Morindone (BioDeep_00000008057)

 

Secondary id: BioDeep_00000862662

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


1,2,5-Trihydroxy-6-methyl-9,10-anthracenedione

化学式: C15H10O5 (270.0528)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C2=C(C=C1)C(=O)C3=C(C2=O)C=CC(=C3O)O)O
InChI: InChI=1S/C15H10O5/c1-6-2-3-7-10(12(6)17)13(18)8-4-5-9(16)15(20)11(8)14(7)19/h2-5,16-17,20H,1H3

描述信息

同义名列表

3 个代谢物同义名

Morindone; 1,2,5-Trihydroxy-6-methyl-9,10-anthracenedione; Morindone



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

38 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 AR, CTNNB1, MDM2, WDHD1
Endosome membrane 1 INSR
Nucleus 8 AR, CTNNB1, GINS2, MCM10, MCM5, MCM6, MDM2, POLE2
cytosol 3 AR, CTNNB1, MDM2
nuclear body 1 POLE2
centrosome 1 CTNNB1
nucleoplasm 10 AR, CTNNB1, GINS2, MCM10, MCM5, MCM6, MDM2, POLE2, PRIM1, WDHD1
Cell membrane 3 CTNNB1, DPP4, INSR
lamellipodium 2 CTNNB1, DPP4
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 2 CTNNB1, DPP4
cell surface 1 DPP4
glutamatergic synapse 2 CTNNB1, MDM2
lysosomal membrane 2 DPP4, GAA
presynaptic membrane 1 CTNNB1
Lysosome 2 GAA, INSR
plasma membrane 7 AR, CTNNB1, DPP4, GAA, GCG, INSR, MDM2
Membrane 7 AR, CTNNB1, DPP4, GAA, INSR, MCM5, PRIM1
apical plasma membrane 1 DPP4
axon 1 INSR
basolateral plasma membrane 1 CTNNB1
caveola 1 INSR
extracellular exosome 4 CTNNB1, DPP4, GAA, INSR
Lysosome membrane 1 GAA
extracellular space 1 GCG
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 CTNNB1
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercellular canaliculus 1 DPP4
protein-containing complex 3 AR, CTNNB1, MDM2
intracellular membrane-bounded organelle 2 GAA, POLE2
postsynaptic density 1 MDM2
Single-pass type I membrane protein 1 INSR
Secreted 3 DPP4, GAA, GCG
extracellular region 3 DPP4, GAA, GCG
Single-pass membrane protein 1 DPP4
neuronal cell body membrane 1 INSR
anchoring junction 1 DPP4
transcription regulator complex 1 CTNNB1
external side of plasma membrane 1 INSR
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 2 MCM10, MDM2
Wnt signalosome 1 CTNNB1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
Single-pass type II membrane protein 1 DPP4
postsynaptic membrane 1 CTNNB1
Apical cell membrane 1 DPP4
Membrane raft 1 DPP4
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 2 CTNNB1, DPP4
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
nuclear speck 1 AR
Late endosome 1 INSR
receptor complex 1 INSR
chromatin 1 AR
cell periphery 1 CTNNB1
Chromosome 3 GINS2, MCM5, MCM6
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Nucleus, nucleolus 1 MDM2
spindle pole 1 CTNNB1
nuclear replication fork 2 MCM10, WDHD1
chromosome, telomeric region 2 MCM5, MCM6
nuclear chromosome 1 GINS2
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
Endomembrane system 2 CTNNB1, DPP4
Nucleus, nucleoplasm 2 MDM2, WDHD1
tertiary granule membrane 1 GAA
euchromatin 1 CTNNB1
secretory granule lumen 1 GCG
endoplasmic reticulum lumen 1 GCG
transcription repressor complex 1 MDM2
endocytic vesicle membrane 1 MDM2
endocytic vesicle 1 DPP4
azurophil granule membrane 1 GAA
beta-catenin-TCF complex 1 CTNNB1
presynaptic active zone cytoplasmic component 1 CTNNB1
protein-DNA complex 2 CTNNB1, GINS2
ficolin-1-rich granule membrane 1 GAA
dendrite membrane 1 INSR
catenin complex 1 CTNNB1
CMG complex 3 GINS2, MCM5, MCM6
lamellipodium membrane 1 DPP4
[Glucagon-like peptide 1]: Secreted 1 GCG
Cell projection, lamellipodium membrane 1 DPP4
Cell projection, invadopodium membrane 1 DPP4
insulin receptor complex 1 INSR
alpha DNA polymerase:primase complex 1 PRIM1
autolysosome lumen 1 GAA
beta-catenin-TCF7L2 complex 1 CTNNB1
MCM complex 2 MCM5, MCM6
[Dipeptidyl peptidase 4 soluble form]: Secreted 1 DPP4
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
primosome complex 1 PRIM1
epsilon DNA polymerase complex 1 POLE2
GINS complex 1 GINS2
DNA-directed RNA polymerase complex 1 PRIM1


文献列表

  • Hafidha Mehallah, Noureddine Djebli, Pham Ngoc Khanh, Nguyen Xuan Ha, Vu Thi Ha, Tran Thu Huong, Do Dinh Tung, Nguyen Manh Cuong. In silico and in vivo study of anti-inflammatory activity of Morinda longissima (Rubiaceae) extract and phytochemicals for treatment of inflammation-mediated diseases. Journal of ethnopharmacology. 2024 Jun; 328(?):118051. doi: 10.1016/j.jep.2024.118051. [PMID: 38493905]
  • Cheok Wui Chee, Nor Hisam Zamakshshari, Vannajan Sanghiran Lee, Iskandar Abdullah, Rozana Othman, Yean Kee Lee, Najihah Mohd Hashim, Nurshamimi Nor Rashid. Morindone from Morinda citrifolia as a potential antiproliferative agent against colorectal cancer cell lines. PloS one. 2022; 17(7):e0270970. doi: 10.1371/journal.pone.0270970. [PMID: 35819953]
  • Yuxiao Yao, Shaoyang Sun, Fei Fei, Jingjing Wang, Youhua Wang, Ranran Zhang, Jing Wu, Lian Liu, Xiuyun Liu, Zhaomeng Cui, Qiang Li, Min Yu, Yongjun Dang, Xu Wang. Screening in larval zebrafish reveals tissue-specific distribution of fifteen fluorescent compounds. Disease models & mechanisms. 2017 09; 10(9):1155-1164. doi: 10.1242/dmm.028811. [PMID: 28754836]
  • H Tosa, M Iinuma, F Asai, T Tanaka, H Nozaki, S Ikeda, K Tsutsui, K Tsutsui, M Yamada, S Fujimori. Anthraquinones from Neonauclea calycina and their inhibitory activity against DNA topoisomerase II. Biological & pharmaceutical bulletin. 1998 Jun; 21(6):641-2. doi: 10.1248/bpb.21.641. [PMID: 9657055]