NCBI Taxonomy: 53931

Xanthocercis (ncbi_taxid: 53931)

found 136 associated metabolites at genus taxonomy rank level.

Ancestor: Angylocalyceae

Child Taxonomies: Xanthocercis zambesiaca, Xanthocercis rabiensis, Xanthocercis madagascariensis

Fisetin

2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one

C15H10O6 (286.047736)


Fisetin is a 7-hydroxyflavonol with additional hydroxy groups at positions 3, 3 and 4. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an antioxidant, an anti-inflammatory agent, a metabolite, a plant metabolite and a geroprotector. It is a 3-hydroxyflavonoid, a 7-hydroxyflavonol and a tetrahydroxyflavone. It is a conjugate acid of a fisetin(1-). Fisetin is a natural product found in Acacia carneorum, Acacia buxifolia, and other organisms with data available. Fisetin is an orally bioavailable naturally occurring polyphenol found in many fruits and vegetables, with potential antioxidant, neuroprotective, anti-inflammatory, antineoplastic, senolytic, and longevity promoting activities. Upon administration, fisetin, as an antioxidant, scavenges free radicals, protect cells from oxidative stress, and is able to upregulate glutathione. It inhibits pro-inflammatory mediators, such as tumor necrosis factor alpha (TNF-a), interleukin-6 (IL-6), and nuclear factor kappa B (NF-kB). Fisetin promotes cellular metabolism, reduces senescence, regulates sirtuin function and may promote longevity. Fisetin also exerts anti-cancer activity by inhibiting certain signaling pathways. It also inhibits certain anti-apoptotic proteins and induces apoptosis in susceptible cells. COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials A 7-hydroxyflavonol with additional hydroxy groups at positions 3, 3 and 4. C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor C26170 - Protective Agent > C1509 - Neuroprotective Agent C26170 - Protective Agent > C275 - Antioxidant Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS 3,7,3,4-tetrahydroxyflavone, also known as 5-desoxyquercetin or fisetinidin, is a member of the class of compounds known as flavonols. Flavonols are compounds that contain a flavone (2-phenyl-1-benzopyran-4-one) backbone carrying a hydroxyl group at the 3-position. Thus, 3,7,3,4-tetrahydroxyflavone is considered to be a flavonoid lipid molecule. 3,7,3,4-tetrahydroxyflavone is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). 3,7,3,4-tetrahydroxyflavone is a bitter tasting compound found in soy bean, which makes 3,7,3,4-tetrahydroxyflavone a potential biomarker for the consumption of this food product. relative retention time with respect to 9-anthracene Carboxylic Acid is 0.847 [Raw Data] CB035_Fisetin_pos_20eV_CB000018.txt [Raw Data] CB035_Fisetin_pos_30eV_CB000018.txt [Raw Data] CB035_Fisetin_pos_40eV_CB000018.txt [Raw Data] CB035_Fisetin_pos_10eV_CB000018.txt [Raw Data] CB035_Fisetin_pos_50eV_CB000018.txt [Raw Data] CB035_Fisetin_neg_10eV_000011.txt [Raw Data] CB035_Fisetin_neg_30eV_000011.txt [Raw Data] CB035_Fisetin_neg_40eV_000011.txt [Raw Data] CB035_Fisetin_neg_20eV_000011.txt [Raw Data] CB035_Fisetin_neg_50eV_000011.txt Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects. Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects. Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

   

Castanospermine

1,6,7,8-Indolizinetetrol, octahydro-, (1S-(1alpha,6beta,7alpha,8beta,8abeta))-

C8H15NO4 (189.100103)


