savinin (BioDeep_00000008381)

PANOMIX_OTCML-2023

代谢物信息卡片

(-)-Hibalactone; (-)-Savinin; NSC 150442;Savinine;Hibalactone

化学式: C20H16O6 (352.0946836)
中文名称: 洒维宁
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 42.5%

分子结构信息

SMILES: C1C(C(=CC2=CC3=C(C=C2)OCO3)C(=O)O1)CC4=CC5=C(C=C4)OCO5
InChI: InChI=1S/C20H16O6/c21-20-15(6-13-2-4-17-19(8-13)26-11-24-17)14(9-22-20)5-12-1-3-16-18(7-12)25-10-23-16/h1-4,6-8,14H,5,9-11H2/b15-6+/t14-/m0/s1

描述信息

A lignan that is dihydrofuran-2(3H)-one (gamma-butyrolactone) substituted by a 1,3-benzodioxol-5-ylmethylidene group at position 3 and a 1,3-benzodioxol-5-ylmethyl group at position 4 (the 3E,4R-isomer). It exhibits antiviral activity against SARS-CoV-2.

同义名列表

4 个代谢物同义名

(-)-Hibalactone; (-)-Savinin; savinin; (-)-Hibalactone; (-)-Savinin; NSC 150442;Savinine;Hibalactone

数据库引用编号

15 个数据库交叉引用编号

ChEBI: CHEBI:9044
KEGG: C10880
PubChem: 5281867
PubChem: 98946
Metlin: METLIN68651
ChEMBL: CHEMBL395263
KNApSAcK: C00002624
KNApSAcK: C00040740
CAS: 493-95-8
PMhub: MS000021994
MetaboLights: MTBLC9044
PubChem: 13063
3DMET: B04184
NIKKAJI: J15.186F
RefMet: Savinin

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

1123434 - Amyris pinnata: 10.1021/NP50015A016
158548 - Aristolochia indica: 10.1021/NP50032A017
187461 - Chamaecyparis formosensis: 10.1016/S0031-9422(99)00074-6
13415 - Chamaecyparis obtusa:
50304 - Eleutherococcus:
50305 - Eleutherococcus nodiflorus: 10.1016/J.JEP.2012.03.034
2803927 - Hypoestes purpurea: 10.1021/NP0497402
50182 - Juniperus chinensis: 10.1016/0031-9422(92)83753-L
58039 - Juniperus communis: 10.3891/ACTA.CHEM.SCAND.15-0455
453927 - Juniperus formosana:
669713 - Juniperus horizontalis: 10.1139/V61-339
99809 - Juniperus rigida: 10.1007/S12272-011-1206-9
177241 - Juniperus thurifera:
2038563 - Justicia hyssopifolia: 10.1002/CHIN.200431180
480358 - Linum corymbulosum: 10.1055/S-2006-947238
69918 - Micranthemum umbrosum:
1071199 - Pterocarpus santalinus: 10.1248/BPB.24.167
37565 - Ruta graveolens: 10.1016/J.PHYTOCHEM.2009.08.007
452792 - Ruta microcarpa: 10.1016/J.PHYTOCHEM.2009.08.007
452794 - Ruta pinnata: 10.1016/J.PHYTOCHEM.2009.08.007
50187 - Taiwania cryptomerioides:
25629 - Taxus baccata: 10.1021/NP040152Y
354528 - Zanthoxylum nitidum:

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Siqi Tang, Chunying Li, Zongwu Suo, Yi Xu, Kaixin Wei, Lei Zhao, Hao Huang, Xiangqian Liu, Dongxu Liu, Xiaojun Li. Neuroprotective Effects of Savinin on LPS-Induced Neuroinflammation In Vivo via Regulating MAPK/NF-κB Pathway and NLRP3 Inflammasome Activation. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041575. [PMID: 36838564]
Tayyab A Mansoor, Pedro M Borralho, Xuan Luo, Silva Mulhovo, Cecília M P Rodrigues, Maria-José U Ferreira. Apoptosis inducing activity of benzophenanthridine-type alkaloids and 2-arylbenzofuran neolignans in HCT116 colon carcinoma cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Jul; 20(10):923-9. doi: 10.1016/j.phymed.2013.03.026. [PMID: 23643093]
Chih-Chun Wen, Yueh-Hsiung Kuo, Jia-Tsrong Jan, Po-Huang Liang, Sheng-Yang Wang, Hong-Gi Liu, Ching-Kuo Lee, Shang-Tzen Chang, Chih-Jung Kuo, Shoei-Sheng Lee, Chia-Chung Hou, Pei-Wen Hsiao, Shih-Chang Chien, Lie-Fen Shyur, Ning-Sun Yang. Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. Journal of medicinal chemistry. 2007 Aug; 50(17):4087-95. doi: 10.1021/jm070295s. [PMID: 17663539]
José Andrés Pérez, Carlos Boluda, Hermelo López, Juan Manuel Trujillo. Justicidone, a novel p-quinone-lignan derivative from Justicia hyssopifolia. Chemical & pharmaceutical bulletin. 2004 Jan; 52(1):130-1. doi: 10.1248/cpb.52.130. [PMID: 14709880]
C T Che, M S Ahmed, S S Kang, D P Waller, A S Bingel, A Martin, P Rajamahendran, N Bunyapraphatsara, D C Lankin, G A Cordell. Studies on Aristolochia III. Isolation and biological evaluation of constituents of Aristolochia indica roots for fertility-regulating activity. Journal of natural products. 1984 Mar; 47(2):331-41. doi: 10.1021/np50032a017. [PMID: 6539809]
J Watkins, A Padfield, J D Alderson. Underlying immunopathology as a cause of adverse responses to two intravenous anaesthetic agents. British medical journal. 1978 May; 1(6121):1180-1. doi: 10.1136/bmj.1.6121.1180. [PMID: 638678]