Nickel Chloride (BioDeep_00000840336)

   


代谢物信息卡片


Nickel Chloride

化学式: Cl2Ni (127.8731)
中文名称: 氯化镍分析滴定液
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: Cl[Ni]Cl
InChI: /q

描述信息

同义名列表

2 个代谢物同义名

Nickel Chloride; Nickel chloride



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ANXA5, BCL2, BCL2L1, CASP3, CASP9, CAT, CDH1, HPGDS, TLR4, TP53
Peripheral membrane protein 1 ANXA5
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 1 BCL2
Mitochondrion membrane 1 BCL2L1
Nucleus 5 BCL2, CASP3, CASP9, CDH1, TP53
cytosol 11 ANXA5, BCL2, BCL2L1, CASP3, CASP9, CAT, CDH1, GPT, GSR, HPGDS, TP53
trans-Golgi network 1 CDH1
centrosome 2 BCL2L1, TP53
nucleoplasm 4 CASP3, CDH1, HPGDS, TP53
Cell membrane 3 CDH1, TLR4, TNF
Cytoplasmic side 1 BCL2L1
lamellipodium 1 CDH1
Multi-pass membrane protein 1 CACNA1I
cell junction 1 CDH1
cell surface 2 TLR4, TNF
glutamatergic synapse 2 CASP3, CDH1
Golgi apparatus 1 CDH1
Golgi membrane 1 INS
lysosomal membrane 1 CP
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 2 CASP3, TNF
postsynapse 1 CDH1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 BCL2L1
endosome 1 CDH1
plasma membrane 5 CACNA1I, CDH1, CP, TLR4, TNF
synaptic vesicle membrane 1 BCL2L1
Membrane 7 ANXA5, BCL2, CACNA1I, CAT, CDH1, TLR4, TP53
extracellular exosome 6 ANXA5, CAT, CDH1, CP, GPT, GSR
endoplasmic reticulum 3 BCL2, BCL2L1, TP53
extracellular space 7 CP, CXCL8, IL10, IL2, IL6, INS, TNF
perinuclear region of cytoplasm 2 CDH1, TLR4
adherens junction 1 CDH1
mitochondrion 6 BCL2, BCL2L1, CASP9, CAT, GSR, TP53
protein-containing complex 4 BCL2, CASP9, CAT, TP53
intracellular membrane-bounded organelle 2 CAT, HPGDS
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 CDH1, TLR4
Secreted 6 CP, CXCL8, IL10, IL2, IL6, INS
extracellular region 10 ANXA5, CAT, CDH1, CP, CXCL8, IL10, IL2, IL6, INS, TNF
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 2 BCL2, BCL2L1
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 2 BCL2, BCL2L1
Mitochondrion matrix 2 BCL2L1, TP53
mitochondrial matrix 4 BCL2L1, CAT, GSR, TP53
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 BCL2L1, TP53
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 2 BCL2, BCL2L1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 3 BCL2, BCL2L1, CDH1
external side of plasma membrane 4 ANXA5, GSR, TLR4, TNF
actin cytoskeleton 1 CDH1
nucleolus 1 TP53
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 2 ANXA5, CAT
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 1 ANXA5
lateral plasma membrane 1 CDH1
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
Zymogen granule membrane 1 ANXA5
chromatin 1 TP53
phagocytic cup 2 TLR4, TNF
Golgi apparatus, trans-Golgi network 1 CDH1
blood microparticle 1 CP
site of double-strand break 1 TP53
endosome lumen 1 INS
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 CP, IL6, INS
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
[Isoform 2]: Nucleus 1 CDH1
[Isoform 1]: Nucleus 1 TP53
death-inducing signaling complex 1 CASP3
apical junction complex 1 CDH1
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 1 CDH1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
caspase complex 1 CASP9
