Skimmetin (BioDeep_00000861538)

Main id: BioDeep_00000000007

 

PANOMIX_OTCML-2023


代谢物信息卡片


InChI=1\C9H6O3\c10-7-3-1-6-2-4-9(11)12-8(6)5-7\h1-5,10

化学式: C9H6O3 (162.03169259999999)
中文名称: 伞形酮, 7-羟基香豆素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC2=C1C=CC(=O)O2)O
InChI: InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H

描述信息

COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Umbelliferone (7-Hydroxycoumarin), a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent.
Umbelliferone (7-Hydroxycoumarin), a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent.

同义名列表

48 个代谢物同义名

InChI=1\C9H6O3\c10-7-3-1-6-2-4-9(11)12-8(6)5-7\h1-5,10; 5-18-01-00386 (Beilstein Handbook Reference); 2H-1-Benzopyran-2-one, 7-hydroxy-; 7-Hydroxy-2H-1-benzopyran-2-one; 7-Hydroxy-2H-chromen-2-one; 7-hydroxychromen-2-one; 7-Hydroxy-2-chromenone; SDCCGMLS-0066941.P001; .beta.-Umbelliferone; Coumarin, 7-hydroxy-; 7-hydroxycoumarine; beta-Umbelliferone; 7-Hydroxycoumarin; Spectrum3_000751; Spectrum2_001962; EINECS 202-240-3; NCGC00095801-01; H24003_ALDRICH; SPECTRUM231084; BSPBio_002362; Umbelliferone; MEGxp0_000814; 7-Oxycoumarin; NCI60_001646; ACon1_000219; KBio3_001582; SPBio_002083; ZINC00058111; Umbelliferon; AIDS-005662; CHEBI:27510; 93979_FLUKA; BRN 0127683; CCRIS 3591; AIDS005662; Hydrangine; Skimmetine; ST5308216; Skimmetin; NSC 19790; Hydrangin; AI3-38054; NSC19790; 93-35-6; C09315; 7 HC; Umbelliferone; Umbelliferone



