Castanospermine (BioDeep_00000000860)

   

PANOMIX_OTCML-2023


代谢物信息卡片


1,6,7,8-Indolizinetetrol, octahydro-, (1S-(1alpha,6beta,7alpha,8beta,8abeta))-

化学式: C8H15NO4 (189.100103)
中文名称: 亚胺糖栗树精胺, 栗精胺
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.85%

分子结构信息

SMILES: C1CN2CC(C(C(C2C1O)O)O)O
InChI: InChI=1S/C8H15NO4/c10-4-1-2-9-3-5(11)7(12)8(13)6(4)9/h4-8,10-13H,1-3H2

描述信息

Castanospermine is a tetrahydroxyindolizidine alkaloid that consists of octahydroindolizine having four hydroxy substituents located at positions 1, 6, 7 and 8 (the 1S,6S,7R,8R,8aR-diastereomer). It has a role as a metabolite, an anti-HIV-1 agent, an anti-inflammatory agent and an EC 3.2.1.* (glycosidase) inhibitor.
Castanospermine is a natural product found in Alexa grandiflora, Alexa wachenheimii, and other organisms with data available.
A tetrahydroxyindolizidine alkaloid that consists of octahydroindolizine having four hydroxy substituents located at positions 1, 6, 7 and 8 (the 1S,6S,7R,8R,8aR-diastereomer).
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D007004 - Hypoglycemic Agents > D065089 - Glycoside Hydrolase Inhibitors
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
D004791 - Enzyme Inhibitors
KEIO_ID C043
Castanospermine inhibits all forms of α- and β-glucosidases, especially glucosidase L.

同义名列表

42 个代谢物同义名

1,6,7,8-Indolizinetetrol, octahydro-, (1S-(1alpha,6beta,7alpha,8beta,8abeta))-; (1S-(1alpha,6beta,7alpha,8beta,8alphabeta))-octahydro-1,6,7,8-indolizinetetrol; Castanospermine, >=94\\% (GC), BioUltra, from Castanospermum australe seeds; (1S,6S,7R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,6,7,8-tetrol; [1S-(1?,6?,7?,8?,8a?)]-Octahydro-1,6,7,8-indolizinetetrol; 1,6,7,8-Indolizinetetrol, octahydro-,?(1S,6S,7R,8R,8aR)-; (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine, 98\\%; (1S,6S,7R,8R,8aR)-octahydroindolizine-1,6,7,8-tetraol; (1S,6S,7R,8R,8aR)-octahydroindolizine-1,6,7,8-tetrol; (1S,6S,7R,8R,8aR)-Octahydro-1,6,7,8-indolizinetetrol; (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine; CASTANOSPERMINE FROM CASTANOSPERMUM AUSTRALE SEEDS; Octahydro-indolizine-1,6,7,8-tetraol, 13; 1,6,7,8-tetrahydroxyoctahydroindolizine; Octahydro-indolizine-1,6,7,8-tetraol; JDVVGAQPNNXQDW-TVNFTVLESA-N; 6,7-diepicastanospermine; CASTANOSPERMINE [MI]; 6-epicastanospermine; 1-epicastanospermine; BCBcMAP01_000133; UNII-Q0I3184XM7; Castanospermine; Indolizine der.; castinospermine; KBio3_000544; KBio2_005408; KBio3_000543; KBio2_002840; KBio2_000272; Bio1_000396; IDI1_034022; Bio1_001374; Bio2_000272; Bio1_000885; Bio2_000752; SMP1_000059; Q0I3184XM7; CAST; 2cbu; CTS; octahydroindolizine-1,6,7,8-tetrol



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Elizabeth C Clarke, Robert A Nofchissey, Chunyan Ye, Steven B Bradfute. The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication. Glycobiology. 2021 05; 31(4):378-384. doi: 10.1093/glycob/cwaa091. [PMID: 32985653]
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  • Yu-Pu Hong, Chen Chen, Wen-Yi Guo, Liang Zhao, Fang-Chao Mei, Ming-Wei Xiang, Wei-Xing Wang. Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis. Archives of medical research. 2016 Aug; 47(6):436-445. doi: 10.1016/j.arcmed.2016.11.007. [PMID: 27986123]
  • Szymon Zubek, Sebastian Mielcarek, Katarzyna Turnau. Hypericin and pseudohypericin concentrations of a valuable medicinal plant Hypericum perforatum L. are enhanced by arbuscular mycorrhizal fungi. Mycorrhiza. 2012 Feb; 22(2):149-56. doi: 10.1007/s00572-011-0391-1. [PMID: 21626142]
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