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Saade Abdalkareem Jasim, Sahar Golgouneh, Mustafa Musa Jaber, Sayit I Indiaminov, Fahad Alsaikhan, Ali Thaeer Hammid, Yasser Fakri Mustafa, Yasir Salam Karim, Mohammed Q Sultan, Maryam Norbakhsh. Effects of short-term exposure to the heavy metal, nickel chloride (Nicl2) on gill histology and osmoregulation components of the gray mullet, Mugil cephalus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Aug; 258(?):109361. doi: 10.1016/j.cbpc.2022.109361. [PMID: 35525465]
  • Imane Salah, Ounassa Adjroud, Awatef Elwej. Protective Effects of Selenium and Zinc Against Nickel Chloride-Induced Hormonal Changes and Oxidative Damage in Thyroid of Pregnant Rats. Biological trace element research. 2022 May; 200(5):2183-2194. doi: 10.1007/s12011-021-02815-x. [PMID: 34247319]
  • Koichi Sato, Chihiro Mogi, Alan J Mighell, Fumikazu Okajima. A missense mutation of Leu74Pro of OGR1 found in familial amelogenesis imperfecta actually causes the loss of the pH-sensing mechanism. Biochemical and biophysical research communications. 2020 06; 526(4):920-926. doi: 10.1016/j.bbrc.2020.04.005. [PMID: 32279993]
  • Omamuyovwi M Ijomone, Mahfuzur R Miah, Grace T Akingbade, Hana Bucinca, Michael Aschner. Nickel-Induced Developmental Neurotoxicity in C. elegans Includes Cholinergic, Dopaminergic and GABAergic Degeneration, Altered Behaviour, and Increased SKN-1 Activity. Neurotoxicity research. 2020 Apr; 37(4):1018-1028. doi: 10.1007/s12640-020-00175-3. [PMID: 32034695]
  • Solomon E Owumi, Yusuff O Olayiwola, Gbenga E Alao, Michael A Gbadegesin, Oyeronke A Odunola. Cadmium and nickel co-exposure exacerbates genotoxicity and not oxido-inflammatory stress in liver and kidney of rats: Protective role of omega-3 fatty acid. Environmental toxicology. 2020 Feb; 35(2):231-241. doi: 10.1002/tox.22860. [PMID: 31639282]
  • Sylwia Terpilowska, Andrzej Krzysztof Siwicki. Pro- and antioxidant activity of chromium(III), iron(III), molybdenum(III) or nickel(II) and their mixtures. Chemico-biological interactions. 2019 Jan; 298(?):43-51. doi: 10.1016/j.cbi.2018.10.028. [PMID: 30389395]
  • Shohei Yokota, Kazuichi Nakamura, Ryo Kamata. A comparative study of nickel nanoparticle and ionic nickel toxicities in zebrafish: histopathological changes and oxidative stress. The Journal of toxicological sciences. 2019; 44(11):737-751. doi: 10.2131/jts.44.737. [PMID: 31708531]
  • Tzu-Chin Wu, Shu-Ting Chan, Chih-Ning Chang, Pei-Syuan Yu, Cheng-Hung Chuang, Shu-Lan Yeh. Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells. Chemico-biological interactions. 2018 Aug; 292(?):101-109. doi: 10.1016/j.cbi.2018.07.010. [PMID: 30016632]
  • Mohammad Hadi Zarei, Seyed Farshad Hosseini Shirazi, Marjan Aghvami, Ahmad Salimi, Jalal Pourahmad. Analysis of cytotoxic effects of nickel on human blood lymphocytes. Toxicology mechanisms and methods. 2018 Feb; 28(2):79-86. doi: 10.1080/15376516.2017.1364314. [PMID: 28774209]
  • T Kuroishi, K Bando, Y Tanaka, K Shishido, M Kinbara, T Ogawa, K Muramoto, Y Endo, S Sugawara. CXCL4 is a novel nickel-binding protein and augments nickel allergy. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2017 Aug; 47(8):1069-1078. doi: 10.1111/cea.12926. [PMID: 28319310]
