrointestinal and liver physiology.
2009 Jun; 296(6):G1307-17. doi:
10.1152/ajpgi.90697.2008. [PMID: 19342507] - Wei Zhao, Feng Zhu, Weiwei Shen, Aifen Fu, Lin Zheng, Zhaowen Yan, Lingzi Zhao, Guohui Fu. Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats.
Acta biochimica et biophysica Sinica.
2009 Apr; 41(4):301-8. doi:
10.1093/abbs/gmp014. [PMID: 19352545] - Weihong Ma, Hui Hui, Pablo Pelegrin, Annmarie Surprenant. Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.
The Journal of pharmacology and experimental therapeutics.
2009 Feb; 328(2):409-18. doi:
10.1124/jpet.108.146365. [PMID: 19023039] - Jing Wang, Zhi-Ren Zhang, Chu-Fang Chou, You-You Liang, Yuchun Gu, He-Ping Ma. Cyclosporine stimulates the renal epithelial sodium channel by elevating cholesterol.
American journal of physiology. Renal physiology.
2009 Feb; 296(2):F284-90. doi:
10.1152/ajprenal.90647.2008. [PMID: 19091785] - Jesús M Banales, Tatyana V Masyuk, Pamela S Bogert, Bing Q Huang, Sergio A Gradilone, Seung-Ok Lee, Angela J Stroope, Anatoliy I Masyuk, Juan F Medina, Nicholas F LaRusso. Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease.
The American journal of pathology.
2008 Dec; 173(6):1637-46. doi:
10.2353/ajpath.2008.080125. [PMID: 18988797] - Sergio Polakof, José L Soengas. Differential effects of in vivo and in vitro lactate treatments on liver carbohydrate metabolism of rainbow trout.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2008 Oct; 151(2):205-10. doi:
10.1016/j.cbpa.2008.06.025. [PMID: 18640283] - N Tajeddine, L Galluzzi, O Kepp, E Hangen, E Morselli, L Senovilla, N Araujo, G Pinna, N Larochette, N Zamzami, N Modjtahedi, A Harel-Bellan, G Kroemer. Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death.
Oncogene.
2008 Jul; 27(30):4221-32. doi:
10.1038/onc.2008.63. [PMID: 18362892] - Dhana Raj Boina, Edwin E Lewis, Jeffrey R Bloomquist. Nematicidal activity of anion transport blockers against Meloidogyne incognita, Caenorhabditis elegans and Heterorhabditis bacteriophora.
Pest management science.
2008 Jun; 64(6):646-53. doi:
10.1002/ps.1591. [PMID: 18407564] - Roland Reinehr, Annika Sommerfeld, Verena Keitel, Susanne Grether-Beck, Dieter Haüssinger. Amplification of CD95 activation by caspase 8-induced endosomal acidification in rat hepatocytes.
The Journal of biological chemistry.
2008 Jan; 283(4):2211-22. doi:
10.1074/jbc.m706853200. [PMID: 18045865] - Lubica Malekova, Jana Tomaskova, Marie Novakova, Peter Stefanik, Juraj Kopacek, Boris Lakatos, Silvia Pastorekova, Olga Krizanova, Albert Breier, Karol Ondrias. Inhibitory effect of DIDS, NPPB, and phloretin on intracellular chloride channels.
Pflugers Archiv : European journal of physiology.
2007 Nov; 455(2):349-57. doi:
10.1007/s00424-007-0300-9. [PMID: 17611769] - Yasuhiro Nakai, Katsuhisa Inoue, Naoki Abe, Mai Hatakeyama, Kin-ya Ohta, Masaki Otagiri, Yayoi Hayashi, Hiroaki Yuasa. Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.
The Journal of pharmacology and experimental therapeutics.
2007 Aug; 322(2):469-76. doi:
10.1124/jpet.107.122606. [PMID: 17475902] - Zuzana Tomaskova, Jana Gaburjakova, Anna Brezova, Marta Gaburjakova. Inhibition of anion channels derived from mitochondrial membranes of the rat heart by stilbene disulfonate--DIDS.