数据库引用编号

14 个数据库交叉引用编号

分类词条

351 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yuanyuan Chen, Xikun Liu, Jie Ma, Weida Wang, Zhaojun Li, Haijie Wu, Zhanxi Lu, Dongming Zhang, Xiaoying Zhang, Yu Zhang, Sen Zhang. Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C/EBPβ. Journal of ethnopharmacology. 2024 Jul; 329(?):118156. doi: 10.1016/j.jep.2024.118156. [PMID: 38583729]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Tong Jin, Cheng Chen. Umbelliferone delays the progression of diabetic nephropathy by inhibiting ferroptosis through activation of the Nrf-2/HO-1 pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022 May; 163(?):112892. doi: 10.1016/j.fct.2022.112892. [PMID: 35278496]
  • Mohamed A M Allam, Akef A Khowailed, Samah Elattar, Ayman M Mahmoud. Umbelliferone ameliorates oxidative stress and testicular injury, improves steroidogenesis and upregulates peroxisome proliferator-activated receptor gamma in type 2 diabetic rats. The Journal of pharmacy and pharmacology. 2022 Apr; 74(4):573-584. doi: 10.1093/jpp/rgab083. [PMID: 34156072]
  • Mirosław Zagaja, Anna Zagaja, Joanna Szala-Rycaj, Aleksandra Szewczyk, Marta Kinga Lemieszek, Grzegorz Raszewski, Marta Andres-Mach. Influence of Umbelliferone on the Anticonvulsant and Neuroprotective Activity of Selected Antiepileptic Drugs: An In Vivo and In Vitro Study. International journal of molecular sciences. 2022 Mar; 23(7):. doi: 10.3390/ijms23073492. [PMID: 35408852]
  • Zongmei Wu, Yana Geng, Manon Buist-Homan, Han Moshage. Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress. Toxicology and applied pharmacology. 2022 02; 436(?):115858. doi: 10.1016/j.taap.2021.115858. [PMID: 34979142]
  • Jian-Wei Zhang, Yuan Xiong, Feng Wang, Fu-Mao Zhang, Xiaodi Yang, Guo-Qiang Lin, Ping Tian, Guangbo Ge, Dingding Gao. Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19. European journal of medicinal chemistry. 2022 Jan; 228(?):114030. doi: 10.1016/j.ejmech.2021.114030. [PMID: 34883292]
  • Tajpreet Kaur, Damanpreet Singh, Devendra Pathak, Amrit P Singh, Balbir Singh. Umbelliferone attenuates glycerol-induced myoglobinuric acute kidney injury through peroxisome proliferator-activated receptor-γ agonism in rats. Journal of biochemical and molecular toxicology. 2021 Nov; 35(11):e22892. doi: 10.1002/jbt.22892. [PMID: 34409680]
  • Xuezhe Piao, Hee Sun Byun, So-Ra Lee, Eunjin Ju, Kyeong Ah Park, Kyung-Cheol Sohn, Khong Trong Quan, Jinbae Lee, MinKyun Na, Gang Min Hur. 8-Geranylumbelliferone isolated from Paramignya trimera triggers RIPK1/RIPK3-dependent programmed cell death upon TNFR1 ligation. Biochemical pharmacology. 2021 10; 192(?):114733. doi: 10.1016/j.bcp.2021.114733. [PMID: 34411570]
  • Fares E M Ali, Emad H M Hassanein, Ali H El-Bahrawy, Zainab M M Omar, Eman K Rashwan, Basil A Abdel-Wahab, Tarek H Abd-Elhamid. Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways. Journal of biochemical and molecular toxicology. 2021 May; 35(5):e22738. doi: 10.1002/jbt.22738. [PMID: 33522649]
  • Peng-Chao Huo, Xiao-Qing Guan, Peng Liu, Yun-Qing Song, Meng-Ru Sun, Rong-Jing He, Li-Wei Zou, Li-Juan Xue, Jin-Hui Shi, Nan Zhang, Zhi-Guo Liu, Guang-Bo Ge. Design, synthesis and biological evaluation of indanone-chalcone hybrids as potent and selective hCES2A inhibitors. European journal of medicinal chemistry. 2021 Jan; 209(?):112856. doi: 10.1016/j.ejmech.2020.112856. [PMID: 33007602]
  • Peng-Chao Huo, Qing Hu, Sheng Shu, Qi-Hang Zhou, Rong-Jing He, Jie Hou, Xiao-Qing Guan, Dong-Zhu Tu, Xu-Dong Hou, Peng Liu, Nan Zhang, Zhi-Guo Liu, Guang-Bo Ge. Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors. Bioorganic & medicinal chemistry. 2021 01; 29(?):115853. doi: 10.1016/j.bmc.2020.115853. [PMID: 33214035]
  • Yang-Liu Xia, Jing-Jing Wang, Shi-Yang Li, Yong Liu, Frank J Gonzalez, Ping Wang, Guang-Bo Ge. Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. Bioorganic & medicinal chemistry. 2021 01; 29(?):115851. doi: 10.1016/j.bmc.2020.115851. [PMID: 33218896]
  • Joanna Sumorek-Wiadro, Adrian Zając, Ewa Langner, Krystyna Skalicka-Woźniak, Aleksandra Maciejczyk, Wojciech Rzeski, Joanna Jakubowicz-Gil. Antiglioma Potential of Coumarins Combined with Sorafenib. Molecules (Basel, Switzerland). 2020 Nov; 25(21):. doi: 10.3390/molecules25215192. [PMID: 33171577]
  • Jae-Sung Park, Beomkoo Chung, Won-Hee Lee, Jayho Lee, Youngbae Suh, Dong-Chan Oh, Ki-Bong Oh, Jongheon Shin. Sortase A-Inhibitory Coumarins from the Folk Medicinal Plant Poncirus trifoliata. Journal of natural products. 2020 10; 83(10):3004-3011. doi: 10.1021/acs.jnatprod.0c00551. [PMID: 32996318]