  • Ahmet Topal, Muhammed Atamanalp, Ertan Oruç, Hüseyin Serkan Erol. Physiological and biochemical effects of nickel on rainbow trout (Oncorhynchus mykiss) tissues: Assessment of nuclear factor kappa B activation, oxidative stress and histopathological changes. Chemosphere. 2017 Jan; 166(?):445-452. doi: 10.1016/j.chemosphere.2016.09.106. [PMID: 27705832]
  • F S Dzugkoeva, I V Mozhaeva, S G Dzugkoev, O I Margieva, A I Tedtoeva, M A Otiev. Oxidative Stress and Biochemical Markers of Endothelial Dysfunction and Organ Damage under Conditions of Experimental Nonferrous Metal Intoxication. Bulletin of experimental biology and medicine. 2016 Dec; 162(2):199-202. doi: 10.1007/s10517-016-3575-z. [PMID: 27909964]
  • Hongrui Guo, Hengmin Cui, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Ling Zhao, Bangyuan Wu, Kejie Chen, Jie Deng. Nickel chloride-induced apoptosis via mitochondria- and Fas-mediated caspase-dependent pathways in broiler chickens. Oncotarget. 2016 Nov; 7(48):79747-79760. doi: 10.18632/oncotarget.12946. [PMID: 27806327]
  • Luca Costa, Alexander Andriatis, Martha Brennich, Jean-Marie Teulon, Shu-Wen W Chen, Jean-Luc Pellequer, Adam Round. Combined small angle X-ray solution scattering with atomic force microscopy for characterizing radiation damage on biological macromolecules. BMC structural biology. 2016 10; 16(1):18. doi: 10.1186/s12900-016-0068-2. [PMID: 27788689]
  • Imed-Eddine Kadi, Faouzi Dahdouh. Vitamin C pretreatment protects from nickel-induced acute nephrotoxicity in mice. Arhiv za higijenu rada i toksikologiju. 2016 Sep; 67(3):210-215. doi: 10.1515/aiht-2016-67-2753. [PMID: 27749260]
  • Spyros Perontsis, Antonios G Hatzidimitriou, Athanasios N Papadopoulos, George Psomas. Nickel-diflunisal complexes: synthesis, characterization, in vitro antioxidant activity and interaction with DNA and albumins. Journal of inorganic biochemistry. 2016 09; 162(?):9-21. doi: 10.1016/j.jinorgbio.2016.06.003. [PMID: 27318424]
  • D V Grigorieva, I V Gorudko, A V Sokolov, V A Kostevich, V B Vasilyev, S N Cherenkevich, O M Panasenko. Myeloperoxidase Stimulates Neutrophil Degranulation. Bulletin of experimental biology and medicine. 2016 Aug; 161(4):495-500. doi: 10.1007/s10517-016-3446-7. [PMID: 27597056]
  • Xiaoqiang Guo, Yanmin Zhang, Qiang Zhang, Pingping Fa, Yaoting Gui, Guoquan Gao, Zhiming Cai. The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells. Toxicology and industrial health. 2016 Jul; 32(7):1286-92. doi: 10.1177/0748233714552687. [PMID: 25427687]
  • Shuang Yin, Hongrui Guo, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Kun Tang, Jian Li. Nickel Chloride (NiCl2) Induces Histopathological Lesions via Oxidative Damage in the Broiler's Bursa of Fabricius. Biological trace element research. 2016 May; 171(1):214-23. doi: 10.1007/s12011-015-0528-8. [PMID: 26440478]
  • Hongrui Guo, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Bangyuan Wu, Kejie Chen, Jie Deng. Nickel chloride (NiCl2) induces endoplasmic reticulum (ER) stress by activating UPR pathways in the kidney of broiler chickens. Oncotarget. 2016 Apr; 7(14):17508-19. doi: 10.18632/oncotarget.7919. [PMID: 26956054]
  • Hongrui Guo, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Bangyuan Wu, Kejie Chen, Jie Deng. Dietary NiCl₂ causes G₂/M cell cycle arrest in the broiler's kidney. Oncotarget. 2015 Nov; 6(34):35964-77. doi: 10.18632/oncotarget.5934. [PMID: 26440151]
