DIDS (BioDeep_00000008744)
代谢物信息卡片
Benzenesulfonic acid, 2,2-(1,2-ethenediyl)bis[5-isothiocyanato-
化学式: C16H10N2O6S4 (453.942172)
中文名称: 4,4′-二异硫氰酰-2,2′-基二磺酸二钠盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(=C\c1ccc(cc1S(=O)(=O)O)N=C=S)/c1ccc(cc1S(=O)(=O)O)N=C=S
InChI: InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:36511
- ChEBI: CHEBI:4286
- KEGG: C11591
- PubChem: 5281951
- PubChem: 40600
- Metlin: METLIN53233
- ChEMBL: CHEMBL1162148
- LipidMAPS: LMPK13090003
- MeSH: 4,4-Diisothiocyanostilbene-2,2-Disulfonic Acid
- CAS: 53005-05-3
- PMhub: MS000022427
- PubChem: 13756
- PDB-CCD: 4DS
- NIKKAJI: J228.028K
- RefMet: DIDS
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Erica de Sousa, Marília Inês Móvio, Théo Henrique de Lima-Vasconcellos, Gabrieli Bovi Dos Santos, Talita Dos Santos Gomes, Lais Takata Walter, Daniela Almeida da Silva, Tiago Rodrigues, Giselle Cerchiaro, Alexandre Hiroaki Kihara. VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway.
Cell death & disease.
2022 04; 13(4):393. doi:
10.1038/s41419-022-04755-3. [PMID: 35449127] - Samer Al-Samir, Maximilian Prill, Claudiu T Supuran, Gerolf Gros, Volker Endeward. CO2 permeability of the rat erythrocyte membrane and its inhibition.
Journal of enzyme inhibition and medicinal chemistry.
2021 Dec; 36(1):1602-1606. doi:
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Marine biotechnology (New York, N.Y.).
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2020 07; 1866(7):165795. doi:
10.1016/j.bbadis.2020.165795. [PMID: 32278009] - Kiran George, Nisha Susan Thomas, Raman Malathi. 4,4'-Diisothiocyanatostilbene-2,2'-disulfonate modulates voltage-gated K+ current and influences cell cycle arrest in androgen sensitive and insensitive human prostate cancer cell lines.
Toxicology mechanisms and methods.
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2013 Jan; 110(5):1767-72. doi:
10.1073/pnas.1216234110. [PMID: 23297242] - Matthew E Pamenter, Guy A Perkins, Xiang Q Gu, Mark H Ellisman, Gabriel G Haddad. DIDS (4,4-diisothiocyanatostilbenedisulphonic acid) induces apoptotic cell death in a hippocampal neuronal cell line and is not neuroprotective against ischemic stress.
PloS one.
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2012; 7(4):e34694. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2012; 30(2):395-406. doi:
10.1159/000339033. [PMID: 22759987] - Matthew E Pamenter, Julie Ryu, Serena T Hua, Guy A Perkins, Vincent L Mendiola, Xiang Q Gu, Mark H Ellisman, Gabriel G Haddad. DIDS prevents ischemic membrane degradation in cultured hippocampal neurons by inhibiting matrix metalloproteinase release.
PloS one.
2012; 7(8):e43995. doi:
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2011 Sep; 462(3):479-87. doi:
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2009 Jul; 284(30):20011-21. doi:
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The Journal of biological chemistry.
2008 Jan; 283(4):2211-22. doi:
10.1074/jbc.m706853200. [PMID: 18045865] - Lubica Malekova, Jana Tomaskova, Marie Novakova, Peter Stefanik, Juraj Kopacek, Boris Lakatos, Silvia Pastorekova, Olga Krizanova, Albert Breier, Karol Ondrias. Inhibitory effect of DIDS, NPPB, and phloretin on intracellular chloride channels.
Pflugers Archiv : European journal of physiology.
2007 Nov; 455(2):349-57. doi:
10.1007/s00424-007-0300-9. [PMID: 17611769] - Yasuhiro Nakai, Katsuhisa Inoue, Naoki Abe, Mai Hatakeyama, Kin-ya Ohta, Masaki Otagiri, Yayoi Hayashi, Hiroaki Yuasa. Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.
