Hexobarbital (BioDeep_00000858464)

   


代谢物信息卡片


2,4,6(1H,3H,5H)-Pyrimidinetrione,5-(1-cyclohexen-1-yl)-1,5-dimethyl-

化学式: C12H16N2O3 (236.1160866)
中文名称: 环已巴比妥
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C(=O)NC(=O)N(C1=O)C)C2=CCCCC2
InChI: InChI=1S/C12H16N2O3/c1-12(8-6-4-3-5-7-8)9(15)13-11(17)14(2)10(12)16/h6H,3-5,7H2,1-2H3,(H,13,15,17)

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CA - Barbiturates, plain
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AF - Barbiturates, plain
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C67084 - Barbiturate
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators

同义名列表

2 个代谢物同义名

2,4,6(1H,3H,5H)-Pyrimidinetrione,5-(1-cyclohexen-1-yl)-1,5-dimethyl-; Hexobarbital



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chaoyu Zhai, Steven M Lonergan, Elisabeth J Huff-Lonergan, Logan G Johnson, Kitty Brown, Jessica E Prenni, Mahesh N Nair. Lipid Peroxidation Products Influence Calpain-1 Functionality In Vitro by Covalent Binding. Journal of agricultural and food chemistry. 2023 May; 71(20):7836-7846. doi: 10.1021/acs.jafc.3c01225. [PMID: 37167568]
  • Rajinikanth Mohan, Sara Spells, Daowen Wang, Zheng Qing Fu. Caffeoylputrescine-hexenal-mediated nonhost resistance against leafhoppers. Trends in plant science. 2022 09; 27(9):837-839. doi: 10.1016/j.tplants.2022.05.009. [PMID: 35660343]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Toshiyuki Tanaka, Ayana Ikeda, Kaori Shiojiri, Rika Ozawa, Kazumi Shiki, Naoko Nagai-Kunihiro, Kenya Fujita, Koichi Sugimoto, Katsuyuki T Yamato, Hideo Dohra, Toshiyuki Ohnishi, Takao Koeduka, Kenji Matsui. Identification of a Hexenal Reductase That Modulates the Composition of Green Leaf Volatiles. Plant physiology. 2018 10; 178(2):552-564. doi: 10.1104/pp.18.00632. [PMID: 30126866]
  • Mehrnaz Riasat, Ali Ashraf Jafari, Atefeh Bahmanzadegan, Ahmad Hatami, Faraneh Zareiyan. The constituents of essential oil in leaves of Karaj accession of Trigonella foenum graecum. Natural product research. 2017 Jul; 31(14):1709-1712. doi: 10.1080/14786419.2017.1286484. [PMID: 28278666]
  • Eşref Demir, Ricard Marcos. Assessing the genotoxic effects of two lipid peroxidation products (4-oxo-2-nonenal and 4-hydroxy-hexenal) in haemocytes and midgut cells of Drosophila melanogaster larvae. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Jul; 105(?):1-7. doi: 10.1016/j.fct.2017.03.036. [PMID: 28343031]
  • Vadim E Tseilikman, Denis A Kozochkin, Eugenia B Manukhina, H Fred Downey, Olga B Tseilikman, Maria E Misharina, Anna A Nikitina, Maria V Komelkova, Maxim S Lapshin, Marina V Kondashevskaya, Svetlana S Lazuko, Oxana V Kusina, Marat V Sahabutdinov. Duration of hexobarbital-induced sleep and monoamine oxidase activities in rat brain: Focus on the behavioral activity and on the free-radical oxidation. General physiology and biophysics. 2016 Apr; 35(2):175-83. doi: 10.4149/gpb_2015039. [PMID: 26689857]
  • Michele M Skopec, Kevin D Kohl, Katharina Schramm, James R Halpert, M Denise Dearing. Using the Specialization Framework to Determine Degree of Dietary Specialization in a Herbivorous Woodrat. Journal of chemical ecology. 2015 Dec; 41(12):1059-68. doi: 10.1007/s10886-015-0654-y. [PMID: 26631406]
  • Lorenzo Siroli, Francesca Patrignani, Diana I Serrazanetti, Giulia Tabanelli, Chiara Montanari, Fausto Gardini, Rosalba Lanciotti. Lactic acid bacteria and natural antimicrobials to improve the safety and shelf-life of minimally processed sliced apples and lamb's lettuce. Food microbiology. 2015 May; 47(?):74-84. doi: 10.1016/j.fm.2014.11.008. [PMID: 25583340]