Castanospermine is a tetrahydroxyindolizidine alkaloid that consists of octahydroindolizine having four hydroxy substituents located at positions 1, 6, 7 and 8 (the 1S,6S,7R,8R,8aR-diastereomer). It has a role as a metabolite, an anti-HIV-1 agent, an anti-inflammatory agent and an EC 3.2.1.* (glycosidase) inhibitor. Castanospermine is a natural product found in Alexa grandiflora, Alexa wachenheimii, and other organisms with data available. A tetrahydroxyindolizidine alkaloid that consists of octahydroindolizine having four hydroxy substituents located at positions 1, 6, 7 and 8 (the 1S,6S,7R,8R,8aR-diastereomer). D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D007004 - Hypoglycemic Agents > D065089 - Glycoside Hydrolase Inhibitors D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents D002491 - Central Nervous System Agents > D000700 - Analgesics D000893 - Anti-Inflammatory Agents D018501 - Antirheumatic Agents D004791 - Enzyme Inhibitors KEIO_ID C043 Castanospermine inhibits all forms of α- and β-glucosidases, especially glucosidase L.

   

Fagomine

3,4-Piperidinediol, 2-(hydroxymethyl)-, (2R,3R,4R)-

C6H13NO3 (147.0895388)


Fagomine is an alkaloid found in the seeds of Castanospermum australe (commonly known as the Black Bean or the Moreton Bay Chestnut) (PMID: 25583438). Castanospermum australe is a large evergreen tree of the legume family native to the east coast of Australia in Queensland and New South Wales, and to the Pacific islands of Vanuatu, New Caledonia, and the island of New Britain (Papua New Guinea). The seeds are poisonous, but become edible when carefully prepared by roasting, cutting up into small pieces, leaching with running water for several days, and pounding into flour (Wikipedia). Fagomine is a member of piperidines. Fagomine is a natural product found in Lycium chinense, Angylocalyx pynaertii, and other organisms with data available. Alkaloid from buckwheat seeds (Fagopyrum esculentum). Fagomine is found in common buckwheat and cereals and cereal products. Fagomine is a mild glycosidase inhibitor. The Ki of the iminosugar Fagomine is 4.8 μM, 39 μM, and 70 μM for Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast), respectively. Fagomine is a mild glycosidase inhibitor. The Ki of the iminosugar Fagomine is 4.8 μM, 39 μM, and 70 μM for Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast), respectively.

   

1-Deoxynojirimycin

2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol, hydrochloride

C6H13NO4 (163.0844538)


1-Deoxynojirimycin is found in fruits. 1-Deoxynojirimycin is an alkaloid from Morus specie Alkaloid from Morus subspecies 1-Deoxynojirimycin is found in fruits. Same as: D09605 1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[1][2]. 1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].

   

3',7-Dihydroxy-4',8-dimethoxyisoflavone

7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-8-methoxy-4H-chromen-4-one

C17H14O6 (314.0790344)


3,7-Dihydroxy-4,8-dimethoxyisoflavone is isolated from Myroxylon balsamum (Tolu balsam). Isolated from Myroxylon balsamum (Tolu balsam)

   

Marsupsin

2,6-dihydroxy-2-[(4-hydroxyphenyl)methyl]-4-methoxy-2,3-dihydro-1-benzofuran-3-one

C16H14O6 (302.0790344)


   

Castanospermine

octahydroindolizine-1,6,7,8-tetrol

C8H15NO4 (189.100103)


   

3-epi-Fagomine

(2R,3R,4S)-2-(hydroxymethyl)piperidine-3,4-diol

C6H13NO3 (147.0895388)


   

1-Deoxynojirimycin

3,4,5-PIPERIDINETRIOL, 2-(HYDROXYMETHYL)-, (2R-(2.ALPHA.,3.BETA.,4.ALPHA.,5.BETA.))-

C6H13NO4 (163.0844538)


Duvoglustat is an optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. It has a role as an EC 3.2.1.20 (alpha-glucosidase) inhibitor, an anti-HIV agent, an anti-obesity agent, a bacterial metabolite, a hypoglycemic agent, a hepatoprotective agent and a plant metabolite. It is a 2-(hydroxymethyl)piperidine-3,4,5-triol and a piperidine alkaloid. An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity. 1-Deoxynojirimycin is a natural product found in Dorstenia psilurus, Cichorium intybus, and other organisms with data available. An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity. D000890 - Anti-Infective Agents > D000998 - Antiviral Agents C87006 - Pharmacological Chaperone D004791 - Enzyme Inhibitors Same as: D09605 1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[1][2]. 1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[1][2].

