wuweizisu C (BioDeep_00000008388)

 

Secondary id: BioDeep_00000230102, BioDeep_00000404386

PANOMIX_OTCML-2023 Antitumor activity


代谢物信息卡片


3,22-dimethoxy-12,13-dimethyl-5,7,18,20-tetraoxapentacyclo[13.7.0.02,10.04,8.017,21]docosa-1(22),2,4(8),9,15,17(21)-hexaene

化学式: C22H24O6 (384.1573)
中文名称: 五味子丙素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 46.67%

分子结构信息

SMILES: CC1CC2=CC3=C(C(=C2C4=C(C5=C(C=C4CC1C)OCO5)OC)OC)OCO3
InChI: InChI=1S/C22H24O6/c1-11-5-13-7-15-19(27-9-25-15)21(23-3)17(13)18-14(6-12(11)2)8-16-20(22(18)24-4)28-10-26-16/h7-8,11-12H,5-6,9-10H2,1-4H3

描述信息

schisandrin C is a natural product found in Schisandra sphenanthera and Schisandra chinensis with data available.
Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis[1]. Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory?and antioxidant effects. Schisandrin C is a molecular glue. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases?research[2][3]. Schisandrin C induces cell apoptosis[1].
Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis[1]. Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory?and antioxidant effects. Schisandrin C is a molecular glue. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases?research[2][3]. Schisandrin C induces cell apoptosis[1].

同义名列表

16 个代谢物同义名

3,22-dimethoxy-12,13-dimethyl-5,7,18,20-tetraoxapentacyclo[13.7.0.02,10.04,8.017,21]docosa-1(22),2,4(8),9,15,17(21)-hexaene; [1,3]Dioxolo[4,5]benzo[1,2:3,4]cycloocta[1,2:4,5]benzo[1,2-d]-1,3-dioxole, 5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-; [1,3]Dioxolo[4,5]benzo[1,2:3,4]cycloocta[1,2:4,5]benzo[1,2-d]-1,3-dioxole,5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-; Schisandrin C, >=98\\% (HPLC); Schizandrin-C;Wuweizisu-C; Schisandrin derivative; Schisandrin dervative; R-(+)-Wuweizisu C; schizandrin C; schisandrin C; schisandrinC; wuweizisu C; Schisandrin; Schizandrin-C; Wuweizisu-C; Schizandrin C



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AKT1, CASP1, CASP3, MAPK14, MAPK8, NLRP3, PPARG, PRKAA2, PTGS2
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 3 HMOX1, PTGS2, UGT1A1
Nucleus 9 AKT1, CASP3, HMOX1, MAPK14, MAPK8, NLRP3, PPARG, PPARGC1A, PRKAA2
cytosol 12 AKT1, CASP1, CASP3, GPT, GSR, HMOX1, MAPK14, MAPK8, NLRP3, PPARG, PPARGC1A, PRKAA2
dendrite 1 PRKAA2
nucleoplasm 8 AKT1, CASP3, HMOX1, MAPK14, MAPK8, PPARG, PPARGC1A, PRKAA2
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 4 AKT1, CASP1, CD86, TNF
Cytoplasmic side 1 HMOX1
lamellipodium 1 AKT1
Golgi apparatus membrane 1 NLRP3
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 2 CD86, TNF
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi apparatus 1 PRKAA2
Golgi membrane 1 NLRP3
neuronal cell body 3 CASP3, PRKAA2, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 NLRP3
plasma membrane 6 AKT1, CASP1, CD86, IFNLR1, TNF, UGT1A1
Membrane 7 AKT1, CD86, HMOX1, IFNLR1, NLRP3, PRKAA2, UGT1A1
axon 2 MAPK8, PRKAA2
caveola 1 PTGS2
extracellular exosome 4 CD86, GPT, GSR, MMP9
endoplasmic reticulum 4 HMOX1, NLRP3, PTGS2, UGT1A1
extracellular space 5 HMOX1, IL10, IL6, MMP9, TNF
perinuclear region of cytoplasm 3 HMOX1, PPARG, UGT1A1
mitochondrion 3 GSR, MAPK14, NLRP3
protein-containing complex 3 AKT1, CASP1, PTGS2
intracellular membrane-bounded organelle 1 PPARG
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 CD86, IFNLR1
Secreted 3 IL10, IL6, NLRP3
extracellular region 6 IL10, IL6, MAPK14, MMP9, NLRP3, TNF
Single-pass membrane protein 1 UGT1A1
mitochondrial outer membrane 1 HMOX1
mitochondrial matrix 1 GSR
centriolar satellite 1 CD86
external side of plasma membrane 3 CD86, GSR, TNF
Secreted, extracellular space, extracellular matrix 1 MMP9
microtubule cytoskeleton 1 AKT1
nucleolus 1 CASP1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Cytoplasm, perinuclear region 1 UGT1A1
Membrane raft 1 TNF
microtubule 1 CASP1
spindle 1 AKT1
Nucleus, PML body 1 PPARGC1A
PML body 1 PPARGC1A
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 MMP9
nuclear speck 2 MAPK14, PRKAA2
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 2 CASP1, NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 PPARG
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 PPARG, PPARGC1A
phagocytic cup 1 TNF
spindle pole 1 MAPK14
Endomembrane system 1 NLRP3
microtubule organizing center 1 NLRP3
cytoplasmic stress granule 1 PRKAA2
ficolin-1-rich granule lumen 2 MAPK14, MMP9
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 2 IL6, PTGS2
tertiary granule lumen 1 MMP9
Single-pass type IV membrane protein 1 HMOX1
AIM2 inflammasome complex 1 CASP1
[Isoform 1]: Nucleus 1 PPARGC1A
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
canonical inflammasome complex 1 CASP1
nucleotide-activated protein kinase complex 1 PRKAA2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 UGT1A1
cytochrome complex 1 UGT1A1
IPAF inflammasome complex 1 CASP1
NLRP1 inflammasome complex 1 CASP1
protease inhibitor complex 1 CASP1
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform B4]: Nucleus 1 PPARGC1A
[Isoform B4-8a]: Cytoplasm 1 PPARGC1A
[Isoform B5]: Nucleus 1 PPARGC1A
[Isoform 9]: Nucleus 1 PPARGC1A


