Sesamol (BioDeep_00000860699)
Main id: BioDeep_00000008346
PANOMIX_OTCML-2023 Antitumor activity
代谢物信息卡片
InChI=1\C7H6O3\c8-5-1-2-6-7(3-5)10-4-9-6\h1-3,8H,4H
化学式: C7H6O3 (138.03169259999999)
中文名称: 芝麻酚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1OC2=C(O1)C=C(C=C2)O
InChI: InChI=1S/C7H6O3/c8-5-1-2-6-7(3-5)10-4-9-6/h1-3,8H,4H2
描述信息
D020011 - Protective Agents > D000975 - Antioxidants
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Sesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC50=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities[1]. Anticancer activities[2].
Sesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC50=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities[1]. Anticancer activities[2].
同义名列表
26 个代谢物同义名
InChI=1\C7H6O3\c8-5-1-2-6-7(3-5)10-4-9-6\h1-3,8H,4H; 5-19-02-00532 (Beilstein Handbook Reference); Methylene ether of oxyhydroquinone; Phenol, 3,4-(methylenedioxy)-; 5-hydroxy-1,3-benzodioxole; 3,4-(Methylenedioxy)phenol; 3,4-Methylenedioxyphenol; SDCCGMLS-0066221.P001; WLN: T56 BO DO CHJ GQ; 1,3-Benzodioxol-5-ol; EINECS 208-561-5; NCGC00091628-01; 5-Benzodioxolol; S3003_ALDRICH; ZINC00164504; 85070_FLUKA; BRN 0127405; S8518_SIGMA; CCRIS 1386; ST5330663; AI3-17298; NSC 59256; 533-31-3; NSC59256; Sesamol; C10832
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:9126
- PubChem: 68289
- ChEMBL: CHEMBL1517998
- CAS: 533-31-3
- medchemexpress: HY-N1417
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
7 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bei-Bei Hu, Wen-Ting Yin, Heng-Bo Zhang, Zhuo-Qing Zhai, Hua-Min Liu, Xue-de Wang. The interaction between lipid oxidation and the Maillard reaction model of lysine-glucose on aroma formation in fragrant sesame oil.
Food research international (Ottawa, Ont.).
2024 Jun; 186(?):114397. doi:
10.1016/j.foodres.2024.114397. [PMID: 38729739] - Parneet Kaur Deol, Indu Pal Kaur, Ravi Dhiman, Harmanjot Kaur, Garima Sharma, Parveen Rishi, Deepa Ghosh. Investigating wound healing potential of sesamol loaded solid lipid nanoparticles: Ex-vivo, in vitro and in-vivo proof of concept.
International journal of pharmaceutics.
2024 Apr; 654(?):123974. doi:
10.1016/j.ijpharm.2024.123974. [PMID: 38447777] - YuChen Jiang, LiShuang Hou, JiaYi Dou, MeiYan Xuan, ZhenYu Cui, LiHua Lian, JiXing Nan, YanLing Wu. Sesamol as a potential candidate for the treatment of hepatic fibrosis, based on its regulation of FXR/LXR axis-mediated inhibition of autophagy through crosstalk between hepatic cells and macrophage.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 123(?):155145. doi:
10.1016/j.phymed.2023.155145. [PMID: 37976698] - Guangyi Wang, Lele Liu, Fuliang Peng, Yuchen Ma, Zeyuan Deng, Hongyan Li. Natural antioxidants enhance the oxidation stability of blended oils enriched in unsaturated fatty acids.
Journal of the science of food and agriculture.
2023 Nov; ?(?):. doi:
10.1002/jsfa.13183. [PMID: 38029376] - Shorouk Mohamed El-Sayyad, Dina M Abo El-Ella, Mohamed M Hafez, Asmaa K Al-Mokaddem, Bassam Mohamed Ali, Magdy M Awny, Soad Z El-Emam. Sesamol defends neuronal damage following cerebral ischemia/reperfusion: a crosstalk of autophagy and Notch1/NLRP3 inflammasome signaling.
Inflammopharmacology.
2023 Oct; ?(?):. doi:
10.1007/s10787-023-01355-1. [PMID: 37848698] - Khadega Khamis Moh Alazoumi, Pradakshina Sharma, Asimul Islam, Humaira Farooqi. Mitigation of the Deleterious Effect of Heavy Metals on the Conformational Stability of Ubiquitin through Osmoprotectants.
Cell biochemistry and biophysics.
2023 Oct; ?(?):. doi:
10.1007/s12013-023-01188-3. [PMID: 37843791] - Preeti Mehta, Rekha Rani, Ravi Gupta, Anshu Mathur, Sankara Sri Venkata Ramakumar. Simultaneous production of high-value lipids in Schizochytrium sp. by synergism of chemical modulators.
Applied microbiology and biotechnology.
2023 Oct; 107(19):6135-6149. doi:
10.1007/s00253-023-12698-8. [PMID: 37555947] - Wenya Zheng, Jinxin Yang, Quanquan Zhang, Minghui Cheng, Horia Shaukat, Hong Qin. Sesamol Alleviates High-Fat Diet-Induced Hepatic Insulin Resistance in C57BL/6 J Mice Through AMPK Activation Mediated by Adipose Adiponectin.