The Journal of pharmacology and experimental therapeutics.
2007 Aug; 322(2):469-76. doi:
10.1124/jpet.107.122606. [PMID: 17475902] - Zuzana Tomaskova, Jana Gaburjakova, Anna Brezova, Marta Gaburjakova. Inhibition of anion channels derived from mitochondrial membranes of the rat heart by stilbene disulfonate--DIDS.
Journal of bioenergetics and biomembranes.
2007 Aug; 39(4):301-11. doi:
10.1007/s10863-007-9090-1. [PMID: 17899339] - Hui Zhang, Nadia Ameen, James E Melvin, Sadasivan Vidyasagar. Acute inflammation alters bicarbonate transport in mouse ileum.
The Journal of physiology.
2007 Jun; 581(Pt 3):1221-33. doi:
10.1113/jphysiol.2007.129262. [PMID: 17395634] - I T Ivanov, A Tolekova, P Chakaarova. Erythrocyte membrane defects in hemolytic anemias found through derivative thermal analysis of electric impedance.
Journal of biochemical and biophysical methods.
2007 Jun; 70(4):641-8. doi:
10.1016/j.jbbm.2007.02.004. [PMID: 17395266] - Christian Barmeyer, Jeff Huaqing Ye, Shafik Sidani, John Geibel, Henry J Binder, Vazhaikkurichi M Rajendran. Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells.
Pflugers Archiv : European journal of physiology.
2007 Jun; 454(3):441-50. doi:
10.1007/s00424-007-0213-7. [PMID: 17492310] - Katja Berginc, Simon Zakelj, Lea Levstik, Darko Ursic, Albin Kristl. Fluorescein transport properties across artificial lipid membranes, Caco-2 cell monolayers and rat jejunum.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2007 May; 66(2):281-5. doi:
10.1016/j.ejpb.2006.10.023. [PMID: 17129714] - Rui Pedrosa, Nuno Gonçalves, Ulrich Hopfer, Pedro A Jose, Patrício Soares-da-Silva. Activity and regulation of Na+-HCO3- cotransporter in immortalized spontaneously hypertensive rat and Wistar-Kyoto rat proximal tubular epithelial cells.
Hypertension (Dallas, Tex. : 1979).
2007 May; 49(5):1186-93. doi:
10.1161/hypertensionaha.106.083444. [PMID: 17325238] - Akira Takahashi, Shin-ichi Miyoshi, Noriko Takata, Masayuki Nakano, Akiko Hamamoto, Kazuaki Mawatari, Nagakatsu Harada, Sumio Shinoda, Yutaka Nakaya. Haemolysin produced by Vibrio mimicus activates two Cl- secretory pathways in cultured intestinal-like Caco-2 cells.
Cellular microbiology.
2007 Mar; 9(3):583-95. doi:
10.1111/j.1462-5822.2006.00809.x. [PMID: 17026482] - Lauren Johnston, Gary Laverty. Vitamin C transport and SVCT1 transporter expression in chick renal proximal tubule cells in culture.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2007 Mar; 146(3):327-34. doi:
10.1016/j.cbpa.2006.11.025. [PMID: 17258485] - Manish M Tiwari, Joseph R Stimers, Philip R Mayeux. Bradykinin-induced chloride conductance in murine proximal tubule epithelial cells.
Molecular and cellular biochemistry.
2007 Mar; 297(1-2):1-8. doi:
10.1007/s11010-006-9315-3. [PMID: 17003950] - S L'Hoste, H Barriere, R Belfodil, I Rubera, C Duranton, M Tauc, C Poujeol, J Barhanin, P Poujeol. Extracellular pH alkalinization by Cl-/HCO3- exchanger is crucial for TASK2 activation by hypotonic shock in proximal cell lines from mouse kidney.
American journal of physiology. Renal physiology.
2007 Feb; 292(2):F628-38. doi:
10.1152/ajprenal.00132.2006. [PMID: 17003225] - Izabela Koszela-Piotrowska, Katarzyna Choma, Piotr Bednarczyk, Krzysztof Dołowy, Adam Szewczyk, Wolfram S Kunz, Lubica Malekova, Viera Kominkova, Karol Ondrias. Stilbene derivatives inhibit the activity of the inner mitochondrial membrane chloride channels.