  • Merhan O Hindam, Rabab H Sayed, Krystyna Skalicka-Woźniak, Barbara Budzyńska, Nesrine S El Sayed. Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer's disease: The role of JAK2/STAT3 and Nrf2/HO-1 signalling pathway modulation. Phytotherapy research : PTR. 2020 Sep; 34(9):2351-2365. doi: 10.1002/ptr.6686. [PMID: 32250498]
  • Rubén Seoane-Rivero, Estibaliz Ruiz-Bilbao, Rodrigo Navarro, José Manuel Laza, José María Cuevas, Beñat Artetxe, Juan M Gutiérrez-Zorrilla, José Luis Vilas-Vilela, Ángel Marcos-Fernandez. Structural Characterization of Mono and Dihydroxylated Umbelliferone Derivatives. Molecules (Basel, Switzerland). 2020 Jul; 25(15):. doi: 10.3390/molecules25153497. [PMID: 32751979]
  • Adnan Amin, Muhammad Hanif, Khizar Abbas, Muhammad Ramzan, Abdur Rasheed, Ali Zaman, Luc Pieters. Studies on effects of umbelliferon derivatives against periodontal bacteria; antibiofilm, inhibition of quorum sensing and molecular docking analysis. Microbial pathogenesis. 2020 Jul; 144(?):104184. doi: 10.1016/j.micpath.2020.104184. [PMID: 32304793]
  • Yao Fu, Xiaoxiao Tian, Lingling Han, Yilin Li, Ying Peng, Jiang Zheng. Mechanism-based inactivation of cytochrome P450 2D6 by Notopterol. Chemico-biological interactions. 2020 May; 322(?):109053. doi: 10.1016/j.cbi.2020.109053. [PMID: 32198085]
  • Wei-Feng Wu, Jia-Nan Wang, Zeng Li, Biao Wei, Juan Jin, Li Gao, Hai-Di Li, Jun Li, Hai-Yong Chen, Xiao-Ming Meng. 7-Hydroxycoumarin protects against cisplatin-induced acute kidney injury by inhibiting necroptosis and promoting Sox9-mediated tubular epithelial cell proliferation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Apr; 69(?):153202. doi: 10.1016/j.phymed.2020.153202. [PMID: 32169782]
  • Xueqin Jiang, Zengjin Liu, Youzhe Yang, Hao Li, Xiaoyi Qi, Wen Xiu Ren, Mingming Deng, Muhan Lü, Jianming Wu, Sicheng Liang. A mitochondria-targeted two-photon fluorescent probe for sensing and imaging pH changes in living cells. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Jan; 224(?):117435. doi: 10.1016/j.saa.2019.117435. [PMID: 31400745]
  • Mohammed F Alotaibi, Fakhria Al-Joufi, Howida S Abou Seif, Mohammed A Alzoghaibi, Laiche Djouhri, Ahmad F Ahmeda, Ayman M Mahmoud. Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling. Drug design, development and therapy. 2020; 14(?):4003-4019. doi: 10.2147/dddt.s265636. [PMID: 33061305]
  • Tomonori Miura, Yusuke Kamiya, Shiori Hina, Yui Kobayashi, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki. Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model. The Journal of toxicological sciences. 2020; 45(11):695-700. doi: 10.2131/jts.45.695. [PMID: 33132243]
  • Su Hui Seong, Md Yousof Ali, Hyun Ah Jung, Jae Sue Choi. Umbelliferone derivatives exert neuroprotective effects by inhibiting monoamine oxidase A, self-amyloidβ aggregation, and lipid peroxidation. Bioorganic chemistry. 2019 11; 92(?):103293. doi: 10.1016/j.bioorg.2019.103293. [PMID: 31557622]
  • Ruben Vanholme, Lisa Sundin, Keletso Carol Seetso, Hoon Kim, Xinyu Liu, Jin Li, Barbara De Meester, Lennart Hoengenaert, Geert Goeminne, Kris Morreel, Jurgen Haustraete, Huei-Hsuan Tsai, Wolfgang Schmidt, Bartel Vanholme, John Ralph, Wout Boerjan. COSY catalyses trans-cis isomerization and lactonization in the biosynthesis of coumarins. Nature plants. 2019 10; 5(10):1066-1075. doi: 10.1038/s41477-019-0510-0. [PMID: 31501530]
  • Jia-Hao Lee, Hui-Ching Mei, I-Chih Kuo, Tzong-Huei Lee, Yu-Hsin Chen, Ching-Kuo Lee. Characterizing Tyrosinase Modulators from the Roots of Angelica keiskei Using Tyrosinase Inhibition Assay and UPLC-MS/MS as the Combinatorial Novel Approach. Molecules (Basel, Switzerland). 2019 Sep; 24(18):. doi: 10.3390/molecules24183297. [PMID: 31510069]
  • Yoon Young Kang, Jihyeon Song, Jun Yeong Kim, Heesun Jung, Woon-Seok Yeo, Yoongho Lim, Hyejung Mok. Byakangelicin as a modulator for improved distribution and bioactivity of natural compounds and synthetic drugs in the brain. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Sep; 62(?):152963. doi: 10.1016/j.phymed.2019.152963. [PMID: 31128487]
  • Xiaoyi Qi, Tongyi Dou, Zhongqiong Wang, Jianming Wu, Ling Yang, Su Zeng, Mingming Deng, Muhan Lü, Sicheng Liang. Inhibition of human cytochrome P450 2A6 by 7-hydroxycoumarin analogues: Analysis of the structure-activity relationship and isoform selectivity. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019 Aug; 136(?):104944. doi: 10.1016/j.ejps.2019.05.022. [PMID: 31163215]