Plant foods for human nutrition (Dordrecht, Netherlands).
2023 Sep; ?(?):. doi:
10.1007/s11130-023-01108-z. [PMID: 37775709] - Likun Huang, Jingshi Yang, Zhishan Liang, Ruilian Liang, Hui Luo, Zhonghui Sun, Dongxue Han, Li Niu. Ternary Heterojunction Graphitic Carbon Nitride/Cupric Sulfide/Titanium Dioxide Photoelectrochemical Sensor for Sesamol Quantification and Antioxidant Synergism.
Biosensors.
2023 Aug; 13(9):. doi:
10.3390/bios13090859. [PMID: 37754093] - Amin F Majdalawieh, Aaram E Eltayeb, Imad A Abu-Yousef, Sarah M Yousef. Hypolipidemic and Anti-Atherogenic Effects of Sesamol and Possible Mechanisms of Action: A Comprehensive Review.
Molecules (Basel, Switzerland).
2023 Apr; 28(8):. doi:
10.3390/molecules28083567. [PMID: 37110801] - Longkai Shi, Emad Karrar, Ruijie Liu, Ming Chang, Xingguo Wang. Comparative effects of sesame lignans (sesamin, sesamolin, and sesamol) on oxidative stress and lipid metabolism in steatosis HepG2 cells.
Journal of food biochemistry.
2022 08; 46(8):e14180. doi:
10.1111/jfbc.14180. [PMID: 35396857] - Nermeen B El-Borai, Basma A Elkhadrawey, Huda O AbuBakr, Anis Anis, Badr E El-Bialy, Hesham S Elsabbagh, Shimaa M Abou-Zeid. Sesamol protects against aluminum oxide nanoparticles-induced hepatorenal toxicity in rats via modulation of oxidative stress, inflammation, apoptosis, and DNA damage.
Environmental toxicology.
2022 Aug; 37(8):1914-1924. doi:
10.1002/tox.23537. [PMID: 35403826] - Malihe Keramat, Mohammad-Taghi Golmakani, Mehrdad Niakousari. Effect of polyglycerol polyricinoleate on the inhibitory mechanism of sesamol during bulk oil oxidation.
Scientific reports.
2022 07; 12(1):11946. doi:
10.1038/s41598-022-16201-7. [PMID: 35831366] - Athar Talebi, Parisa Hayat, Ali Ghanbari, Maryam Ardekanian, Sam Zarbakhsh. Sesamol protects the function and structure of rat ovaries against side effects of cyclophosphamide by decreasing oxidative stress and apoptosis.
The journal of obstetrics and gynaecology research.
2022 Jul; 48(7):1786-1794. doi:
10.1111/jog.15315. [PMID: 35613704] - Lei Wang, Weixuan Chen, Yujie Tian, Xiaorong Duan, Yi Yuan, Na Wang, Chao Xu, Xuebo Liu, Zhigang Liu. Preventive Effects of Sesamol on Deep-Frying Oil-Induced Liver Metabolism Disorders by Altering Gut Microbiota and Protecting Gut Barrier Integrity.
Molecular nutrition & food research.
2022 05; 66(9):e2101122. doi:
10.1002/mnfr.202101122. [PMID: 35184393] - Bing Xia, Xiaoning Liu, Xiaohan Li, Yutang Wang, Danna Wang, Rongwei Kou, Li Zhang, Renjie Shi, Jin Ye, Xiaowei Bo, Qian Liu, Beita Zhao, Xuebo Liu. Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis mice: the potential involvement of the gut-brain axis.
Food & function.
2022 Mar; 13(5):2865-2883. doi:
10.1039/d1fo03888e. [PMID: 35179534] - Sônia Mendes da Silva Navarro, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Marcos Roberto de Oliveira. Sesamol prevents mitochondrial impairment and pro-inflammatory alterations in the human neuroblastoma SH-SY5Y cells: role for Nrf2.
Metabolic brain disease.
2022 03; 37(3):607-617. doi:
10.1007/s11011-021-00875-5. [PMID: 35000053] - Min-Min Hu, Wen-Ya Zheng, Ming-Hui Cheng, Zi-Yu Song, Horia Shaukat, Mahnoor Atta, Hong Qin. Sesamol Reverses Myofiber-Type Conversion in Obese States via Activating the SIRT1/AMPK Signal Pathway.
Journal of agricultural and food chemistry.
2022 Feb; 70(7):2253-2264. doi:
10.1021/acs.jafc.1c08036. [PMID: 35166533] - Zhendong Bao, Yuanmin Zhu, Yumei Feng, Kai Zhang, Meng Zhang, Zhikuan Wang, Longjiang Yu. Enhancement of lipid accumulation and docosahexaenoic acid synthesis in Schizochytrium sp. H016 by exogenous supplementation of sesamol.
Bioresource technology.
2022 Feb; 345(?):126527. doi:
10.1016/j.biortech.2021.126527. [PMID: 34896539] - Daiki Oikawa, Satoshi Yamashita, Seiji Takahashi, Toshiyuki Waki, Koichi Kikuchi, Takaaki Abe, Takane Katayama, Toru Nakayama. (+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis.