  • Mohammad Safi Shalamzari, Ariane Kahnt, Reinhilde Vermeylen, Tadeusz E Kleindienst, Michael Lewandowski, Filip Cuyckens, Willy Maenhaut, Magda Claeys. Characterization of polar organosulfates in secondary organic aerosol from the green leaf volatile 3-Z-hexenal. Environmental science & technology. 2014 Nov; 48(21):12671-8. doi: 10.1021/es503226b. [PMID: 25271849]
  • Chang Yeol Yang, Junheon Kim, Seung-Joon Ahn, Dong-Hwan Kim, Myoung Rae Cho. Identification of the female-produced sex pheromone of the plant bug Apolygus spinolae. Journal of chemical ecology. 2014 Mar; 40(3):244-9. doi: 10.1007/s10886-014-0407-3. [PMID: 24647725]
  • Satoshi Endo, Toshiyuki Matsunaga, Atsuko Matsumoto, Yuki Arai, Satoshi Ohno, Ossama El-Kabbani, Kazuo Tajima, Yasuo Bunai, Shigeru Yamano, Akira Hara, Yukio Kitade. Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D₂, and other endogenous and xenobiotic carbonyl compounds. Biochemical pharmacology. 2013 Nov; 86(9):1366-75. doi: 10.1016/j.bcp.2013.08.024. [PMID: 23994167]
  • Sandeep Banu, Balaji Bhaskar, Premkumar Balasekar. Hepatoprotective and antioxidant activity of Leucas aspera against D-galactosamine induced liver damage in rats. Pharmaceutical biology. 2012 Dec; 50(12):1592-5. doi: 10.3109/13880209.2012.685130. [PMID: 22992009]
  • Ozgür Devrim Can, Umide Demir Ozkay. Effects of Hypericum montbretti extract on the central nervous system and involvement of GABA (A)/Benzodiazepine receptors in its pharmacological activity. Phytotherapy research : PTR. 2012 Nov; 26(11):1695-700. doi: 10.1002/ptr.4629. [PMID: 22395896]
  • Toshihiro Hirao, Atsushi Okazawa, Kazuo Harada, Akio Kobayashi, Toshiya Muranaka, Kazumasa Hirata. Green leaf volatiles enhance methyl jasmonate response in Arabidopsis. Journal of bioscience and bioengineering. 2012 Nov; 114(5):540-5. doi: 10.1016/j.jbiosc.2012.06.010. [PMID: 22795666]
  • Markus Buchhaupt, Jan Christopher Guder, Maria Magdalena Walburga Etschmann, Jens Schrader. Synthesis of green note aroma compounds by biotransformation of fatty acids using yeast cells coexpressing lipoxygenase and hydroperoxide lyase. Applied microbiology and biotechnology. 2012 Jan; 93(1):159-68. doi: 10.1007/s00253-011-3482-1. [PMID: 21789493]
  • Kenji Matsui, Kohichi Sugimoto, Jun'ichi Mano, Rika Ozawa, Junji Takabayashi. Differential metabolisms of green leaf volatiles in injured and intact parts of a wounded leaf meet distinct ecophysiological requirements. PloS one. 2012; 7(4):e36433. doi: 10.1371/journal.pone.0036433. [PMID: 22558466]
  • Neetu Sharma, Sangeeta Shukla. Hepatoprotective potential of aqueous extract of Butea monosperma against CCl(4) induced damage in rats. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2011 Nov; 63(7-8):671-6. doi: 10.1016/j.etp.2010.05.009. [PMID: 20561774]
  • O O Adeyemi, A J Akindele, O K Yemitan, F R Aigbe, F I Fagbo. Anticonvulsant, anxiolytic and sedative activities of the aqueous root extract of Securidaca longepedunculata Fresen. Journal of ethnopharmacology. 2010 Jul; 130(2):191-5. doi: 10.1016/j.jep.2010.04.028. [PMID: 20435127]
  • Teresa Domínguez, M Luisa Hernández, Joyce C Pennycooke, Pedro Jiménez, José Manuel Martínez-Rivas, Carlos Sanz, Eric J Stockinger, José J Sánchez-Serrano, Maite Sanmartín. Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. Plant physiology. 2010 Jun; 153(2):655-65. doi: 10.1104/pp.110.154815. [PMID: 20382895]