   

1-Hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-2-one

1-Hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-2-one

C16H16O5 (288.0997686)


   

8-O-Methylretusin

5-Hydroxy-3,7,3,4-tetramethoxy-8-O-methylflavone

C17H14O5 (298.0841194)


   

Carpusin

2,6-Dihydroxy-2- (4-hydroxybenzyl) -4-methoxybenzofuran-3 (2H) -one

C16H14O6 (302.0790344)


   

3-Hydroxy-8-O-methylretusin

3-Hydroxy-8-O-methylretusin

C17H14O6 (314.0790344)


   

2,5-DIDEOXY-2,5-IMINO-D-MANNITOL

2,5-DIDEOXY-2,5-IMINO-D-MANNITOL

C6H13NO4 (163.0844538)


   

Fagomine

3,4-Piperidinediol, 2-(hydroxymethyl)-, (2R,3R,4R)-

C6H13NO3 (147.0895388)


Fagomine is a mild glycosidase inhibitor. The Ki of the iminosugar Fagomine is 4.8 μM, 39 μM, and 70 μM for Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast), respectively. Fagomine is a mild glycosidase inhibitor. The Ki of the iminosugar Fagomine is 4.8 μM, 39 μM, and 70 μM for Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast), respectively.

   

Viset

InChI=1\C15H10O6\c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7\h1-6,16-18,20

C15H10O6 (286.047736)


COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor C26170 - Protective Agent > C1509 - Neuroprotective Agent C26170 - Protective Agent > C275 - Antioxidant Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects. Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects. Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

   

3-epi-Fagomine

3-epi-Fagomine

C6H13NO3 (147.0895388)


A member of the class of hydroxypiperidines that is piperidine carrying a hydroxymethyl substituent at position 2 as well as two hydroxy substituents at positions 3 and 4 (the 2R,3R,4S-diastereomer).

   

DMDP

2R,5R-Dihydroxymethyl-3R,4R-dihydroxy-pyrrolidine

C6H13NO4 (163.0844538)


   

7,8-dihydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one

7,8-dihydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one

C16H12O6 (300.06338519999997)


   

3-(3,4-dimethoxyphenyl)-7-hydroxy-8-methoxychromen-4-one

3-(3,4-dimethoxyphenyl)-7-hydroxy-8-methoxychromen-4-one

C18H16O6 (328.0946836)


   

2-{[4-hydroxy-2-(hydroxymethyl)piperidin-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

2-{[4-hydroxy-2-(hydroxymethyl)piperidin-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

C12H23NO8 (309.1423598)


   

1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-2-one

1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-2-one

C16H16O4 (272.1048536)


   

3-(3,4-dihydroxyphenyl)-2-hydroxy-1-(4-hydroxy-2-methoxyphenyl)propan-1-one

3-(3,4-dihydroxyphenyl)-2-hydroxy-1-(4-hydroxy-2-methoxyphenyl)propan-1-one

C16H16O6 (304.0946836)


   

2-{[3-hydroxy-2-(hydroxymethyl)piperidin-4-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

2-{[3-hydroxy-2-(hydroxymethyl)piperidin-4-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

C12H23NO8 (309.1423598)


   

2-(hydroxymethyl)piperidine-3,4-diol

2-(hydroxymethyl)piperidine-3,4-diol

C6H13NO3 (147.0895388)


   

2-[(3,4-dihydroxyphenyl)methyl]-2,6-dihydroxy-1-benzofuran-3-one

2-[(3,4-dihydroxyphenyl)methyl]-2,6-dihydroxy-1-benzofuran-3-one

C15H12O6 (288.06338519999997)