  • Mireia Casasampere, Núria Bielsa, Daniel Riba, Laura Bassas, Ruijuan Xu, Cungui Mao, Gemma Fabriàs, José-Luis Abad, Antonio Delgado, Josefina Casas. New fluorogenic probes for neutral and alkaline ceramidases. Journal of lipid research. 2019 06; 60(6):1174-1181. doi: 10.1194/jlr.d092759. [PMID: 30926626]
  • Serena Fiorito, Federica Ianni, Francesca Preziuso, Francesco Epifano, Luca Scotti, Tonino Bucciarelli, Salvatore Genovese. UHPLC-UV/Vis Quantitative Analysis of Hydroxylated and O-prenylated Coumarins in Pomegranate Seed Extracts. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24101963. [PMID: 31121819]
  • Han-Qing Wang, Sha-Sha Wang, Kuok Chiufai, Qi Wang, Xiao-Lan Cheng. Umbelliferone ameliorates renal function in diabetic nephropathy rats through regulating inflammation and TLR/NF-κB pathway. Chinese journal of natural medicines. 2019 May; 17(5):346-354. doi: 10.1016/s1875-5364(19)30040-8. [PMID: 31171269]
  • Qingpeng Wang, Yan Chen, Guoshuai Li, Zhifang Liu, Jing Ma, Min Liu, Dacheng Li, Jun Han, Bingquan Wang. Synthesis and evaluation of bi-functional 7-hydroxycoumarin platinum(IV) complexes as antitumor agents. Bioorganic & medicinal chemistry. 2019 05; 27(10):2112-2121. doi: 10.1016/j.bmc.2019.04.009. [PMID: 30981607]
  • Dan Li, Zhuoliang Gu, Jingdong Zhang, Shuren Ma. Protective effect of inducible aldo-keto reductases on 4-hydroxynonenal- induced hepatotoxicity. Chemico-biological interactions. 2019 May; 304(?):124-130. doi: 10.1016/j.cbi.2019.02.012. [PMID: 30849339]
  • Zhang Sen, Wang Weida, Ma Jie, Sheng Li, Zhang Dongming, Chen Xiaoguang. Coumarin glycosides from Hydrangea paniculata slow down the progression of diabetic nephropathy by targeting Nrf2 anti-oxidation and smad2/3-mediated profibrosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Apr; 57(?):385-395. doi: 10.1016/j.phymed.2018.12.045. [PMID: 30849675]
  • Tahani Hijazin, Alzahraa Radwan, Sara Abouzeid, Gerald Dräger, Dirk Selmar. Uptake and modification of umbelliferone by various seedlings. Phytochemistry. 2019 Jan; 157(?):194-199. doi: 10.1016/j.phytochem.2018.10.032. [PMID: 30439620]
  • Liang Yang, Lintong Wu, Xiaoyuan Yao, Shiyuan Zhao, Jiao Wang, Shili Li, Wei Ding. Hydroxycoumarins: New, effective plant-derived compounds reduce Ralstonia pseudosolanacearum populations and control tobacco bacterial wilt. Microbiological research. 2018 Oct; 215(?):15-21. doi: 10.1016/j.micres.2018.05.011. [PMID: 30172302]
  • Emad H M Hassanein, Wafaa R Mohamed, Abdel-Gawad S Shalkami, Marwa M Khalaf, Ramadan A M Hemeida. Renoprotective effects of umbelliferone on methotrexate-induced renal injury through regulation of Nrf-2/Keap-1, P38MAPK/NF-κB, and apoptosis signaling pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Jun; 116(Pt B):152-160. doi: 10.1016/j.fct.2018.03.041. [PMID: 29608980]
  • Luca Scotti, Salvatore Genovese, Tonino Bucciarelli, Filippo Martini, Francesco Epifano, Serena Fiorito, Francesca Preziuso, Vito Alessandro Taddeo. Analysis of biologically active oxyprenylated phenylpropanoids in Tea tree oil using selective solid-phase extraction with UHPLC-PDA detection. Journal of pharmaceutical and biomedical analysis. 2018 May; 154(?):174-179. doi: 10.1016/j.jpba.2018.03.004. [PMID: 29549856]
  • Vincenzo Ferrone, Salvatore Genovese, Maura Carlucci, Matteo Tiecco, Raimondo Germani, Francesca Preziuso, Francesco Epifano, Giuseppe Carlucci, Vito Alessandro Taddeo. A green deep eutectic solvent dispersive liquid-liquid micro-extraction (DES-DLLME) for the UHPLC-PDA determination of oxyprenylated phenylpropanoids in olive, soy, peanuts, corn, and sunflower oil. Food chemistry. 2018 Apr; 245(?):578-585. doi: 10.1016/j.foodchem.2017.10.135. [PMID: 29287412]
  • Mayuresh S Garud, Yogesh A Kulkarni. Attenuation of renal damage in type I diabetic rats by umbelliferone - a coumarin derivative. Pharmacological reports : PR. 2017 Dec; 69(6):1263-1269. doi: 10.1016/j.pharep.2017.06.014. [PMID: 29128808]
  • Md Yousof Ali, Su Hui Seong, Machireddy Rajeshkumar Reddy, Sung Yong Seo, Jae Sue Choi, Hyun Ah Jung. Kinetics and Molecular Docking Studies of 6-Formyl Umbelliferone Isolated from Angelica decursiva as an Inhibitor of Cholinesterase and BACE1. Molecules (Basel, Switzerland). 2017 Sep; 22(10):. doi: 10.3390/molecules22101604. [PMID: 28946641]