Biochemical and biophysical research communications.
2022 01; 590(?):158-162. doi:
10.1016/j.bbrc.2021.12.088. [PMID: 34974305] - Wenya Zheng, Ziyu Song, Sha Li, Minmin Hu, Horia Shaukat, Hong Qin. Protective Effects of Sesamol against Liver Oxidative Stress and Inflammation in High-Fat Diet-Induced Hepatic Steatosis.
Nutrients.
2021 Dec; 13(12):. doi:
10.3390/nu13124484. [PMID: 34960036] - Longkai Shi, Emad Karrar, Xingguo Wang. Sesamol ameliorates hepatic lipid accumulation and oxidative stress in steatosis HepG2 cells via the PPAR signaling pathway.
Journal of food biochemistry.
2021 11; 45(11):e13976. doi:
10.1111/jfbc.13976. [PMID: 34664288] - Yang Yang, Yuan Qu, Xiaoqiang Lv, Ruijin Zhao, Jing Yu, Suying Hu, Jingqi Kang, Yaling Zhang, Ye Gong, Tingting Cui, Xin Zhang, Yaping Yan. Sesamol supplementation alleviates nonalcoholic steatohepatitis and atherosclerosis in high-fat, high carbohydrate and high-cholesterol diet-fed rats.
Food & function.
2021 Oct; 12(19):9347-9359. doi:
10.1039/d1fo01517f. [PMID: 34606548] - Shaymaa A Abd-Algaleel, Abdelkader A Metwally, Hend Mohamed Abdel-Bar, Dina H Kassem, Rania M Hathout. Synchronizing In Silico, In Vitro, and In Vivo Studies for the Successful Nose to Brain Delivery of an Anticancer Molecule.
Molecular pharmaceutics.
2021 10; 18(10):3763-3776. doi:
10.1021/acs.molpharmaceut.1c00276. [PMID: 34460250] - Shimaa M Abou-Zeid, Basma A Elkhadrawey, Anis Anis, Huda O AbuBakr, Badr E El-Bialy, Hesham S Elsabbagh, Nermeen B El-Borai. Neuroprotective effect of sesamol against aluminum nanoparticle-induced toxicity in rats.
Environmental science and pollution research international.
2021 Oct; 28(38):53767-53780. doi:
10.1007/s11356-021-14587-x. [PMID: 34037932] - Khalid Ibrahim Sallam, Samir Mohammed Abd-Elghany, Kálmán Imre, Adriana Morar, Viorel Herman, Mohamed Abdallah Hussein, Mahmoud Ahmed Mahros. Ensuring safety and improving keeping quality of meatballs by addition of sesame oil and sesamol as natural antimicrobial and antioxidant agents.
Food microbiology.
2021 Oct; 99(?):103834. doi:
10.1016/j.fm.2021.103834. [PMID: 34119118] - Yundong Xie, Jiping Liu, Yongheng Shi, Bin Wang, Xiaoping Wang, Wei Wang, Meng Sun, Xinya Xu, Haihui Jiang, Min Guo, Yiyi He, Cuicui Ren, Lifei Cheng. The combination of sesamol and clofibric acid moieties leads to a novel potent hypolipidemic agent with antioxidant, anti-inflammatory and hepatoprotective activity.
Bioorganic & medicinal chemistry letters.
2021 07; 44(?):128121. doi:
10.1016/j.bmcl.2021.128121. [PMID: 34015506] - Hatice Baş, Fatma Gökçe Apaydın, Suna Kalender, Yusuf Kalender. Lead nitrate and cadmium chloride induced hepatotoxicity and nephrotoxicity: Protective effects of sesamol on biochemical indices and pathological changes.
Journal of food biochemistry.
2021 07; 45(7):e13769. doi:
10.1111/jfbc.13769. [PMID: 34021611] - Lipeng Han, Jiahui Li, Shujie Wang, Weiwei Cheng, Lukai Ma, Guoqin Liu, Dongxue Han, Li Niu. The inhibitory effects of sesamol and sesamolin on the glycidyl esters formation during deodorization of vegetables oils.
Journal of the science of food and agriculture.
2021 Jul; 101(9):3605-3612. doi:
10.1002/jsfa.10989. [PMID: 33275282] - Audrey Damiens, Mohammad Taghi Alebrahim, Estelle Léonard, Antoine Fayeulle, Christophe Furman, Jean-Louis Hilbert, Ali Siah, Muriel Billamboz. Sesamol-based terpenoids as promising bio-sourced crop protection compounds against the wheat pathogen Zymoseptoria tritici.
Pest management science.
2021 May; 77(5):2403-2414. doi:
10.1002/ps.6269. [PMID: 33415837] - Xintian Wang, Kun Yu, Chen Cheng, Dengfeng Peng, Xiao Yu, Hongjian Chen, Yashu Chen, David Julian McClements, Qianchun Deng. Effect of sesamol on the physical and chemical stability of plant-based flaxseed oil-in-water emulsions stabilized by proteins or phospholipids.
Food & function.