  • Emmanuelle Guillot, Emuri Abe, Emilie Gautier, Djillali Annane, Jean-Claude Alvarez. [Human toxicokinetic of hexobarbital after acute multi-drug intoxication]. Therapie. 2009 Sep; 64(5):325-30. doi: 10.2515/therapie/2009053. [PMID: 19863908]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • C D Sreedevi, P G Latha, P Ancy, S R Suja, S Shyamal, V J Shine, S Sini, G I Anuja, S Rajasekharan. Hepatoprotective studies on Sida acuta Burm. f. Journal of ethnopharmacology. 2009 Jul; 124(2):171-5. doi: 10.1016/j.jep.2009.04.055. [PMID: 19422907]
  • Bertrand Schatz, Champlain Djieto-Lordon, Laurent Dormont, Jean-Marie Bessière, Doyle McKey, Rumsaïs Blatrix. A simple non-specific chemical signal mediates defence behaviour in a specialised ant-plant mutualism. Current biology : CB. 2009 May; 19(9):R361-2. doi: 10.1016/j.cub.2009.03.026. [PMID: 19439255]
  • Imen Oueslati, Faouzia M Haddada, Hédia Manaï, Wissem Zarrouk, Wael Taamalli, Xavier Fernandez, Louisette Lizzani-Cuvelier, Mokhtar Zarrouk. Characterization of volatiles in virgin olive oil produced in the Tunisian area of Tataouine. Journal of agricultural and food chemistry. 2008 Sep; 56(17):7992-8. doi: 10.1021/jf801022c. [PMID: 18690679]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Holy N Rabetafika, Cédric Gigot, Marie-Laure Fauconnier, Marc Ongena, Jacqueline Destain, Patrick du Jardin, Jean-Paul Wathelet, Philippe Thonart. Sugar beet leaves as new source of hydroperoxide lyase in a bioprocess producing green-note aldehydes. Biotechnology letters. 2008 Jun; 30(6):1115-9. doi: 10.1007/s10529-008-9652-2. [PMID: 18259877]
  • Peng-Ying Zhang, Kao-Shan Chen, Pei-Qing He, Sheng-Hao Liu, Wan-Feng Jiang. Effects of crop development on the emission of volatiles in leaves of Lycopersicon esculentum and its inhibitory activity to Botrytis cinerea and Fusarium oxysporum. Journal of integrative plant biology. 2008 Jan; 50(1):84-91. doi: 10.1111/j.1744-7909.2007.00597.x. [PMID: 18666955]
  • Monika Bhadauria, Satendra Kumar Nirala, Sangeeta Shukla. Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride. Molecular and cellular biochemistry. 2007 Aug; 302(1-2):215-24. doi: 10.1007/s11010-007-9443-4. [PMID: 17410408]
  • Francisco T Arroyo, Javier Moreno, Paula Daza, Lidiya Boianova, Fernando Romero. Antifungal activity of strawberry fruit volatile compounds against Colletotrichum acutatum. Journal of agricultural and food chemistry. 2007 Jul; 55(14):5701-7. doi: 10.1021/jf0703957. [PMID: 17567029]
  • M D Dearing, M M Skopec, M J Bastiani. Detoxification rates of wild herbivorous woodrats (Neotoma). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2006 Dec; 145(4):419-22. doi: 10.1016/j.cbpa.2006.07.016. [PMID: 16962347]
  • B Singh, B K Chandan, N Sharma, V Bhardwaj, N K Satti, V N Gupta, B D Gupta, K A Suri, O P Suri. Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn. Phytotherapy research : PTR. 2006 Oct; 20(10):831-9. doi: 10.1002/ptr.1856. [PMID: 16841368]
  • Sini Sadasivan, P G Latha, J M Sasikumar, S Rajashekaran, S Shyamal, V J Shine. Hepatoprotective studies on Hedyotis corymbosa (L.) Lam. Journal of ethnopharmacology. 2006 Jun; 106(2):245-9. doi: 10.1016/j.jep.2006.01.002. [PMID: 16495024]
  • Kaori Shiojiri, Rika Ozawa, Kenji Matsui, Kyutaro Kishimoto, Soichi Kugimiya, Junji Takabayashi. Role of the lipoxygenase/lyase pathway of host-food plants in the host searching behavior of two parasitoid species, Cotesia glomerata and Cotesia plutellae. Journal of chemical ecology. 2006 May; 32(5):969-79. doi: 10.1007/s10886-006-9047-6. [PMID: 16739017]