  • Salvatore Genovese, Hitoshi Ashida, Yoko Yamashita, Tomoya Nakgano, Masaki Ikeda, Shirasaya Daishi, Francesco Epifano, Vito Alessandro Taddeo, Serena Fiorito. The interaction of auraptene and other oxyprenylated phenylpropanoids with glucose transporter type 4. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2017 Aug; 32(?):74-79. doi: 10.1016/j.phymed.2017.06.005. [PMID: 28732810]
  • Ruijie He, Yanjun Zhang, Liangdeng Wu, Hui Nie, Yan Huang, Buming Liu, Shengping Deng, Ruiyun Yang, Shuai Huang, Zhijie Nong, Jun Li, Haiyan Chen. Benzofuran glycosides and coumarins from the bark of Streblus indicus (Bur.) Corner. Phytochemistry. 2017 Jun; 138(?):170-177. doi: 10.1016/j.phytochem.2017.01.011. [PMID: 28284566]
  • Rita de Cássia L Lima, Simone M Gramsbergen, Johannes Van Staden, Anna K Jäger, Kenneth T Kongstad, Dan Staerk. Advancing HPLC-PDA-HRMS-SPE-NMR Analysis of Coumarins in Coleonema album by Use of Orthogonal Reversed-Phase C18 and Pentafluorophenyl Separations. Journal of natural products. 2017 04; 80(4):1020-1027. doi: 10.1021/acs.jnatprod.6b01020. [PMID: 28248501]
  • Li Wang, Hai-Long Wu, Xiao-Li Yin, Yong Hu, Hui-Wen Gu, Ru-Qin Yu. Simultaneous determination of umbelliferone and scopoletin in Tibetan medicine Saussurea laniceps and traditional Chinese medicine Radix angelicae pubescentis using excitation-emission matrix fluorescence coupled with second-order calibration method. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2017 Jan; 170(?):104-10. doi: 10.1016/j.saa.2016.07.018. [PMID: 27423108]
  • Ryosuke Munakata, Alexandre Olry, Fazeelat Karamat, Vincent Courdavault, Akifumi Sugiyama, Yoshiaki Date, Célia Krieger, Prisca Silie, Emilien Foureau, Nicolas Papon, Jérémy Grosjean, Kazufumi Yazaki, Frédéric Bourgaud, Alain Hehn. Molecular evolution of parsnip (Pastinaca sativa) membrane-bound prenyltransferases for linear and/or angular furanocoumarin biosynthesis. The New phytologist. 2016 07; 211(1):332-44. doi: 10.1111/nph.13899. [PMID: 26918393]
  • Sudhakar Raja Subramaniam, Elizabeth M Ellis. Umbelliferone and esculetin protect against N-nitrosodiethylamine-induced hepatotoxicity in rats. Cell biology international. 2016 Jul; 40(7):761-9. doi: 10.1002/cbin.10611. [PMID: 27080985]
  • Govindan Sangaran Jagadeesh, Mohamed Fizur Nagoor Meeran, Palanisamy Selvaraj. Activation of β1-adrenoceptor triggers oxidative stress mediated myocardial membrane destabilization in isoproterenol induced myocardial infarcted rats: 7-hydroxycoumarin and its counter action. European journal of pharmacology. 2016 Apr; 777(?):70-7. doi: 10.1016/j.ejphar.2016.02.063. [PMID: 26930228]
  • Kristoffer Dalhoff, Michele Gottardi, Andreas Kretschmann, Nina Cedergreen. What causes the difference in synergistic potentials of propiconazole and prochloraz toward pyrethroids in Daphnia magna?. Aquatic toxicology (Amsterdam, Netherlands). 2016 Mar; 172(?):95-102. doi: 10.1016/j.aquatox.2015.12.007. [PMID: 26784738]
  • Govindan Sangaran Jagadeesh, M F Nagoor Meeran, Palanisamy Selvaraj. Protective Effects of 7-Hydroxycoumarin on Dyslipidemia and Cardiac Hypertrophy in Isoproterenol-Induced Myocardial Infarction in Rats. Journal of biochemical and molecular toxicology. 2016 Mar; 30(3):120-7. doi: 10.1002/jbt.21770. [PMID: 26995004]
  • Ramith Ramu, Prithvi S Shirahatti, Nanjunda Swamy S, Farhan Zameer, Bhadrapura Lakkappa Dhananjaya, Nagendra Prasad M N. Assessment of In Vivo Antidiabetic Properties of Umbelliferone and Lupeol Constituents of Banana (Musa sp. var. Nanjangud Rasa Bale) Flower in Hyperglycaemic Rodent Model. PloS one. 2016; 11(3):e0151135. doi: 10.1371/journal.pone.0151135. [PMID: 27003006]
  • Seeta Poudel, Yunjung Kim, Yun Tai Kim, Youngseok Lee. Gustatory receptors required for sensing umbelliferone in Drosophila melanogaster. Insect biochemistry and molecular biology. 2015 Nov; 66(?):110-8. doi: 10.1016/j.ibmb.2015.10.010. [PMID: 26524963]
  • Ciprian Briciu-Burghina, Brendan Heery, Fiona Regan. Continuous fluorometric method for measuring β-glucuronidase activity: comparative analysis of three fluorogenic substrates. The Analyst. 2015 Sep; 140(17):5953-64. doi: 10.1039/c5an01021g. [PMID: 26225370]
  • Lan Wei, Xiaobo Wang, Shanxue Mu, Lixin Sun, Zhiguo Yu. Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions. Journal of separation science. 2015 Jun; 38(12):2093-100. doi: 10.1002/jssc.201401398. [PMID: 25866087]
  • Die Gao, Yong-lan Zhang, Pan Xu, Ye-xin Lin, Feng-qing Yang, Jian-hui Liu, Hai-wen Zhu, Zhi-ning Xia. In vitro evaluation of dual agonists for PPARγ/β from the flower of Edgeworthia gardneri (wall.) Meisn. Journal of ethnopharmacology. 2015 Mar; 162(?):14-9. doi: 10.1016/j.jep.2014.12.034. [PMID: 25557029]