文献列表

  • Di He, Xinyi Pei, Bo Liu, Jiajing Li, Juane Dong, Thomas Efferth, Pengda Ma. Lignan contents of Schisandra chinensis (Turcz.) Baill. from different origins-A new model for evaluating the content of prominent components of Chinese herbs. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155361. doi: 10.1016/j.phymed.2024.155361. [PMID: 38552434]
  • Jia Zhao, Guang Xu, Xiaorong Hou, Wenqing Mu, Huijie Yang, Wei Shi, Jincai Wen, Tingting Liu, Zhixin Wu, Jun Bai, Ping Zhang, Zhongxia Wang, Xiaohe Xiao, Wenjun Zou, Zhaofang Bai, Xiaoyan Zhan. Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication. Journal of ethnopharmacology. 2023 Mar; ?(?):116427. doi: 10.1016/j.jep.2023.116427. [PMID: 37001770]
  • Miran Jang, Soo-Im Choi. Schisandrin C isolated from Schisandra chinensis fruits inhibits lipid accumulation by regulating adipogenesis and lipolysis through AMPK signaling in 3T3-L1 adipocytes. Journal of food biochemistry. 2022 12; 46(12):e14454. doi: 10.1111/jfbc.14454. [PMID: 36200699]
  • Yiwen Zhang, Saiyu Li, Panpan Yang, Qian Zhang, Huarong Xu, Kaishun Bi, Qing Li. A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154273. doi: 10.1016/j.phymed.2022.154273. [PMID: 36044818]
  • Qiangqiang Tao, Wei Wei, Xiaoqing Lv, Jian Guo, Yaotian Tao, Mingming Zhang, Ge He, Zhi Li, Shuangying Gui, Xiaodong Ma. SAR study culminates in a series of HDAC6 selective inhibitors featuring Schisandrin C-analogous Cap as potential immunomodulatory agents for cancer therapy. Bioorganic chemistry. 2022 10; 127(?):105992. doi: 10.1016/j.bioorg.2022.105992. [PMID: 35785553]
  • Wen-Zhang Dai, Zhao-Fang Bai, Ting-Ting He, Xiao-Yan Zhan, Qiang Li, Jing Zhao, Xiao-He Xiao. [Schisandrin C improves acetaminophen-induced liver injury in mice by regulating Nrf2 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Oct; 47(19):5299-5305. doi: 10.19540/j.cnki.cjcmm.20220421.704. [PMID: 36472037]
  • Yiwen Zhang, Xinyan Lv, Ran Liu, Mingyang Zhang, Haopeng Liu, Hao Gao, Qian Zhang, Huarong Xu, Qing Li, Kaishun Bi. An integrated strategy for ascertaining quality marker of Schisandra chinensis (Turcz.) Baill based on correlation analysis between depression-related monoaminergic metabolites and chemical components profiling. Journal of chromatography. A. 2019 Aug; 1598(?):122-131. doi: 10.1016/j.chroma.2019.03.056. [PMID: 31047662]
  • Peili Zhu, Junkui Li, Xiuqiong Fu, Zhiling Yu. Schisandra fruits for the management of drug-induced liver injury in China: A review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Jun; 59(?):152760. doi: 10.1016/j.phymed.2018.11.020. [PMID: 31004881]
  • Maarit Kortesoja, Elina Karhu, Elin Soffia Olafsdottir, Jona Freysdottir, Leena Hanski. Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells. Free radical biology & medicine. 2019 02; 131(?):309-317. doi: 10.1016/j.freeradbiomed.2018.12.019. [PMID: 30578916]