  • Hongrui Guo, Huidan Deng, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Bangyuan Wu, Kejie Chen. Nickel chloride (NiCl2)-caused inflammatory responses via activation of NF-κB pathway and reduction of anti-inflammatory mediator expression in the kidney. Oncotarget. 2015 Oct; 6(30):28607-20. doi: 10.18632/oncotarget.5759. [PMID: 26417933]
  • Hongrui Guo, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Bangyuan Wu, Kejie Chen, Jie Deng. Modulation of the PI3K/Akt Pathway and Bcl-2 Family Proteins Involved in Chicken's Tubular Apoptosis Induced by Nickel Chloride (NiCl₂). International journal of molecular sciences. 2015 Sep; 16(9):22989-3011. doi: 10.3390/ijms160922989. [PMID: 26404262]
  • Yunlei Han, Rui Wang, Zhirong Yang, Yuhua Zhan, Yao Ma, Shuzhen Ping, Liwen Zhang, Min Lin, Yongliang Yan. 1-Aminocyclopropane-1-Carboxylate Deaminase from Pseudomonas stutzeri A1501 Facilitates the Growth of Rice in the Presence of Salt or Heavy Metals. Journal of microbiology and biotechnology. 2015 Jul; 25(7):1119-28. doi: 10.4014/jmb.1412.12053. [PMID: 25674802]
  • Ahmet Topal, Muhammed Atamanalp, Ertan Oruç, Mesut Bünyami Halıcı, Melda Şişecioğlu, Hüseyin Serkan Erol, Arzu Gergit, Bahar Yılmaz. Neurotoxic effects of nickel chloride in the rainbow trout brain: Assessment of c-Fos activity, antioxidant responses, acetylcholinesterase activity, and histopathological changes. Fish physiology and biochemistry. 2015 Jun; 41(3):625-34. doi: 10.1007/s10695-015-0033-1. [PMID: 25666867]
  • V V Ivanishchev, E A Abramova. Accumulation of nickel ions in seedlings of Vicia sativa L. and manifestations of oxidative stress. Environmental science and pollution research international. 2015 May; 22(10):7897-905. doi: 10.1007/s11356-015-4173-8. [PMID: 25655753]
  • Salha Boulila, Abdelfattah Elfeki, Hassane Oudadesse, Hafed Elfeki. Substitution effects of a carbonated hydroxyapatite biomaterial against intoxication chloride nickel-exposed rats. Toxicology mechanisms and methods. 2015 Mar; 25(3):155-65. doi: 10.3109/15376516.2014.1003358. [PMID: 25560666]
  • Jason Brocato, Michelle Hernandez, Freda Laulicht, Hong Sun, Magdy Shamy, Mansour A Alghamdi, Mamdouh I Khoder, Thomas Kluz, Lung-Chi Chen, Max Costa. In Vivo Exposures to Particulate Matter Collected from Saudi Arabia or Nickel Chloride Display Similar Dysregulation of Metabolic Syndrome Genes. Journal of toxicology and environmental health. Part A. 2015; 78(23-24):1421-36. doi: 10.1080/15287394.2015.1095689. [PMID: 26692068]
  • Mohd Kafeel Ahmad Ansari, Altaf Ahmad, Shahid Umar, Munir Hussain Zia, Muhammad Iqbal, Gary Owens. Genotypic variation in phytoremediation potential of Indian mustard exposed to nickel stress: a hydroponic study. International journal of phytoremediation. 2015; 17(1-6):135-44. doi: 10.1080/15226514.2013.862206. [PMID: 25237724]
  • Hongrui Guo, Bangyuan Wu, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Jie Deng, Shuang Yin, Jian Li, Kun Tang. NiCl2-down-regulated antioxidant enzyme mRNA expression causes oxidative damage in the broiler(')s kidney. Biological trace element research. 2014 Dec; 162(1-3):288-95. doi: 10.1007/s12011-014-0132-3. [PMID: 25253428]