  • Najla Ben Akacha, Olfa Boubaker, Mohamed Gargouri. Production of hexenol in a two-enzyme system: kinetic study and modelling. Biotechnology letters. 2005 Dec; 27(23-24):1875-8. doi: 10.1007/s10529-005-3896-x. [PMID: 16328983]
  • Hui Duan, Meng-Yu Huang, Kathryn Palacio, Mary A Schuler. Variations in CYP74B2 (hydroperoxide lyase) gene expression differentially affect hexenal signaling in the Columbia and Landsberg erecta ecotypes of Arabidopsis. Plant physiology. 2005 Nov; 139(3):1529-44. doi: 10.1104/pp.105.067249. [PMID: 16258015]
  • Jureepan Saranak, Kenneth W Foster. Photoreceptor for curling behavior in Peranema trichophorum and evolution of eukaryotic rhodopsins. Eukaryotic cell. 2005 Oct; 4(10):1605-12. doi: 10.1128/ec.4.10.1605-1612.2005. [PMID: 16215167]
  • Hirotada Fukushige, David F Hildebrand. A simple and efficient system for green note compound biogenesis by use of certain lipoxygenase and hydroperoxide lyase sources. Journal of agricultural and food chemistry. 2005 Aug; 53(17):6877-82. doi: 10.1021/jf047954j. [PMID: 16104814]
  • P J Innocenzi, D Hall, J V Cross, H Hesketh. Attraction of male European tarnished plant bug, Lygus rugulipennis to components of the female sex pheromone in the field. Journal of chemical ecology. 2005 Jun; 31(6):1401-13. doi: 10.1007/s10886-005-5293-2. [PMID: 16222779]
  • Adrian Mondry. Antiglucocorticoid RU38486 reduces net protein catabolism in experimental acute renal failure. BMC nephrology. 2005 Feb; 6(?):2. doi: 10.1186/1471-2369-6-2. [PMID: 15715918]
  • Chunhui Deng, Ning Li, Weimin Zhu, Ji Qian, Xiaofeng Yang, Xiangmin Zhang. Rapid determination of C6-aldehydes in tomato plant emission by gas chromatography-mass spectrometry and solid-phase microextraction with on-fiber derivatization. Journal of separation science. 2005 Feb; 28(2):172-6. doi: 10.1002/jssc.200401912. [PMID: 15754825]
  • Reiko Takenoshita, Satoshi Toki. [New aspects of hexobarbital metabolism: stereoselective metabolism, new metabolic pathway via GSH conjugation, and 3-hydroxyhexobarbital dehydrogenases]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2004 Dec; 124(12):857-71. doi: 10.1248/yakushi.124.857. [PMID: 15577260]
  • Guoping Chen, Rachel Hackett, David Walker, Andy Taylor, Zhefeng Lin, Donald Grierson. Identification of a specific isoform of tomato lipoxygenase (TomloxC) involved in the generation of fatty acid-derived flavor compounds. Plant physiology. 2004 Sep; 136(1):2641-51. doi: 10.1104/pp.104.041608. [PMID: 15347800]
  • André Kessler, Rayko Halitschke, Ian T Baldwin. Silencing the jasmonate cascade: induced plant defenses and insect populations. Science (New York, N.Y.). 2004 Jul; 305(5684):665-8. doi: 10.1126/science.1096931. [PMID: 15232071]
  • S R Suja, P G Latha, P Pushpangadan, S Rajasekharan. Evaluation of hepatoprotective effects of Helminthostachys zeylanica (L.) Hook against carbon tetrachloride-induced liver damage in Wistar rats. Journal of ethnopharmacology. 2004 May; 92(1):61-6. doi: 10.1016/j.jep.2004.01.019. [PMID: 15099849]
  • Mei Hong, Barbara A Zilinskas, Douglas C Knipple, Chee Kok Chin. cis-3-Hexenal production in tobacco is stimulated by 16-carbon monounsaturated fatty acids. Phytochemistry. 2004 Jan; 65(2):159-68. doi: 10.1016/j.phytochem.2003.10.013. [PMID: 14732275]