  • Yu-jie Wang, Rong Tan, Li-shi Zhou, Rui Gu, Yi Zhang. [Phenylpropanoids from Saussureae hieracioides]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Jan; 38(1):101-3. doi: . [PMID: 26214878]
  • João Cleverson Gasparetto, Rosângela Gonçalves Peccinini, Thais Martins Guimarães de Francisco, Letícia Bonâncio Cerqueira, Francinete Ramos Campos, Roberto Pontarolo. A kinetic study of the main guaco metabolites using syrup formulation and the identification of an alternative route of coumarin metabolism in humans. PloS one. 2015; 10(3):e0118922. doi: 10.1371/journal.pone.0118922. [PMID: 25757073]
  • Abdur Rauf, Rehan Khan, Haroon Khan, Harukuni Tokuda. Cytotoxic, antitumour-promoting and inhibition of protein denaturation effects of flavonoids, isolated from Potentilla evestita Th. Wolf. Natural product research. 2015; 29(18):1775-8. doi: 10.1080/14786419.2014.999336. [PMID: 25588733]
  • Hang Liu, Ji-zhong Shen, Hai-xia Zhang. [Chemical constituents from stems of Clausena excavata]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Nov; 37(11):2012-5. doi: . [PMID: 26027123]
  • Myung-Joo Kim, Mi-Ok Sim, Hae-In Lee, Ju Ri Ham, Kwon-Il Seo, Mi-Kyung Lee. Dietary umbelliferone attenuates alcohol-induced fatty liver via regulation of PPARα and SREBP-1c in rats. Alcohol (Fayetteville, N.Y.). 2014 Nov; 48(7):707-15. doi: 10.1016/j.alcohol.2014.08.008. [PMID: 25262573]
  • Jarinyaporn Naowaboot, Choon Hee Chung, Ran Choi, Patchareewan Pannangpetch. Umbelliferone increases the expression of adipocyte-specific genes in 3T3-L1 adipocyte. Phytotherapy research : PTR. 2014 Nov; 28(11):1671-5. doi: 10.1002/ptr.5180. [PMID: 24853372]
  • Satyanarayanaraju Sagi, Bharathi Avula, Yan-Hong Wang, Jianping Zhao, Ikhlas A Khan. Quantitative determination of seven chemical constituents and chemo-type differentiation of chamomiles using high-performance thin-layer chromatography. Journal of separation science. 2014 Oct; 37(19):2797-804. doi: 10.1002/jssc.201400646. [PMID: 25073627]
  • Mohamed R Mohamed, Manal A Emam, Nahla S Hassan, Abeer I Mogadem. Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression. Environmental toxicology and pharmacology. 2014 Sep; 38(2):531-41. doi: 10.1016/j.etap.2014.08.004. [PMID: 25170823]
  • Guo-Shun Shan, Liang-Xiao Zhang, Qi-Miao Zhao, Hong-Bin Xiao, Rong-Jie Zhuo, Gang Xu, Hong Jiang, Xian-Min You, Tian-Zhu Jia. Metabolomic study of raw and processed Atractylodes macrocephala Koidz by LC-MS. Journal of pharmaceutical and biomedical analysis. 2014 Sep; 98(?):74-84. doi: 10.1016/j.jpba.2014.05.010. [PMID: 24893211]
  • Yuheng Lin, Yajun Yan. Biotechnological production of plant-specific hydroxylated phenylpropanoids. Biotechnology and bioengineering. 2014 Sep; 111(9):1895-9. doi: 10.1002/bit.25237. [PMID: 24752627]
  • Mi-Ok Sim, Ju Ri Ham, Hae-In Lee, Kwon-Il Seo, Mi-Kyung Lee. Long-term supplementation of umbelliferone and 4-methylumbelliferone alleviates high-fat diet induced hypertriglyceridemia and hyperglycemia in mice. Chemico-biological interactions. 2014 Jun; 216(?):9-16. doi: 10.1016/j.cbi.2014.03.003. [PMID: 24661945]
  • Yong Zhao, Chang-An Geng, Chang-Li Sun, Yun-Bao Ma, Xiao-Yan Huang, Tuan-Wu Cao, Kang He, Hao Wang, Xue-Mei Zhang, Ji-Jun Chen. Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris. Fitoterapia. 2014 Jun; 95(?):187-93. doi: 10.1016/j.fitote.2014.03.017. [PMID: 24685503]
  • Tao Yi, Lin Zhu, Yi-Na Tang, Jian-Ye Zhang, Zhi-Tao Liang, Jun Xu, Zhong-Zhen Zhao, Zhi-Ling Yu, Zhao-Xiang Bian, Zhi-Jun Yang, Hu-Biao Chen. An integrated strategy based on UPLC-DAD-QTOF-MS for metabolism and pharmacokinetic studies of herbal medicines: Tibetan "Snow Lotus" herb (Saussurea laniceps), a case study. Journal of ethnopharmacology. 2014 May; 153(3):701-13. doi: 10.1016/j.jep.2014.03.031. [PMID: 24661968]
  • Daniel Pushparaju Yeggoni, Mahesh Gokara, Darla Mark Manidhar, Aparna Rachamallu, Sailaja Nakka, Cirandur Suresh Reddy, Rajagopal Subramanyam. Binding and molecular dynamics studies of 7-hydroxycoumarin derivatives with human serum albumin and its pharmacological importance. Molecular pharmaceutics. 2014 Apr; 11(4):1117-31. doi: 10.1021/mp500051f. [PMID: 24495045]
  • Rong Tan, Yu-Jie Wang, Yu-Xin Zhang, Li-Shi Zhou, Er Tan, A Ping, Yi Zhang. [Determination of skimmin, scopolin and umbelliferone in Tibetan medicine Saussurea hieracioides by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 Mar; 39(6):1054-7. doi: . [PMID: 24956850]