Cellular & molecular biology letters.
2007; 12(4):493-508. doi:
10.2478/s11658-007-0019-9. [PMID: 17457523] - Julia E Raftos, Stephney Whillier, Bogdan E Chapman, Philip W Kuchel. Kinetics of uptake and deacetylation of N-acetylcysteine by human erythrocytes.
The international journal of biochemistry & cell biology.
2007; 39(9):1698-706. doi:
10.1016/j.biocel.2007.04.014. [PMID: 17544838] - Valentina Benfenati, Grazia Paola Nicchia, Maria Svelto, Carmela Rapisarda, Antonio Frigeri, Stefano Ferroni. Functional down-regulation of volume-regulated anion channels in AQP4 knockdown cultured rat cortical astrocytes.
Journal of neurochemistry.
2007 Jan; 100(1):87-104. doi:
10.1111/j.1471-4159.2006.04164.x. [PMID: 17064359] - L Bernucci, M Henríquez, P Díaz, G Riquelme. Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane.
Placenta.
2006 Nov; 27(11-12):1082-95. doi:
10.1016/j.placenta.2005.12.007. [PMID: 16564089] - In-Ra Seo, Sang Hyun Moh, Eun Hui Lee, Gerhard Meissner, Do Han Kim. Aldolase potentiates DIDS activation of the ryanodine receptor in rabbit skeletal sarcoplasmic reticulum.
The Biochemical journal.
2006 Oct; 399(2):325-33. doi:
10.1042/bj20060701. [PMID: 16817780] - Ashley M Toye, Mark D Parker, Christopher M Daly, Jing Lu, Leila V Virkki, Marc F Pelletier, Walter F Boron. The human NBCe1-A mutant R881C, associated with proximal renal tubular acidosis, retains function but is mistargeted in polarized renal epithelia.
American journal of physiology. Cell physiology.
2006 Oct; 291(4):C788-801. doi:
10.1152/ajpcell.00094.2006. [PMID: 16707554] - Alexander C Whitley, Douglas H Sweet, Thomas Walle. Site-specific accumulation of the cancer preventive dietary polyphenol ellagic acid in epithelial cells of the aerodigestive tract.
The Journal of pharmacy and pharmacology.
2006 Sep; 58(9):1201-9. doi:
10.1211/jpp.58.9.0006. [PMID: 16945178] - Xiao-Yan Pan, Guo-Qiang Chen, Li Cai, Stephen Buscemi, Guo-Hui Fu. Anion exchanger 2 mediates the action of arsenic trioxide.
British journal of haematology.
2006 Sep; 134(5):491-9. doi:
10.1111/j.1365-2141.2006.06224.x. [PMID: 17018029] - N Lambot, P Lybaert, A Boom, J Delogne-Desnoeck, A M Vanbellinghen, G Graff, P Lebrun, S Meuris. Evidence for a clathrin-mediated recycling of albumin in human term placenta.
Biology of reproduction.
2006 Jul; 75(1):90-7. doi:
10.1095/biolreprod.105.050021. [PMID: 16495477] - Felix Knauf, Nilufar Mohebbi, Carsten Teichert, Diana Herold, Blanka Rogina, Stephen Helfand, Maik Gollasch, Friedrich C Luft, Peter S Aronson. The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates.
The Biochemical journal.
2006 Jul; 397(1):25-9. doi:
10.1042/bj20060409. [PMID: 16608441] - Rossella Elisei, Agnese Vivaldi, Raffaele Ciampi, Pinuccia Faviana, Fulvio Basolo, Ferruccio Santini, Claudio Traino, Furio Pacini, Aldo Pinchera. Treatment with drugs able to reduce iodine efflux significantly increases the intracellular retention time in thyroid cancer cells stably transfected with sodium iodide symporter complementary deoxyribonucleic acid.
The Journal of clinical endocrinology and metabolism.