2021 Mar; 12(5):2090-2101. doi:
10.1039/d0fo02420a. [PMID: 33554990] - Zhi-Ping Che, Jin-Ming Yang, Xi-Jie Shan, Yue-E Tian, Sheng-Ming Liu, Xiao-Min Lin, Jia Jiang, Mei Hu, Gen-Qiang Chen. Synthesis and insecticidal activity of sulfonate derivatives of sesamol against Mythimna separata in vivo.
Journal of Asian natural products research.
2020 Jul; 22(7):678-688. doi:
10.1080/10286020.2019.1616289. [PMID: 31120307] - Yun Hee Jeong, Gyeong Han Jeong, Yong-Ha Jeong, Tae Hoon Kim. Identification of sesamol byproducts produced by plasma treatment with inhibition of advanced glycation endproducts formation and ONOO- scavenging activities.
Food chemistry.
2020 Jun; 314(?):126196. doi:
10.1016/j.foodchem.2020.126196. [PMID: 31954286] - Dong Ho Lee, Seo-Hyuk Chang, Dong Kwon Yang, No-Joon Song, Ui Jeong Yun, Kye Won Park. Sesamol Increases Ucp1 Expression in White Adipose Tissues and Stimulates Energy Expenditure in High-Fat Diet-Fed Obese Mice.
Nutrients.
2020 May; 12(5):. doi:
10.3390/nu12051459. [PMID: 32443555] - Yazhen Chen, Hetong Lin, Mengshi Lin, Yongzhan Zheng, Jicheng Chen. Effect of roasting and in vitro digestion on phenolic profiles and antioxidant activity of water-soluble extracts from sesame.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 May; 139(?):111239. doi:
10.1016/j.fct.2020.111239. [PMID: 32145351] - Hai-Yan Xu, Liang Yu, Ji-Hua Chen, Li-Na Yang, Cui Lin, Xiu-Quan Shi, Hong Qin. Sesamol Alleviates Obesity-Related Hepatic Steatosis via Activating Hepatic PKA Pathway.
Nutrients.
2020 Jan; 12(2):. doi:
10.3390/nu12020329. [PMID: 31991934] - HeeSun Na, ChulKyoon Mok, JaeHwan Lee. Effects of plasma treatment on the oxidative stability of vegetable oil containing antioxidants.
Food chemistry.
2020 Jan; 302(?):125306. doi:
10.1016/j.foodchem.2019.125306. [PMID: 31416004] - Zeeshan Fatima, Saif Hameed. Lipidomic Insight of Anticandidal Perillyl Alcohol and Sesamol Induced Candida Membrane Disruption: Implications of Lipid Alteration, Impaired Fluidity and Flippase Activity.
Infectious disorders drug targets.
2020; 20(6):784-797. doi:
10.2174/1871526519666191023125020. [PMID: 31657691] - Amin F Majdalawieh, Zeenah R Mansour. Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action.
European journal of pharmacology.
2019 Jul; 855(?):75-89. doi:
10.1016/j.ejphar.2019.05.008. [PMID: 31063773] - Jinjin Diao, Xinyu Song, Jinyu Cui, Liangsen Liu, Mengliang Shi, Fangzhong Wang, Weiwen Zhang. Rewiring metabolic network by chemical modulator based laboratory evolution doubles lipid production in Crypthecodinium cohnii.
Metabolic engineering.
2019 01; 51(?):88-98. doi:
10.1016/j.ymben.2018.10.004. [PMID: 30393203] - Adriane Ribeiro Duarte, Aline Lukasievicz Chenet, Fhelipe Jolner Souza de Almeida, Cláudia Marlise Balbinotti Andrade, Marcos Roberto de Oliveira. The inhibition of heme oxigenase-1 (HO-1) abolishes the mitochondrial protection induced by sesamol in LPS-treated RAW 264.7 cells.
Chemico-biological interactions.
2018 Dec; 296(?):171-178. doi:
10.1016/j.cbi.2018.09.012. [PMID: 30261164] - Bo Ren, Tian Yuan, Zhijun Diao, Chenxi Zhang, Zhigang Liu, Xuebo Liu. Protective effects of sesamol on systemic oxidative stress-induced cognitive impairments via regulation of Nrf2/Keap1 pathway.
Food & function.
2018 Nov; 9(11):5912-5924. doi:
10.1039/c8fo01436a. [PMID: 30375618] - Manuel A Santos Basurto, Anaberta Cardador Martínez, Eduardo Castaño Tostado, Moustapha Bah, Rosalía Reynoso Camacho, Silvia L Amaya Llano. Study of the Interactions Occurring During the Encapsulation of Sesamol within Casein Micelles Reformed from Sodium Caseinate Solutions.
Journal of food science.
2018 Sep; 83(9):2295-2304. doi:
10.1111/1750-3841.14293. [PMID: 30085358] - Seungmi Hong, Mi-Ja Kim, Sungkwon Park, Suyong Lee, Jonggil Lee, JaeHwan Lee. Effects of Hydrogen-Donating or Metal-Chelating Antioxidants on the Oxidative Stability of Organogels Made of Beeswax and Grapeseed Oil Exposed to Light Irradiation.
Journal of food science.