  • Xing-Nuo Li, Sheng-Qiang Tong, Dong-Ping Cheng, Qing-Yong Li, Ji-Zhong Yan. Coumarins from Edgeworthia chrysantha. Molecules (Basel, Switzerland). 2014 Feb; 19(2):2042-8. doi: 10.3390/molecules19022042. [PMID: 24531219]
  • Fazeelat Karamat, Alexandre Olry, Ryosuke Munakata, Takao Koeduka, Akifumi Sugiyama, Cedric Paris, Alain Hehn, Frédéric Bourgaud, Kazufumi Yazaki. A coumarin-specific prenyltransferase catalyzes the crucial biosynthetic reaction for furanocoumarin formation in parsley. The Plant journal : for cell and molecular biology. 2014 Feb; 77(4):627-38. doi: 10.1111/tpj.12409. [PMID: 24354545]
  • Jie Li, Qian Shen, Chen-Hao Bao, Li-Ting Chen, Xiang-Rong Li. A new dicoumarinyl ether from the roots of Stellera chamaejasme L. Molecules (Basel, Switzerland). 2014 Jan; 19(2):1603-7. doi: 10.3390/molecules19021603. [PMID: 24473216]
  • Nasser Zangiabadi, Hossein Mohtashami, Mahboobeh Hojatipour, Mandana Jafari, Majid Asadi-Shekaari, Mohammad Shabani. The effect of Angipars on diabetic neuropathy in STZ-induced diabetic male rats: a study on behavioral, electrophysiological, sciatic histological and ultrastructural indices. TheScientificWorldJournal. 2014; 2014(?):721547. doi: 10.1155/2014/721547. [PMID: 25614895]
  • Luciana M Kabeya, Carolina N Fuzissaki, Silvia H Taleb-Contini, Ana Maria da C Ferreira, Zeki Naal, Everton O L Santos, Andréa S G Figueiredo-Rinhel, Ana Elisa C S Azzolini, Roberta B Vermelho, Alberto Malvezzi, Antonia T-do Amaral, João Luis C Lopes, Yara Maria Lucisano-Valim. 7-Hydroxycoumarin modulates the oxidative metabolism, degranulation and microbial killing of human neutrophils. Chemico-biological interactions. 2013 Oct; 206(1):63-75. doi: 10.1016/j.cbi.2013.08.010. [PMID: 23994743]
  • Michal Kielbus, Krystyna Skalicka-Wozniak, Aneta Grabarska, Witold Jeleniewicz, Magdalena Dmoszynska-Graniczka, Andrew Marston, Krzysztof Polberg, Piotr Gawda, Janusz Klatka, Andrzej Stepulak. 7-substituted coumarins inhibit proliferation and migration of laryngeal cancer cells in vitro. Anticancer research. 2013 Oct; 33(10):4347-56. doi: . [PMID: 24123002]
  • Saoussen Ben Salem, Aymen Jabrane, Fethia Harzallah-Skhiri, Hichem Ben Jannet. New bioactive dihydrofuranocoumarins from the roots of the Tunisian Ferula lutea (Poir.) Maire. Bioorganic & medicinal chemistry letters. 2013 Jul; 23(14):4248-52. doi: 10.1016/j.bmcl.2013.04.081. [PMID: 23746477]
  • Hamid Reza Monsef-Esfahani, Mohsen Amini, Navid Goodarzi, Fatemeh Saiedmohammadi, Reza Hajiaghaee, Mohammad Ali Faramarzi, Zahra Tofighi, Mohammad Hossein Ghahremani. Coumarin compounds of Biebersteinia multifida roots show potential anxiolytic effects in mice. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2013 Jun; 21(1):51. doi: 10.1186/2008-2231-21-51. [PMID: 23803166]
  • Laura Mercolini, Roberto Mandrioli, Anna Ferranti, Vittorio Sorella, Michele Protti, Francesco Epifano, Massimo Curini, Maria Augusta Raggi. Quantitative evaluation of auraptene and umbelliferone, chemopreventive coumarins in citrus fruits, by HPLC-UV-FL-MS. Journal of agricultural and food chemistry. 2013 Feb; 61(8):1694-701. doi: 10.1021/jf303060b. [PMID: 23083450]
  • H A M Mutsaers, M J G Wilmer, D Reijnders, J Jansen, P H H van den Broek, M Forkink, E Schepers, G Glorieux, R Vanholder, L P van den Heuvel, J G Hoenderop, R Masereeuw. Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration. Biochimica et biophysica acta. 2013 Jan; 1832(1):142-50. doi: 10.1016/j.bbadis.2012.09.006. [PMID: 23017367]
  • Yun-Wei Shi, Cai-Ping Wang, Xing Wang, Yuan-Li Zhang, Lei Liu, Ru-Wei Wang, Jian-Feng Ye, Lin-Shui Hu, Ling-Dong Kong. Uricosuric and nephroprotective properties of Ramulus Mori ethanol extract in hyperuricemic mice. Journal of ethnopharmacology. 2012 Oct; 143(3):896-904. doi: 10.1016/j.jep.2012.08.023. [PMID: 22967667]
  • Dan Li, Elizabeth M Ellis. Inducible protection of human astrocytoma 1321N1 cells against hydrogen peroxide and aldehyde toxicity by 7-hydroxycoumarin is associated with the upregulation of aldo-keto reductases. Neurotoxicology. 2012 Oct; 33(5):1368-74. doi: 10.1016/j.neuro.2012.08.015. [PMID: 22964423]
  • Nallely E Sandoval-Montemayor, Abraham García, Elizabeth Elizondo-Treviño, Elvira Garza-González, Laura Alvarez, María del Rayo Camacho-Corona. Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. Molecules (Basel, Switzerland). 2012 Sep; 17(9):11173-84. doi: 10.3390/molecules170911173. [PMID: 22992784]
  • Xia Liu, Yan-Ling Liu, Xiao-Feng Niu, Lin Qi. [Study on the chemical constituents of Chloranthus multistachys]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Aug; 35(8):1254-6. doi: . [PMID: 23320357]