  • Jing-Jing Wu, Yun-Feng Cao, Liang Feng, Yu-Qi He, James Y Hong, Tong-Yi Dou, Ping Wang, Da-Cheng Hao, Guang-Bo Ge, Ling Yang. A Naturally Occurring Isoform-Specific Probe for Highly Selective and Sensitive Detection of Human Cytochrome P450 3A5. Journal of medicinal chemistry. 2017 05; 60(9):3804-3813. doi: 10.1021/acs.jmedchem.7b00001. [PMID: 28441491]
  • Lian-lin Su, Xue Cheng, De Ji, Li-jun Wang, Xi-yan Ding, Tu-lin Lu, Chun-qin Mao, Ji Zhang. [Analysis of lignans and their metabolites derived from Schisandra chinensis and vinegar Schisandra chinensis in rats’ plasma, bile, urine and faeces based on UHPLC-QTOF/MS]. Yao xue xue bao = Acta pharmaceutica Sinica. 2016 10; 51(10):1600-8. doi: . [PMID: 29932608]
  • Jin-Hui Song, Li Cui, Li-Bin An, Wen-Tao Li, Zhong-Ze Fang, Yan-Yan Zhang, Pei-Pei Dong, Xue Wu, Li-Xuan Wang, Frank J Gonzalez, Xiao-Yu Sun, De-Wei Zhao. Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis. Phytotherapy research : PTR. 2015 Oct; 29(10):1658-64. doi: 10.1002/ptr.5395. [PMID: 26084208]
  • Tao Yang, Shan Liu, Tian-Hui Zheng, Yan-Yan Tao, Cheng-Hai Liu. Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe. Journal of ethnopharmacology. 2015 May; 166(?):305-12. doi: 10.1016/j.jep.2015.03.024. [PMID: 25794805]
  • Yiming Jiang, Xiaomei Fan, Ying Wang, Huasen Tan, Pan Chen, Hang Zeng, Min Huang, Huichang Bi. Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation. Chemico-biological interactions. 2015 Apr; 231(?):83-9. doi: 10.1016/j.cbi.2015.02.022. [PMID: 25753323]
  • Li-shi Zheng, Shu-shan Du, Qian Cai. [Study on chemical constituents from Schisandra chinensis stem]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Oct; 37(10):1803-6. doi: . [PMID: 25895389]
  • Xin Song, Pu Ding, Xian-Kuan Li, Ting Chen, Liang Chen, Bing Wang. [Effect of forchlorfenuron on fruit morphology and lignans content of Schisandra chinensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 May; 39(9):1579-83. doi: . [PMID: 25095364]
  • Haitao Liu, Hongwu Lai, Xinyue Jia, Jiushi Liu, Zhao Zhang, Yaodong Qi, Jin Zhang, Junbin Song, Chongming Wu, Bengang Zhang, Peigen Xiao. Comprehensive chemical analysis of Schisandra chinensis by HPLC-DAD-MS combined with chemometrics. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Sep; 20(12):1135-43. doi: 10.1016/j.phymed.2013.05.001. [PMID: 23880331]
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  • Ju-Xian Song, Xiang Lin, Ricky Ngok-Shun Wong, Stephen Cho-Wing Sze, Yao Tong, Pang-Chui Shaw, Yan-Bo Zhang. Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells. Phytotherapy research : PTR. 2011 Mar; 25(3):435-43. doi: 10.1002/ptr.3269. [PMID: 20740476]
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