   

(1s,7r,8ar)-octahydroindolizine-1,6,7,8-tetrol

(1s,7r,8ar)-octahydroindolizine-1,6,7,8-tetrol

C8H15NO4 (189.100103)


   

(2r,3r,4s,5s,6r)-2-{[(2r,3r,4r)-4-hydroxy-2-(hydroxymethyl)piperidin-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

(2r,3r,4s,5s,6r)-2-{[(2r,3r,4r)-4-hydroxy-2-(hydroxymethyl)piperidin-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

C12H23NO8 (309.1423598)


   

3-(4-hydroxy-3-methoxyphenyl)-8-(3-hydroxy-4-methoxyphenyl)-2-(hydroxymethyl)-2h,3h-[1,4]dioxino[2,3-h]chromen-7-one

3-(4-hydroxy-3-methoxyphenyl)-8-(3-hydroxy-4-methoxyphenyl)-2-(hydroxymethyl)-2h,3h-[1,4]dioxino[2,3-h]chromen-7-one

C26H22O9 (478.1263762)


   

(2r)-2-hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one

(2r)-2-hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one

C16H16O5 (288.0997686)


   

(2s)-2-[(3,4-dihydroxyphenyl)methyl]-2,6-dihydroxy-1-benzofuran-3-one

(2s)-2-[(3,4-dihydroxyphenyl)methyl]-2,6-dihydroxy-1-benzofuran-3-one

C15H12O6 (288.06338519999997)


   

(2s,3r,4s,5r,6r)-2-{[(2r,3r,4r)-4-hydroxy-2-(hydroxymethyl)piperidin-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

(2s,3r,4s,5r,6r)-2-{[(2r,3r,4r)-4-hydroxy-2-(hydroxymethyl)piperidin-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

C12H23NO8 (309.1423598)


   

(2r,3r,4r,5s,6r)-2,6-bis(hydroxymethyl)piperidine-3,4,5-triol

(2r,3r,4r,5s,6r)-2,6-bis(hydroxymethyl)piperidine-3,4,5-triol

C7H15NO5 (193.09501799999998)


   

(1r)-1-hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-2-one

(1r)-1-hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-2-one

C16H16O5 (288.0997686)


   

(2r,3r,4s,5s,6r)-2-{[(2r,3r,4r)-3-hydroxy-2-(hydroxymethyl)piperidin-4-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

(2r,3r,4s,5s,6r)-2-{[(2r,3r,4r)-3-hydroxy-2-(hydroxymethyl)piperidin-4-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

C12H23NO8 (309.1423598)


   

(2s,3r,4s,5r,6r)-2-{[(2r,3r,4r)-3-hydroxy-2-(hydroxymethyl)piperidin-4-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

(2s,3r,4s,5r,6r)-2-{[(2r,3r,4r)-3-hydroxy-2-(hydroxymethyl)piperidin-4-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

C12H23NO8 (309.1423598)


   

(2s)-2,6-dihydroxy-2-[(4-hydroxyphenyl)methyl]-4-methoxy-1-benzofuran-3-one

(2s)-2,6-dihydroxy-2-[(4-hydroxyphenyl)methyl]-4-methoxy-1-benzofuran-3-one

C16H14O6 (302.0790344)


   

(2r,3s,4s)-2-(hydroxymethyl)piperidine-3,4-diol

(2r,3s,4s)-2-(hydroxymethyl)piperidine-3,4-diol

C6H13NO3 (147.0895388)


   

2-hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one

2-hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one

C16H16O5 (288.0997686)


   

(2r)-3-(3,4-dihydroxyphenyl)-2-hydroxy-1-(4-hydroxy-2-methoxyphenyl)propan-1-one

(2r)-3-(3,4-dihydroxyphenyl)-2-hydroxy-1-(4-hydroxy-2-methoxyphenyl)propan-1-one

C16H16O6 (304.0946836)