Journal of bioenergetics and biomembranes.
2007 Aug; 39(4):301-11. doi:
10.1007/s10863-007-9090-1. [PMID: 17899339] - Hui Zhang, Nadia Ameen, James E Melvin, Sadasivan Vidyasagar. Acute inflammation alters bicarbonate transport in mouse ileum.
The Journal of physiology.
2007 Jun; 581(Pt 3):1221-33. doi:
10.1113/jphysiol.2007.129262. [PMID: 17395634] - I T Ivanov, A Tolekova, P Chakaarova. Erythrocyte membrane defects in hemolytic anemias found through derivative thermal analysis of electric impedance.
Journal of biochemical and biophysical methods.
2007 Jun; 70(4):641-8. doi:
10.1016/j.jbbm.2007.02.004. [PMID: 17395266] - Christian Barmeyer, Jeff Huaqing Ye, Shafik Sidani, John Geibel, Henry J Binder, Vazhaikkurichi M Rajendran. Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells.
Pflugers Archiv : European journal of physiology.
2007 Jun; 454(3):441-50. doi:
10.1007/s00424-007-0213-7. [PMID: 17492310] - Katja Berginc, Simon Zakelj, Lea Levstik, Darko Ursic, Albin Kristl. Fluorescein transport properties across artificial lipid membranes, Caco-2 cell monolayers and rat jejunum.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2007 May; 66(2):281-5. doi:
10.1016/j.ejpb.2006.10.023. [PMID: 17129714] - Rui Pedrosa, Nuno Gonçalves, Ulrich Hopfer, Pedro A Jose, Patrício Soares-da-Silva. Activity and regulation of Na+-HCO3- cotransporter in immortalized spontaneously hypertensive rat and Wistar-Kyoto rat proximal tubular epithelial cells.
Hypertension (Dallas, Tex. : 1979).
2007 May; 49(5):1186-93. doi:
10.1161/hypertensionaha.106.083444. [PMID: 17325238] - Akira Takahashi, Shin-ichi Miyoshi, Noriko Takata, Masayuki Nakano, Akiko Hamamoto, Kazuaki Mawatari, Nagakatsu Harada, Sumio Shinoda, Yutaka Nakaya. Haemolysin produced by Vibrio mimicus activates two Cl- secretory pathways in cultured intestinal-like Caco-2 cells.
Cellular microbiology.
2007 Mar; 9(3):583-95. doi:
10.1111/j.1462-5822.2006.00809.x. [PMID: 17026482] - Lauren Johnston, Gary Laverty. Vitamin C transport and SVCT1 transporter expression in chick renal proximal tubule cells in culture.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2007 Mar; 146(3):327-34. doi:
10.1016/j.cbpa.2006.11.025. [PMID: 17258485] - Manish M Tiwari, Joseph R Stimers, Philip R Mayeux. Bradykinin-induced chloride conductance in murine proximal tubule epithelial cells.
Molecular and cellular biochemistry.
2007 Mar; 297(1-2):1-8. doi:
10.1007/s11010-006-9315-3. [PMID: 17003950] - S L'Hoste, H Barriere, R Belfodil, I Rubera, C Duranton, M Tauc, C Poujeol, J Barhanin, P Poujeol. Extracellular pH alkalinization by Cl-/HCO3- exchanger is crucial for TASK2 activation by hypotonic shock in proximal cell lines from mouse kidney.
American journal of physiology. Renal physiology.
2007 Feb; 292(2):F628-38. doi:
10.1152/ajprenal.00132.2006. [PMID: 17003225] - Izabela Koszela-Piotrowska, Katarzyna Choma, Piotr Bednarczyk, Krzysztof Dołowy, Adam Szewczyk, Wolfram S Kunz, Lubica Malekova, Viera Kominkova, Karol Ondrias. Stilbene derivatives inhibit the activity of the inner mitochondrial membrane chloride channels.
Cellular & molecular biology letters.