2018 Apr; 83(4):885-891. doi:
10.1111/1750-3841.14085. [PMID: 29524218] - Parichehr Hassanzadeh, Fatemeh Atyabi, Rassoul Dinarvand, Ahmad-Reza Dehpour, Morteza Azhdarzadeh, Meshkat Dinarvand. Application of nanostructured lipid carriers: the prolonged protective effects for sesamol in in vitro and in vivo models of ischemic stroke via activation of PI3K signalling pathway.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2017 Dec; 25(1):25. doi:
10.1186/s40199-017-0191-z. [PMID: 29262855] - Sandeep Hans, Sharda Sharma, Saif Hameed, Zeeshan Fatima. Sesamol exhibits potent antimycobacterial activity: Underlying mechanisms and impact on virulence traits.
Journal of global antimicrobial resistance.
2017 09; 10(?):228-237. doi:
10.1016/j.jgar.2017.06.007. [PMID: 28735047] - Zhigang Liu, Qinglian Qiao, Yali Sun, Yuwei Chen, Bo Ren, Xuebo Liu. Sesamol ameliorates diet-induced obesity in C57BL/6J mice and suppresses adipogenesis in 3T3-L1 cells via regulating mitochondria-lipid metabolism.
Molecular nutrition & food research.
2017 08; 61(8):. doi:
10.1002/mnfr.201600717. [PMID: 28012248] - Puttaraju Srikantamurthy Yashaswini, Bettadahalli Sadashivaiah, Talahalli Ravichandra Ramaprasad, Sridevi Annapurna Singh. In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans.
The Journal of nutritional biochemistry.
2017 03; 41(?):151-157. doi:
10.1016/j.jnutbio.2016.12.010. [PMID: 28095362] - Carmelo Puglia, Maria Rosaria Lauro, Alessia Offerta, Lucia Crascì, Lucia Micicchè, Anna Maria Panico, Francesco Bonina, Giovanni Puglisi. Nanostructured Lipid Carriers (NLC) as Vehicles for Topical Administration of Sesamol: In Vitro Percutaneous Absorption Study and Evaluation of Antioxidant Activity.
Planta medica.
2017 Mar; 83(5):398-404. doi:
10.1055/s-0042-105293. [PMID: 27124246] - Zhigang Liu, Yali Sun, Qinglian Qiao, Tong Zhao, Wentong Zhang, Bo Ren, Qian Liu, Xuebo Liu. Sesamol ameliorates high-fat and high-fructose induced cognitive defects via improving insulin signaling disruption in the central nervous system.
Food & function.
2017 Feb; 8(2):710-719. doi:
10.1039/c6fo01562j. [PMID: 28102395] - Rishi Bhardwaj, S N Sanyal, Kim Vaiphei, Vandita Kakkar, Parneet Kaur Deol, Indu Pal Kaur, Tranum Kaur. Sesamol Induces Apoptosis by Altering Expression of Bcl-2 and Bax Proteins and Modifies Skin Tumor Development in Balb/c Mice.
Anti-cancer agents in medicinal chemistry.
2017; 17(5):726-733. doi:
10.2174/1871520616666160819103249. [PMID: 27539478] - P S Yashaswini, A G Appu Rao, Sridevi A Singh. Inhibition of lipoxygenase by sesamol corroborates its potential anti-inflammatory activity.
International journal of biological macromolecules.
2017 Jan; 94(Pt B):781-787. doi:
10.1016/j.ijbiomac.2016.06.048. [PMID: 27316769] - Moiz A Ansari, Zeeshan Fatima, Saif Hameed. Mechanistic insights into the mode of action of anticandidal sesamol.
Microbial pathogenesis.
2016 Sep; 98(?):140-8. doi:
10.1016/j.micpath.2016.07.004. [PMID: 27392701] - Neha Singh, Neeraj Khullar, Vandita Kakkar, Indu Pal Kaur. Hepatoprotective effects of sesamol loaded solid lipid nanoparticles in carbon tetrachloride induced sub-chronic hepatotoxicity in rats.
Environmental toxicology.
2016 May; 31(5):520-32. doi:
10.1002/tox.22064. [PMID: 25410024] - Min Kim, Yoo-Jung Lee, Seung-Cheol Jee, Inho Choi, Jung-Suk Sung. Anti-adipogenic effects of sesamol on human mesenchymal stem cells.
Biochemical and biophysical research communications.
2016 Jan; 469(1):49-54. doi:
10.1016/j.bbrc.2015.11.070. [PMID: 26616060] - Harvey A Schwertner, John J Stankus. Characterization of the Fluorescent Spectra and Intensities of Various Lignans: Application to HPLC Analysis with Fluorescent Detection†.
Journal of chromatographic science.
2015 Oct; 53(9):1481-4. doi:
10.1093/chromsci/bmv041. [PMID: 25896657] - Neha Singh, Neeraj Khullar, Vandita Kakkar, Indu Pal Kaur. Sesamol loaded solid lipid nanoparticles: a promising intervention for control of carbon tetrachloride induced hepatotoxicity.
BMC complementary and alternative medicine.