  • Ilzira A Minigaliyeva, Boris A Katsnelson, Larisa I Privalova, Vladimir B Gurvich, Vladimir G Panov, Anatoly N Varaksin, Oleg H Makeyev, Marina P Sutunkova, Nadezhda V Loginova, Ekaterina P Kireyeva, Ekaterina V Grigoryeva, Tatyana V Slyshkina, Eugenia V Ganebnykh, Svetlana V Grebenkina. Toxicodynamic and toxicokinetic descriptors of combined chromium (VI) and nickel toxicity. International journal of toxicology. 2014 Nov; 33(6):498-505. doi: 10.1177/1091581814555915. [PMID: 25355735]
  • Ignacio I Fuentes, Francisco Espadas-Gil, Carlos Talavera-May, Gabriela Fuentes, Jorge M Santamaría. Capacity of the aquatic fern (Salvinia minima Baker) to accumulate high concentrations of nickel in its tissues, and its effect on plant physiological processes. Aquatic toxicology (Amsterdam, Netherlands). 2014 Oct; 155(?):142-50. doi: 10.1016/j.aquatox.2014.06.016. [PMID: 25019564]
  • S Boulila, A El Feki, H Oudadesse, C Kallel, H El Feki. Detoxification of rats subjected to nickel chloride by a biomaterial-based carbonated orthophosphate. Annales pharmaceutiques francaises. 2014 Sep; 72(5):348-62. doi: 10.1016/j.pharma.2014.03.004. [PMID: 25220231]
  • Faouzi Dahdouh, Maximilian Raane, Frank Thévenod, Wing-Kee Lee. Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1. Archives of toxicology. 2014 Apr; 88(4):881-92. doi: 10.1007/s00204-014-1194-x. [PMID: 24448832]
  • Naissan Hussainzada, John A Lewis, Christine E Baer, Danielle L Ippolito, David A Jackson, Jonathan D Stallings. Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish. BMC pharmacology & toxicology. 2014 Mar; 15(?):15. doi: 10.1186/2050-6511-15-15. [PMID: 24612858]
  • I A Minigalieva, E P Kireeva, E V Grigor'eva. [Certain toxicodynamic and toxicokinetic features of combined subchronic intoxication with hexavalent chromium and nickel]. Meditsina truda i promyshlennaia ekologiia. 2014; ?(6):35-9. doi: NULL. [PMID: 25282813]
  • Matin Arefifard, Majid Mahdieh, Mohammadreza Amirjani. Study of the effect of nickel heavy metals on some physiological parameters of Catharanthus roseus. Natural product research. 2014; 28(18):1499-502. doi: 10.1080/14786419.2014.913240. [PMID: 24870880]
  • Andrea Cove-Smith, Christopher J Mulgrew, Olena Rudyk, Neelanjana Dutt, Linda M McLatchie, Michael J Shattock, Bruce M Hendry. Anti-proliferative actions of T-type calcium channel inhibition in Thy1 nephritis. The American journal of pathology. 2013 Aug; 183(2):391-401. doi: 10.1016/j.ajpath.2013.04.029. [PMID: 23746655]
  • Jiřina Kročková, Peter Massányi, Alexander V Sirotkin, Norbert Lukáč, Anton Kováčik. Nickel-induced structural and functional alterations in porcine granulosa cells in vitro. Biological trace element research. 2013 Aug; 154(2):190-5. doi: 10.1007/s12011-013-9733-5. [PMID: 23784734]
  • Ounassa Adjroud. The toxic effects of nickel chloride on liver, erythropoiesis, and development in Wistar albino preimplanted rats can be reversed with selenium pretreatment. Environmental toxicology. 2013 May; 28(5):290-8. doi: 10.1002/tox.20719. [PMID: 21618677]
  • Bangyuan Wu, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Jianying Huang, Qin Luo, Yubing Deng, Hesong Wang, Juan Liu. Changes of the serum cytokine contents in broilers fed on diets supplemented with nickel chloride. Biological trace element research. 2013 Feb; 151(2):234-9. doi: 10.1007/s12011-012-9554-y. [PMID: 23179351]
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