  • Sadayoshi Furuta, Osafumi Shimada, Naomi Doi, Kiyoharu Ukai, Terutake Nakagawa, Jyo Watanabe, Masakazu Imaizumi. General pharmacology of KP-102 (GHRP-2), a potent growth hormone-releasing peptide. Arzneimittel-Forschung. 2004; 54(12):868-80. doi: 10.1055/s-0031-1297042. [PMID: 15646371]
  • Márta Dregus, Karl-Heinz Engel. Volatile constituents of uncooked rhubarb (Rheum rhabarbarum L.) stalks. Journal of agricultural and food chemistry. 2003 Oct; 51(22):6530-6. doi: 10.1021/jf030399l. [PMID: 14558774]
  • Eun Joo Kim, Rae Kyong Lee, Jeong Eun Suh, Sang Seop Han, Joon Kyum Kim. Safety pharmacology of CKD-602, a novel anticancer agent. Arzneimittel-Forschung. 2003; 53(4):272-9. doi: 10.1055/s-0031-1297108. [PMID: 12785124]
  • Minke A Noordermeer, Wouter Van Der Goot, Aukje J Van Kooij, Jan Willem Veldsink, Gerrit A Veldink, Johannes F G Vliegenthart. Development of a biocatalytic process for the production of c6-aldehydes from vegetable oils by soybean lipoxygenase and recombinant hydroperoxide lyase. Journal of agricultural and food chemistry. 2002 Jul; 50(15):4270-4. doi: 10.1021/jf0202685. [PMID: 12105957]
  • V E Nebol'sin, G A Zheltukhina, V V Krzhechkovskaia, V L Kovaleva, R P Evstigneeva. [The effect of gamma-L-glutamylhistamine analogues on the severity of experimental anaphylactic reaction, hormonal status and liver cytochrome P450 system]. Voprosy meditsinskoi khimii. 2001 May; 47(3):301-7. doi: . [PMID: 11558312]
  • W Klinger, E Karge, U Demme, M Kretzschmar. Interactions of melatonin with the liver microsomal cytochrome P450 system of rats and humans in vitro and effects on the P450 system and the antioxidative status in rat liver after acute treatment. European journal of drug metabolism and pharmacokinetics. 2001 Jan; 26(1-2):31-5. doi: 10.1007/bf03190373. [PMID: 11554431]
  • H Weichert, A Kolbe, C Wasternack, I Feussner. Formation of 4-hydroxy-2-alkenals in barley leaves. Biochemical Society transactions. 2000 Dec; 28(6):850-1. doi: ". [PMID: 11171229]
  • K Matsui, S Kurishita, A Hisamitsu, T Kajiwara. A lipid-hydrolysing activity involved in hexenal formation. Biochemical Society transactions. 2000 Dec; 28(6):857-60. doi: . [PMID: 11171233]
  • M L Fauconnier, J Delcarte, P Hoyaux, P du Jardin, M Marlier. Potato tubers exhibit both homolytic and heterolytic hydroperoxide fatty acid-cleaving activities. Biochemical Society transactions. 2000 Dec; 28(6):853-5. doi: 10.1042/bst0280853. [PMID: 11171231]
  • M S Wright, D M Greene-McDowelle, H J Zeringue, D Bhatnagar, T E Cleveland. Effects of volatile aldehydes from Aspergillus-resistant varieties of corn on Aspergillus parasiticus growth and aflatoxin biosynthesis. Toxicon : official journal of the International Society on Toxinology. 2000 Sep; 38(9):1215-23. doi: 10.1016/s0041-0101(99)00221-4. [PMID: 10736475]
  • S Korkmaz, G Wahlström. Physical dependence after benzodiazepine treatments in rats: Comparison of short and long treatments with diazepam and lorazepam. Journal of studies on alcohol. 1999 Jul; 60(4):546-54. doi: 10.15288/jsa.1999.60.546. [PMID: 10463812]
  • H Fuhrmann, H P Sallmann. Amount and type of unsaturated aldehydes in chicken plasma and tissues depend more on dietary lipids than on vitamin E status. Lipids. 1999; 34 Suppl(?):S253-4. doi: 10.1007/bf02562310. [PMID: 10419170]
  • T Shizawa, K Inaba, F Yoshida, T Iizuka, K Hijikuro, R Yanoshita, T Kamitani. Mechanisms of non-drowsiness after oral administration of TMK688, a novel antiallergic drug. Arzneimittel-Forschung. 1998 Oct; 48(10):979-84. doi: NULL. [PMID: 9825114]