2015 May; 15(?):142. doi:
10.1186/s12906-015-0655-y. [PMID: 25935744] - Wei-Yu Chen, Fang-Yu Chen, An-Sheng Lee, Kuan-Hsiang Ting, Chia-Ming Chang, Jing-Fang Hsu, Wei-Shine Lee, Joen-Rong Sheu, Chu-Huang Chen, Ming-Yi Shen. Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro.
Journal of natural products.
2015 Feb; 78(2):225-33. doi:
10.1021/np500700z. [PMID: 25692815] - T Geetha, Meenakshi Kapila, Om Prakash, Parneet Kaur Deol, Vandita Kakkar, Indu Pal Kaur. Sesamol-loaded solid lipid nanoparticles for treatment of skin cancer.
Journal of drug targeting.
2015 Feb; 23(2):159-69. doi:
10.3109/1061186x.2014.965717. [PMID: 25268273] - Anand Kamal Sachdeva, Shubham Misra, Indu Pal Kaur, Kanwaljit Chopra. Neuroprotective potential of sesamol and its loaded solid lipid nanoparticles in ICV-STZ-induced cognitive deficits: behavioral and biochemical evidence.
European journal of pharmacology.
2015 Jan; 747(?):132-40. doi:
10.1016/j.ejphar.2014.11.014. [PMID: 25449035] - S Khan, A Kumar, J S Adhikari, M A Rizvi, N K Chaudhury. Protective effect of sesamol against ⁶⁰Co γ-ray-induced hematopoietic and gastrointestinal injury in C57BL/6 male mice.
Free radical research.
2015; 49(11):1344-61. doi:
10.3109/10715762.2015.1071485. [PMID: 26156438] - T Geetha, Parneet Kaur Deol, Indu Pal Kaur. Role of sesamol-loaded floating beads in gastric cancers: a pharmacokinetic and biochemical evidence.
Journal of microencapsulation.
2015; 32(5):478-87. doi:
NULL. [PMID: 26268954] - Ram M Thushara, Mahadevappa Hemshekhar, Manoj Paul, Mahalingam Shanmuga Sundaram, Rohith L Shankar, Kempaiah Kemparaju, Kesturu S Girish. Crocin prevents sesamol-induced oxidative stress and apoptosis in human platelets.
Journal of thrombosis and thrombolysis.
2014 Oct; 38(3):321-30. doi:
10.1007/s11239-014-1056-7. [PMID: 24705676] - Montra Srisayam, Natthida Weerapreeyakul, Sahapat Barusrux, Waraporn Tanthanuch, Kanjana Thumanu. Application of FTIR microspectroscopy for characterization of biomolecular changes in human melanoma cells treated by sesamol and kojic acid.
Journal of dermatological science.
2014 Mar; 73(3):241-50. doi:
10.1016/j.jdermsci.2013.11.002. [PMID: 24296160] - Montra Srisayam, Natthida Weerapreeyakul, Sahapat Barusrux, Kwanjai Kanokmedhakul. Antioxidant, antimelanogenic, and skin-protective effect of sesamol.
Journal of cosmetic science.
2014 Mar; 65(2):69-79. doi:
. [PMID: 24797023] - Victor Raj Mohan Chandrasekaran, Dur-Zong Hsu, Ming-Yie Liu. Beneficial effect of sesame oil on heavy metal toxicity.
JPEN. Journal of parenteral and enteral nutrition.
2014 Feb; 38(2):179-85. doi:
10.1177/0148607113490960. [PMID: 23744838] - S Jnaneshwari, M Hemshekhar, R M Thushara, M Shanmuga Sundaram, M Sebastin Santhosh, K Sunitha, R L Shankar, K Kemparaju, K S Girish. Sesamol ameliorates cyclophosphamide-induced hepatotoxicity by modulating oxidative stress and inflammatory mediators.
Anti-cancer agents in medicinal chemistry.
2014; 14(7):975-83. doi:
10.2174/1871520613666131224123346. [PMID: 24372526] - Zhigang Liu, Qisen Xiang, Lihui Du, Ge Song, Yutang Wang, Xuebo Liu. The interaction of sesamol with DNA and cytotoxicity, apoptosis, and localization in HepG2 cells.
Food chemistry.
2013 Nov; 141(1):289-96. doi:
10.1016/j.foodchem.2013.02.105. [PMID: 23768360] - Mahadevappa Hemshekhar, Ram Mohan Thushara, Sadashivaiah Jnaneshwari, Sannaningaiah Devaraja, Kempaiah Kemparaju, Kesturu Subbaiah Girish. Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status.
European journal of nutrition.
2013 Oct; 52(7):1787-99. doi:
10.1007/s00394-012-0482-6. [PMID: 23269651] - A Kaur, S Jindal, I P Kaur, K Chopra. Effect of sesamol on the pathophysiological changes induced by surgical menopause in rodents.
Climacteric : the journal of the International Menopause Society.
2013 Aug; 16(4):426-37. doi:
10.3109/13697137.2012.696292. [PMID: 23017032] - Pawan G Nayak, Piya Paul, Punit Bansal, Nampurath Gopalan Kutty, Karkala Sreedhara Ranganath Pai. Sesamol prevents doxorubicin-induced oxidative damage and toxicity on H9c2 cardiomyoblasts.