2007; 12(4):493-508. doi:
10.2478/s11658-007-0019-9. [PMID: 17457523] - Julia E Raftos, Stephney Whillier, Bogdan E Chapman, Philip W Kuchel. Kinetics of uptake and deacetylation of N-acetylcysteine by human erythrocytes.
The international journal of biochemistry & cell biology.
2007; 39(9):1698-706. doi:
10.1016/j.biocel.2007.04.014. [PMID: 17544838] - Valentina Benfenati, Grazia Paola Nicchia, Maria Svelto, Carmela Rapisarda, Antonio Frigeri, Stefano Ferroni. Functional down-regulation of volume-regulated anion channels in AQP4 knockdown cultured rat cortical astrocytes.
Journal of neurochemistry.
2007 Jan; 100(1):87-104. doi:
10.1111/j.1471-4159.2006.04164.x. [PMID: 17064359] - L Bernucci, M Henríquez, P Díaz, G Riquelme. Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane.
Placenta.
2006 Nov; 27(11-12):1082-95. doi:
10.1016/j.placenta.2005.12.007. [PMID: 16564089] - In-Ra Seo, Sang Hyun Moh, Eun Hui Lee, Gerhard Meissner, Do Han Kim. Aldolase potentiates DIDS activation of the ryanodine receptor in rabbit skeletal sarcoplasmic reticulum.
The Biochemical journal.
2006 Oct; 399(2):325-33. doi:
10.1042/bj20060701. [PMID: 16817780] - Ashley M Toye, Mark D Parker, Christopher M Daly, Jing Lu, Leila V Virkki, Marc F Pelletier, Walter F Boron. The human NBCe1-A mutant R881C, associated with proximal renal tubular acidosis, retains function but is mistargeted in polarized renal epithelia.
American journal of physiology. Cell physiology.
2006 Oct; 291(4):C788-801. doi:
10.1152/ajpcell.00094.2006. [PMID: 16707554] - Alexander C Whitley, Douglas H Sweet, Thomas Walle. Site-specific accumulation of the cancer preventive dietary polyphenol ellagic acid in epithelial cells of the aerodigestive tract.
The Journal of pharmacy and pharmacology.
2006 Sep; 58(9):1201-9. doi:
10.1211/jpp.58.9.0006. [PMID: 16945178] - Xiao-Yan Pan, Guo-Qiang Chen, Li Cai, Stephen Buscemi, Guo-Hui Fu. Anion exchanger 2 mediates the action of arsenic trioxide.
British journal of haematology.
2006 Sep; 134(5):491-9. doi:
10.1111/j.1365-2141.2006.06224.x. [PMID: 17018029] - N Lambot, P Lybaert, A Boom, J Delogne-Desnoeck, A M Vanbellinghen, G Graff, P Lebrun, S Meuris. Evidence for a clathrin-mediated recycling of albumin in human term placenta.
Biology of reproduction.
2006 Jul; 75(1):90-7. doi:
10.1095/biolreprod.105.050021. [PMID: 16495477] - Felix Knauf, Nilufar Mohebbi, Carsten Teichert, Diana Herold, Blanka Rogina, Stephen Helfand, Maik Gollasch, Friedrich C Luft, Peter S Aronson. The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates.
The Biochemical journal.
2006 Jul; 397(1):25-9. doi:
10.1042/bj20060409. [PMID: 16608441] - Rossella Elisei, Agnese Vivaldi, Raffaele Ciampi, Pinuccia Faviana, Fulvio Basolo, Ferruccio Santini, Claudio Traino, Furio Pacini, Aldo Pinchera. Treatment with drugs able to reduce iodine efflux significantly increases the intracellular retention time in thyroid cancer cells stably transfected with sodium iodide symporter complementary deoxyribonucleic acid.
The Journal of clinical endocrinology and metabolism.
2006 Jun; 91(6):2389-95. doi:
10.1210/jc.2005-2480. [PMID: 16537683] - Fukashi Ishibashi. Chronic high glucose inhibits albumin reabsorption by lysosomal alkalinization in cultured porcine proximal tubular epithelial cells (LLC-PK1).