  • H Oelschläger, D Rothley, W Klinger, E Karge, H Vogelsang. Chromatographic resolution of ciprofibrate and interaction of the racemate and both enantiomers with rat liver microsomes in vitro. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 1998 Sep; 50(4-6):323-9. doi: 10.1016/s0940-2993(98)80012-2. [PMID: 9784004]
  • T Nakashima, N Matsumoto, K Kashima. Treatment with bovine gallstones exacerbates liver damage, but enhances hepatoprotection by bear gall powder in carbon tetrachloride-intoxicated rats. Japanese journal of pharmacology. 1998 Mar; 76(3):271-7. doi: 10.1254/jjp.76.271. [PMID: 9593220]
  • M C Lu. Studies on the sedative effect of Cistanche deserticola. Journal of ethnopharmacology. 1998 Jan; 59(3):161-5. doi: 10.1016/s0378-8741(97)00108-6. [PMID: 9507899]
  • M Goerig, J Schulte am Esch. [Helmut Weese--an attempt at an appreciation of his importance for German-language anesthesia]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS. 1997 Nov; 32(11):678-85. doi: 10.1055/s-2007-995135. [PMID: 9498888]
  • K K Anand, B Singh, A K Saxena, B K Chandan, V N Gupta, V Bhardwaj. 3,4,5-Trihydroxy benzoic acid (gallic acid), the hepatoprotective principle in the fruits of Terminalia belerica-bioassay guided activity. Pharmacological research. 1997 Oct; 36(4):315-21. doi: 10.1006/phrs.1997.0236. [PMID: 9425622]
  • M D Wang, G Wahlström, T Bäckström. Pregnenolone sulphate and pregnenolone do not interact with 5 beta-pregnanolone- and hexobarbitone-induced anaesthesia in the rat. British journal of anaesthesia. 1997 Mar; 78(3):328-31. doi: 10.1093/bja/78.3.328. [PMID: 9135318]
  • W Klinger, E Karge, M Kretzschmar, M Rost, H P Schulze, R Dargel, C Reinemann, H Rein. Luminol-and lucigenin-amplified chemiluminescence with rat liver microsomes. Kinetics and influence of ascorbic acid, glutathione, dimethylsulfoxide, N-t-butyl-a-phenyl-nitrone, copper-ions and a copper complex, catalase, superoxide dismutase, hexobarbital and aniline. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 1996 Jul; 48(5):447-60. doi: 10.1016/s0940-2993(96)80055-8. [PMID: 8765690]
  • B K Tan, B H Bay, K H Sit, K Y Sim, A Hsu. Acute zinc administration prolongs hexobarbitone-induced sleeping time in C57/6J mice. Pharmacological research. 1995 Oct; 32(4):233-6. doi: 10.1016/s1043-6618(05)80027-1. [PMID: 8866839]
  • E N Barkova, O V Gurov. [Daily dynamics of the duration of hexenal narcosis in experimental hepatosis]. Biulleten' eksperimental'noi biologii i meditsiny. 1995 May; 119(5):540-3. doi: . [PMID: 7579256]
  • S Korkmaz, E Ljungblad, G Wahlström. Interaction between flumazenil and the anesthetic effects of hexobarbital in the rat. Brain research. 1995 Apr; 676(2):371-7. doi: 10.1016/0006-8993(95)00132-a. [PMID: 7614008]
  • K Wada, T Kurihara, M Yagi, R Kobayashi, H Kaminaga, K Toi, M Haga. Columbin isolated from calumbae radix affects the sleeping time of anesthetized mice. Biological & pharmaceutical bulletin. 1995 Apr; 18(4):634-6. doi: 10.1248/bpb.18.634. [PMID: 7655444]
  • A K Agrawal, N A Pampori, B H Shapiro. Neonatal phenobarbital-induced defects in age- and sex-specific growth hormone profiles regulating monooxygenases. The American journal of physiology. 1995 Mar; 268(3 Pt 1):E439-45. doi: 10.1152/ajpendo.1995.268.3.e439. [PMID: 7900791]
  • S I Shedlofsky, B C Israel, C J McClain, D B Hill, R A Blouin. Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism. The Journal of clinical investigation. 1994 Dec; 94(6):2209-14. doi: 10.1172/jci117582. [PMID: 7989576]