The Journal of pharmacy and pharmacology.
2013 Jul; 65(7):1083-93. doi:
10.1111/jphp.12073. [PMID: 23738736] - Govindasamy Hemalatha, Kodukkur Viswanathan Pugalendi, Ramalingam Saravanan. Modulatory effect of sesamol on DOCA-salt-induced oxidative stress in uninephrectomized hypertensive rats.
Molecular and cellular biochemistry.
2013 Jul; 379(1-2):255-65. doi:
10.1007/s11010-013-1647-1. [PMID: 23576423] - Nitesh Kumar, Jayesh Mudgal, Vipan K Parihar, Pawan G Nayak, N Gopalan Kutty, C Mallikarjuna Rao. Sesamol treatment reduces plasma cholesterol and triacylglycerol levels in mouse models of acute and chronic hyperlipidemia.
Lipids.
2013 Jun; 48(6):633-8. doi:
10.1007/s11745-013-3778-2. [PMID: 23504268] - Anusha Chennuru, Mohamed T S Saleem. Antioxidant, lipid lowering, and membrane stabilization effect of sesamol against doxorubicin-induced cardiomyopathy in experimental rats.
BioMed research international.
2013; 2013(?):934239. doi:
10.1155/2013/934239. [PMID: 24228260] - Dur-Zong Hsu, Yi-Wei Chen, Pei-Yi Chu, Srinivasan Periasamy, Ming-Yie Liu. Protective effect of 3,4-methylenedioxyphenol (sesamol) on stress-related mucosal disease in rats.
BioMed research international.
2013; 2013(?):481827. doi:
10.1155/2013/481827. [PMID: 23984371] - Anil Kumar, Gurleen Kaur, Harikesh Kalonia, Puneet Rinwa. Evaluation of sesamol and buspirone in stress induced anxiety in mice.
Indian journal of pharmacology.
2013 Jan; 45(1):49-53. doi:
10.4103/0253-7613.106435. [PMID: 23543858] - Phani Krishna Kondamudi, Hemalatha Kovelamudi, Geetha Mathew, Pawan G Nayak, C Mallikarjuna Rao, Rekha R Shenoy. Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats.
Pharmacological reports : PR.
2013; 65(3):658-65. doi:
10.1016/s1734-1140(13)71043-0. [PMID: 23950588] - Lakshmanan Vennila, Kodukkur Viswanathan Pugalendi. Efficacy of sesamol on plasma and tissue lipids in isoproterenol-induced cardiotoxicity in Wistar rats.
Archives of pharmacal research.
2012 Aug; 35(8):1465-70. doi:
10.1007/s12272-012-0817-0. [PMID: 22941490] - Lee Recht, Aliza Zarka, Sammy Boussiba. Patterns of carbohydrate and fatty acid changes under nitrogen starvation in the microalgae Haematococcus pluvialis and Nannochloropsis sp.
Applied microbiology and biotechnology.
2012 Jun; 94(6):1495-503. doi:
10.1007/s00253-012-3940-4. [PMID: 22361859] - P-Y Chu, P Srinivasan, J-F Deng, M-Y Liu. Sesamol attenuates oxidative stress-mediated experimental acute pancreatitis in rats.
Human & experimental toxicology.
2012 Apr; 31(4):397-404. doi:
10.1177/0960327111426583. [PMID: 22076497] - Xiaoping Wang, Huanping Lin, Yan Gu. Multiple roles of dihomo-γ-linolenic acid against proliferation diseases.
Lipids in health and disease.
2012 Feb; 11(?):25. doi:
10.1186/1476-511x-11-25. [PMID: 22333072] - Bunichiro Ashibe, Yu Nakajima, Yuka Fukui, Kiyoto Motojima. PPARα as a Transcriptional Regulator for Detoxification of Plant Diet-Derived Unfavorable Compounds.
PPAR research.
2012; 2012(?):814945. doi:
10.1155/2012/814945. [PMID: 22577367] - Philippe Jeandet, Bertrand Delaunois, Aziz Aziz, David Donnez, Yann Vasserot, Sylvain Cordelier, Eric Courot. Metabolic engineering of yeast and plants for the production of the biologically active hydroxystilbene, resveratrol.
Journal of biomedicine & biotechnology.
2012; 2012(?):579089. doi:
10.1155/2012/579089. [PMID: 22654481] - Tao Ke, Caihua Dong, Han Mao, Yingzhong Zhao, Hong Chen, Hongyan Liu, Xuyan Dong, Chaobo Tong, Shengyi Liu. Analysis of expression sequence tags from a full-length-enriched cDNA library of developing sesame seeds (Sesamum indicum).
BMC plant biology.
2011 Dec; 11(?):180. doi:
10.1186/1471-2229-11-180. [PMID: 22195973] - Vandita Kakkar, Anil Kumar Mishra, Krishna Chuttani, Kanwaljit Chopra, Indu Pal Kaur. Delivery of sesamol-loaded solid lipid nanoparticles to the brain for menopause-related emotional and cognitive central nervous system derangements.
Rejuvenation research.