  • Sandra Roche, Louise Sewell, Justine Meiller, Kasper Pedersen, Rajesh Rajpal, Peter O'Gorman, Martin Clynes, Robert O'Connor. Development, validation and application of a sensitive LC-MS/MS method for the quantification of thalidomide in human serum, cells and cell culture medium. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Aug; 902(?):16-26. doi: 10.1016/j.jchromb.2012.06.008. [PMID: 22771235]
  • Lian Zhou, Randy C Dockens, Peggy Liu-Kreyche, Scott J Grossman, Ramaswamy A Iyer. In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jun; 40(6):1093-103. doi: 10.1124/dmd.111.043596. [PMID: 22381334]
  • Hyun Ah Jung, Jin Ju Park, Md Nurul Islam, Seung Eun Jin, Byung-Sun Min, Je-Hyun Lee, Hee Sook Sohn, Jae Sue Choi. Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation. Archives of pharmacal research. 2012 Jun; 35(6):1021-35. doi: 10.1007/s12272-012-0610-0. [PMID: 22870812]
  • Hanneke G M Wittgen, Jeroen J M W van den Heuvel, Petra H H van den Broek, Sanna Siissalo, Geny M M Groothuis, Inge A M de Graaf, Jan B Koenderink, Frans G M Russel. Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jun; 40(6):1076-9. doi: 10.1124/dmd.111.044438. [PMID: 22415933]
  • Ralph Peterli, Robert E Steinert, Bettina Woelnerhanssen, Thomas Peters, Caroline Christoffel-Courtin, Markus Gass, Beatrice Kern, Markus von Fluee, Christoph Beglinger. Metabolic and hormonal changes after laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy: a randomized, prospective trial. Obesity surgery. 2012 May; 22(5):740-8. doi: 10.1007/s11695-012-0622-3. [PMID: 22354457]
  • Krystyna Skalicka-Woźniak, Kazimierz Głowniak. Pressurized liquid extraction of coumarins from fruits of Heracleum leskowii with application of solvents with different polarity under increasing temperature. Molecules (Basel, Switzerland). 2012 Apr; 17(4):4133-41. doi: 10.3390/molecules17044133. [PMID: 22481536]
  • Lei He, Shunli Yang, Desong Wu, Tao Cui, Di Wei, Zhongtao Ding. [Coumarins from Skimmia arborescens and its anti-inflammatory effect]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Mar; 37(6):811-3. doi: . [PMID: 22715728]
  • Amani S Awaad, Nabilah A Al-Jaber, Gamal A Soliman, Mounerah R Al-Outhman, Mohamed E Zain, John E Moses, Reham M El-Meligy. New biological activities of Casimiroa edulis leaf extract and isolated compounds. Phytotherapy research : PTR. 2012 Mar; 26(3):452-7. doi: 10.1002/ptr.3690. [PMID: 22173732]
  • Min Hong, Hong-Yu Ma, Xiang-Rui Wu, Yong-Qing Hua, Quan Zhu, Hong-Wei Fan. A method of hepatocyte extraction conjugated with HPLC is established for screening potential active components in Chinese medicines--probing Herba Artemisiae Scopariae as an exemplifying approach. Molecules (Basel, Switzerland). 2012 Feb; 17(2):1468-82. doi: 10.3390/molecules17021468. [PMID: 22310168]
  • Xing Su, Xiang-kun Li, Tao Wu, Tong Zhang, Zhen-tao Wang. [Fingerprint analysis of Glehniae Radix by TLC]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Feb; 35(2):210-3. doi: . [PMID: 22822664]
  • Seitaro Matsumoto, Masaharu Mizutani, Kanzo Sakata, Bun-Ichi Shimizu. Molecular cloning and functional analysis of the ortho-hydroxylases of p-coumaroyl coenzyme A/feruloyl coenzyme A involved in formation of umbelliferone and scopoletin in sweet potato, Ipomoea batatas (L.) Lam. Phytochemistry. 2012 Feb; 74(?):49-57. doi: 10.1016/j.phytochem.2011.11.009. [PMID: 22169019]
  • Amani S Awaad, Gamal A Soliman, Dalia F El-Sayed, Omimah D El-Gindi, Saleh I Alqasoumi. Hepatoprotective activity of Cyperus alternifolius on carbon tetrachloride-induced hepatotoxicity in rats. Pharmaceutical biology. 2012 Feb; 50(2):155-61. doi: 10.3109/13880209.2011.580351. [PMID: 22235884]
  • Christiaan J Malherbe, Dalene De Beer, Elizabeth Joubert. Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives. International journal of molecular sciences. 2012; 13(3):3101-3133. doi: 10.3390/ijms13033101. [PMID: 22489144]
  • Vijayalakshmi, Shalini Adiga, Priyanka Bhat, Abhishek Chaturvedi, K L Bairy, Shobha Kamath. Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats. Indian journal of pharmacology. 2012 Jan; 44(1):82-7. doi: 10.4103/0253-7613.91873. [PMID: 22345876]
  • Jie Sun, Shao-fang Liu, Chu-shu Zhang, Li-na Yu, Jie Bi, Feng Zhu, Qing-li Yang. Chemical composition and antioxidant activities of Broussonetia papyrifera fruits. PloS one. 2012; 7(2):e32021. doi: 10.1371/journal.pone.0032021. [PMID: 22389678]