2006 Jun; 91(6):2389-95. doi:
10.1210/jc.2005-2480. [PMID: 16537683] - Fukashi Ishibashi. Chronic high glucose inhibits albumin reabsorption by lysosomal alkalinization in cultured porcine proximal tubular epithelial cells (LLC-PK1).
Diabetes research and clinical practice.
2006 Jun; 72(3):223-30. doi:
10.1016/j.diabres.2005.10.019. [PMID: 16313995] - Weifeng Song, Siriporn C Chattipakorn, Lori L McMahon. Glycine-gated chloride channels depress synaptic transmission in rat hippocampus.
Journal of neurophysiology.
2006 Apr; 95(4):2366-79. doi:
10.1152/jn.00386.2005. [PMID: 16381810] - Roger J Thompson, Hillary C S R Akana, Claire Finnigan, Kathryn E Howell, John H Caldwell. Anion channels transport ATP into the Golgi lumen.
American journal of physiology. Cell physiology.
2006 Feb; 290(2):C499-514. doi:
10.1152/ajpcell.00585.2004. [PMID: 16403948] - Yvonne Neye, Martina Düfer, Gisela Drews, Peter Krippeit-Drews. HIV protease inhibitors: suppression of insulin secretion by inhibition of voltage-dependent K+ currents and anion currents.
The Journal of pharmacology and experimental therapeutics.
2006 Jan; 316(1):106-12. doi:
10.1124/jpet.105.090589. [PMID: 16162820] - M Pusch, G Zifarelli, A R Murgia, A Picollo, E Babini. Channel or transporter? The CLC saga continues.
Experimental physiology.
2006 Jan; 91(1):149-52. doi:
10.1113/expphysiol.2005.031799. [PMID: 16179405] - Astrid Stumpf, Joana Almaca, Karl Kunzelmann, Kerstin Wenners-Epping, Stephan M Huber, Johannes Haberle, Sabine Falk, Angelika Duebbers, Mike Walte, Hans Oberleithner, Hermann Schillers. IADS, a decomposition product of DIDS activates a cation conductance in Xenopus oocytes and human erythrocytes: new compound for the diagnosis of cystic fibrosis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2006; 18(4-5):243-52. doi:
10.1159/000097671. [PMID: 17167229] - Takashi Araki, Matsuhiko Hayashi, Takao Saruta. Anion-exchange blocker enhances cytoplasmic vacuole formation and cell death in serum-deprived mouse kidney epithelial cells in mice.
Cell biology international.
2006 Jan; 30(1):93-100. doi:
10.1016/j.cellbi.2005.10.020. [PMID: 16376114] - Min Xia, Mengjun Hou, Huilian Zhu, Jing Ma, Zhihong Tang, Qing Wang, Yan Li, Dongsheng Chi, Xiaoping Yu, Ting Zhao, Pinghua Han, Xiaodong Xia, Wenhua Ling. Anthocyanins induce cholesterol efflux from mouse peritoneal macrophages: the role of the peroxisome proliferator-activated receptor {gamma}-liver X receptor {alpha}-ABCA1 pathway.
The Journal of biological chemistry.
2005 Nov; 280(44):36792-801. doi:
10.1074/jbc.m505047200. [PMID: 16107338] - Kimberly Matulef, Merritt Maduke. Side-dependent inhibition of a prokaryotic ClC by DIDS.
Biophysical journal.
2005 Sep; 89(3):1721-30. doi:
10.1529/biophysj.105.066522. [PMID: 15994902] - Sachar Lambert, Johannes Oberwinkler. Characterization of a proton-activated, outwardly rectifying anion channel.
The Journal of physiology.
2005 Aug; 567(Pt 1):191-213. doi:
10.1113/jphysiol.2005.089888. [PMID: 15961423] - David Pérez-Morga, Benoit Vanhollebeke, Françoise Paturiaux-Hanocq, Derek P Nolan, Laurence Lins, Fabrice Homblé, Luc Vanhamme, Patricia Tebabi, Annette Pays, Philippe Poelvoorde, Alain Jacquet, Robert Brasseur, Etienne Pays. Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes.
Science (New York, N.Y.).
2005 Jul; 309(5733):469-72. doi:
10.1126/science.1114566. [PMID: 16020735]