2011 Dec; 14(6):597-604. doi:
10.1089/rej.2011.1193. [PMID: 21978086] - Annia Galano, Juan Raúl Alvarez-Idaboy, Misaela Francisco-Márquez. Physicochemical insights on the free radical scavenging activity of sesamol: importance of the acid/base equilibrium.
The journal of physical chemistry. B.
2011 Nov; 115(44):13101-9. doi:
10.1021/jp208315k. [PMID: 21967544] - Victor Raj Mohan Chandrasekaran, Se-Ping Chien, Dur-Zong Hsu, Ming-Yie Liu. Anti-hepatotoxic effects of 3,4-methylenedioxyphenol and N-acetylcysteine in acutely acetaminophen-overdosed mice.
Human & experimental toxicology.
2011 Oct; 30(10):1609-15. doi:
10.1177/0960327110394226. [PMID: 21239480] - Ying-Hui Chen, Sew-Fen Leu, Chun-Yi Jen, Bu-Miin Huang. Effects of sesamol on apoptosis and steroidogenesis in MA-10 mouse Leydig tumor cells.
Journal of agricultural and food chemistry.
2011 Sep; 59(18):9885-91. doi:
10.1021/jf2021539. [PMID: 21863802] - Chifumi Kinugasa, Aki Naemura, Kanae Hyodo, Yoshiki Nakai, Masumi Katsuta, Junichiro Yamamoto. Experimental antithrombotic effects of sesame seed whole grains and extracts.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2011 Sep; 22(6):526-31. doi:
10.1097/mbc.0b013e328347b085. [PMID: 21577091] - Ismene A Dontas, Katerina A Marinou, Dimitrios Iliopoulos, Nektaria Tsantila, George Agrogiannis, Apostolos Papalois, Theodore Karatzas. Changes of blood biochemistry in the rabbit animal model in atherosclerosis research; a time- or stress-effect.
Lipids in health and disease.
2011 Aug; 10(?):139. doi:
10.1186/1476-511x-10-139. [PMID: 21838924] - Jatuporn Wichitsranoi, Natthida Weerapreeyakul, Patcharee Boonsiri, Chatri Settasatian, Nongnuch Settasatian, Nantarat Komanasin, Suchart Sirijaichingkul, Yaovalak Teerajetgul, Nuchanart Rangkadilok, Naruemon Leelayuwat. Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans.
Nutrition journal.
2011 Aug; 10(?):82. doi:
10.1186/1475-2891-10-82. [PMID: 21827664] - Shubham Misra, Vinod Tiwari, Anurag Kuhad, Kanwaljit Chopra. Modulation of nitrergic pathway by sesamol prevents cognitive deficits and associated biochemical alterations in intracerebroventricular streptozotocin administered rats.
European journal of pharmacology.
2011 Jun; 659(2-3):177-86. doi:
10.1016/j.ejphar.2011.03.026. [PMID: 21463622] - Baldeep Kumar, Anurag Kuhad, Kanwaljit Chopra. Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences.
Psychopharmacology.
2011 Apr; 214(4):819-28. doi:
10.1007/s00213-010-2094-2. [PMID: 21103863] - Zhekang Ying, Nisharahmed Kherada, Thomas Kampfrath, Georgeta Mihai, Orlando Simonetti, Rajagopal Desikan, Karuppaiyah Selvendiran, Qinghua Sun, Ouiliana Ziouzenkova, Sampath Parthasarathy, Sanjay Rajagopalan. A modified sesamol derivative inhibits progression of atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology.
2011 Mar; 31(3):536-42. doi:
10.1161/atvbaha.110.219287. [PMID: 21183734] - K C Nam, K S Seo, C Jo, D U Ahn. Electrostatic spraying of antioxidants on the oxidative quality of ground beef.
Journal of animal science.
2011 Mar; 89(3):826-32. doi:
10.2527/jas.2010-3326. [PMID: 21097682] - Prisna Pianjing, Apinya Thiantanawat, Nuchanart Rangkadilok, Piyajit Watcharasit, Chulabhorn Mahidol, Jutamaad Satayavivad. Estrogenic activities of sesame lignans and their metabolites on human breast cancer cells.
Journal of agricultural and food chemistry.
2011 Jan; 59(1):212-21. doi:
10.1021/jf102006w. [PMID: 21141889] - Nishant P Visavadiya, A V R L Narasimhacharya. Ameliorative effects of herbal combinations in hyperlipidemia.
Oxidative medicine and cellular longevity.
2011; 2011(?):160408. doi:
10.1155/2011/160408. [PMID: 21941605] - Srinivasan Periasamy, Fan-E Mo, Shin-Yi Chen, Chih-Ching Chang, Ming-Yie Liu. Sesamol attenuates isoproterenol-induced acute myocardial infarction via inhibition of matrix metalloproteinase-2 and -9 expression in rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2011; 27(3-4):273-80. doi:
10.1159/000327953. [PMID: 21471716] - S Ramachandran, N Rajendra Prasad, S Karthikeyan. Sesamol inhibits UVB-induced ROS generation and subsequent oxidative damage in cultured human skin dermal fibroblasts.
Archives of dermatological research.
2010 Dec; 302(10):733-44. doi:
10.1007/s00403-010-1072-1. [PMID: 20697726]