  • A Barber, G D Bartoszyk, H M Bender, R Gottschlich, H E Greiner, J Harting, F Mauler, K O Minck, R D Murray, M Simon. A pharmacological profile of the novel, peripherally-selective kappa-opioid receptor agonist, EMD 61753. British journal of pharmacology. 1994 Dec; 113(4):1317-27. doi: 10.1111/j.1476-5381.1994.tb17142.x. [PMID: 7889287]
  • S Dimova, M Koleva, D Rangelova, T Stoytchev. Liver enzyme activities after multiple administration of nifedipine in mice. Pharmacology & toxicology. 1994 Nov; 75(5):315-8. doi: 10.1111/j.1600-0773.1994.tb00366.x. [PMID: 7870704]
  • M Behne, V Lischke, F Asskali, S Probst, R Hermann, J Vettermann. Midazolam does not antagonize fentanyl-mediated analgesia in surgical patients. Journal of clinical anesthesia. 1994 Nov; 6(6):481-6. doi: 10.1016/0952-8180(94)90088-4. [PMID: 7880511]
  • J Kulcsár-Gergely, E Pósán, A Kulcsár. Metabolic actions of a single atenolol and metoprolol dose. Arzneimittel-Forschung. 1994 Nov; 44(11):1183-5. doi: NULL. [PMID: 7848328]
  • W Reanmongkol, K Matsumoto, A Itharat, H Watanabe. Antinociceptive effects of Randia siamensis extract and its constituent, pseudoginsenoside-RP1 in experimental animals. Biological & pharmaceutical bulletin. 1994 Sep; 17(9):1206-9. doi: 10.1248/bpb.17.1206. [PMID: 7841940]
  • T A Zolotareva, A Iu Grishanova, L F Guliaeva, V V Liakhovich, G A Gorchakova. [The characteristics of the effect of centimeter-range microwaves on drug pharmacokinetics in the body of experimental animals]. Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury. 1994 May; ?(3):15-7. doi: NULL. [PMID: 7941466]
  • S Ansher, W Thompson, R Watson. Alterations of hepatic drug metabolism in mice following infection with the murine retrovirus LP-BM5. Immunopharmacology. 1994 May; 27(3):215-23. doi: 10.1016/0162-3109(94)90018-3. [PMID: 8071061]
  • M Ozawa, Y Nakada, K Sugimachi, F Yabuuchi, T Akai, E Mizuta, S Kuno, M Yamaguchi. Pharmacological characterization of the novel anxiolytic beta-carboline abecarnil in rodents and primates. Japanese journal of pharmacology. 1994 Mar; 64(3):179-87. doi: 10.1254/jjp.64.179. [PMID: 7912751]
  • K Groen, D D Breimer, E J Jansen, C F van Bezooijen. The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study. The Journal of pharmacology and experimental therapeutics. 1994 Feb; 268(2):531-6. doi: . [PMID: 8113964]
  • A Adedoyin, C Prakash, D O'Shea, I A Blair, G R Wilkinson. Stereoselective disposition of hexobarbital and its metabolites: relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects. Pharmacogenetics. 1994 Feb; 4(1):27-38. doi: NULL. [PMID: 8004130]
  • S Ansher, W Thompson, J Bridgewater, P Snoy. Pertussis toxin-induced alterations of murine hepatic drug metabolism following administration of diphtheria and tetanus toxoids and pertussis vaccine adsorbed. Infection and immunity. 1993 Oct; 61(10):4240-7. doi: 10.1128/iai.61.10.4240-4247.1993. [PMID: 8406812]
  • B C Israel, R A Blouin, W McIntyre, S I Shedlofsky. Effects of interferon-alpha monotherapy on hepatic drug metabolism in cancer patients. British journal of clinical pharmacology. 1993 Sep; 36(3):229-35. doi: 10.1111/j.1365-2125.1993.tb04222.x. [PMID: 9114909]
  • V Dall, U Orntoft, A Schmidt, L Nordholm. Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital. Pharmacology, biochemistry, and behavior. 1993 Sep; 46(1):73-6. doi: 10.1016/0091-3057(93)90319-o. [PMID: 8255925]
