Dunnione (BioDeep_00000008031)

 

Secondary id: BioDeep_00001876762

human metabolite blood metabolite natural product


代谢物信息卡片


2,3,3-trimethyl-2H,3H,4H,5H-naphtho[1,2-b]furan-4,5-dione

化学式: C15H14O3 (242.0943)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C2=C(O1)C3=CC=CC=C3C(=O)C2=O)(C)C
InChI: InChI=1S/C15H14O3/c1-8-15(2,3)11-13(17)12(16)9-6-4-5-7-10(9)14(11)18-8/h4-8H,1-3H3

描述信息

同义名列表

3 个代谢物同义名

2,3,3-trimethyl-2H,3H,4H,5H-naphtho[1,2-b]furan-4,5-dione; Dunnione; Dunnione



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 BCL2, CASP3, CST3, MSMP, NCF1, NQO1, SIRT1, STAT3
Peripheral membrane protein 2 GORASP1, NCF1
Endoplasmic reticulum membrane 2 BCL2, HMOX1
Nucleus 8 BCL2, CASP3, GABPA, HMOX1, NQO1, PARP1, SIRT1, STAT3
cytosol 10 BCL2, CASP3, HMOX1, NCF1, NCF2, NQO1, NQO2, PARP1, SIRT1, STAT3
dendrite 2 NCF1, NQO1
nuclear body 1 PARP1
nucleoplasm 7 CASP3, GABPA, HMOX1, NQO2, PARP1, SIRT1, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 2 NOX1, TNF
Cytoplasmic side 3 GORASP1, HMOX1, NCF1
Multi-pass membrane protein 1 NOX1
Golgi apparatus membrane 1 GORASP1
Synapse 1 NQO1
cell surface 2 F3, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 2 CST3, GORASP1
Golgi membrane 1 GORASP1
neuronal cell body 4 CASP3, NCF1, NQO1, TNF
Cytoplasm, cytosol 3 NCF1, NQO1, PARP1
acrosomal vesicle 1 NCF2
plasma membrane 7 CST3, F3, NCF1, NCF2, NOX1, STAT3, TNF
Membrane 8 BCL2, F3, HMOX1, NCF1, NCF2, NOX1, NQO1, PARP1
extracellular exosome 2 CST3, NQO2
endoplasmic reticulum 3 BCL2, CST3, HMOX1
extracellular space 7 CST3, F3, HMOX1, IL17A, IL22, MSMP, TNF
perinuclear region of cytoplasm 1 HMOX1
mitochondrion 3 BCL2, PARP1, SIRT1
protein-containing complex 2 BCL2, PARP1
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 1 F3
Secreted 5 CST3, IL17A, IL22, IL23A, MSMP
extracellular region 5 CST3, IL17A, IL22, IL23A, TNF
cytoplasmic side of plasma membrane 1 NCF1
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
[Isoform 1]: Membrane 1 F3
[Isoform 2]: Secreted 1 F3
anchoring junction 1 NOX1
transcription regulator complex 2 PARP1, STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 F3, IL17A, TNF
nucleolus 2 PARP1, SIRT1
Early endosome 1 NOX1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 CST3
heterochromatin 1 SIRT1
Membrane raft 1 TNF
pore complex 1 BCL2
cis-Golgi network 1 GORASP1
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
collagen-containing extracellular matrix 1 F3
nuclear inner membrane 1 SIRT1
chromatin 4 GABPA, PARP1, SIRT1, STAT3
cell projection 1 NOX1
phagocytic cup 1 TNF
Chromosome 1 PARP1
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
site of double-strand break 1 PARP1
fibrillar center 1 SIRT1
nuclear envelope 2 PARP1, SIRT1
euchromatin 1 SIRT1
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CST3
endoplasmic reticulum lumen 2 CST3, IL23A
tertiary granule lumen 1 CST3
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
protein-DNA complex 1 PARP1
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
site of DNA damage 1 PARP1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
NADPH oxidase complex 3 NCF1, NCF2, NOX1
Cell projection, invadopodium membrane 1 NOX1
serine-type peptidase complex 1 F3
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
phagolysosome 2 NCF1, NCF2
interleukin-23 complex 1 IL23A
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Vanessa Winiewski, Mariana Mesquita Fonseca, Marcos José Salvador, Eduardo Lemos de Sá, Maria Élida Alves Stefanello. Three new naphthoquinones from the tubers of Sinningia mauroana. Natural product research. 2023 Jan; 37(2):263-268. doi: 10.1080/14786419.2021.1969564. [PMID: 34498959]
  • Dipendra Khadka, Hyung-Jin Kim, Gi-Su Oh, AiHua Shen, SeungHoon Lee, Su-Bin Lee, Subham Sharma, Seon Young Kim, Arpana Pandit, Seong-Kyu Choe, Tae Hwan Kwak, Sei-Hoon Yang, Hyuk Sim, Gwang Hyeon Eom, Raekil Park, Hong-Seob So. Augmentation of NAD+ levels by enzymatic action of NAD(P)H quinone oxidoreductase 1 attenuates adriamycin-induced cardiac dysfunction in mice. Journal of molecular and cellular cardiology. 2018 11; 124(?):45-57. doi: 10.1016/j.yjmcc.2018.10.001. [PMID: 30291911]
  • Saeed Nazari Soltan Ahmad, Nadereh Rashtchizadeh, Hassan Argani, Leila Roshangar, Amir Ghorbani Haghjo, Davoud Sanajou, Fatemeh Panah, Zahra Ashrafi Jigheh, Siavoush Dastmalchi, Mehran Mesgari-Abbasi. Dunnione protects against experimental cisplatin-induced nephrotoxicity by modulating NQO1 and NAD+ levels. Free radical research. 2018 Jul; 52(7):808-817. doi: 10.1080/10715762.2018.1475732. [PMID: 29865885]
  • Adson S Soares, Felipe L Barbosa, André L Rüdiger, David L Hughes, Marcos J Salvador, Aleksander R Zampronio, Maria Élida A Stefanello. Naphthoquinones of Sinningia reitzii and Anti-inflammatory/Antinociceptive Activities of 8-Hydroxydehydrodunnione. Journal of natural products. 2017 06; 80(6):1837-1843. doi: 10.1021/acs.jnatprod.6b01186. [PMID: 28598175]
  • Dilamara R Scharf, Maria H Verdan, Marcos A Ribeiro, Edesio L Simionatto, Eduardo L Sá, Marcos J Salvador, Andersson Barison, Maria E A Stefanello. Naphthochromenes and Related Constituents from the Tubers of Sinningia allagophylla. Journal of natural products. 2016 Apr; 79(4):792-8. doi: 10.1021/acs.jnatprod.5b00799. [PMID: 27043314]
  • Bhupinder P S Khambay, Duncan Batty, Philip J Jewess, Geoffrey L Bateman, Derek W Hollomon. Mode of action and pesticidal activity of the natural product dunnione and of some analogues. Pest management science. 2003 Feb; 59(2):174-82. doi: 10.1002/ps.632. [PMID: 12587871]