Diabetes research and clinical practice.
2006 Jun; 72(3):223-30. doi:
10.1016/j.diabres.2005.10.019. [PMID: 16313995] - Weifeng Song, Siriporn C Chattipakorn, Lori L McMahon. Glycine-gated chloride channels depress synaptic transmission in rat hippocampus.
Journal of neurophysiology.
2006 Apr; 95(4):2366-79. doi:
10.1152/jn.00386.2005. [PMID: 16381810] - Roger J Thompson, Hillary C S R Akana, Claire Finnigan, Kathryn E Howell, John H Caldwell. Anion channels transport ATP into the Golgi lumen.
American journal of physiology. Cell physiology.
2006 Feb; 290(2):C499-514. doi:
10.1152/ajpcell.00585.2004. [PMID: 16403948] - Yvonne Neye, Martina Düfer, Gisela Drews, Peter Krippeit-Drews. HIV protease inhibitors: suppression of insulin secretion by inhibition of voltage-dependent K+ currents and anion currents.
The Journal of pharmacology and experimental therapeutics.
2006 Jan; 316(1):106-12. doi:
10.1124/jpet.105.090589. [PMID: 16162820] - M Pusch, G Zifarelli, A R Murgia, A Picollo, E Babini. Channel or transporter? The CLC saga continues.
Experimental physiology.
2006 Jan; 91(1):149-52. doi:
10.1113/expphysiol.2005.031799. [PMID: 16179405] - Astrid Stumpf, Joana Almaca, Karl Kunzelmann, Kerstin Wenners-Epping, Stephan M Huber, Johannes Haberle, Sabine Falk, Angelika Duebbers, Mike Walte, Hans Oberleithner, Hermann Schillers. IADS, a decomposition product of DIDS activates a cation conductance in Xenopus oocytes and human erythrocytes: new compound for the diagnosis of cystic fibrosis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2006; 18(4-5):243-52. doi:
10.1159/000097671. [PMID: 17167229] - Takashi Araki, Matsuhiko Hayashi, Takao Saruta. Anion-exchange blocker enhances cytoplasmic vacuole formation and cell death in serum-deprived mouse kidney epithelial cells in mice.
Cell biology international.
2006 Jan; 30(1):93-100. doi:
10.1016/j.cellbi.2005.10.020. [PMID: 16376114] - Min Xia, Mengjun Hou, Huilian Zhu, Jing Ma, Zhihong Tang, Qing Wang, Yan Li, Dongsheng Chi, Xiaoping Yu, Ting Zhao, Pinghua Han, Xiaodong Xia, Wenhua Ling. Anthocyanins induce cholesterol efflux from mouse peritoneal macrophages: the role of the peroxisome proliferator-activated receptor {gamma}-liver X receptor {alpha}-ABCA1 pathway.
The Journal of biological chemistry.
2005 Nov; 280(44):36792-801. doi:
10.1074/jbc.m505047200. [PMID: 16107338] - Kimberly Matulef, Merritt Maduke. Side-dependent inhibition of a prokaryotic ClC by DIDS.
Biophysical journal.
2005 Sep; 89(3):1721-30. doi:
10.1529/biophysj.105.066522. [PMID: 15994902] - Sachar Lambert, Johannes Oberwinkler. Characterization of a proton-activated, outwardly rectifying anion channel.
The Journal of physiology.
2005 Aug; 567(Pt 1):191-213. doi:
10.1113/jphysiol.2005.089888. [PMID: 15961423] - David Pérez-Morga, Benoit Vanhollebeke, Françoise Paturiaux-Hanocq, Derek P Nolan, Laurence Lins, Fabrice Homblé, Luc Vanhamme, Patricia Tebabi, Annette Pays, Philippe Poelvoorde, Alain Jacquet, Robert Brasseur, Etienne Pays. Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes.
Science (New York, N.Y.).
2005 Jul; 309(5733):469-72. doi:
10.1126/science.1114566. [PMID: 16020735]