  • R Takenoshita, T Nakamura, S Toki. Hexobarbital metabolism: a new metabolic pathway to produce 1,5-dimethylbarbituric acid and cyclohexenone-glutathione adduct via 3'-oxohexobarbital. Xenobiotica; the fate of foreign compounds in biological systems. 1993 Aug; 23(8):925-34. doi: 10.3109/00498259309059419. [PMID: 8284947]
  • K Wada, K Sasaki, K Miura, M Yagi, Y Kubota, T Matsumoto, M Haga. Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. Biological & pharmaceutical bulletin. 1993 Feb; 16(2):210-2. doi: 10.1248/bpb.16.210. [PMID: 8364459]
  • S Ansher, W Thompson, P Snoy, W Habig. Role of endotoxin in alterations of hepatic drug metabolism by diphtheria and tetanus toxoids and pertussis vaccine adsorbed. Infection and immunity. 1992 Sep; 60(9):3790-8. doi: 10.1128/iai.60.9.3790-3798.1992. [PMID: 1500188]
  • A Sternitzke, W Legrum, K J Netter. Effects of phenolic smoke condensates and their components on hepatic drug metabolizing systems. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1992 Sep; 30(9):771-81. doi: 10.1016/0278-6915(92)90079-z. [PMID: 1427515]
  • A M Vermeulen, F M Belpaire, F De Smet, M T Rosseel, M G Bogaert. Influence of age on stereoselective pharmacokinetics and metabolism of hexobarbital in the rat. Mechanisms of ageing and development. 1992 Sep; 65(2-3):167-75. doi: 10.1016/0047-6374(92)90033-a. [PMID: 1434946]
  • K Ensing, J P Franke, A Temmink, X H Chen, R A de Zeeuw. Application of Empore C-8 extraction disks for screening urine in systematic toxicological analysis. Journal of forensic sciences. 1992 Mar; 37(2):460-6. doi: NULL. [PMID: 1354247]
  • G Ugazio, A Bosio, E Burdino, L Ghigo, C Nebbia. Lethality, hexobarbital narcosis and behavior in rats exposed to atrazine, bentazon or molinate. Research communications in chemical pathology and pharmacology. 1991 Dec; 74(3):349-61. doi: . [PMID: 1775725]
  • C Prakash, A Adedoyin, G R Wilkinson, I A Blair. Enantiospecific quantification of hexobarbital and its metabolites in biological fluids by gas chromatography/electron capture negative ion chemical ionization mass spectrometry. Biological mass spectrometry. 1991 Sep; 20(9):559-64. doi: 10.1002/bms.1200200909. [PMID: 1782205]
  • T Ikeda, S Tsuda, Y Shirasu. Metabolic induction of the hepatic cytochrome P450 system by chlorfenvinphos in rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1991 Aug; 17(2):361-7. doi: 10.1016/0272-0590(91)90225-s. [PMID: 1765223]
  • A M Vermeulen, M T Rosseel, F M Belpaire. High-performance liquid chromatographic method for the simultaneous determination of R-(-)- and S-(+)-hexobarbital in rat plasma. Journal of chromatography. 1991 Jul; 567(2):472-9. doi: 10.1016/0378-4347(91)80154-5. [PMID: 1939480]
  • A K Agrawal, N A Pampori, B H Shapiro. Sex- and dose-dependent effects of neonatally administered aspartate on the ultradian patterns of circulating growth hormone regulating hexobarbital metabolism and action. Toxicology and applied pharmacology. 1991 Mar; 108(1):96-106. doi: 10.1016/0041-008x(91)90272-g. [PMID: 1672477]
  • Z Ben-Zvi, B Weissman-Teitellman, S Katz, A Danon. Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis?. Archives of toxicology. 1990; 64(4):299-304. doi: 10.1007/bf01972990. [PMID: 2386430]
  • M I Bushma, L B Zavodnik, P I Lukienko. [Effect of the diethylamide of nicotinic acid (cordiamine) on the hydroxylating function of the liver]. Farmakologiia i toksikologiia. 1989 Jul; 52(4):56-9. doi: NULL. [PMID: 2806530]